LOCUS       NM_001395721            1583 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TNF superfamily member 13b (Tnfsf13b), mRNA.
ACCESSION   NM_001395721 XM_006253482
VERSION     NM_001395721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Herrock,O., Deer,E., Amaral,L.M., Campbell,N., Whitney,D.,
            Ingram,N., Cornelius,D.C., Turner,T., Hardy-Hardin,J., Booz,G.W.,
            Ibrahim,T. and LaMarca,B.
  TITLE     Inhibiting B cell activating factor attenuates preeclamptic
            symptoms in placental ischemic rats
  JOURNAL   Am J Reprod Immunol 89 (4), e13693 (2023)
   PUBMED   36794639
  REMARK    GeneRIF: Inhibiting B cell activating factor attenuates
            preeclamptic symptoms in placental ischemic rats.
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Khlaiphuengsin,A., Chuaypen,N., Hirankarn,N., Avihingsanon,A.,
            Crane,M., Lewin,S.R. and Tangkijvanich,P.
  TITLE     Circulating BAFF and CXCL10 levels predict response to pegylated
            interferon in patients with HBeAg-positive chronic hepatitis B
  JOURNAL   Asian Pac J Allergy Immunol 39 (2), 129-135 (2021)
   PUBMED   30660173
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Jia,X., Wei,F., Sun,X., Chang,Y., Xu,S., Yang,X., Wang,C. and
            Wei,W.
  TITLE     CP-25 attenuates the inflammatory response of fibroblast-like
            synoviocytes co-cultured with BAFF-activated CD4(+) T cells
  JOURNAL   J Ethnopharmacol 189, 194-201 (2016)
   PUBMED   27196292
  REMARK    GeneRIF: CP-25 attenuates the inflammatory response of
            fibroblast-like synoviocytes from arthritic rats co-cultured with
            BAFF-activated CD4(+) T cells.
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Wei,F., Xu,S., Jia,X., Sun,X., Yang,X., Wei,W. and Chang,Y.
  TITLE     BAFF and its receptors involved in the inflammation progress in
            adjuvant induced arthritis rats
  JOURNAL   Int Immunopharmacol 31, 1-8 (2016)
   PUBMED   26688104
  REMARK    GeneRIF: increased spleen levels at early stage of adjuvant induced
            arthritis
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian tumor necrosis factor
            ligand genes
  JOURNAL   Immunogenetics 68 (2), 125-132 (2016)
   PUBMED   26646413
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Guan,Z.B., Dan,W.B., Shui,Y., Ye,J.L. and Zhang,S.Q.
  TITLE     cDNA cloning, expression and bioactivity of porcine BAFF
  JOURNAL   Dev Comp Immunol 31 (12), 1211-1219 (2007)
   PUBMED   17499850
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Qian,Y., Qin,J., Cui,G., Naramura,M., Snow,E.C., Ware,C.F.,
            Fairchild,R.L., Omori,S.A., Rickert,R.C., Scott,M., Kotzin,B.L. and
            Li,X.
  TITLE     Act1, a negative regulator in CD40- and BAFF-mediated B cell
            survival
  JOURNAL   Immunity 21 (4), 575-587 (2004)
   PUBMED   15485634
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Ye,Q., Wang,L., Wells,A.D., Tao,R., Han,R., Davidson,A., Scott,M.L.
            and Hancock,W.W.
  TITLE     BAFF binding to T cell-expressed BAFF-R costimulates T cell
            proliferation and alloresponses
  JOURNAL   Eur J Immunol 34 (10), 2750-2759 (2004)
   PUBMED   15368291
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Ng,L.G., Sutherland,A.P., Newton,R., Qian,F., Cachero,T.G.,
            Scott,M.L., Thompson,J.S., Wheway,J., Chtanova,T., Groom,J.,
            Sutton,I.J., Xin,C., Tangye,S.G., Kalled,S.L., Mackay,F. and
            Mackay,C.R.
  TITLE     B cell-activating factor belonging to the TNF family (BAFF)-R is
            the principal BAFF receptor facilitating BAFF costimulation of
            circulating T and B cells
  JOURNAL   J Immunol 173 (2), 807-817 (2004)
   PUBMED   15240667
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Rahman,Z.S., Rao,S.P., Kalled,S.L. and Manser,T.
  TITLE     Normal induction but attenuated progression of germinal center
            responses in BAFF and BAFF-R signaling-deficient mice
  JOURNAL   J Exp Med 198 (8), 1157-1169 (2003)
   PUBMED   14557413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 2, 2021 this sequence version replaced XM_006253482.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LN874414.1, SRR26360186.443167.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               JAXUCZ010000016.1  86193997-86194499   c
            504-588             JAXUCZ010000016.1  86193825-86193909   c
            589-645             JAXUCZ010000016.1  86180389-86180445   c
            646-758             JAXUCZ010000016.1  86169371-86169483   c
            759-909             JAXUCZ010000016.1  86169140-86169290   c
            910-1583            JAXUCZ010000016.1  86164377-86165050   c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1583
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /note="TNF superfamily member 13b"
                     /db_xref="GeneID:498666"
                     /db_xref="RGD:1561519"
     exon            1..503
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1022
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     13b; tumor necrosis factor ligand 7a; B-cell-activating
                     factor; tumor necrosis factor superfamily member 13b"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     13B"
                     /protein_id="NP_001382650.1"
                     /db_xref="GeneID:498666"
                     /db_xref="RGD:1561519"
                     /translation="MVTYSKGPDLQSAPLGMDKSAKNLPPPRLCFCPEKGEDMKVGYV
                     PITPQKEGAWVGICRDRRLLAATLLLALLSSSFTAMSLYQLAVLQADLMSLRMELQSY
                     RSSATPAAPGAPGLSAGVKLPTPAAPGPHNSSRGQRNRRAFQGPEETVIQDCLQLIAD
                     SNTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYTDPIFAMGH
                     VIQRKKIHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIAKLEEGDEIQLAIPRENA
                     QISRNGDDTFFGALKLL"
     exon            504..588
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /inference="alignment:Splign:2.1.0"
     exon            589..645
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /inference="alignment:Splign:2.1.0"
     exon            646..758
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /inference="alignment:Splign:2.1.0"
     exon            759..909
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1583
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; RGD1561519; Tnlg7a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattgagca atcaatggaa ggccagagcc agagaaccta cttcagggta gcaaaagatg
       61 cagaagagag aaagtcagga gagtgccatg ctctgagggc agcctcctga gacacagatg
      121 acaggaaatg acctaccccc atggtcactt actccaaagg cccagacctt caaagtgctc
      181 ctcttggaat ggataagtct gcaaagaacc tgccaccacc gcgcctctgt ttttgccctg
      241 agaaaggaga agatatgaaa gtgggatatg ttcccatcac tccgcagaag gagggtgcct
      301 gggttgggat ctgcagggac agacggctgc tggctgctac cctcctgctg gctctgttgt
      361 ccagcagttt cacagcgatg tccttgtacc agttggctgt cctgcaagca gacctgatga
      421 gcctgcgcat ggagctgcag agctaccgaa gttcagcgac acccgccgcc ccgggggctc
      481 cagggttgtc cgcgggagtc aaactcccaa cacccgcagc tcctggaccc cacaactcca
      541 gccgaggcca aaggaacaga cgcgctttcc agggaccgga ggaaacagtc attcaagact
      601 gtctgcagct gattgcagac agcaacacgc cgactatacg aaaaggaact tacacatttg
      661 ttccatggct tctcagcttt aaaagaggaa acgccttgga ggagaaagag aacaaaatag
      721 tggtgaggca aacaggctat ttcttcatct acagccaggt tctgtacacg gaccccatct
      781 ttgccatggg tcatgtcatc cagaggaaga aaatacacgt gtttggggat gagctgagcc
      841 tggtgactct gttccgatgc atccagaata tgccgaaaac actgcccaac aattcctgct
      901 actccgctgg catcgcgaag ctggaagaag gggacgagat tcagcttgca atacctcggg
      961 agaatgccca gatttcacgg aacggagacg acaccttctt tggtgcccta aaactgctgt
     1021 gacccacttg ctggagtatg tgaccccttc cctcctcttc tctgtacctc cgagggagaa
     1081 acggaccact ggagataaca aaagaggggg aacgtcgtca ccggaagttt tcccgtgagc
     1141 tgttgaatct ggtccaaagc aggaaataca acaggcagcc acatccaaag tgggtcatgt
     1201 gagttatgag aaatggagcc acatccaaaa tgacaggact aggaaggctg tttactcctg
     1261 tcctatgcca acacgcaccg ccgcaccctt gcttttcgcc gtgggaggca cacgttccga
     1321 atgcggggag atttccttgt tttgtgattc accgtgagaa gagggcccac ctttccaggt
     1381 cactgaagca ttcacgcaaa gtctcaggat ttaccctccc tcctcatgct aagtacgcgc
     1441 gcctctttcc caggtaacac tttggaaagg ttttgtgttg ggttgtttgt ttttaaatct
     1501 aggagtctgg aactggctat agacaagaat acttaacaaa ttcaactgta aaataaactt
     1561 aattaaaacc gtttaagtgt taa
//
