LOCUS       NM_130426               2924 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TNF receptor superfamily member 1B (Tnfrsf1b),
            mRNA.
ACCESSION   NM_130426
VERSION     NM_130426.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Keck,M., Flamant,M., Mougenot,N., Favier,S., Atassi,F., Barbier,C.,
            Nadaud,S., Lompre,A.M., Hulot,J.S. and Pavoine,C.
  TITLE     Cardiac inflammatory CD11b/c cells exert a protective role in
            hypertrophied cardiomyocyte by promoting TNFR2- and Orai3-
            dependent signaling
  JOURNAL   Sci Rep 9 (1), 6047 (2019)
   PUBMED   30988334
  REMARK    GeneRIF: Cardiac inflammatory CD11b/c cells exert a protective role
            in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3-
            dependent signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Shen,G.Y., Ren,H., Huang,J.J., Zhang,Z.D., Zhao,W.H., Yu,X.,
            Shang,Q., Qiu,T., Zhang,Y.Z., Tang,J.J., Liang,D., Yang,Z.D. and
            Jiang,X.B.
  TITLE     Plastrum Testudinis Extracts Promote BMSC Proliferation and
            Osteogenic Differentiation by Regulating Let-7f-5p and the
            TNFR2/PI3K/AKT Signaling Pathway
  JOURNAL   Cell Physiol Biochem 47 (6), 2307-2318 (2018)
   PUBMED   29975930
  REMARK    GeneRIF: results suggested that PTE may promote BMSC proliferation
            and osteogenic differentiation via a mechanism associated with the
            regulation of Let-7f-5p and the TNFR2/PI3K/AKT signaling pathway.
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Gao,H., Danzi,M.C., Choi,C.S., Taherian,M., Dalby-Hansen,C.,
            Ellman,D.G., Madsen,P.M., Bixby,J.L., Lemmon,V.P., Lambertsen,K.L.
            and Brambilla,R.
  TITLE     Opposing Functions of Microglial and Macrophagic TNFR2 in the
            Pathogenesis of Experimental Autoimmune Encephalomyelitis
  JOURNAL   Cell Rep 18 (1), 198-212 (2017)
   PUBMED   28052249
REFERENCE   4  (bases 1 to 2924)
  AUTHORS   Wang,M., Wang,L., Huang,C., Wang,I.W. and Turrentine,M.W.
  TITLE     Regulation of myocardial stromal cell-derived factor 1alpha/CXCL12
            by tumor necrosis factor signaling
  JOURNAL   J Surg Res 207, 155-163 (2017)
   PUBMED   27979472
  REMARK    GeneRIF: TNF plays an inhibitory role in modulating myocardial
            SDF-1 production and blockade of TNF signaling by ablation of TNFR1
            and TNFR2 genes increased SDF-1 expression in the heart. These data
            expand on TNF signaling-initiated mechanisms in myocardium, which
            may lend a more complete understanding of SDF-1 and TNFR-derived
            actions in hopes of advancing ischemic heart injury treatments.
REFERENCE   5  (bases 1 to 2924)
  AUTHORS   Madsen,P.M., Motti,D., Karmally,S., Szymkowski,D.E.,
            Lambertsen,K.L., Bethea,J.R. and Brambilla,R.
  TITLE     Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in
            Experimental Autoimmune Encephalomyelitis by Promoting
            Oligodendrocyte Differentiation and Remyelination
  JOURNAL   J Neurosci 36 (18), 5128-5143 (2016)
   PUBMED   27147664
REFERENCE   6  (bases 1 to 2924)
  AUTHORS   Sippy,B.D., Hofman,F.M., Wallach,D. and Hinton,D.R.
  TITLE     Increased expression of tumor necrosis factor-alpha receptors in
            the brains of patients with AIDS
  JOURNAL   J Acquir Immune Defic Syndr Hum Retrovirol 10 (5), 511-521 (1995)
   PUBMED   8548330
REFERENCE   7  (bases 1 to 2924)
  AUTHORS   Erickson,S.L., de Sauvage,F.J., Kikly,K., Carver-Moore,K.,
            Pitts-Meek,S., Gillett,N., Sheehan,K.C., Schreiber,R.D.,
            Goeddel,D.V. and Moore,M.W.
  TITLE     Decreased sensitivity to tumour-necrosis factor but normal T-cell
            development in TNF receptor-2-deficient mice
  JOURNAL   Nature 372 (6506), 560-563 (1994)
   PUBMED   7990930
REFERENCE   8  (bases 1 to 2924)
  AUTHORS   Aderka,D., Wysenbeek,A., Engelmann,H., Cope,A.P., Brennan,F.,
            Molad,Y., Hornik,V., Levo,Y., Maini,R.N., Feldmann,M. et al.
  TITLE     Correlation between serum levels of soluble tumor necrosis factor
            receptor and disease activity in systemic lupus erythematosus
  JOURNAL   Arthritis Rheum 36 (8), 1111-1120 (1993)
   PUBMED   8393677
REFERENCE   9  (bases 1 to 2924)
  AUTHORS   Aderka,D., Englemann,H., Hornik,V., Skornick,Y., Levo,Y.,
            Wallach,D. and Kushtai,G.
  TITLE     Increased serum levels of soluble receptors for tumor necrosis
            factor in cancer patients
  JOURNAL   Cancer Res 51 (20), 5602-5607 (1991)
   PUBMED   1655258
REFERENCE   10 (bases 1 to 2924)
  AUTHORS   Goodwin,R.G., Anderson,D., Jerzy,R., Davis,T., Brannan,C.I.,
            Copeland,N.G., Jenkins,N.A. and Smith,C.A.
  TITLE     Molecular cloning and expression of the type 1 and type 2 murine
            receptors for tumor necrosis factor
  JOURNAL   Mol Cell Biol 11 (6), 3020-3026 (1991)
   PUBMED   1645445
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF498039.2.
            
            On Jun 10, 2007 this sequence version replaced NM_130426.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF498039.2, AY344841.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2924
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /note="TNF receptor superfamily member 1B"
                     /db_xref="GeneID:156767"
                     /db_xref="RGD:621238"
     exon            1..147
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1494
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /note="p75; TNF-R2; TNF-RII; TNFR-II; p80 TNF-alpha
                     receptor; tumor necrosis factor receptor 2; tumor necrosis
                     factor receptor type II; tumor necrosis factor receptor
                     superfamily, member 1b"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 1B precursor"
                     /protein_id="NP_569110.1"
                     /db_xref="GeneID:156767"
                     /db_xref="RGD:621238"
                     /translation="MAPAALWVALVVELQLWATGHTVPAKVVLTPYKPEPGNQCQISQ
                     EYYDKKAQMCCAKCPPGQYAKHFCNKTSDTVCADCAAGMFTQVWNHLHTCLSCSSSCS
                     DDQVETHNCTKKQNRVCACNADSYCALKLHSGNCRQCMKLSKCGPGFGVARSRTSNGN
                     VICSACAPGTFSDTTSSTDVCRPHRICSILAIPGNASTDAVCASESPTPSAVPRTIYV
                     SQPEPTRSQPMDQEPGPSQTPHIPVSLGSTPIIEPSITGGISLPIGLIVGLTTLGLLM
                     LGLANCFILVQRKKKPSCLQRETMVPHLPDDKSQDAIGLEQQHLLTTAPSSSSSSLES
                     SASAGDRRAPPGGHPQARVTAEAQGSQEACAGSRSSDSSHGSHGTHVNVTCIVNVCSS
                     SDHSSQCSSQASTTVGDPDANPSGSPKDEQVPFSQEECPSQSQWETTETLQNHDKPFP
                     LGVPDVGMKPNQPGWYDQIAVKVP"
     exon            148..250
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..379
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..532
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..626
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..859
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..937
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..972
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1180
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..2894
                     /gene="Tnfrsf1b"
                     /gene_synonym="Tnfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaccagc tagagcgcag cagaggcacg agagctccag gcgcaagagc gggagctacc
       61 gccgccccta tggcgcccgc cgccctctgg gtcgcgctgg tcgtcgaact gcagctgtgg
      121 gccaccgggc acacagtgcc cgccaaggtt gtcttgacac cctacaagcc agaacctggg
      181 aaccagtgcc agatctcaca ggagtactat gacaagaagg ctcagatgtg ctgtgctaag
      241 tgtccccctg gccagtatgc aaaacacttc tgcaacaaga cttcagacac cgtgtgtgcg
      301 gactgtgcgg caggcatgtt tacccaggtc tggaaccatc tgcatacatg cctgagctgc
      361 agttcttcct gtagtgatga ccaggtggag acccacaact gcactaaaaa acagaaccga
      421 gtgtgtgctt gcaacgctga cagttactgt gccttgaaat tgcattctgg gaactgtcga
      481 cagtgcatga agctgagcaa gtgtggccct ggcttcggag tggcccgttc aagaacctca
      541 aatggaaacg tgatatgcag tgcctgtgcc ccagggacgt tctctgacac cacatcatcc
      601 acagatgtgt gcaggcccca ccgcatttgt agcatcctgg ctattcctgg aaatgcaagc
      661 acagatgcag tctgtgcatc cgagtcccca actccaagcg ctgttccaag gacaatctac
      721 gtatctcagc cagagcccac aagatcccag cccatggatc aagagccagg gcctagccaa
      781 actccacaca tccctgtgtc cttgggttca acccccatca ttgaaccaag catcacgggt
      841 ggcatctctc ttccaattgg tctgatcgtt ggactgacaa ctctgggtct gctgatgtta
      901 ggactggcga actgcttcat cctggtgcag aggaaaaaga agccctcctg cctacaacga
      961 gaaaccatgg tgcctcatct gcctgatgac aaatcccagg atgcaatagg ccttgaacag
     1021 cagcacctat tgaccacagc acccagttcc agcagcagct ccctggagag ctcagccagc
     1081 gctggggaca ggagagcgcc ccctgggggt catccccaag caagagtcac agcggaggcc
     1141 caagggtctc aggaagcctg tgccggctcc aggagttcag attcttccca tggcagccac
     1201 gggacccatg tcaacgtcac ctgcatcgtg aacgtctgta gcagctctga ccacagctct
     1261 cagtgttctt cccaagccag caccacggtg ggagacccag atgctaaccc ttcagggtct
     1321 ccaaaggatg agcaggtccc cttttcccag gaggagtgtc cctctcagtc ccagtgggag
     1381 accacagaga cactgcagaa ccatgacaag ccctttcccc ttggtgtgcc tgatgtgggt
     1441 atgaagccca accaaccagg ctggtatgac cagattgctg tcaaagtgcc ttgacccatg
     1501 acaggggcaa caccctgtaa agggaccccc ctaggccctg aacccatgga acttcatgac
     1561 tttttctgag cccgtttcct ttagtggcct ctacagttcc agttgcaggt caactgaggg
     1621 ctgaggcagc tagagtggtc aaaaacagcc ttggtgtttc atgggggcag tcccaggaag
     1681 cccttgttct tctgtgaccc tctggatctc ctgggtgctc tggctgattc ttgtttctga
     1741 aaggccccag aattttccct tctaaggagt taacatcctc ttccatatgc tttgagaaag
     1801 gatagcacag ctcttcagcg tgaatgctga cactgcaggg cagtgtctga ggtaagtagg
     1861 aggaagtagt cccctggtag ggcacagagg cccttcagat tagtgcaaga ctcttaggaa
     1921 gaaccctctc ccaacacact gaaatcctga tgccccaaca ggcaggattg ctctgttgta
     1981 gggtgctggg gctggggctc agtagtccag tgtgcttttt gccctgggtt tgatccgcag
     2041 tactcaaaaa gtacacagac agtagacaga gacagcacag gctacccccc ctgtgtggat
     2101 tttatcctct gcctttgact tttactccag tgggcacaca gaagcctgga gctccttctc
     2161 ctggccttct catgaacagt tccaaggcca taccttcctt cagggaatct cagggactgt
     2221 agagttccca ggcccctgca gccacctgtc tcgtcctacc tcagcctgga gcactctgtc
     2281 taattcccca accacttggt actgtactcg ctgtgaccca agtgcatgtc cgggttatgc
     2341 actgtgagtt ggaacagcca atggcgtcag ttgaagggcc cacgcagaaa cagctgaagc
     2401 cagctatttt gccaaaggat tcatgcttat tttctaatcg acctgctccc ctagcgtgcc
     2461 tggaggggaa gagttcagga gacttctgaa gacagaagaa gttgagcctc aggtgcttgg
     2521 atgccatgct cacagattcc acaggatatg aacttgttag aggagcccag ttgttaccat
     2581 ggagacttaa aaagctcagc cctctggaat caagatattg gacacttggg acagacttgt
     2641 taggtctctg tagcatcgga ctggagaagc gaagggacac gtctgccccc tggtggccag
     2701 tcctgggatg gcctcgggcc gcctaggcaa caaaaagaat gaattggaaa agactgcttc
     2761 tgggtgcggc ctcagctcct gtgcttgtgt ggatccctac atggtgtgtg tgtgcgtgct
     2821 aaggagtatt tgtcctgtat gctggacaga attcctgctt ataaatgctt ttcgttgctg
     2881 ttttgcacac tgataaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
