LOCUS       NM_012675               1687 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus tumor necrosis factor (Tnf), mRNA.
ACCESSION   NM_012675
VERSION     NM_012675.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Wushouer,X., Aximujiang,K., Kadeer,N., Aihemaiti,A., Zhong,L. and
            Yunusi,K.
  TITLE     Effect of huankuile on colon injury in rats with ulcerative colitis
            by reducing TNF-alpha and MMP9
  JOURNAL   Eur J Med Res 29 (1), 102 (2024)
   PUBMED   38321559
  REMARK    GeneRIF: Effect of huankuile on colon injury in rats with
            ulcerative colitis by reducing TNF-alpha and MMP9.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Liu,M., Gong,S., Sheng,X., Zhang,Z. and Yang,J.
  TITLE     Mechanism of TNF- alpha inducing apoptosis and autophagy of
            chondrocytes by activating NF- kappa B signal pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (15), 95-98 (2023)
   PUBMED   38279481
  REMARK    GeneRIF: Mechanism of TNF- alpha inducing apoptosis and autophagy
            of chondrocytes by activating NF- kappa B signal pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Jiang,X.S., Fu,B.L., Yang,X.X. and Qin,H.Y.
  TITLE     TNF-alpha Mediated the Disruption of Hepatic Tight Junction
            Expression in Blood-Biliary Barrier of Colitis via Downregulating
            PI3K/AKT Signaling Pathway
  JOURNAL   Biol Pharm Bull 46 (12), 1769-1777 (2023)
   PUBMED   37899248
  REMARK    GeneRIF: TNF-alpha Mediated the Disruption of Hepatic Tight
            Junction Expression in Blood-Biliary Barrier of Colitis via
            Downregulating PI3K/AKT Signaling Pathway.
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Guo,J., Meng,X., Zheng,Y.M., Zhao,S.K., Qiang,C. and Zhou,L.B.
  TITLE     Cigarette Smoke Mediates Nasal Epithelial Barrier Dysfunction via
            TNF-alpha
  JOURNAL   Am J Rhinol Allergy 37 (6), 646-655 (2023)
   PUBMED   37424240
  REMARK    GeneRIF: Cigarette Smoke Mediates Nasal Epithelial Barrier
            Dysfunction via TNF-alpha.
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Duan,Y., Li,Q., Zhou,Y., Chen,S., Li,Y. and Zang,Y.
  TITLE     Activation of the TNF-alpha-Necroptosis Pathway in
            Parvalbumin-Expressing Interneurons of the Anterior Cingulate
            Cortex Contributes to Neuropathic Pain
  JOURNAL   Int J Mol Sci 24 (20), 15454 (2023)
   PUBMED   37895135
  REMARK    GeneRIF: Activation of the TNF-alpha-Necroptosis Pathway in
            Parvalbumin-Expressing Interneurons of the Anterior Cingulate
            Cortex Contributes to Neuropathic Pain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Fleisher,L.N., Ferrell,J.B. and McGahan,M.C.
  TITLE     Synergistic uveitic effects of tumor necrosis factor-alpha and
            interleukin-1 beta
  JOURNAL   Invest Ophthalmol Vis Sci 33 (7), 2120-2127 (1992)
   PUBMED   1318867
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Manthey,C.L., Kossmann,T., Allen,J.B., Corcoran,M.L., Brandes,M.E.
            and Wahl,S.M.
  TITLE     Role of Kupffer cells in developing streptococcal cell wall
            granulomas. Streptococcal cell wall induction of inflammatory
            cytokines and mediators
  JOURNAL   Am J Pathol 140 (5), 1205-1214 (1992)
   PUBMED   1580332
REFERENCE   9  (bases 1 to 1687)
  AUTHORS   De,M., Sanford,T.R. and Wood,G.W.
  TITLE     Interleukin-1, interleukin-6, and tumor necrosis factor alpha are
            produced in the mouse uterus during the estrous cycle and are
            induced by estrogen and progesterone
  JOURNAL   Dev Biol 151 (1), 297-305 (1992)
   PUBMED   1577194
REFERENCE   10 (bases 1 to 1687)
  AUTHORS   Williams,A.F., Barclay,A.N., Letarte-Muirhead,M. and Morris,R.J.
  TITLE     Rat thy-1 antigens from thymus and brain: their tissue
            distribution, purification, and chemical composition
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 51-61 (1977)
   PUBMED   70317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883046.1.
            
            On Oct 1, 2009 this sequence version replaced NM_012675.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107671.1, HQ201305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               BX883046.1         51955-52284         c
            331-385             BX883046.1         51401-51455         c
            386-433             BX883046.1         51205-51252         c
            434-1687            BX883046.1         49666-50919         c
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1687
                     /gene="Tnf"
                     /gene_synonym="RATTNF; TNF-alpha; Tnfa"
                     /note="tumor necrosis factor"
                     /db_xref="GeneID:24835"
                     /db_xref="RGD:3876"
     exon            1..330
                     /gene="Tnf"
                     /gene_synonym="RATTNF; TNF-alpha; Tnfa"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..852
                     /gene="Tnf"
                     /gene_synonym="RATTNF; TNF-alpha; Tnfa"
                     /note="cachectin; tumor necrosis factor ligand superfamily
                     member 2; tumor necrosis factor (TNF superfamily, member
                     2)"
                     /codon_start=1
                     /product="tumor necrosis factor"
                     /protein_id="NP_036807.1"
                     /db_xref="GeneID:24835"
                     /db_xref="RGD:3876"
                     /translation="MSTESMIRDVELAEEALPKKMGGLQNSRRCLCLSLFSFLLVAGA
                     TTLFCLLNFGVIGPNKEEKFPNGLPLISSMAQTLTLRSSSQNSSDKPVAHVVANHQAE
                     EQLEWLSQRANALLANGMDLKDNQLVVPADGLYLIYSQVLFKGQGCPDYVLLTHTVSR
                     FAISYQEKVSLLSAIKSPCPKDTPEGAELKPWYEPMYLGGVFQLEKGDLLSAEVNLPK
                     YLDITESGQVYFGVIAL"
     exon            331..385
                     /gene="Tnf"
                     /gene_synonym="RATTNF; TNF-alpha; Tnfa"
                     /inference="alignment:Splign:2.1.0"
     exon            386..433
                     /gene="Tnf"
                     /gene_synonym="RATTNF; TNF-alpha; Tnfa"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1687
                     /gene="Tnf"
                     /gene_synonym="RATTNF; TNF-alpha; Tnfa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccaaggga ccagccagga gggagaacag caactccaga acaccctggt actaactccc
       61 agaaaagcaa gcaaccagcc aggcaggttc cgtccctctc atacactggc ccgaggcaac
      121 acatctccct ccggaaagga caccatgagc acggaaagca tgatccgaga tgtggaactg
      181 gcagaggagg cgctccccaa aaagatgggg ggcctccaga actccaggcg gtgtctgtgc
      241 ctcagcctct tctcattcct gctcgtggcg ggggccacca cgctcttctg tctactgaac
      301 ttcggggtga tcggtcccaa caaggaggag aagttcccaa atgggctccc tctcatcagt
      361 tccatggccc agaccctcac actcagatca tcttctcaaa actcgagtga caagcccgta
      421 gcccacgtcg tagcaaacca ccaagcggag gagcagctgg agtggctgag ccagcgtgcc
      481 aacgccctcc tggccaatgg catggatctc aaagacaacc aactggtggt accagcagat
      541 gggctgtacc ttatctactc ccaggttctc ttcaagggac aaggctgccc cgactacgtg
      601 ctcctcaccc acaccgtcag ccgatttgcc atttcatacc aggagaaagt cagcctcctc
      661 tctgccatca agagcccttg ccctaaggac acccctgagg gagctgagct caagccctgg
      721 tatgagccca tgtacctggg aggagtcttc cagctggaga agggggacct gctcagcgct
      781 gaggtcaacc tgcccaagta cttagacatc acggagtccg ggcaggtcta ctttggagtc
      841 attgctctgt gaggcgactg gcgtgttcat ccgttctcta cccagcccct gtccccgact
      901 ctgaccccca ttactctgac ccctttatcg tctactcctc agagccccca atctgtgtcc
      961 ttctaactta gaaagggaat tgtggctctg ggtccaactc cgggctcaga atttccaaca
     1021 actacgatgc tcagaaacac acgagacgct gaagtagtgg cctggattgc gggctgctca
     1081 tgagccgcca ccggcaagga ttccaatggg ctttcggaac tcactggatc ccggaatgtc
     1141 gatgcctgag tggatcgggg gagtggaggg gggagtggat caggctgcct ctggctcaca
     1201 aggctgctga agatgtctca ggcctccctt ccttccttcc ttccctccct cagagcttcc
     1261 cagactgttc cctgaggcac agcgcccagc cttccttacg gaaccccctc tatttataat
     1321 tgcacctgtg actatttatt tattatttat tatttattta tttgcttatg aatgtattta
     1381 tttggaaggc cggggcgtcc tggaggaccc agcgttggga agctgtcttc aggccaacat
     1441 gttttctgtg aaaacggagc taaactacca gctatcccca tctggtcccc cacccctgcc
     1501 tcgttgcctc cccccttttc ttttgcttat gtttaaaaca agatatttat ctaacccagt
     1561 tgtcttaata atgctgattt ggtgaccagg ctgtcgctac atcactgaac ctctgctccc
     1621 cacgggagcc gtgactgtaa tcgccctacg ggtcattgag agaaataaag ttcgcttgga
     1681 aaagaaa
//
