LOCUS       NM_001108207            4350 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus TNF receptor superfamily member 21 (Tnfrsf21),
            mRNA.
ACCESSION   NM_001108207 XM_001067689 XM_236992
VERSION     NM_001108207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4350)
  AUTHORS   Zhang,D., Cao,X., Li,J. and Zhao,G.
  TITLE     MiR-210 inhibits NF-kappaB signaling pathway by targeting DR6 in
            osteoarthritis
  JOURNAL   Sci Rep 5, 12775 (2015)
   PUBMED   26244598
  REMARK    GeneRIF: The results demonstrated that miR-210 decreased
            inflammation in articular cavity in OA rats by targeting DR6 and
            inhibiting NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4350)
  AUTHORS   Wang,Y., Zhao,D., Pan,B., Song,Z., Shah,S.Z.A., Yin,X., Zhou,X. and
            Yang,L.
  TITLE     Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced
            Axonal Degeneration in Rat Spinal Neurons
  JOURNAL   J Mol Neurosci 56 (4), 966-976 (2015)
   PUBMED   25898930
REFERENCE   3  (bases 1 to 4350)
  AUTHORS   Hu,Y., Lee,X., Shao,Z., Apicco,D., Huang,G., Gong,B.J.,
            Pepinsky,R.B. and Mi,S.
  TITLE     A DR6/p75(NTR) complex is responsible for beta-amyloid-induced
            cortical neuron death
  JOURNAL   Cell Death Dis 4 (4), e579 (2013)
   PUBMED   23559013
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4350)
  AUTHORS   Zeng,L., Li,T., Xu,D.C., Liu,J., Mao,G., Cui,M.Z., Fu,X. and Xu,X.
  TITLE     Death receptor 6 induces apoptosis not through type I or type II
            pathways, but via a unique mitochondria-dependent pathway by
            interacting with Bax protein
  JOURNAL   J Biol Chem 287 (34), 29125-29133 (2012)
   PUBMED   22761420
REFERENCE   5  (bases 1 to 4350)
  AUTHORS   Mi,S., Lee,X., Hu,Y., Ji,B., Shao,Z., Yang,W., Huang,G., Walus,L.,
            Rhodes,K., Gong,B.J., Miller,R.H. and Pepinsky,R.B.
  TITLE     Death receptor 6 negatively regulates oligodendrocyte survival,
            maturation and myelination
  JOURNAL   Nat Med 17 (7), 816-821 (2011)
   PUBMED   21725297
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4350)
  AUTHORS   Klima,M., Zajedova,J., Doubravska,L. and Andera,L.
  TITLE     Functional analysis of the posttranslational modifications of the
            death receptor 6
  JOURNAL   Biochim Biophys Acta 1793 (10), 1579-1587 (2009)
   PUBMED   19654028
REFERENCE   7  (bases 1 to 4350)
  AUTHORS   Schmidt,C.S., Liu,J., Zhang,T., Song,H.Y., Sandusky,G., Mintze,K.,
            Benschop,R.J., Glasebrook,A., Yang,D.D. and Na,S.
  TITLE     Enhanced B cell expansion, survival, and humoral responses by
            targeting death receptor 6
  JOURNAL   J Exp Med 197 (1), 51-62 (2003)
   PUBMED   12515813
REFERENCE   8  (bases 1 to 4350)
  AUTHORS   Liu,J., Na,S., Glasebrook,A., Fox,N., Solenberg,P.J., Zhang,Q.,
            Song,H.Y. and Yang,D.D.
  TITLE     Enhanced CD4+ T cell proliferation and Th2 cytokine production in
            DR6-deficient mice
  JOURNAL   Immunity 15 (1), 23-34 (2001)
   PUBMED   11485735
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236992.4, XM_001067689.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..4350
                     /gene="Tnfrsf21"
                     /note="TNF receptor superfamily member 21"
                     /db_xref="GeneID:316256"
                     /db_xref="RGD:1307308"
     exon            1..543
                     /gene="Tnfrsf21"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..2415
                     /gene="Tnfrsf21"
                     /note="death receptor 6; tumor necrosis factor receptor
                     superfamily, member 21"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 21 precursor"
                     /protein_id="NP_001101677.1"
                     /db_xref="GeneID:316256"
                     /db_xref="RGD:1307308"
                     /translation="MGTSASSITALASCSRIAGQVGATMVAGSLLLLGFLSTITAQPE
                     QKTLSLTGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPSGTFTRHENG
                     IERCHDCSQPCPRPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKKG
                     TENEDVRCKQCARGTFSDVPSSVMKCRAHTDCLGQNLMVVKQGTKETDNVCGVHLSSS
                     STTPSSPGIATFSHPEHTESHDVPSSTYEPQGMNSTDSNSTASVRTKVPSDIQEETVP
                     DNTSSTSGKESTNRTLPNPPQLTHQQGPHHRHILKLLPSSMEATGEKSSTAIKAPKRG
                     HPRQNPHKHFDINEHLPWMIVLFLLLVLVLIVVCSIRKSSRTLKKGPRQDPSAIMEKA
                     GLKKSLTPTQNREKWIYYRNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSN
                     GYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDK
                     LALPMSPSPLSPSPIPSPNVKLENSTLLTVEPSPLDKNKGFFVDESEPLLRCDSTSSG
                     SSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPEELRVIEEIPQAEDK
                     LDRLFEIIGVKSQEASQTLLDSVYSHLPDLL"
     exon            544..1195
                     /gene="Tnfrsf21"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1690
                     /gene="Tnfrsf21"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1956
                     /gene="Tnfrsf21"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2185
                     /gene="Tnfrsf21"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..4350
                     /gene="Tnfrsf21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgtgtcc ccgagctgag tggccatccg actcagtccc tcaccggccg gtctgggcag
       61 cggaggagac gagtggttgg tagtggctgg aagcttcgct atgggaagtc gctctttagc
      121 actgtcgccg ctcgccctgc tccctggttc tccgcagccg ctgtcgctgg agagcaccgg
      181 gaggcgcggg ttgcaagcgc gcctgcttct ccccgcccgg gcgccagcgc ccctgggcag
      241 gtgctgagcg ccttctccga gcctcccctg ctgcctccct cttccgccta gccgccttgc
      301 tgctgcagtg cacatgggct gctggaggta gatgggctca ccgcccgtga ggcggcggtg
      361 gatgcggcgc tgggcagaaa cagccaccga ttccagctgc cgtggggccg agcgcccgga
      421 gcgccgctgc gagccccggg ctcagccatg gggacctccg caagcagcat caccgccctc
      481 gcctcttgca gccgcatcgc cggccaagtt ggagccacga tggtcgccgg ctcccttctc
      541 ttgcttgggt tcctcagcac catcacagcc caaccagaac aaaagactct gagtctcacg
      601 ggcacgtacc gccacgttga ccgtaccact ggccaggtgc taacctgcga caagtgtccg
      661 gcaggaacgt atgtctccga gcactgtacc aacacgagcc tgcgagtctg cagcagctgc
      721 ccctcgggga cctttaccag gcatgagaac ggcatagaga gatgccatga ctgtagtcag
      781 ccatgcccac ggccgatgat tgagagatta ccttgtgctg ccttgactga ccgagaatgc
      841 atctgcccac ccggaatgta tcagtctaat gggacctgcg ctccccacac ggtgtgcccc
      901 gtgggctggg gtgtgaggaa gaaagggaca gagaatgaag atgtgcggtg taagcagtgt
      961 gctcgcggta ccttctctga cgtgccttcc agtgtgatga agtgtagagc ccacacggac
     1021 tgtctgggtc agaacctgat ggtggtcaag caggggacta aggagacaga caacgtctgt
     1081 ggcgtgcacc tgtcctcctc cagcacgacc ccatcttccc ctggcatagc taccttttct
     1141 catcctgagc acacggaatc ccacgatgtc ccctcctcca cctatgagcc ccaaggcatg
     1201 aactcaacag attccaactc tactgcctct gttagaacta aggtaccaag tgacatccag
     1261 gaagagacag tgcctgacaa tacaagctcc acgagtggga aggagagcac gaacaggacc
     1321 ctgccaaacc caccacaact tacccaccag caaggccccc accacagaca cattctgaag
     1381 ctgctgccat catccatgga ggccactggt gagaagtcca gcacagccat caaggccccc
     1441 aagaggggcc atcccagaca gaacccacac aagcatttcg acatcaacga gcatttgccc
     1501 tggatgattg tactcttcct tctgctggtc ctggtgctca ttgtggtgtg cagtatccga
     1561 aagagctcta ggactctcaa gaaggggccc cggcaggatc ccagtgccat catggaaaag
     1621 gcagggctga agaagtcctt gactccaacc cagaaccggg agaaatggat ctactaccgc
     1681 aatggccacg gtattgacat cctgaagctt gtagcagcgc aggtgggaag ccagtggaag
     1741 gacatctatc agtttctttg caacgccagc gagagggagg tggctgcctt ctccaatgga
     1801 tacactgcag accatgaacg agcctatgca gctctgcagc actggaccat ccggggccct
     1861 gaggccagcc ttgctcagct catcagcgcc ttgcgccagc accgacgcaa tgatgttgtg
     1921 gagaagattc gtgggctgat ggaagatact acgcagttgg aaaccgacaa actggctctc
     1981 cccatgagcc ccagtccgct tagcccgagc cccattccca gtcctaacgt gaaacttgag
     2041 aattccactc tcctgacagt ggagccctca cccctggaca agaacaaggg cttcttcgtg
     2101 gacgagtcgg agccccttct gcgttgtgac tccacgtcca gcggctcttc agcactgagc
     2161 aggaatggct cctttataac caaagaaaag aaggacacag tgttgcggca ggtccgcctg
     2221 gacccctgtg acttgcagcc catctttgac gacatgctgc acatcctgaa tccggaagag
     2281 ctgcgggtaa tcgaagagat tccccaggct gaggacaaac tggaccgtct cttcgagatc
     2341 attggggtca agagccaaga agccagccag accctcttgg actctgtgta cagccatctt
     2401 cctgacctat tgtagaacac cggggcactg cgttcaggaa atcagcctac tggcagagtg
     2461 atttcatttc ttttctgact tttgtgtttt ggtgtgtgcg tgtatgtatg tgtttaacag
     2521 agtatatggc tggtgcttga gtttggggct ctttctttct ttctttcttt ctttccttct
     2581 ttctttcttt tctcttcttg aaagtgaatg tataaagcct tttcaatgta taactgttcg
     2641 aaaatgccca ccactaaagt ttttttttta agttccatat attctccatt tttgccttct
     2701 tatatatttt caacactatt ctgtgcactt taaaaactta acatagacgc ggtgtgactt
     2761 ttcccatatg ctggattcca agactttgaa cttcttaaaa aacataatgg catcttgtga
     2821 cttctctaag tagacataag tctgccaaca tcaacgccta ctttgtctgt tttaattatc
     2881 actgctctct gtcgtattgt ttgtccttca cgagcgtttc taaggacgga gggaggctac
     2941 gaccctgttg atgactgtaa ctctattaga ttttgagttg tcttttttca tgtcttgttc
     3001 tatagttcat attcacgacg gaaacttgac cacactctct atcgctcgct gtatggtttt
     3061 cgtctggaca tcgtacactg cttgtaactt gtgctcccct taatgctact aagctctggg
     3121 ctggagaatg aaatccttaa gtccccagga cttgctgttt cagtggcttg acacctgggc
     3181 caccaaagaa ctcgatcttc atcttttagg aacacctttg ctgcaccttg gaaaaccact
     3241 ttatgcccag ctttgcttta aaagatattt ttcttatttt ttttattccc ctctctctct
     3301 ctctctctct ctctctctct ctctctctct ctctctctct caatacacat agtctatagg
     3361 tccagtctgc cctcaaggcc ttgctgggtt tcctttgtca tccaaccact ttcgttaaaa
     3421 atggctgcag ctgtaagaac tcctgtccga taaatttgca actacgctct ctcatttatc
     3481 aacctgtcct ctgatgctca gttgtcagac tctaatgcag agctagacgc ccactgcctt
     3541 tgtgtgggtg ggcttagtgg tgaggaactg atatcagaaa aatgccttca agtatactaa
     3601 tttattaata aatattaggt gtttgttact tgcgtgattt tggtgtgttt actacttaac
     3661 tttccccttt gcctctgttc aggttctagc tctggtcttc tcttggggaa gaatgtgtgt
     3721 tctgaaagcc tcctcctgcc caatctgtaa atcacacaca ttagcacaag tcccttttgg
     3781 agaggtaccc ggaggttcag tgcgcagggc tttgataaga actgccaagc ctttcctagt
     3841 ctttcgagtt aaaccacagg cttttatttc ctccaggtaa tgttttttac ctgtggggca
     3901 atctgcacac ctccacagac ttctagctaa aacctcagtg tccctgacga actccagagg
     3961 gctttctcgg cagtgaggcg ggtgtagttt tgtgttggtg ggatttctca agttcactgc
     4021 tggtttcctt taggaccccg cctctgcaga attccaatga ctagacgcta gcaattttaa
     4081 cttcctcttt ctgtgagaac ctggaagtgg atactgtatg cactgtgacg ctcatgtcag
     4141 caactgggga gtgtcttctg gtttcattcc tctccttgtg gcagctttca agaagaacac
     4201 cccagtttcc cttccctctt gttggtggaa aataagaact ctgaggccag gtagtggtag
     4261 tacatgcctt taatctattg gaagagagag gcaggaggat attgagtttg aagccagcct
     4321 ggggagttcc aggacatcca tggctaccct
//
