LOCUS       NM_013091               2115 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus TNF receptor superfamily member 1A (Tnfrsf1a),
            mRNA.
ACCESSION   NM_013091
VERSION     NM_013091.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Baez,B.B., Bacaglio,C.R., Prendergast,J.M., Rozes-Salvador,V.,
            Sheikh,K.A., Bianchet,M., Farah,M.H., Schnaar,R.L., Bisbal,M. and
            Lopez,P.H.H.
  TITLE     Tumor necrosis factor alpha receptor 1A transduces the inhibitory
            effect on axon regeneration triggered by IgG anti-ganglioside GD1a
            antibodies
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167315 (2024)
   PUBMED   38897255
  REMARK    GeneRIF: Tumor necrosis factor alpha receptor 1A transduces the
            inhibitory effect on axon regeneration triggered by IgG
            anti-ganglioside GD1a antibodies.
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Wahida,A., Muller,M., Hiergeist,A., Popper,B., Steiger,K.,
            Branca,C., Tschurtschenthaler,M., Engleitner,T., Donakonda,S., De
            Coninck,J., Ollinger,R., Pfautsch,M.K., Muller,N., Silva,M.,
            Usluer,S., Thiele Orberg,E., Bottcher,J.P., Pfarr,N., Anton,M.,
            Slotta-Huspenina,J.B., Nerlich,A.G., Madl,T., Basic,M., Bleich,A.,
            Berx,G., Ruland,J., Knolle,P.A., Rad,R., Adolph,T.E.,
            Vandenabeele,P., Kanegane,H., Gessner,A., Jost,P.J. and Yabal,M.
  TITLE     XIAP restrains TNF-driven intestinal inflammation and dysbiosis by
            promoting innate immune responses of Paneth and dendritic cells
  JOURNAL   Sci Immunol 6 (65), eabf7235 (2021)
   PUBMED   34739338
  REMARK    GeneRIF: TNFR1 drives the cell death of Paneth cells within the
            small intestine. This contributes to microibal dysbiosis and
            pathology in susceptible mice.
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   de Magalhaes,S.F., Manzo,L.P., de Faria,F.M., de
            Oliveira-Fusaro,M.C., Nishijima,C.M., Vieira,W.F., Bonet,I.J.M.,
            Dos Santos,G.G., Tambeli,C.H. and Parada,C.A.
  TITLE     Inflammatory pain in peripheral tissue depends on the activation of
            the TNF-alpha type 1 receptor in the primary afferent neuron
  JOURNAL   Eur J Neurosci 53 (2), 376-389 (2021)
   PUBMED   32979866
  REMARK    GeneRIF: Inflammatory pain in peripheral tissue depends on the
            activation of the TNF-alpha type 1 receptor in the primary afferent
            neuron.
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Gao,X.Z., Zhang,Z.X. and Han,G.L.
  TITLE     MiR-29a-3p Enhances the Viability of Rat Neuronal Cells that
            Injured by Oxygen-Glucose Deprivation/Reoxygenation Treatment
            Through Targeting TNFRSF1A and Regulating NF-kappaB Signaling
            Pathway
  JOURNAL   J Stroke Cerebrovasc Dis 29 (11), 105210 (2020)
   PUBMED   33066952
  REMARK    GeneRIF: MiR-29a-3p Enhances the Viability of Rat Neuronal Cells
            that Injured by Oxygen-Glucose Deprivation/Reoxygenation Treatment
            Through Targeting TNFRSF1A and Regulating NF-kappaB Signaling
            Pathway.
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Wang,W.M., Xu,X.S. and Miao,C.M.
  TITLE     Kupffer Cell-Derived TNF-alpha Triggers the Apoptosis of Hepatic
            Stellate Cells through TNF-R1/Caspase 8 due to ER Stress
  JOURNAL   Biomed Res Int 2020, 8035671 (2020)
   PUBMED   32802876
  REMARK    GeneRIF: Kupffer Cell-Derived TNF-alpha Triggers the Apoptosis of
            Hepatic Stellate Cells through TNF-R1/Caspase 8 due to ER Stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Hsu,H., Xiong,J. and Goeddel,D.V.
  TITLE     The TNF receptor 1-associated protein TRADD signals cell death and
            NF-kappa B activation
  JOURNAL   Cell 81 (4), 495-504 (1995)
   PUBMED   7758105
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Langkopf,F. and Atzpodien,J.
  TITLE     Soluble tumour necrosis factor receptors as prognostic factors in
            cancer patients
  JOURNAL   Lancet 344 (8914), 57-58 (1994)
   PUBMED   7912320
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   Aderka,D., Englemann,H., Hornik,V., Skornick,Y., Levo,Y.,
            Wallach,D. and Kushtai,G.
  TITLE     Increased serum levels of soluble receptors for tumor necrosis
            factor in cancer patients
  JOURNAL   Cancer Res 51 (20), 5602-5607 (1991)
   PUBMED   1655258
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Goodwin,R.G., Anderson,D., Jerzy,R., Davis,T., Brannan,C.I.,
            Copeland,N.G., Jenkins,N.A. and Smith,C.A.
  TITLE     Molecular cloning and expression of the type 1 and type 2 murine
            receptors for tumor necrosis factor
  JOURNAL   Mol Cell Biol 11 (6), 3020-3026 (1991)
   PUBMED   1645445
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   Himmler,A., Maurer-Fogy,I., Kronke,M., Scheurich,P.,
            Pfizenmaier,K., Lantz,M., Olsson,I., Hauptmann,R., Stratowa,C. and
            Adolf,G.R.
  TITLE     Molecular cloning and expression of human and rat tumor necrosis
            factor receptor chain (p60) and its soluble derivative, tumor
            necrosis factor-binding protein
  JOURNAL   DNA Cell Biol 9 (10), 705-715 (1990)
   PUBMED   1702293
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013091.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF329977.1, AF329981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               JAXUCZ010000004.1  159837119-159837393
            276-429             JAXUCZ010000004.1  159844421-159844574
            430-558             JAXUCZ010000004.1  159844737-159844865
            559-708             JAXUCZ010000004.1  159845168-159845317
            709-787             JAXUCZ010000004.1  159845510-159845588
            788-861             JAXUCZ010000004.1  159847691-159847764
            862-975             JAXUCZ010000004.1  159847900-159848013
            976-1004            JAXUCZ010000004.1  159848397-159848425
            1005-1314           JAXUCZ010000004.1  159848602-159848911
            1315-2115           JAXUCZ010000004.1  159849016-159849816
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2115
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /note="TNF receptor superfamily member 1A"
                     /db_xref="GeneID:25625"
                     /db_xref="RGD:621237"
     exon            1..275
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1622
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /note="p55; p60; TNF-R1; TNF-RI; TNFR-I; tumor necrosis
                     factor receptor 1; tumor necrosis factor receptor type I;
                     tumor necrosis factor receptor superfamily, member 1a"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 1A precursor"
                     /protein_id="NP_037223.2"
                     /db_xref="GeneID:25625"
                     /db_xref="RGD:621237"
                     /translation="MGLPIVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDNLC
                     PQGKYAHPKNNSICCTKCHKGTYLVSDCPSPGQETVCEVCDKGTFTASQNHVRQCLSC
                     KTCRKEMFQVEISPCKADMDTVCGCKKNQFQRYLSETHFQCVDCSPCFNGTVTIPCKE
                     KQNTVCNCHAGFFLSGNECTPCSHCKKNQECMKLCLPPVANVTNPQDSGTAVLLPLVI
                     FLGLCLLFFICISLLCRYPQWRPRVYSIICRDSAPVKEVEGEGIVTKPLTPASIPAFS
                     PNPGFNPTLGFSTTPRFSPPVSSTPISPVFGPSNWHNFVPPVREVVPTQGADPLLYGS
                     LNPVPIPAPVRKWEDVVAAQPQRLDTADPAMLYAVVDGVPPTRWKEFMRLLGLSEHEI
                     ERLELQNGRCLREAHYSMLEAWRRRTPRHEATLDVVGRVLCDMNLRGCLENIRETLES
                     PAHSSTTHLPR"
     exon            276..429
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..558
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..708
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..787
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..861
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..975
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1004
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1314
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..2115
                     /gene="Tnfrsf1a"
                     /gene_synonym="TNFR-1; Tnfr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttctccga gttttctgaa ctctggctca tgatcgggct tactggatac gagatcctgg
       61 aggaccgtac cctgatctcc atctacctct gactttgagc ctttctaacc cggggctcac
      121 gctgccaaca cccgggccac ctggtccgat cgtcttactt cattcaccag cgttgccaat
      181 tgctgccctg tccccagccc caatggggga gtgagagagg ccactgccgg ccggacatgg
      241 gtctccccat cgtgcctggc ctgctgctgt cactggtgct cctggctctg ctgatgggga
      301 tacacccgtc aggggtcacc ggactggttc cttctcttgg tgaccgggag aagagggata
      361 atttgtgtcc ccagggaaag tatgcccatc caaagaataa ttccatctgc tgcaccaagt
      421 gccacaaagg aacctacttg gtgagtgact gtccaagccc agggcaggaa acagtctgcg
      481 aggtgtgtga taaaggcacc tttacagctt cgcagaacca cgtcagacag tgtctcagtt
      541 gcaagacatg tcggaaagaa atgttccagg tggagatttc tccttgcaaa gctgacatgg
      601 acaccgtgtg tggctgcaag aagaaccaat tccagcgcta cctgagtgag acgcatttcc
      661 agtgtgtgga ctgcagcccc tgcttcaatg gcaccgtgac aatcccctgt aaggagaaac
      721 agaacaccgt gtgtaactgc cacgcaggat tctttctaag cggaaatgag tgcacccctt
      781 gcagccactg caagaaaaat caggaatgta tgaagctgtg cctacctcca gttgcaaatg
      841 tcacaaaccc ccaggactca ggtactgccg tgctgttgcc tctggttatc ttcctaggtc
      901 tttgcctttt attctttatc tgcatcagtc tactgtgccg atatccccag tggaggccca
      961 gggtctactc catcatttgt agggattcag ctcctgtcaa agaggtggag ggtgaaggaa
     1021 ttgttactaa gcccctaact ccagcctcta tcccagcctt cagccccaac cccggcttca
     1081 accccactct gggcttcagc accaccccac gcttcagtcc tcctgtctcc agtaccccca
     1141 tcagccccgt cttcggtcct agtaactggc acaacttcgt gccacctgta agagaggtgg
     1201 tcccaaccca gggtgctgac cctctcctct acggatccct caaccctgtg ccaatccccg
     1261 cccctgttcg gaaatgggaa gacgtcgtcg cggcccagcc acaacggctt gacactgcag
     1321 accctgcgat gctgtatgct gtggtggatg gcgtgcctcc gacacgctgg aaggagttca
     1381 tgcggctcct ggggctgagc gagcacgaga tcgagcggct ggagctgcag aacgggcgtt
     1441 gcctccgcga ggctcattac agcatgctgg aagcctggcg gcgccgcaca ccgcgacacg
     1501 aggccacgct ggacgtagtg ggccgcgtgc tttgcgacat gaacctgcgt ggctgcctgg
     1561 agaacatccg cgagactcta gaaagccctg cccactcgtc cacgacccac ctcccgcgat
     1621 aaggccacac ccccacctca ggaacgggac tcgaaggacc atcctgctag atgccctgct
     1681 tccctgtgaa cctcctcttt ggtcctctag ggggcaggct cgatctggca gccacttcct
     1741 tggtgctacc gacttggtgt acatagcttt tcccagctgc cgaggacagc ctgtgccagc
     1801 cacttgtgca tggcagggaa gtgtgccatc tgctcccaga cagctgaggg tgccaaaagc
     1861 caggagaggt gattgtggag aaaaagcaca atctatctga tacccacttg ggatgcaagg
     1921 acccaaacaa agcttctcag ggcctcctca gttgatttct gggccctttt cacagtagat
     1981 aaaacagtct ttgtattgat tatatcacac taatggatga acggttgaac tccctaaggt
     2041 aggggcaagc acagaacagt ggggtctcca gctggagccc ccgactcttg taaatacact
     2101 aaaaatctaa aagtg
//
