LOCUS       NM_001001513            1576 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus TNF superfamily member 12 (Tnfsf12), mRNA.
ACCESSION   NM_001001513 XM_340826
VERSION     NM_001001513.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1576)
  AUTHORS   Zhang H and Wang R.
  TITLE     TWEAK Knockdown Alleviates Post-Cardiac Arrest Brain Injury via the
            p38 MAPK/NF-kappaB Pathway
  JOURNAL   Discov Med 35 (177), 503-516 (2023)
   PUBMED   37553304
  REMARK    GeneRIF: TWEAK Knockdown Alleviates Post-Cardiac Arrest Brain
            Injury via the p38 MAPK/NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 1576)
  AUTHORS   Soliman NA, Abo El Gheit RE, Abdel Ghafar MT, AbuoHashish NA,
            Ibrahim MAA, Abo Safia HS, El-Saka MH and Elshamy AM.
  TITLE     Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-kappaB
            intricate network in experimentally doxorubicin-induced
            cardiotoxicity in rats: The role of curcumin
  JOURNAL   J Biochem Mol Toxicol 35 (8), e22829 (2021)
   PUBMED   34047412
  REMARK    GeneRIF: Unraveling the biomechanistic role of
            Rac1/TWEAK/Fn14/NF-kappaB intricate network in experimentally
            doxorubicin-induced cardiotoxicity in rats: The role of curcumin.
REFERENCE   3  (bases 1 to 1576)
  AUTHORS   Zhang J, Dong B, Hao J, Yi S, Cai W and Luo Z.
  TITLE     LncRNA Snhg3 contributes to dysfunction of cerebral microvascular
            cells in intracerebral hemorrhage rats by activating the
            TWEAK/Fn14/STAT3 pathway
  JOURNAL   Life Sci 237, 116929 (2019)
   PUBMED   31610210
  REMARK    GeneRIF: High TWEAK expression is associated with intracerebral
            hemorrhage.
REFERENCE   4  (bases 1 to 1576)
  AUTHORS   Reyes LM, Shah A, Quon A, Morton JS and Davidge ST.
  TITLE     The role of the tumor necrosis factor (TNF)-related weak inducer of
            apoptosis (TWEAK) in offspring exposed to prenatal hypoxia
  JOURNAL   J Dev Orig Health Dis 9 (6), 661-669 (2018)
   PUBMED   29249219
  REMARK    GeneRIF: Prenatal hypoxia in rats was not associated with
            differences in Fn-14 protein expression in either male or female
            offspring. Cardiomyocytes from prenatal hypoxic male, but not
            female, offspring had decreased proliferation compared with
            controls. Activation of the TWEAK/Fn-14 pathway leads to increased
            proliferation but does not appear to contribute to the reduced
            cardiomyocyte proliferative capacity in males.
REFERENCE   5  (bases 1 to 1576)
  AUTHORS   Padrao AI, Figueira AC, Faustino-Rocha AI, Gama A, Loureiro MM,
            Neuparth MJ, Moreira-Goncalves D, Vitorino R, Amado F, Santos LL,
            Oliveira PA, Duarte JA and Ferreira R.
  TITLE     Long-term exercise training prevents mammary tumorigenesis-induced
            muscle wasting in rats through the regulation of TWEAK signalling
  JOURNAL   Acta Physiol (Oxf) 219 (4), 803-813 (2017)
   PUBMED   27228549
  REMARK    GeneRIF: the present study provides molecular evidences that the
            interaction between endurance training and mammary tumorigenesis is
            mediated by TWEAK signalling
REFERENCE   6  (bases 1 to 1576)
  AUTHORS   Li HL, Zhuo ML, Wang D, Wang AB, Cai H, Sun LH, Yang Q, Huang Y,
            Wei YS, Liu PP, Liu DP and Liang CC.
  TITLE     Targeted cardiac overexpression of A20 improves left ventricular
            performance and reduces compensatory hypertrophy after myocardial
            infarction
  JOURNAL   Circulation 115 (14), 1885-1894 (2007)
   PUBMED   17389268
  REMARK    Erratum:[Circulation. 2020 Oct 13;142(15):e238. PMID: 33044851]
REFERENCE   7  (bases 1 to 1576)
  AUTHORS   Mueller AM, Pedre X, Kleiter I, Hornberg M, Steinbrecher A and
            Giegerich G.
  TITLE     Targeting fibroblast growth factor-inducible-14 signaling protects
            from chronic relapsing experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 159 (1-2), 55-65 (2005)
   PUBMED   15652403
REFERENCE   8  (bases 1 to 1576)
  AUTHORS   Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q,
            Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ,
            Borrow J and Wang Q.
  TITLE     Identification of an angiogenic factor that when mutated causes
            susceptibility to Klippel-Trenaunay syndrome
  JOURNAL   Nature 427 (6975), 640-645 (2004)
   PUBMED   14961121
REFERENCE   9  (bases 1 to 1576)
  AUTHORS   Saitoh T, Nakayama M, Nakano H, Yagita H, Yamamoto N and Yamaoka S.
  TITLE     TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB
            activation
  JOURNAL   J Biol Chem 278 (38), 36005-36012 (2003)
   PUBMED   12840022
  REMARK    GeneRIF: TWEAK (Tnfsf12) is a member of the TNF superfamily that
            has been shown to induce angiogenesis, apoptosis in tumor cells,
            and NF-kappaB activation through binding to its receptor,
            fibroblast growth factor-inducible 14
REFERENCE   10 (bases 1 to 1576)
  AUTHORS   Nakayama M, Harada N, Okumura K and Yagita H.
  TITLE     Characterization of murine TWEAK and its receptor (Fn14) by
            monoclonal antibodies
  JOURNAL   Biochem Biophys Res Commun 306 (4), 819-825 (2003)
   PUBMED   12821115
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079107.1.
            
            On Mar 27, 2005 this sequence version replaced NM_001001513.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079107.1, FQ221626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132307, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1576
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /note="TNF superfamily member 12"
                     /db_xref="GeneID:360548"
                     /db_xref="RGD:1359620"
     exon            1..452
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1043
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /note="TNF-related weak inducer of apoptosis; tumor
                     necrosis factor ligand 4a; tumor necrosis factor
                     superfamily member 12"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     12"
                     /protein_id="NP_001001513.2"
                     /db_xref="GeneID:360548"
                     /db_xref="RGD:1359620"
                     /translation="MAARRSQRRRGRRGEPGTALLAPLVLSLGLALACLGLLLVVVSL
                     GSWATLSAQEPSQEELTAEDHREPPELNPQTVESQDVVPFLEQLVRPRRSVSKGRKAR
                     PRRAIAAHYEVHPQPGQDGAQAGVDGTVSGWEETKINSSSPLRYDRQIGEFTVIRAGL
                     YYLYCQVHFDEGKAVYLKLDLLVNGVLALRCLEEFSATAASSPGPQLRLCQVSGLLPL
                     RPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH"
     exon            453..500
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            501..576
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            577..630
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            631..666
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            667..791
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1538
                     /gene="Tnfsf12"
                     /gene_synonym="Tnlg4a; TWEAK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgtccac ttctgctttc actggccctc agaggccttg gtctggagtg ccactgcggt
       61 cgcctgctag cacgcgccag ggcacaggac tcctctttct tgcaaagcac tccggggagg
      121 ctggagttta atcacacaaa cagtgtccgg cttcctgtcc tcatccgccc ccctccggcc
      181 cgcttccctg gtccctccct ctcccctggc ccgatccgcc caccagctcc ccctccccat
      241 ccctcgggtc ccgggatggg ggggcggtga ggcaggcaca gccccccgcc cccatggccg
      301 cccgtcggag ccagaggcgg agggggcgcc ggggggagcc gggcaccgcc ctgctggccc
      361 cgctggtgct gagcctgggc ctggcgttgg cctgccttgg cctcctgctg gtcgtggtca
      421 gcctggggag ctgggcaacg ctgtctgccc aggagccttc tcaggaggag ctgacagcag
      481 aggaccaccg ggagccccct gaactgaatc cccagacagt ggaaagccag gatgtggtac
      541 ctttcctgga acaactagtc cggcctcgaa gaagtgtttc taaaggccgg aaggcgcggc
      601 ctcgccgagc tattgcagcc cattatgagg ttcatccaca gccaggacag gatggagcac
      661 aggcaggtgt ggatgggaca gtgagtggct gggaagagac caaaatcaac agctccagcc
      721 ctctgcgcta tgaccgccag attggggaat ttacggtcat cagggctggg ctctactacc
      781 tgtactgtca ggtgcacttt gatgagggga aggcagtcta cctgaagctg gacttgctgg
      841 tgaatggtgt gctggccctg cgctgcctgg aagaattctc agccacagca gcgagctctc
      901 ctgggcccca gctccgtctg tgccaggtgt ctgggctgtt gcctctgcgg ccagggtctt
      961 cccttcggat ccgtaccctc ccctgggctc atcttaaggc tgcccccttc cttacctact
     1021 ttggactctt tcaagttcac tgaggggtcc tgctctccca ggttctttaa actttaacct
     1081 aacagctccc agagcaccac agcacctccc caccccacgc ccactcctcc accctctagc
     1141 tgttccttgc tccagtcctg tcctctcttc caaggcagcc agggcttgat gacatgtttt
     1201 ccattccaca gacatattcc cgttcttctg taacctccca ccccaccaca gctgcccgcc
     1261 tcacgagctc ccaaagcccc cacgtacccg actaccccgc cccaaccctg ggaccctgtt
     1321 tttactgact atgtgcatca ggcatcaaga taggctggac ctggtggcag gaagccaaag
     1381 aacctgggac taggccagaa gttcccaaat gtgaggggaa agagatggag acaagctcct
     1441 ccctggatcc ctgtggattt tgaaaagata ctatttttat tattattgtg acaaaatgtt
     1501 aaatggatat taaagagaat aaatcatgat ttctcttcaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaa
//
