LOCUS       NP_037002                401 aa            linear   ROD 19-AUG-2024
DEFINITION  tumor necrosis factor receptor superfamily member 11B precursor
            [Rattus norvegicus].
ACCESSION   NP_037002
VERSION     NP_037002.1
DBSOURCE    REFSEQ: accession NM_012870.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 401)
  AUTHORS   Wu,Z., Duan,S., Li,M., Zhang,A., Yang,H., Luo,J., Cheng,R. and
            Hu,T.
  TITLE     Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an
            experimental rat apical periodontitis model
  JOURNAL   Int Endod J 57 (9), 1315-1325 (2024)
   PUBMED   38923421
  REMARK    GeneRIF: Autophagy regulates bone loss via the RANKL/RANK/OPG axis
            in an experimental rat apical periodontitis model.
REFERENCE   2  (residues 1 to 401)
  AUTHORS   Zhou,J., Guo,L., Yang,Y., Liu,Y. and Zhang,C.
  TITLE     Mechanical force regulates root resorption in rats through RANKL
            and OPG
  JOURNAL   BMC Oral Health 22 (1), 290 (2022)
   PUBMED   35842599
  REMARK    GeneRIF: Mechanical force regulates root resorption in rats through
            RANKL and OPG.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 401)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P., Puzio,I.,
            Kushnir,V., Brezvyn,O., Muzyka,V. and Kotsyumbas,I.
  TITLE     The Influence of Prenatal Fumonisin Exposure on Bone Properties, as
            well as OPG and RANKL Expression and Immunolocalization, in Newborn
            Offspring Is Sex and Dose Dependent
  JOURNAL   Int J Mol Sci 22 (24), 13234 (2021)
   PUBMED   34948030
  REMARK    GeneRIF: The Influence of Prenatal Fumonisin Exposure on Bone
            Properties, as well as OPG and RANKL Expression and
            Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 401)
  AUTHORS   Sabry,M., Mostafa,S., Kamar,S., Rashed,L. and Estaphan,S.
  TITLE     The cross-talk between matrix metalloproteinase-9, RANKL/OPG system
            and cardiovascular risk factors in ovariectomized rat model of
            postmenopausal osteoporosis
  JOURNAL   PLoS One 16 (10), e0258254 (2021)
   PUBMED   34610044
  REMARK    GeneRIF: The cross-talk between matrix metalloproteinase-9,
            RANKL/OPG system and cardiovascular risk factors in ovariectomized
            rat model of postmenopausal osteoporosis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 401)
  AUTHORS   Wang,L.Y., Wang,B., Cong,B.B., Cui,T., Du,Y.Q. and Song,Y.
  TITLE     [Effect of different orthodontic forces on the expression of T
            helper cell 17 cell-related cytokines in the pressure side of
            periodontal tissue in rats]
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 39 (2), 143-152 (2021)
   PUBMED   33834668
  REMARK    GeneRIF: [Effect of different orthodontic forces on the expression
            of T helper cell 17 cell-related cytokines in the pressure side of
            periodontal tissue in rats].
REFERENCE   6  (residues 1 to 401)
  AUTHORS   Cundy,T., Hegde,M., Naot,D., Chong,B., King,A., Wallace,R.,
            Mulley,J., Love,D.R., Seidel,J., Fawkner,M., Banovic,T.,
            Callon,K.E., Grey,A.B., Reid,I.R., Middleton-Hardie,C.A. and
            Cornish,J.
  TITLE     A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an
            idiopathic hyperphosphatasia phenotype
  JOURNAL   Hum Mol Genet 11 (18), 2119-2127 (2002)
   PUBMED   12189164
REFERENCE   7  (residues 1 to 401)
  AUTHORS   Wise,G.E., Yao,S., Zhang,Q. and Ren,Y.
  TITLE     Inhibition of osteoclastogenesis by the secretion of
            osteoprotegerin in vitro by rat dental follicle cells and its
            implications for tooth eruption
  JOURNAL   Arch Oral Biol 47 (3), 247-254 (2002)
   PUBMED   11839361
  REMARK    GeneRIF: except for the period of time in tooth eruption, where
            osteoclast formation is needed to form an eruption pathway,
            secretion of OPG (osteoprotegerin) prevents resorption of alveolar
            bone and subsequent disruption of the periodontal ligament
REFERENCE   8  (residues 1 to 401)
  AUTHORS   Yang,X., Halladay,D., Onyia,J.E., Martin,T.J. and Chandrasekhar,S.
  TITLE     Protein Kinase C is a mediator of the synthesis and secretion of
            osteoprotegerin in osteoblast-like cells
  JOURNAL   Biochem Biophys Res Commun 290 (1), 42-46 (2002)
   PUBMED   11779130
REFERENCE   9  (residues 1 to 401)
  AUTHORS   Gold,B.G., Zeleny-Pooley,M., Chaturvedi,P. and Wang,M.S.
  TITLE     Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds
            nerve regeneration
  JOURNAL   Neuroreport 9 (3), 553-558 (1998)
   PUBMED   9512405
REFERENCE   10 (residues 1 to 401)
  AUTHORS   Simonet,W.S., Lacey,D.L., Dunstan,C.R., Kelley,M., Chang,M.S.,
            Luthy,R., Nguyen,H.Q., Wooden,S., Bennett,L., Boone,T.,
            Shimamoto,G., DeRose,M., Elliott,R., Colombero,A., Tan,H.L.,
            Trail,G., Sullivan,J., Davy,E., Bucay,N., Renshaw-Gegg,L.,
            Hughes,T.M., Hill,D., Pattison,W., Campbell,P., Sander,S., Van,G.,
            Tarpley,J., Derby,P., Lee,R. and Boyle,W.J.
  TITLE     Osteoprotegerin: a novel secreted protein involved in the
            regulation of bone density
  JOURNAL   Cell 89 (2), 309-319 (1997)
   PUBMED   9108485
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081830.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081830.1, U94330.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q32"
     Protein         1..401
                     /product="tumor necrosis factor receptor superfamily
                     member 11B precursor"
                     /note="Osteoprotegerin"
                     /calculated_mol_wt=43670
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2541
     Region          7..151
                     /region_name="TNFRSF11B"
                     /note="Tumor necrosis factor receptor superfamily member
                     11B (TNFRSF11B), also known as Osteoprotegerin (OPG);
                     cd10581"
                     /db_xref="CDD:276907"
     Region          7..62
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276907"
     mat_peptide     22..401
                     /product="Tumor necrosis factor receptor superfamily
                     member 11B. /id=PRO_0000034589"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1)"
                     /calculated_mol_wt=43670
     Region          24..62
                     /region_name="TNFR-Cys 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1)"
     Region          65..105
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276907"
     Region          65..105
                     /region_name="TNFR-Cys 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1)"
     Site            98
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1)"
     Region          107..145
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276907"
     Region          107..142
                     /region_name="TNFR-Cys 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1)"
     Region          124..>187
                     /region_name="TNFRSF"
                     /note="Tumor necrosis factor receptor superfamily
                     (TNFRSF); cl22855"
                     /db_xref="CDD:473981"
     Region          145..186
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276924"
     Region          145..185
                     /region_name="TNFR-Cys 4"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1)"
     Site            165
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1)"
     Site            178
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1)"
     Region          278..365
                     /region_name="Death"
                     /note="Death domain; pfam00531"
                     /db_xref="CDD:459845"
     Site            289
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1)"
     Site            400
                     /site_type="other"
                     /note="Involved in dimerization. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (O08727.1)"
     CDS             1..401
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /coded_by="NM_012870.2:105..1310"
                     /db_xref="GeneID:25341"
                     /db_xref="RGD:619802"
ORIGIN      
        1 mnkwlccall vfldiiewtt qetfppkylh ydpetgrqll cdkcapgtyl kqhctvrrkt
       61 lcvpcpdysy tdswhtsdec vycspvckel qtvkqecnrt hnrvceceeg rylelefclk
      121 hrscppglgv lqagtpernt vckrcpdgff sgetsskapc rkhtncsslg llliqkgnat
      181 hdnvcsgnre atqncgidvt lceeaffrfa vptkiipnwl svlvdslpgt kvnaesveri
      241 krrhssqeqt fqllklwkhq nrdqemvkki iqdidlcess vqrhighanl tteqlrilme
      301 slpgkkispd eiertrktck pseqllklls lwrikngdqd tlkglmyalk hlkayhfpkt
      361 vthslrktir flhsftmyrl yqklflemig nqvqsvkisc l
//
