LOCUS       NM_053382               1401 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Rattus norvegicus TNF alpha induced protein 6 (Tnfaip6), mRNA.
ACCESSION   NM_053382 XM_001065494
VERSION     NM_053382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1401)
  AUTHORS   Li C, Li X, Shi Z, Wu P, Fu J, Tang J and Qing L.
  TITLE     Exosomes from LPS-preconditioned bone marrow MSCs accelerated
            peripheral nerve regeneration via M2 macrophage polarization:
            Involvement of TSG-6/NF-kappaB/NLRP3 signaling pathway
  JOURNAL   Exp Neurol 356, 114139 (2022)
   PUBMED   35690131
  REMARK    GeneRIF: Exosomes from LPS-preconditioned bone marrow MSCs
            accelerated peripheral nerve regeneration via M2 macrophage
            polarization: Involvement of TSG-6/NF-kappaB/NLRP3 signaling
            pathway.
REFERENCE   2  (bases 1 to 1401)
  AUTHORS   Tang B, Song M, Xie X, Le D, Tu Q, Wu X and Chen M.
  TITLE     Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs
            Regulates Activated Astrocytes by Inhibiting NF-kappaB Signaling
            Pathway to Ameliorate Blood Brain Barrier Damage After
            Intracerebral Hemorrhage
  JOURNAL   Neurochem Res 46 (9), 2387-2402 (2021)
   PUBMED   34145502
  REMARK    GeneRIF: Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted
            by BMSCs Regulates Activated Astrocytes by Inhibiting NF-kappaB
            Signaling Pathway to Ameliorate Blood Brain Barrier Damage After
            Intracerebral Hemorrhage.
REFERENCE   3  (bases 1 to 1401)
  AUTHORS   Usunier B, Brossard C, L'Homme B, Linard C, Benderitter M, Milliat
            F and Chapel A.
  TITLE     HGF and TSG-6 Released by Mesenchymal Stem Cells Attenuate Colon
            Radiation-Induced Fibrosis
  JOURNAL   Int J Mol Sci 22 (4), 1790 (2021)
   PUBMED   33670243
  REMARK    GeneRIF: HGF and TSG-6 Released by Mesenchymal Stem Cells Attenuate
            Colon Radiation-Induced Fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1401)
  AUTHORS   Chen Y, Tang X, Li P, Zhou Y, Xue T, Liu J and Yu C.
  TITLE     Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate
            Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via
            Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein
  JOURNAL   Biomed Res Int 2019, 9845709 (2019)
   PUBMED   30984789
  REMARK    GeneRIF: TSG-6 plays a key role in the treatment of
            ischemia/reperfusion injury-induced acute kidney injury with Bone
            Marrow Derived Mesenchymal Stromal Cells, which may be due to its
            effect on promoting renal tubular epithelial cells proliferation by
            modulating inflammation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1401)
  AUTHORS   Hu Y, Li G, Zhang Y, Liu N, Zhang P, Pan C, Nie H, Li Q and Tang Z.
  TITLE     Upregulated TSG-6 Expression in ADSCs Inhibits the BV2
            Microglia-Mediated Inflammatory Response
  JOURNAL   Biomed Res Int 2018, 7239181 (2018)
   PUBMED   30584538
  REMARK    GeneRIF: Regulate the inflammatory response in LPS-activated BV2
            microglia by upregulating TSG-6 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1401)
  AUTHORS   Sanggaard KW, Scavenius C, Rasmussen AJ, Wisniewski HG, Thogersen
            IB and Enghild JJ.
  TITLE     The TSG-6/HC2-mediated transfer is a dynamic process shuffling
            heavy chains between glycosaminoglycans
  JOURNAL   J Biol Chem 285 (29), 21988-21993 (2010)
   PUBMED   20463016
REFERENCE   7  (bases 1 to 1401)
  AUTHORS   Forteza R, Casalino-Matsuda SM, Monzon ME, Fries E, Rugg MS, Milner
            CM and Day AJ.
  TITLE     TSG-6 potentiates the antitissue kallikrein activity of
            inter-alpha-inhibitor through bikunin release
  JOURNAL   Am J Respir Cell Mol Biol 36 (1), 20-31 (2007)
   PUBMED   16873769
REFERENCE   8  (bases 1 to 1401)
  AUTHORS   Park YD, Lyou YJ, Lee KJ, Lee DY and Yang JM.
  TITLE     Towards profiling the gene expression of fibroblasts from atopic
            dermatitis patients: human 8K complementary DNA microarray
  JOURNAL   Clin Exp Allergy 36 (5), 649-657 (2006)
   PUBMED   16650051
REFERENCE   9  (bases 1 to 1401)
  AUTHORS   Fulop C, Szanto S, Mukhopadhyay D, Bardos T, Kamath RV, Rugg MS,
            Day AJ, Salustri A, Hascall VC, Glant TT and Mikecz K.
  TITLE     Impaired cumulus mucification and female sterility in tumor
            necrosis factor-induced protein-6 deficient mice
  JOURNAL   Development 130 (10), 2253-2261 (2003)
   PUBMED   12668637
REFERENCE   10 (bases 1 to 1401)
  AUTHORS   Yoshioka S, Ochsner S, Russell DL, Ujioka T, Fujii S, Richards JS
            and Espey LL.
  TITLE     Expression of tumor necrosis factor-stimulated gene-6 in the rat
            ovary in response to an ovulatory dose of gonadotropin
  JOURNAL   Endocrinology 141 (11), 4114-4119 (2000)
   PUBMED   11089543
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158666.1.
            
            On Aug 28, 2008 this sequence version replaced XM_001065494.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158666.1, FQ228783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..1401
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /note="TNF alpha induced protein 6"
                     /db_xref="GeneID:84397"
                     /db_xref="RGD:621359"
     exon            1..109
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..843
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /note="tumor necrosis factor alpha induced protein 6"
                     /codon_start=1
                     /product="tumor necrosis factor-inducible gene 6 protein
                     precursor"
                     /protein_id="NP_445834.1"
                     /db_xref="GeneID:84397"
                     /db_xref="RGD:621359"
                     /translation="MVFLLCLCVLLWEEAHGWGFKNGIFHNSIWLEQAAGVYHREARA
                     GRYKLTYAEAKAVCEYEGGRLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPN
                     CGFGKTGIIDYGIRLNRSERWDAYCYNPNAKECGGVFTDPKRIFKSPGFPNEYDDNQV
                     CYWHIRLKYGQRIHLSFLDFDLEHDPGCLADYVEIYDSYDDVHGFVGRYCGDELPEDI
                     ISTGNVMTLKFLSDASVTAGGFQIKYVTVDPAPKSNQGKNTTMTGNKKFLAGRFSHL"
     exon            110..247
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /inference="alignment:Splign:2.1.0"
     exon            248..409
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /inference="alignment:Splign:2.1.0"
     exon            410..638
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /inference="alignment:Splign:2.1.0"
     exon            639..679
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1376
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgcaactg aagatatggt cttcctcctt tgcttatgcg tcttgctgtg ggaagaggct
       61 cacggatggg gattcaagaa tggaatcttt cataattcca tatggcttga acaagcagca
      121 ggcgtatacc atagagaagc ccgggctggc agatacaagc taacctatgc agaagccaag
      181 gcggtatgtg aatatgaagg tggccgtctt gcaacctaca agcagctaga agcagccaga
      241 aagattggat tccatgtctg tgctgctggg tggatggcca agggtagagt tgggtacccc
      301 attgtgaaac ctgggcccaa ctgtggattt ggcaaaaccg gcatcattga ttatggaatc
      361 cggctcaaca ggagcgagcg gtgggacgcc tattgctaca acccgaacgc aaaggagtgt
      421 ggtggtgtct ttacagaccc gaagcgaatc tttaaatccc caggcttccc aaatgagtat
      481 gacgacaacc aggtttgcta ctggcacatc cggctcaagt acggtcagcg aattcacctg
      541 agctttttgg actttgacct tgaacatgat ccaggctgtt tggctgacta tgtagaaata
      601 tatgacagtt atgacgatgt ccacggcttt gtaggaagat actgcggtga tgaacttcca
      661 gaagacatca tcagcacagg aaatgtcatg accttgaagt ttctgagtga tgcgtccgtc
      721 acagccggag gcttccagat taaatacgtc acagtggatc ctgcacctaa atccaatcaa
      781 ggcaaaaata caactatgac tggaaataaa aagttcttag ctggacggtt tagccatcta
      841 taattcttat ttttttttta aaaaaaaaga tgttcaaaac atccagtaca atatttatat
      901 ttgtagcttt tggacctcat ttgttctcaa ttttgtattt tttgttatta acatgtattt
      961 attattttcg tgaatgtgaa agcaatatgt aattgtgggg gaaattgaaa actacagaaa
     1021 acttcgaatg agttaaaaaa aaacaactca taattgtact acacagaaat aactaatgtt
     1081 aacatttttt aatgtttgtc tttcattcgt ttttctactt atagtatttg tatatatgta
     1141 actctgtgat ttgcatttga cttttggcat tctgccttat gtatagtttt ataacctgat
     1201 atttttgact ttaacgtttt agagctcaag caatttccga gatcactgag ttttctataa
     1261 actggaactt tgagtagttg taaatgtgat tgtcccctgc cttatttaaa ctaagtttat
     1321 atcaggattt aaggttgatt tcataaatgg tgttgtaata aatacttttg gacataaaaa
     1381 aaaaaaaaaa aaaaaaaaaa a
//
