LOCUS       NM_001025773            1410 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TNF receptor superfamily member 9 (Tnfrsf9),
            mRNA.
ACCESSION   NM_001025773 XM_575963
VERSION     NM_001025773.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Zhao,X., Su,H., Huang,X., Xie,L., Liu,Z., Liu,X. and Suo,X.
  TITLE     Molecular cloning and protein characterization of swine 4-1BB
  JOURNAL   Vet Immunol Immunopathol 153 (1-2), 35-44 (2013)
   PUBMED   23453329
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Shi,Y., Hu,S., Song,Q., Yu,S., Zhou,X., Yin,J., Qin,L. and Qian,H.
  TITLE     Gene silencing of 4-1BB by RNA interference inhibits acute
            rejection in rats with liver transplantation
  JOURNAL   Biomed Res Int 2013, 192738 (2013)
   PUBMED   23484089
  REMARK    GeneRIF: gene silencing of 4-1BB by RNA interference inhibits the
            acute rejection in rats with liver transplantation.
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Zhang,J., Chen,G., Zhou,D. and Wang,Z.
  TITLE     Expression of CD137 in the cerebral artery after experimental
            subarachnoid hemorrhage in rats: a pilot study
  JOURNAL   Brain Res 1386, 200-208 (2011)
   PUBMED   21352817
  REMARK    GeneRIF: Upregulation of CD137 in the cerebral arterial wall may be
            important in the development of cerebral vasospasm following
            subarachnoid hemorrhage.
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Haga,T., Suzuki,J., Kosuge,H., Ogawa,M., Saiki,H., Haraguchi,G.,
            Maejima,Y., Isobe,M. and Uede,T.
  TITLE     Attenuation of experimental autoimmune myocarditis by blocking T
            cell activation through 4-1BB pathway
  JOURNAL   J Mol Cell Cardiol 46 (5), 719-727 (2009)
   PUBMED   19233196
  REMARK    GeneRIF: Blockade of T cell activation through the 4-1BB/4-1BBL
            pathway regulates development of experimental autoimmune
            myocarditis.
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Abe,J., Ueha,S., Suzuki,J., Tokano,Y., Matsushima,K. and
            Ishikawa,S.
  TITLE     Increased Foxp3(+) CD4(+) regulatory T cells with intact
            suppressive activity but altered cellular localization in murine
            lupus
  JOURNAL   Am J Pathol 173 (6), 1682-1692 (2008)
   PUBMED   19008373
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Shao,Z., Sun,F., Koh,D.R. and Schwarz,H.
  TITLE     Characterisation of soluble murine CD137 and its association with
            systemic lupus
  JOURNAL   Mol Immunol 45 (15), 3990-3999 (2008)
   PUBMED   18640726
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Goodwin,R.G., Din,W.S., Davis-Smith,T., Anderson,D.M., Gimpel,S.D.,
            Sato,T.A., Maliszewski,C.R., Brannan,C.I., Copeland,N.G.,
            Jenkins,N.A. et al.
  TITLE     Molecular cloning of a ligand for the inducible T cell gene 4-1BB:
            a member of an emerging family of cytokines with homology to tumor
            necrosis factor
  JOURNAL   Eur J Immunol 23 (10), 2631-2641 (1993)
   PUBMED   8405064
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097483.1.
            
            On Jul 22, 2005 this sequence version replaced XM_575963.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1410
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="TNF receptor superfamily member 9"
                     /db_xref="GeneID:500590"
                     /db_xref="RGD:1598208"
     exon            1..405
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            406..530
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..1207
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="tumor necrosis factor receptor superfamily, member
                     9"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 9 precursor"
                     /protein_id="NP_001020944.1"
                     /db_xref="GeneID:500590"
                     /db_xref="RGD:1598208"
                     /translation="MGSSCYNMVVTVLLVVGTEEVRATRNPCDSCEAGTFCSKYPPVC
                     TSCPPSTYSSTGGQPNCDICRVCQGYFRFKKPCSSTHNAECECVEGFHCLGPKCTRCE
                     KDCRPGQELTEQGCKNCGLGTFNDQDGAGVCRPWTNCSLDGRSVLKNGTKEKDVVCGP
                     PVVSLSPSTTPSAVTTPERESGERPLQVLTLFLALTLALLLFLIFIILWFSVPKWLRK
                     KFPHIFKQPFKKAVRTAQEEDACSCRFPEEEEGGGGSYEL"
     exon            531..635
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            636..773
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            774..843
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            844..974
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1109
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1386
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaaggt cagctgggtg ttttctctgc ctctctgagc taacaggctt tccaccgtag
       61 tggctgcctt ccaagtgttc actggtgaaa aggaacgatt gagattttgt ggggtgggga
      121 atcctgtgaa gggatcttta atatcgagtt attttcagta ttagggttaa accaaagaaa
      181 aacgtccaaa caaacaaaca aaaaaaatca agcaaagaag aaaagtctaa gatctgggtc
      241 aggctgtgac gctgtagctg cagctgcccc accccccacc atccgaccat cggtcattcc
      301 tggaattcag gtgctgaagg ccagccctca gcgtaaagag ctgacagaga ccctgtggcc
      361 aggggttctg agttccagcc accattcatt ctttttcacc tttggtgtcc tgtgcatgtg
      421 acgtttcgct atgggaagca gctgttacaa catggtggtc accgtgctgc tggtggtggg
      481 caccgaggag gtgagagcca cgcggaaccc ctgtgacagc tgtgaggctg ggactttctg
      541 cagtaaatac cctccggtct gcaccagctg ccctccaagt acctactcca gcacaggtgg
      601 acagccgaac tgtgacatct gcagagtgtg tcaaggctat ttcaggttca agaagccttg
      661 ctcctctacc cacaacgcag agtgtgagtg cgtggaggga ttccactgct tggggccaaa
      721 gtgtaccagg tgtgagaagg actgcaggcc cggccaggaa ctaacggagc agggttgtaa
      781 aaactgtggc ttgggaacgt ttaatgacca ggacggcgcc ggcgtctgcc gaccctggac
      841 gaactgctct ctagacggaa ggtctgtgct taagaatggg accaaggaga aagacgtggt
      901 ctgtggaccc cctgtggtca gcctctctcc cagtaccact cctagtgctg tgactactcc
      961 agagagagaa tcaggagagc gccccttgca ggttcttacc ttgttcctgg cgctgacatt
     1021 agcgctgctc ctgttcctga tcttcatcat tctctggttc tctgtgccca aatggctcag
     1081 gaagaagttc ccccacatat tcaagcaacc atttaagaag gcggttagaa ctgctcaaga
     1141 ggaagatgct tgtagctgcc ggtttccaga ggaagaagaa ggaggaggag gaagctacga
     1201 gctgtaatgt gccatcctag gagatgtggg gaccctcagg aaaccgagaa gcactaagac
     1261 ccccaccctc ctagggagta gcacaagtta ccccaccccc ctgttcttaa aaccatccta
     1321 gatggcattt gagcacgcac cccgtccaag tctcttctga tgctaatata tttgttaatt
     1381 tttaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
