LOCUS       NM_057149               2251 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus TNF superfamily member 11 (Tnfsf11), mRNA.
ACCESSION   NM_057149 XM_003751521 XM_006252374
VERSION     NM_057149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2251)
  AUTHORS   Wu,Z., Duan,S., Li,M., Zhang,A., Yang,H., Luo,J., Cheng,R. and
            Hu,T.
  TITLE     Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an
            experimental rat apical periodontitis model
  JOURNAL   Int Endod J 57 (9), 1315-1325 (2024)
   PUBMED   38923421
  REMARK    GeneRIF: Autophagy regulates bone loss via the RANKL/RANK/OPG axis
            in an experimental rat apical periodontitis model.
REFERENCE   2  (bases 1 to 2251)
  AUTHORS   Lim,J.H., Kim,H.Y., Kang,H.G., Jeong,H.J. and Kim,H.M.
  TITLE     RANKL down-regulates the mast cell proliferation through inducing
            senescence
  JOURNAL   Cytokine 159, 156018 (2022)
   PUBMED   36054965
  REMARK    GeneRIF: RANKL down-regulates the mast cell proliferation through
            inducing senescence.
REFERENCE   3  (bases 1 to 2251)
  AUTHORS   Zhou,J., Guo,L., Yang,Y., Liu,Y. and Zhang,C.
  TITLE     Mechanical force regulates root resorption in rats through RANKL
            and OPG
  JOURNAL   BMC Oral Health 22 (1), 290 (2022)
   PUBMED   35842599
  REMARK    GeneRIF: Mechanical force regulates root resorption in rats through
            RANKL and OPG.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2251)
  AUTHORS   Han,S.Y. and Kim,Y.K.
  TITLE     Yukmijihwang-Tang Suppresses Receptor Activator of Nuclear Factor
            Kappa-B Ligand (RANKL)-Induced Osteoclast Differentiation and
            Prevents Ovariectomy (OVX)-Mediated Bone Loss
  JOURNAL   Molecules 26 (24), 7579 (2021)
   PUBMED   34946658
  REMARK    GeneRIF: Yukmijihwang-Tang Suppresses Receptor Activator of Nuclear
            Factor Kappa-B Ligand (RANKL)-Induced Osteoclast Differentiation
            and Prevents Ovariectomy (OVX)-Mediated Bone Loss.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2251)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P., Puzio,I.,
            Kushnir,V., Brezvyn,O., Muzyka,V. and Kotsyumbas,I.
  TITLE     The Influence of Prenatal Fumonisin Exposure on Bone Properties, as
            well as OPG and RANKL Expression and Immunolocalization, in Newborn
            Offspring Is Sex and Dose Dependent
  JOURNAL   Int J Mol Sci 22 (24), 13234 (2021)
   PUBMED   34948030
  REMARK    GeneRIF: The Influence of Prenatal Fumonisin Exposure on Bone
            Properties, as well as OPG and RANKL Expression and
            Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2251)
  AUTHORS   Odgren,P.R., Kim,N., van Wesenbeeck,L., MacKay,C., Mason-Savas,A.,
            Safadi,F.F., Popoff,S.N., Lengner,C., van-Hul,W., Choi,Y. and
            Marks,S.C. Jr.
  TITLE     Evidence that the rat osteopetrotic mutation toothless (tl) is not
            in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene
  JOURNAL   Int J Dev Biol 45 (8), 853-859 (2001)
   PUBMED   11804028
  REMARK    GeneRIF: the toothless (tl) osteopetrotic rat mutation is not in
            the TNFSF11 locus
REFERENCE   7  (bases 1 to 2251)
  AUTHORS   Xu,J., Tan,J.W., Huang,L., Gao,X.H., Laird,R., Liu,D., Wysocki,S.
            and Zheng,M.H.
  TITLE     Cloning, sequencing, and functional characterization of the rat
            homologue of receptor activator of NF-kappaB ligand
  JOURNAL   J Bone Miner Res 15 (11), 2178-2186 (2000)
   PUBMED   11092398
REFERENCE   8  (bases 1 to 2251)
  AUTHORS   Fata,J.E., Kong,Y.Y., Li,J., Sasaki,T., Irie-Sasaki,J.,
            Moorehead,R.A., Elliott,R., Scully,S., Voura,E.B., Lacey,D.L.,
            Boyle,W.J., Khokha,R. and Penninger,J.M.
  TITLE     The osteoclast differentiation factor osteoprotegerin-ligand is
            essential for mammary gland development
  JOURNAL   Cell 103 (1), 41-50 (2000)
   PUBMED   11051546
REFERENCE   9  (bases 1 to 2251)
  AUTHORS   Kong,Y.Y., Yoshida,H., Sarosi,I., Tan,H.L., Timms,E.,
            Capparelli,C., Morony,S., Oliveira-dos-Santos,A.J., Van,G.,
            Itie,A., Khoo,W., Wakeham,A., Dunstan,C.R., Lacey,D.L., Mak,T.W.,
            Boyle,W.J. and Penninger,J.M.
  TITLE     OPGL is a key regulator of osteoclastogenesis, lymphocyte
            development and lymph-node organogenesis
  JOURNAL   Nature 397 (6717), 315-323 (1999)
   PUBMED   9950424
REFERENCE   10 (bases 1 to 2251)
  AUTHORS   Anderson,D.M., Maraskovsky,E., Billingsley,W.L., Dougall,W.C.,
            Tometsko,M.E., Roux,E.R., Teepe,M.C., DuBose,R.F., Cosman,D. and
            Galibert,L.
  TITLE     A homologue of the TNF receptor and its ligand enhance T-cell
            growth and dendritic-cell function
  JOURNAL   Nature 390 (6656), 175-179 (1997)
   PUBMED   9367155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 13, 2022 this sequence version replaced NM_057149.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.54384.1,
                                           SRR26643292.54782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680414, SAMN06680432
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               JAXUCZ010000015.1  60114104-60114479   c
            377-544             JAXUCZ010000015.1  60105734-60105901   c
            545-590             JAXUCZ010000015.1  60090136-60090181   c
            591-689             JAXUCZ010000015.1  60089958-60090056   c
            690-2251            JAXUCZ010000015.1  60083008-60084569   c
FEATURES             Location/Qualifiers
     source          1..2251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..2251
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="TNF superfamily member 11"
                     /db_xref="GeneID:117516"
                     /db_xref="RGD:620784"
     exon            1..376
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1111
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="osteoprotegerin ligand; osteoclast differentiation
                     factor; TNF-related activation-induced cytokine; receptor
                     activator of nuclear factor kappa-B ligand; tumor necrosis
                     factor (ligand) superfamily, member 11; tumor necrosis
                     factor superfamily member 11"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     11"
                     /protein_id="NP_476490.2"
                     /db_xref="GeneID:117516"
                     /db_xref="RGD:620784"
                     /translation="MRRASRDYGKYLRGSEEMGSCPGVPHEGPLHPAPSAPAPAPPPA
                     ASRFMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTRCFYRILRLRENTGLQD
                     STLESEDTEALPDSCRRMKQAFQGAVQRELQHIVGPQRFSGVPAMMEGSWLDVARRGK
                     PEAQPFAHLTINAANIPSGSHKVSLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLY
                     ANICFRHHETSGSVPADYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSI
                     NVGGFFKLRAGEEISVQVSNPSLLDPDQDATYFGAFKVQDID"
     exon            377..544
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     exon            545..590
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     exon            591..689
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     exon            690..2251
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatctctc ctgagtccca gagagtcact gtctggacct cggtgaaccg gtcggggcgg
       61 gggccgcctg gccgggagtc tgctcggcgg cgggaagccg aggaagggag agagcgatcg
      121 cggagcaggg cgcccgaact ccgggcgccg cgccatgcgc cgggccagcc gagactacgg
      181 caagtacctg cgcggctcgg aggagatggg cagttgccct ggcgtcccac acgagggtcc
      241 gctgcatccc gcgccttcag caccggctcc agcgccgccc cccgccgcct cccgcttcat
      301 gttcctggcg ctcctggggc tgggactggg tcaggtggtc tgcagcatcg ctctgttcct
      361 gtactttcga gcgcagatgg atcctaacag aatatcagaa gacagcacgc gctgcttcta
      421 cagaattctg agactccgtg aaaatacagg tttgcaggac tcgactctgg agagcgaaga
      481 cacagaagca ctacctgact catgcaggag aatgaaacaa gcctttcaag gggccgtgca
      541 aagggaatta caacacattg tggggccaca gcgcttctca ggagttccag ctatgatgga
      601 aggttcgtgg ctcgatgtgg cccggcgggg caagcctgag gctcagccgt ttgctcacct
      661 caccatcaat gctgccaaca tcccatcggg ttcccataaa gtcagtctgt cctcttggta
      721 ccatgatcga ggctgggcca agatctctaa catgacgtta agcaacggaa aactaagggt
      781 taaccaagat ggcttctatt acctgtacgc caacatttgc ttcaggcatc atgaaacctc
      841 agggagcgta cctgcggact atcttcagct gatggtatat gtcgttaaaa ccagcatcaa
      901 aatcccaagt tcgcataacc tgatgaaagg ggggagcact aagaactggt cagggaattc
      961 tgaattccac ttttattcca taaacgttgg aggatttttc aagctccggg ctggtgagga
     1021 aattagcgtc caggtgtcca acccttccct gttggatccg gatcaagatg cgacgtactt
     1081 tggggctttc aaagttcaag acatagactg agacttgttt tgtggagcct tagcatggat
     1141 atgctagatg tttggaaggt tcttaaaaca tggatgatgt agatacatgt gtaagactac
     1201 taagagacgt ggcccacgtt gtacaaaact cacggtcctc tctcgaccct gtacaggtca
     1261 tgtatataca aagtccatag gggatattag actcatggtg atcacacaat ggtttttaca
     1321 attttgaaat gaattcctag aattaaacca aattggaaga ggtataccca tgcttataaa
     1381 aaaaatcgca tgtgagctat ggaagggtca tacatagtct ctgggtctaa ctcctgggcc
     1441 tgtgccactg agaacctcga aattaagagg gtaccgttac attgcagaga aatgatggtt
     1501 tgaaaggtta agttcttttg aattgttaca ttgcgctgga acctgcaaat aagttctttt
     1561 ttctaatgag gagagaaaaa tatatgtatt tttatataat atctaaagtt atatttcagg
     1621 tgtaatgttt tctgtgcaaa atattgtaaa ttatatttgt gctatagtat ttgattcaaa
     1681 atatttaaaa atgtctcact gttgacatat ttaatgtttt aaatgtacag atgtatttaa
     1741 ctggtgcact ttgtaattcc cccccccccc gagggtactt gtagttaagg gggaagaatt
     1801 ctggttctgg tgaccacatg tagtttgttt ctttattctt tttaacttaa tagagttttc
     1861 agacttgtca agcctatgca aacaaaaaaa attaaaatga atatcttgaa taacaagtag
     1921 gatgttggtc accaggtgcc tttcaaattt agaagctaat tgactttagg agctgacata
     1981 gtcaaaaagg attcacaata ggctactgag atctgtcagg agtatttatg taattatcga
     2041 acaggtgtct ttttctacaa gagctacaaa ttgtaaattt tgtttctttc tttctttttt
     2101 tttttaatag aaaaggtact gtggtttatc agccaaaaca caatctactt tttaaatttt
     2161 agtgaaagtt attttattat acctgtacaa taaaagcatt gtctctgaat gttaattttt
     2221 ttggtacaaa aataaatttg tacaaaacct g
//
