LOCUS       NM_012870               2832 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus TNF receptor superfamily member 11B (Tnfrsf11b),
            mRNA.
ACCESSION   NM_012870
VERSION     NM_012870.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2832)
  AUTHORS   Wu,Z., Duan,S., Li,M., Zhang,A., Yang,H., Luo,J., Cheng,R. and
            Hu,T.
  TITLE     Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an
            experimental rat apical periodontitis model
  JOURNAL   Int Endod J 57 (9), 1315-1325 (2024)
   PUBMED   38923421
  REMARK    GeneRIF: Autophagy regulates bone loss via the RANKL/RANK/OPG axis
            in an experimental rat apical periodontitis model.
REFERENCE   2  (bases 1 to 2832)
  AUTHORS   Zhou,J., Guo,L., Yang,Y., Liu,Y. and Zhang,C.
  TITLE     Mechanical force regulates root resorption in rats through RANKL
            and OPG
  JOURNAL   BMC Oral Health 22 (1), 290 (2022)
   PUBMED   35842599
  REMARK    GeneRIF: Mechanical force regulates root resorption in rats through
            RANKL and OPG.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2832)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P., Puzio,I.,
            Kushnir,V., Brezvyn,O., Muzyka,V. and Kotsyumbas,I.
  TITLE     The Influence of Prenatal Fumonisin Exposure on Bone Properties, as
            well as OPG and RANKL Expression and Immunolocalization, in Newborn
            Offspring Is Sex and Dose Dependent
  JOURNAL   Int J Mol Sci 22 (24), 13234 (2021)
   PUBMED   34948030
  REMARK    GeneRIF: The Influence of Prenatal Fumonisin Exposure on Bone
            Properties, as well as OPG and RANKL Expression and
            Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2832)
  AUTHORS   Sabry,M., Mostafa,S., Kamar,S., Rashed,L. and Estaphan,S.
  TITLE     The cross-talk between matrix metalloproteinase-9, RANKL/OPG system
            and cardiovascular risk factors in ovariectomized rat model of
            postmenopausal osteoporosis
  JOURNAL   PLoS One 16 (10), e0258254 (2021)
   PUBMED   34610044
  REMARK    GeneRIF: The cross-talk between matrix metalloproteinase-9,
            RANKL/OPG system and cardiovascular risk factors in ovariectomized
            rat model of postmenopausal osteoporosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2832)
  AUTHORS   Wang,L.Y., Wang,B., Cong,B.B., Cui,T., Du,Y.Q. and Song,Y.
  TITLE     [Effect of different orthodontic forces on the expression of T
            helper cell 17 cell-related cytokines in the pressure side of
            periodontal tissue in rats]
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 39 (2), 143-152 (2021)
   PUBMED   33834668
  REMARK    GeneRIF: [Effect of different orthodontic forces on the expression
            of T helper cell 17 cell-related cytokines in the pressure side of
            periodontal tissue in rats].
REFERENCE   6  (bases 1 to 2832)
  AUTHORS   Cundy,T., Hegde,M., Naot,D., Chong,B., King,A., Wallace,R.,
            Mulley,J., Love,D.R., Seidel,J., Fawkner,M., Banovic,T.,
            Callon,K.E., Grey,A.B., Reid,I.R., Middleton-Hardie,C.A. and
            Cornish,J.
  TITLE     A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an
            idiopathic hyperphosphatasia phenotype
  JOURNAL   Hum Mol Genet 11 (18), 2119-2127 (2002)
   PUBMED   12189164
REFERENCE   7  (bases 1 to 2832)
  AUTHORS   Wise,G.E., Yao,S., Zhang,Q. and Ren,Y.
  TITLE     Inhibition of osteoclastogenesis by the secretion of
            osteoprotegerin in vitro by rat dental follicle cells and its
            implications for tooth eruption
  JOURNAL   Arch Oral Biol 47 (3), 247-254 (2002)
   PUBMED   11839361
  REMARK    GeneRIF: except for the period of time in tooth eruption, where
            osteoclast formation is needed to form an eruption pathway,
            secretion of OPG (osteoprotegerin) prevents resorption of alveolar
            bone and subsequent disruption of the periodontal ligament
REFERENCE   8  (bases 1 to 2832)
  AUTHORS   Yang,X., Halladay,D., Onyia,J.E., Martin,T.J. and Chandrasekhar,S.
  TITLE     Protein Kinase C is a mediator of the synthesis and secretion of
            osteoprotegerin in osteoblast-like cells
  JOURNAL   Biochem Biophys Res Commun 290 (1), 42-46 (2002)
   PUBMED   11779130
REFERENCE   9  (bases 1 to 2832)
  AUTHORS   Gold,B.G., Zeleny-Pooley,M., Chaturvedi,P. and Wang,M.S.
  TITLE     Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds
            nerve regeneration
  JOURNAL   Neuroreport 9 (3), 553-558 (1998)
   PUBMED   9512405
REFERENCE   10 (bases 1 to 2832)
  AUTHORS   Simonet,W.S., Lacey,D.L., Dunstan,C.R., Kelley,M., Chang,M.S.,
            Luthy,R., Nguyen,H.Q., Wooden,S., Bennett,L., Boone,T.,
            Shimamoto,G., DeRose,M., Elliott,R., Colombero,A., Tan,H.L.,
            Trail,G., Sullivan,J., Davy,E., Bucay,N., Renshaw-Gegg,L.,
            Hughes,T.M., Hill,D., Pattison,W., Campbell,P., Sander,S., Van,G.,
            Tarpley,J., Derby,P., Lee,R. and Boyle,W.J.
  TITLE     Osteoprotegerin: a novel secreted protein involved in the
            regulation of bone density
  JOURNAL   Cell 89 (2), 309-319 (1997)
   PUBMED   9108485
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081830.1.
            
            On Sep 16, 2004 this sequence version replaced NM_012870.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081830.1, U94330.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q32"
     gene            1..2832
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="TNF receptor superfamily member 11B"
                     /db_xref="GeneID:25341"
                     /db_xref="RGD:619802"
     exon            1..137
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1310
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Osteoprotegerin"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 11B precursor"
                     /protein_id="NP_037002.1"
                     /db_xref="GeneID:25341"
                     /db_xref="RGD:619802"
                     /translation="MNKWLCCALLVFLDIIEWTTQETFPPKYLHYDPETGRQLLCDKC
                     APGTYLKQHCTVRRKTLCVPCPDYSYTDSWHTSDECVYCSPVCKELQTVKQECNRTHN
                     RVCECEEGRYLELEFCLKHRSCPPGLGVLQAGTPERNTVCKRCPDGFFSGETSSKAPC
                     RKHTNCSSLGLLLIQKGNATHDNVCSGNREATQNCGIDVTLCEEAFFRFAVPTKIIPN
                     WLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDL
                     CESSVQRHIGHANLTTEQLRILMESLPGKKISPDEIERTRKTCKPSEQLLKLLSLWRI
                     KNGDQDTLKGLMYALKHLKAYHFPKTVTHSLRKTIRFLHSFTMYRLYQKLFLEMIGNQ
                     VQSVKISCL"
     exon            138..504
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     exon            505..696
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     exon            697..921
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     exon            922..2786
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgttgcc cagaccttat ataaaacgtc atgttcgcct gggcagcaga gaagcaccta
       61 gcactggccc agcggctgcc gcctgaggtt tccagaggac cacaatgaac aagtggctgt
      121 gctgtgcact cctggtgttc ttggacatca ttgaatggac aacccaggaa acctttcctc
      181 caaaatactt gcattatgac ccagaaaccg gacgtcagct cttgtgtgac aaatgtgctc
      241 ctggcaccta cctaaaacag cactgcacag tcaggaggaa gacactgtgt gtcccttgcc
      301 ctgactactc ttatacagac agctggcaca cgagtgatga atgcgtgtac tgcagccccg
      361 tgtgcaagga actgcagacc gtgaaacagg agtgcaaccg cacccacaac cgagtgtgcg
      421 aatgtgagga agggcgctac ctggagctcg aattctgctt gaagcaccgg agctgtcccc
      481 caggcttggg tgtgctgcag gctgggaccc cagagcgaaa cacggtttgc aaaagatgtc
      541 cggatgggtt cttctcaggt gagacgtcat cgaaagcacc ctgtaggaaa cacaccaact
      601 gcagctcact tggcctcctg ctaattcaga aaggaaatgc aacacatgac aatgtatgtt
      661 ccggaaacag agaagcaact caaaattgtg gaatagatgt caccctgtgc gaagaggcat
      721 tcttcaggtt tgctgtgcct accaagatta taccgaattg gctgagtgtt ctggtggaca
      781 gtttgcctgg gaccaaagtg aatgcagaga gtgtagagag gataaaacgg agacacagct
      841 cgcaagagca aactttccag ctacttaagc tgtggaagca tcaaaacaga gaccaggaaa
      901 tggtgaagaa gatcatccaa gacattgacc tctgtgaaag cagtgtgcaa cggcatatcg
      961 gccacgcgaa cctcaccaca gagcagctcc gcatcttgat ggagagcttg cctgggaaga
     1021 agatcagccc agacgagatt gagagaacga gaaagacctg caaacccagc gagcagctcc
     1081 tgaagctact gagcttgtgg aggatcaaaa atggagacca agacaccttg aagggcctga
     1141 tgtacgcact caagcacttg aaagcatacc actttcccaa aaccgtcacc cacagtctga
     1201 ggaagaccat caggttcttg cacagcttca ccatgtaccg attgtatcag aaactctttc
     1261 tagaaatgat agggaatcag gttcaatcag tgaagataag ctgcttatag ttaggaatgg
     1321 tcactgggct gtttcttcag gatgggccaa cactgatgga gcagatggct gcttctccgg
     1381 ctcttgaaat ggcagttgat tcctttctca tcagttggtg ggaatgaaga tcctccagcc
     1441 caacacacac actggggagt ctgagtcagg agagtgaggc aggctatttg ataattgtgc
     1501 aaagctgcca ggtgtacacc tagaaagtca agcaccctga gaaagaggat atttttataa
     1561 cctcaaacat aggccctttc cttcctctcc ttatggatga gtactcagaa ggcttctact
     1621 atcttctgtg tcatccctag atgaaggcct cttttattta tttttttatt ctttttttcg
     1681 gagctgggga ccgaacccag ggccttgcgc ttgcgaggca agtgctctac cactgagcta
     1741 aatctccaac ccctgaaggc ctctttcttt ctgcctctga tagtctatga cattcttttt
     1801 tctacaattc gtatcaggtg cacgagcctt atcccatttg taggtttcta ggcaagttga
     1861 ccgttagcta tttttccctc tgaagatttg attcgagttg cagacttggc tagacaagca
     1921 ggggtaggtt atggtagttt atttaacaga ctgccaccag gagtccagtg tttcttgttc
     1981 ctctgtagtt gtacctaagc tgactccaag tacatttagt atgaaaaata atcaacaaat
     2041 tttattcctt ctatcaacat tggctagctt tgtttcaggg cactaaaaga aactactata
     2101 tggagaaaga attgatattg cccccaacgt tcaacaaccc aatagtttat ccagctgtca
     2161 tgcctggttc agtgtctact gactatgcgc cctcttatta ctgcatgcag taattcaact
     2221 ggaaatagta ataataataa tagaaataaa atctagactc cattggatct ctctgaatat
     2281 gggaatatct aacttaagaa gctttgagat ttcagttgtg ttaaaggctt ttattaaaaa
     2341 gctgatgctc ttctgtaaaa gttactaata tatctgtaag actattacag tattgctatt
     2401 tatatccatc cagatatatt ttgtacatat tataatccta gagagaaatg tcgtaggatt
     2461 taattttaga aagaaaaaaa ttctgtttac tattgtgaca aataaaagag ataaaatata
     2521 tttttaatag aaactttgta gtgttttcca ataggtacta tcaggtttcc agtgtggaat
     2581 gtttttataa tataatttta tctgtataaa atgtaatatc attttataga aaaatgtatt
     2641 atgtactcag ttgtttgtca gaaagtgtat gaactataaa ttatctaaat attagatgct
     2701 ctgagaaatt gaatgtacct ttatttaagg atttttgtga tcgcactata taaataacat
     2761 cattaaagtt ttcaaattat ttttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2821 aaaaaaaaaa aa
//
