LOCUS       NM_013049               1017 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus TNF receptor superfamily member 4 (Tnfrsf4),
            mRNA.
ACCESSION   NM_013049
VERSION     NM_013049.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Zhao,M., Li,Y., Wei,X., Zhang,Q., Jia,H., Quan,S., Cao,D., Wang,L.,
            Yang,T., Zhao,J., Pei,M., Tian,S., Yu,Y., Guo,Y. and Yang,X.
  TITLE     Negative immune factors might predominate local tumor immune status
            and promote carcinogenesis in cervical carcinoma
  JOURNAL   Virol J 14 (1), 5 (2017)
   PUBMED   28086903
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Zhang,N., Li,G., Xiao,B., Liu,Y., Cai,Y., Sun,X. and Liang,J.
  TITLE     [Dynamic change OX40/OX40L mRNA in experimental allergic neuritis]
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 35 (9), 964-968 (2010)
   PUBMED   20871162
  REMARK    GeneRIF: OX40 and OX40L may play a role in the pathogenesis of
            experimental allegic neuritis.
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Abe,J., Ueha,S., Suzuki,J., Tokano,Y., Matsushima,K. and
            Ishikawa,S.
  TITLE     Increased Foxp3(+) CD4(+) regulatory T cells with intact
            suppressive activity but altered cellular localization in murine
            lupus
  JOURNAL   Am J Pathol 173 (6), 1682-1692 (2008)
   PUBMED   19008373
REFERENCE   4  (bases 1 to 1017)
  AUTHORS   Chen,Z., Herman,A.E., Matos,M., Mathis,D. and Benoist,C.
  TITLE     Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
  JOURNAL   J Exp Med 202 (10), 1387-1397 (2005)
   PUBMED   16301745
REFERENCE   5  (bases 1 to 1017)
  AUTHORS   Song,J., Salek-Ardakani,S., Rogers,P.R., Cheng,M., Van Parijs,L.
            and Croft,M.
  TITLE     The costimulation-regulated duration of PKB activation controls T
            cell longevity
  JOURNAL   Nat Immunol 5 (2), 150-158 (2004)
   PUBMED   14730361
  REMARK    Erratum:[Nat Immunol. 2004 Nov;5(11):1190]
REFERENCE   6  (bases 1 to 1017)
  AUTHORS   Pippig,S.D., Pena-Rossi,C., Long,J., Godfrey,W.R., Fowell,D.J.,
            Reiner,S.L., Birkeland,M.L., Locksley,R.M., Barclay,A.N. and
            Killeen,N.
  TITLE     Robust B cell immunity but impaired T cell proliferation in the
            absence of CD134 (OX40)
  JOURNAL   J Immunol 163 (12), 6520-6529 (1999)
   PUBMED   10586044
REFERENCE   7  (bases 1 to 1017)
  AUTHORS   al-Shamkhani,A., Birkeland,M.L., Puklavec,M., Brown,M.H., James,W.
            and Barclay,A.N.
  TITLE     OX40 is differentially expressed on activated rat and mouse T cells
            and is the sole receptor for the OX40 ligand
  JOURNAL   Eur J Immunol 26 (8), 1695-1699 (1996)
   PUBMED   8765008
REFERENCE   8  (bases 1 to 1017)
  AUTHORS   Stuber,E., Neurath,M., Calderhead,D., Fell,H.P. and Strober,W.
  TITLE     Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine
            family, induces proliferation and differentiation in murine splenic
            B cells
  JOURNAL   Immunity 2 (5), 507-521 (1995)
   PUBMED   7749983
REFERENCE   9  (bases 1 to 1017)
  AUTHORS   Mallett,S., Fossum,S. and Barclay,A.N.
  TITLE     Characterization of the MRC OX40 antigen of activated CD4 positive
            T lymphocytes--a molecule related to nerve growth factor receptor
  JOURNAL   EMBO J 9 (4), 1063-1068 (1990)
   PUBMED   2157591
REFERENCE   10 (bases 1 to 1017)
  AUTHORS   Paterson,D.J., Jefferies,W.A., Green,J.R., Brandon,M.R.,
            Corthesy,P., Puklavec,M. and Williams,A.F.
  TITLE     Antigens of activated rat T lymphocytes including a molecule of
            50,000 Mr detected only on CD4 positive T blasts
  JOURNAL   Mol Immunol 24 (12), 1281-1290 (1987)
   PUBMED   2828930
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X17037.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="PVG/DA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1017
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /note="TNF receptor superfamily member 4"
                     /db_xref="GeneID:25572"
                     /db_xref="RGD:3920"
     exon            1..144
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..830
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /note="tumor necrosis factor superfamily, member 4;
                     Tax-transcriptionally activated glycoprotein 1; MRC OX40;
                     OX40 antigen; OX40L receptor; tumor necrosis factor
                     (ligand) superfamily member 4; tumor necrosis factor
                     receptor superfamily, member 4"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 4 precursor"
                     /protein_id="NP_037181.1"
                     /db_xref="GeneID:25572"
                     /db_xref="RGD:3920"
                     /translation="MYVWVQQPTAFLLLGLSLGVTVKLNCVKDTYPSGHKCCRECQPG
                     HGMVSRCDHTRDTVCHPCEPGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTEDTVC
                     QCRPGTQPRQDSSHKLGVDCVPCPPGHFSPGSNQACKPWTNCTLSGKQIRHPASNSLD
                     TVCEDRSLLATLLWETQRTTFRPTTVPSTTVWPRTSQLPSTPTLVAPEGPAFAVILGL
                     GLGLLAPLTVLLALYLLRKAWRSPNTPKPCWGNSFRTPIQEEQTDTHFTLAKI"
     exon            145..267
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..375
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..442
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..639
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..759
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1017
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1017
                     /gene="Tnfrsf4"
                     /gene_synonym="Ox40; Txgp1"
                     /note="polyA site"
ORIGIN      
        1 gaacacagac aaggatgtat gtgtgggttc agcagcccac agcatttctg ctcctgggac
       61 tctcacttgg agttacagtg aagctcaact gtgttaaaga tacctacccc agtggtcaca
      121 agtgctgtcg tgagtgccag ccaggccatg gtatggtgag ccgctgtgat cacaccaggg
      181 acactgtatg tcatccatgt gagcctggct tctacaatga ggctgtcaat tacgacacct
      241 gcaagcagtg tacacagtgc aaccaccgaa gtggaagtga actcaagcag aactgcacac
      301 ctactgagga tactgtctgc cagtgtagac caggcaccca accccggcaa gacagcagcc
      361 acaagcttgg agttgactgt gttccctgcc cccctggcca cttttctcca ggcagcaacc
      421 aagcctgcaa gccctggacc aattgtacct tatctggaaa gcagatccgc cacccagcca
      481 gtaacagctt ggacacagtc tgtgaagaca gaagcctcct ggccacactg ctctgggaga
      541 cccagcgcac tacattcagg ccaaccactg tcccgtccac cacagtctgg cccaggactt
      601 ctcagttgcc ctctacaccc accttggtgg ctcctgaggg ccctgcattt gctgttatcc
      661 taggcctagg cctgggcttg ctggctccct tgactgtcct gctagccttg tacctgctcc
      721 gaaaggcttg gagatcgccc aacactccca aaccttgttg gggaaacagc ttcaggaccc
      781 ctatccagga ggagcagacc gacacacact ttactctagc caagatctga gcaataccac
      841 aggagtggat tttatggggc acagacagcc catatcctga tgcctgcctg ccagggccct
      901 ccacaccgtt ctaggcgctg ggctggctgt gcactctccc atgtatgctg tgcatactac
      961 ctgcctggtg gcactcctaa taaacatgct cgcagctgtg agtctgtcac tggccct
//
