LOCUS       NM_001014039            1433 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus TNF alpha induced protein 8 like 2 (Tnfaip8l2),
            mRNA.
ACCESSION   NM_001014039 XM_227431
VERSION     NM_001014039.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   DU,Y., Liu,X., Xiao,C., Li,J., Sheng,Z., Wang,Y., Wang,R. and Yu,X.
  TITLE     TIPE2 regulates periodontal inflammation by inhibiting NF-kappaB
            p65 phosphorylation
  JOURNAL   J Appl Oral Sci 31, e20230162 (2023)
   PUBMED   37493703
  REMARK    GeneRIF: TIPE2 regulates periodontal inflammation by inhibiting
            NF-kappaB p65 phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Sun,X., Li,X., Zhou,Y., Wang,Y. and Liu,X.
  TITLE     Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and
            Neuropathic Pain Induced by Sciatic Nerve Injury Through
            Inactivating NF-kappaB and JNK
  JOURNAL   Neurochem Res 47 (10), 3167-3177 (2022)
   PUBMED   35842555
  REMARK    GeneRIF: Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and
            Neuropathic Pain Induced by Sciatic Nerve Injury Through
            Inactivating NF-kappaB and JNK.
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Kong,Q., Yuan,M., Ming,T., Fang,Q., Wu,X. and Song,X.
  TITLE     Expression and regulation of tumor necrosis factor-alpha-induced
            protein-8-like 2 is associated with acute lung injury induced by
            myocardial ischemia reperfusion in diabetic rats
  JOURNAL   Microvasc Res 130, 104009 (2020)
   PUBMED   32333940
  REMARK    GeneRIF: Expression and regulation of tumor necrosis
            factor-alpha-induced protein-8-like 2 is associated with acute lung
            injury induced by myocardial ischemia reperfusion in diabetic rats.
REFERENCE   4  (bases 1 to 1433)
  AUTHORS   Shi,C., Wang,Y., Zhuang,G., Qi,Z., Li,Y. and Yin,P.
  TITLE     Tumor necrosis factor-alpha-induced protein-8 like 2 regulates
            lipopolysaccharide-induced rat rheumatoid arthritis immune
            responses and is associated with Rac activation and interferon
            regulatory factor 3 phosphorylation
  JOURNAL   Mol Med Rep 16 (5), 6346-6353 (2017)
   PUBMED   28849230
  REMARK    GeneRIF: TIPE2 regulates lipopolysaccharide-induced rat rheumatoid
            arthritis immune responses and is associated with Rac1 activation
            and IRF3 phosphorylation.
REFERENCE   5  (bases 1 to 1433)
  AUTHORS   Liu,M.W., Liu,R., Wu,H.Y., Zhang,W., Xia,J., Dong,M.N., Yu,W.,
            Wang,Q., Xie,F.M., Wang,R., Huang,Y.Q. and Qian,C.Y.
  TITLE     Protective effect of Xuebijing injection on D-galactosamine- and
            lipopolysaccharide-induced acute liver injury in rats through the
            regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing
            TIPE2 expression
  JOURNAL   Int J Mol Med 38 (5), 1419-1432 (2016)
   PUBMED   27666960
  REMARK    GeneRIF: Expression of tumor necrosis factor (TNF)alphainduced
            protein 8-like 2 (TIPE2), matrix metalloproteinase-9 (MMP-9) and
            heme oxygenase-1 (HO-1) and mitogen-activated protein kinase (MAPK)
            signaling was modulated by Xuebijing injection (XBJ).
REFERENCE   6  (bases 1 to 1433)
  AUTHORS   Luan,Y.Y., Yao,Y.M., Zhang,L., Dong,N., Zhang,Q.H., Yu,Y. and
            Sheng,Z.Y.
  TITLE     Expression of tumor necrosis factor-alpha induced protein 8 like-2
            contributes to the immunosuppressive property of CD4(+)CD25(+)
            regulatory T cells in mice
  JOURNAL   Mol Immunol 49 (1-2), 219-226 (2011)
   PUBMED   21963221
REFERENCE   7  (bases 1 to 1433)
  AUTHORS   Xi,W., Hu,Y., Liu,Y., Zhang,J., Wang,L., Lou,Y., Qu,Z., Cui,J.,
            Zhang,G., Liang,X., Ma,C., Gao,C., Chen,Y. and Liu,S.
  TITLE     Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in
            humans and mice
  JOURNAL   Mol Immunol 48 (9-10), 1203-1208 (2011)
   PUBMED   21466895
REFERENCE   8  (bases 1 to 1433)
  AUTHORS   Zhang,G., Hao,C., Lou,Y., Xi,W., Wang,X., Wang,Y., Qu,Z., Guo,C.,
            Chen,Y., Zhang,Y. and Liu,S.
  TITLE     Tissue-specific expression of TIPE2 provides insights into its
            function
  JOURNAL   Mol Immunol 47 (15), 2435-2442 (2010)
   PUBMED   20663561
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079019.1.
            
            On Apr 20, 2005 this sequence version replaced XM_227431.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079019.1, CK470001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1433
                     /gene="Tnfaip8l2"
                     /gene_synonym="RGD1310519"
                     /note="TNF alpha induced protein 8 like 2"
                     /db_xref="GeneID:310663"
                     /db_xref="RGD:1310519"
     exon            1..160
                     /gene="Tnfaip8l2"
                     /gene_synonym="RGD1310519"
                     /inference="alignment:Splign:2.1.0"
     exon            161..329
                     /gene="Tnfaip8l2"
                     /gene_synonym="RGD1310519"
                     /inference="alignment:Splign:2.1.0"
     exon            330..1386
                     /gene="Tnfaip8l2"
                     /gene_synonym="RGD1310519"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..913
                     /gene="Tnfaip8l2"
                     /gene_synonym="RGD1310519"
                     /note="tumor necrosis factor, alpha-induced protein 8-like
                     protein 2; TIPE2; TNFAIP8-like protein 2; TNF
                     alpha-induced protein 8-like protein 2; tumor necrosis
                     factor, alpha-induced protein 8-like 2"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein
                     8-like protein 2"
                     /protein_id="NP_001014061.1"
                     /db_xref="GeneID:310663"
                     /db_xref="RGD:1310519"
                     /translation="MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYR
                     VSKEYTHSRSKAQRVIKDLIKVAVKVAVLHRSGCFSPGELALATRFRQKLRQGAMTAL
                     SFGEVDFTFEAAVLAGLLIECREILLELVEHHLTPKSHDRIRHVFDHYSDPDLLTALY
                     GPDFTQHLDKICDGLRKLLDEGKL"
ORIGIN      
        1 gtcacatctt caggcaccct cttttgctgt gcattctctc caacagagat aatcctcacc
       61 cccagtgaca atgactgtgt gtggcactca accagaatcc aagtgtccaa ctgaggtctt
      121 tctgctgaac ttgggcccca cctagatcat gatttgttgg gctgctcttg ggacactgga
      181 cttcttggtg acagtggtga tgaaccggag gtggagagta ggtaggcggg gcttggggtg
      241 gggctagacc aaagggcctc taaggagctt ctcctttctg ctagctctca gacacatcca
      301 aagcaagacc ggcacccagc gcacagcagt cacagaccac atagggtcac ctagcaccat
      361 ggagtccttc agctcaaaga gtctggcact acaagcggag aagaagctgc tgagtaaaat
      421 ggctggtcgg tccgtggcgc atctctttat cgatgagact agcagcgagg tgctagacga
      481 gctttaccgc gtctccaaag aatacacgca cagccggtcc aaggcacaac gggtgatcaa
      541 agacctcatc aaggtggccg tcaaggtggc ggtgctgcac cgcagtggct gctttagccc
      601 tggggagctg gctctggcta cacgatttcg ccagaagctg cggcagggtg cgatgactgc
      661 acttagcttt ggtgaggtgg acttcacctt tgaggctgct gtgctagcag gtctgctcat
      721 cgagtgccgg gagattctgc tggagctggt ggagcaccac ctcacaccca agtcacatga
      781 ccgcatcaga cacgtgtttg atcactactc tgaccctgac ctgctgactg ccctctacgg
      841 gcccgacttc actcagcacc ttgacaagat ctgtgatggg ctccggaagc ttctagacga
      901 ggggaagctc tgaggctcct gagctcagca cactggactt tggcaaaatg actgaccggg
      961 aaacgacact tcgggctttc taacccgcac aaatgctttt caatcccctg gcttcattct
     1021 ctcccaagag tgctattgac accgaggcca cccccacccc caaactgctg gtggaataaa
     1081 gtaagactga gctgagtgag gcggctctcc catccagttc cagtaaagga aacagctgac
     1141 tgaagaagaa gtgaaactcc gatccgcctc tcccaggatg gctgcacaga acaggggatc
     1201 ctccttctcc acaaacccaa ggaaggggac actaaaggcc agaccaggaa ggtggccatc
     1261 ggagacctcc tggatctcct ccagttggag gcagcacttg gacacacaca gatgctgtgt
     1321 ttcagagctt ctagaaggag ctgagggaag ggaggcacag gggaaataaa accactgaaa
     1381 catgcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
