LOCUS       NM_145681               1122 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TNF superfamily member 10 (Tnfsf10), mRNA.
ACCESSION   NM_145681
VERSION     NM_145681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1122)
  AUTHORS   Wang,M., Wei,Y., Wang,X., Ma,F., Zhu,W., Chen,X., Zhong,X., Li,S.,
            Zhang,J., Liu,G., Wang,Y. and Ma,Y.
  TITLE     TRAIL inhibition by soluble death receptor 5 protects against acute
            myocardial infarction in rats
  JOURNAL   Heart Vessels 38 (3), 448-458 (2023)
   PUBMED   36344842
  REMARK    GeneRIF: TRAIL inhibition by soluble death receptor 5 protects
            against acute myocardial infarction in rats.
REFERENCE   2  (bases 1 to 1122)
  AUTHORS   Kahraman,S., Yilmaz,O., Altunbas,H.A., Dirice,E. and Sanlioglu,A.D.
  TITLE     TRAIL induces proliferation in rodent pancreatic beta cells via AKT
            activation
  JOURNAL   J Mol Endocrinol 66 (4), 325-338 (2021)
   PUBMED   33875613
  REMARK    GeneRIF: TRAIL induces proliferation in rodent pancreatic beta
            cells via AKT activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1122)
  AUTHORS   Chyuan,I.T., Tsai,H.F., Liao,H.J., Wu,C.S. and Hsu,P.N.
  TITLE     An apoptosis-independent role of TRAIL in suppressing joint
            inflammation and inhibiting T-cell activation in inflammatory
            arthritis
  JOURNAL   Cell Mol Immunol 15 (9), 846-857 (2018)
   PUBMED   28392572
  REMARK    GeneRIF: results provide a novel apoptosis-independent, immune
            regulatory role for TRAIL in suppressing inflammatory arthritis and
            shed light on the development of effective new therapies for
            autoimmune inflammatory diseases.
REFERENCE   4  (bases 1 to 1122)
  AUTHORS   Li,C., Mo,Z., Lei,J., Li,H., Fu,R., Huang,Y., Luo,S. and Zhang,L.
  TITLE     Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain
            damage rat model via suppression of TRAIL signaling pathway
  JOURNAL   Int J Biochem Cell Biol 99, 169-177 (2018)
   PUBMED   29635023
  REMARK    GeneRIF: High Trail expression is associated with hypoxic-ischemic
            brain damage.
REFERENCE   5  (bases 1 to 1122)
  AUTHORS   Fu,Y., Chang,Y., Chen,S., Li,Y., Chen,Y., Sun,G., Yu,S., Ye,N.,
            Li,C. and Sun,Y.
  TITLE     BAG3 promotes the phenotypic transformation of primary rat vascular
            smooth muscle cells via TRAIL
  JOURNAL   Int J Mol Med 41 (5), 2917-2926 (2018)
   PUBMED   29484366
  REMARK    GeneRIF: BAG3 promoted the proliferation and migration of primary
            rat vascular smooth muscle cells (VSMCs) in a time-dependent
            manner. BAG3 significantly increased the expression of TRAIL while
            had no effects on its receptors. TRAIL knockdown or blocking by
            neutralizing antibody inhibited the proliferation of VSMCs induced
            by BAG3.
REFERENCE   6  (bases 1 to 1122)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   7  (bases 1 to 1122)
  AUTHORS   Lamhamedi-Cherradi,S.E., Zheng,S.J., Maguschak,K.A., Peschon,J. and
            Chen,Y.H.
  TITLE     Defective thymocyte apoptosis and accelerated autoimmune diseases
            in TRAIL-/- mice
  JOURNAL   Nat Immunol 4 (3), 255-260 (2003)
   PUBMED   12577054
REFERENCE   8  (bases 1 to 1122)
  AUTHORS   Schneider,P., Olson,D., Tardivel,A., Browning,B., Lugovskoy,A.,
            Gong,D., Dobles,M., Hertig,S., Hofmann,K., Van Vlijmen,H.,
            Hsu,Y.M., Burkly,L.C., Tschopp,J. and Zheng,T.S.
  TITLE     Identification of a new murine tumor necrosis factor receptor locus
            that contains two novel murine receptors for tumor necrosis
            factor-related apoptosis-inducing ligand (TRAIL)
  JOURNAL   J Biol Chem 278 (7), 5444-5454 (2003)
   PUBMED   12466268
REFERENCE   9  (bases 1 to 1122)
  AUTHORS   Vindrieux,D., Devonec,M., Benahmed,M. and Grataroli,R.
  TITLE     Identification of tumor necrosis factor-alpha-related
            apoptosis-inducing ligand (TRAIL) and its receptors in adult rat
            ventral prostate
  JOURNAL   Mol Cell Endocrinol 198 (1-2), 115-121 (2002)
   PUBMED   12573821
  REMARK    GeneRIF: TRAIL protein, mRNA, and its receptor proteins and mRNA
            were identified in rat ventral prostate epithelial cells.
REFERENCE   10 (bases 1 to 1122)
  AUTHORS   Grataroli,R., Vindrieux,D., Gougeon,A. and Benahmed,M.
  TITLE     Expression of tumor necrosis factor-alpha-related
            apoptosis-inducing ligand and its receptors in rat testis during
            development
  JOURNAL   Biol Reprod 66 (6), 1707-1715 (2002)
   PUBMED   12021051
  REMARK    GeneRIF: TRAIL and its receptors are expressed in the testis during
            normal development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 11, 2015 this sequence version replaced NM_145681.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF030546.1, AY115578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000002.1  112136939-112137082
            145-282             JAXUCZ010000002.1  112144096-112144233
            283-325             JAXUCZ010000002.1  112146953-112146995
            326-430             JAXUCZ010000002.1  112151981-112152085
            431-1122            JAXUCZ010000002.1  112153115-112153806
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..1122
                     /gene="Tnfsf10"
                     /gene_synonym="Tnlg6a; Trail"
                     /note="TNF superfamily member 10"
                     /db_xref="GeneID:246775"
                     /db_xref="RGD:628734"
     CDS             1..876
                     /gene="Tnfsf10"
                     /gene_synonym="Tnlg6a; Trail"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     10; tumor necrosis factor ligand 6a; tumor necrosis factor
                     superfamily member 10"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     10"
                     /protein_id="NP_663714.2"
                     /db_xref="GeneID:246775"
                     /db_xref="RGD:628734"
                     /translation="MPSTGNLKGPSFSQHFTMTVICIVLLQVLLQALTVAVTYMYFNN
                     EVKQLQDNYSKIGLACFSKEDGDFWDSTDEGILNRPCLQVKRQLYQLIEEVTLRTFEK
                     TISTVPEKQLSTPPLPRGRRPQRVAAHITGITRRSNLALIPISKDGKTLGQKIETWES
                     SRRGHSFLNHVHLRNGELVIQEEGLYYIYSQTYYRFKEAKEASKTVSKDGGRIKQMVQ
                     YIYKYTSYPDPILLMKSARNSCWSREAEYGLYSIYQGGLFELKENDRIFVSVTNEHLM
                     DLDQEASFFGAFLIN"
     exon            1..144
                     /gene="Tnfsf10"
                     /gene_synonym="Tnlg6a; Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            145..282
                     /gene="Tnfsf10"
                     /gene_synonym="Tnlg6a; Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            283..325
                     /gene="Tnfsf10"
                     /gene_synonym="Tnlg6a; Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            326..430
                     /gene="Tnfsf10"
                     /gene_synonym="Tnlg6a; Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            431..1122
                     /gene="Tnfsf10"
                     /gene_synonym="Tnlg6a; Trail"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccttcca ccgggaacct gaagggcccc agcttcagtc agcacttcac gatgacggtg
       61 atctgcatag tgctcctgca ggtgctcctg caggccttga ctgtggctgt gacttacatg
      121 tacttcaaca acgaggtgaa acagctacag gacaattact ccaaaatcgg actagcttgc
      181 ttctcaaaag aagatgggga tttttgggac tccactgacg aggggatttt gaacagacct
      241 tgcttgcagg tcaagaggca actgtatcag ctcattgaag aggtgacttt gagaaccttt
      301 gagaaaacca tctctacagt tccagaaaag cagctaagca ctcctccctt gcccagaggt
      361 agaagacccc agagagtggc agctcacatt accgggatca ctcggagaag caacttagcc
      421 ttaattccaa tctccaagga tggaaagacc ttgggccaga agatagaaac ctgggagtcc
      481 tctcggagag ggcattcatt tctcaaccat gtgcacttga gaaacggaga gctggtgatc
      541 caggaggagg gcctgtatta catctactcc caaacgtact accggttcaa ggaggctaaa
      601 gaagcttcca agacagtctc gaaggacgga gggaggatca aacagatggt gcagtacatc
      661 tacaaataca ccagctaccc cgatcccata ctgctgatga agagtgccag aaatagctgc
      721 tggtccagag aagctgagta cggactgtac tccatctatc agggggggct gttcgagctc
      781 aaagaaaatg acaggatttt tgtttccgtg acgaatgagc atttgatgga cctggatcaa
      841 gaagccagtt tctttggagc ctttttaatt aactagacga cctgcaatga tcaaacacac
      901 ccctaaaata cccagtaata ttctaggtcg aaggcatccc aagaaagtga ctaaactggt
      961 tagggtatgg cctggctgca gaaacctcag ggcagatgtg acagaaaggc agctagaaca
     1021 cagcaccctc aggccaaaaa cccagccata gacaccaggt ttcattgagg gacttgcttt
     1081 gttcccccaa aatgagatcg ctgtaggctt tcaatgatct ac
//
