LOCUS       NM_053861               7002 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tenascin C (Tnc), mRNA.
ACCESSION   NM_053861 XM_008763757
VERSION     NM_053861.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7002)
  AUTHORS   Wu,H., Yang,M., Yan,C., Liu,M., Wang,H. and Zhang,W.
  TITLE     Tenascin C activates the toll-like receptor 4/NF-kappaB signaling
            pathway to promote the development of polycystic ovary syndrome
  JOURNAL   Mol Med Rep 29 (6) (2024)
   PUBMED   38666538
  REMARK    GeneRIF: Tenascin C activates the toll-like receptor 4/NF-kappaB
            signaling pathway to promote the development of polycystic ovary
            syndrome.
REFERENCE   2  (bases 1 to 7002)
  AUTHORS   Kolanowski,T.J., Wargocka-Matuszewska,W., Zimna,A., Cheda,L.,
            Zyprych-Walczak,J., Rugowska,A., Drabik,M., Fiedorowicz,M.,
            Krajewski,S., Steczek,L., Kozanecki,C., Rogulski,Z., Rozwadowska,N.
            and Kurpisz,M.
  TITLE     Multiparametric Evaluation of Post-MI Small Animal Models Using
            Metabolic ([18F]FDG) and Perfusion-Based (SYN1) Heart Viability
            Tracers
  JOURNAL   Int J Mol Sci 22 (22), 12591 (2021)
   PUBMED   34830471
  REMARK    GeneRIF: Multiparametric Evaluation of Post-MI Small Animal Models
            Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart
            Viability Tracers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7002)
  AUTHORS   Tong,X., Zhang,J., Shen,M. and Zhang,J.
  TITLE     Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via
            PI3K/Akt/NF-kappaB Signaling Pathway in Subarachnoid Hemorrhage
            Cell Model
  JOURNAL   J Stroke Cerebrovasc Dis 29 (1), 104485 (2020)
   PUBMED   31706751
  REMARK    GeneRIF: TNC gene silencing relieved neuronal apoptosis and
            neuroinflammation by activating the PI3K/Akt/ NF-kappaB signaling
            pathway in subarachnoid hemorrhage.
REFERENCE   4  (bases 1 to 7002)
  AUTHORS   Li,H., Ge,X., Pan,K., Sui,M., Cai,H., Cui,C., Li,C. and Lu,S.
  TITLE     The Predictive Role of Tenascin-C and Cellular Communication
            Network Factor 3 (CCN3) in Post Hepatectomy Liver Failure in a Rat
            Model and 50 Patients Following Partial Hepatectomy
  JOURNAL   Med Sci Monit 25, 6755-6766 (2019)
   PUBMED   31494663
  REMARK    GeneRIF: This study aimed to investigate the role of TNC and CCN3
            as prognostic factors for post hepatectomy liver failure (PHLF) in
            a rat model of partial hepatectomy and 50 patients following
            partial hepatectomy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7002)
  AUTHORS   Zhao,B., Hu,M., Wu,H., Ren,C., Wang,J. and Cui,S.
  TITLE     Tenascin-C expression and its associated pathway in BMSCs following
            co-culture with mechanically stretched ligament fibroblasts
  JOURNAL   Mol Med Rep 15 (5), 2465-2472 (2017)
   PUBMED   28447748
  REMARK    GeneRIF: these results indicated that in an indirect coculture
            system, pelvic ligament fibroblasts with mechanical stretch
            stimulation may promote the synthesis of tenascinC and BMSC
            differentiation into pelvic ligament fibroblasts.
REFERENCE   6  (bases 1 to 7002)
  AUTHORS   Kida,H., Taga,M., Minaguchi,H., Hanazono,M., Ohashi,T., Sakakura,T.
            and Kusakabe,M.
  TITLE     The change in tenascin expression in mouse uterus during early
            pregnancy
  JOURNAL   J Assist Reprod Genet 14 (1), 44-50 (1997)
   PUBMED   9013311
REFERENCE   7  (bases 1 to 7002)
  AUTHORS   Sakai,T., Furukawa,Y., Chiquet-Ehrismann,R., Nakamura,M.,
            Kitagawa,S., Ikemura,T. and Matsumoto,K.
  TITLE     Tenascin-X expression in tumor cells and fibroblasts:
            glucocorticoids as negative regulators in fibroblasts
  JOURNAL   J Cell Sci 109 (Pt 8), 2069-2077 (1996)
   PUBMED   8856503
REFERENCE   8  (bases 1 to 7002)
  AUTHORS   Thesleff,I., Vaahtokari,A., Vainio,S. and Jowett,A.
  TITLE     Molecular mechanisms of cell and tissue interactions during early
            tooth development
  JOURNAL   Anat Rec 245 (2), 151-161 (1996)
   PUBMED   8769660
  REMARK    Review article
REFERENCE   9  (bases 1 to 7002)
  AUTHORS   LaFleur,D.W., Fagin,J.A., Forrester,J.S., Rubin,S.A. and
            Sharifi,B.G.
  TITLE     Cloning and characterization of alternatively spliced isoforms of
            rat tenascin. Platelet-derived growth factor-BB markedly stimulates
            expression of spliced variants of tenascin mRNA in arterial smooth
            muscle cells
  JOURNAL   J Biol Chem 269 (32), 20757-20763 (1994)
   PUBMED   7519614
REFERENCE   10 (bases 1 to 7002)
  AUTHORS   Ocklind,G., Talts,J., Fassler,R., Mattsson,A. and Ekblom,P.
  TITLE     Expression of tenascin in developing and adult mouse lymphoid
            organs
  JOURNAL   J Histochem Cytochem 41 (8), 1163-1169 (1993)
   PUBMED   7687262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_008763757.3, NM_053861.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: EU596506.1, SRR23984936.420719.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000005.1  82475958-82476131   c
            175-756             JAXUCZ010000005.1  82451024-82451605   c
            757-2166            JAXUCZ010000005.1  82448443-82449852   c
            2167-2430           JAXUCZ010000005.1  82446437-82446700   c
            2431-2546           JAXUCZ010000005.1  82445478-82445593   c
            2547-2703           JAXUCZ010000005.1  82444633-82444789   c
            2704-2973           JAXUCZ010000005.1  82440989-82441258   c
            2974-3159           JAXUCZ010000005.1  82440019-82440204   c
            3160-3249           JAXUCZ010000005.1  82439651-82439740   c
            3250-3513           JAXUCZ010000005.1  82437737-82438000   c
            3514-3786           JAXUCZ010000005.1  82431100-82431372   c
            3787-4059           JAXUCZ010000005.1  82430316-82430588   c
            4060-4332           JAXUCZ010000005.1  82425972-82426244   c
            4333-4605           JAXUCZ010000005.1  82423458-82423730   c
            4606-4878           JAXUCZ010000005.1  82413321-82413593   c
            4879-5001           JAXUCZ010000005.1  82408093-82408215   c
            5002-5145           JAXUCZ010000005.1  82406836-82406979   c
            5146-5265           JAXUCZ010000005.1  82404518-82404637   c
            5266-5409           JAXUCZ010000005.1  82402466-82402609   c
            5410-5540           JAXUCZ010000005.1  82401598-82401728   c
            5541-5673           JAXUCZ010000005.1  82398606-82398738   c
            5674-5825           JAXUCZ010000005.1  82397920-82398071   c
            5826-5922           JAXUCZ010000005.1  82396985-82397081   c
            5923-6084           JAXUCZ010000005.1  82396007-82396168   c
            6085-6248           JAXUCZ010000005.1  82393432-82393595   c
            6249-7002           JAXUCZ010000005.1  82391340-82392093   c
FEATURES             Location/Qualifiers
     source          1..7002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..7002
                     /gene="Tnc"
                     /note="tenascin C"
                     /db_xref="GeneID:116640"
                     /db_xref="RGD:621057"
     exon            1..174
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            175..756
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..6359
                     /gene="Tnc"
                     /note="Tn-C AD1; tenascin-C AD1 domain"
                     /codon_start=1
                     /product="tenascin precursor"
                     /protein_id="NP_446313.2"
                     /db_xref="GeneID:116640"
                     /db_xref="RGD:621057"
                     /translation="MGAVTWLLPGIFLALFALTPEGGVLKKVIRHKRESGLNLTLPEE
                     NQPVVFNHIYNIKLPMGSQCSVDLESTSGEKDLSPTPESSGSFQEHTVDGENQIVFTH
                     RINIPRRACGCAAAPDVKELLSRLEELEMLVSSLREQCTMGTGCCLQPAEGRLDSRPF
                     CSGRGNFSAEGCGCVCEPGWKGPNCSEPECPGNCNLRGQCLDGQCICDQGFTGEDCSQ
                     LACPNDCNDQGKCVNGVCVCFEGYAGLDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAG
                     EDCNEPLCFNNCNNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEE
                     GFTGEDCGELTCPNNCQGHGQCEEGQCVCNEGFAGADCSEKRCPADCHHHGRCLNGQC
                     ECDDGFTGADCGELQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGHCV
                     QGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQR
                     GRCVDGQCICEDGFTGSDCAELSCPGDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSD
                     CHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVAGRCICNEGYTGVDCSEVS
                     PPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIREL
                     EPGVEYFIHVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFE
                     TWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKV
                     TTTRLDAPSQIEVRDITDTTALITWSKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDN
                     QYSIGNLKPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWR
                     NVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGVGVSAVKGDK
                     EGDPATINAATEIDAPRDLQVSETTQDSLTLFWKTPLAKFDRYRLNYSLPTGQSIEIQ
                     LPKDATSHVLTDLEPGQEYTVLLTAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWD
                     GLRLNWTADDLAYEYFVIQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYG
                     VARGYKTPVLSAETFTGKTPSLGEVTVAEVGWDALKLNWTAPEGAYTNFFIQVLEADM
                     TQTVQNLTVPGGLRSVDLPGLKAATRYYITVRGVTQDFSTAPLSVEVLTEEIPQLGGL
                     SVTEVSWDSLTLNWTTDDLAYKHFIIQVQEANNVEAAQNLTVSGSLRVVDIPGLKADT
                     PYRVSIYGVIQGYRTPMLSADVSTAKEPEIGNLNISDVTPESFNLSWTATDGIFDMFT
                     IEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYLSGIAPSIRTKTISTTATTE
                     AEPEVDNLLVSDATPDGFRLSWTADEGIFDSFVIRIRDTKKQSEPQEITLPSPDRTRD
                     ITGLREATEYEIELYGISRGRRSQPVSAIATTAMGSPKEIMFSDITENAATVSWRAPT
                     AQVESFRITYVPVTGGPPSMVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFEESDPVS
                     GSLITALDGPSGLLTANITDSEALAMWQPAIATVDSYVISYTGERVPEITRTVSGNTV
                     EFELHDLEPATEYTLSVFAEKGHQKSSTIATKFTTDLDSPRELTATEVQSETALLTWR
                     PPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTARIQALSGSLRSKL
                     IQTIFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWI
                     VFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQDHGES
                     AYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCALSY
                     KGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSNFRNLEGRR
                     KRA"
     exon            757..2166
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2430
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2546
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2703
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2973
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3159
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3249
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3513
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3786
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..4059
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4332
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            4333..4605
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4878
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            4879..5001
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..5145
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5146..5265
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5266..5409
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5410..5540
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5541..5673
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5674..5825
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5826..5922
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            5923..6084
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            6085..6248
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
     exon            6249..7002
                     /gene="Tnc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacagcct gcctactgtc acgcgtctct cccgcgcgct gaacacacac cctagcctct
       61 ggtgggcaca gacagtggct ggggagacgc tagggactgc gcgcttggga actcgcccag
      121 gtacttctct gagccggtgc acccagagac cttgatttct ccgacctgga atagatcttt
      181 cttccatgaa gactggagac gttcaactgt attcttttaa gtacatctaa ataccaaatt
      241 ctactggaag ttcaggcacc ctacagatct agagacacct agccaatcca acctctacca
      301 tgggggccgt gacctggcta ttgccaggca tcttcctagc tttgtttgcc ctcactcctg
      361 aaggtggggt cctcaagaaa gtcatcaggc acaagcgaga gagtgggctg aacttgacct
      421 tgccagagga gaatcagcca gtggtgttca accatatcta caacatcaag ttgcccatgg
      481 gttctcagtg ctcagtggat ctagagtcaa cgagtggaga gaaagacctg agccccacac
      541 cagagtccag tggaagcttc caggagcata cagtggatgg ggaaaatcag attgtgttca
      601 cacaccgcat caacatccct cgtcgggcct gtggctgtgc cgcagctcca gatgtgaagg
      661 agctcctgag cagactggag gaactggaga tgttggtatc ttctctaagg gagcagtgca
      721 ccatgggtac aggctgttgc ctccaacctg cagaaggccg tctggacagc aggcccttct
      781 gcagcggcag gggtaacttc agtgctgaag gttgtggctg tgtctgtgaa ccaggctgga
      841 aaggtcccaa ctgctctgag cctgaatgcc ctggaaactg taatctcaga ggccagtgcc
      901 ttgatggaca gtgtatctgt gaccagggtt tcactgggga agactgcagc cagctagcct
      961 gtcccaatga ctgcaatgac cagggcaagt gtgtgaatgg ggtctgtgtg tgcttcgaag
     1021 gctatgccgg ccttgactgt ggcctggaag tctgcccagt gccgtgcagc gaggaacacg
     1081 ggatgtgtgt ggatggcagg tgtgtgtgca aagatggctt tgctggtgaa gactgcaatg
     1141 agcccctttg cttcaacaac tgcaacaacc gtgggcggtg tgtggagaac gaatgcgtct
     1201 gtgatgaggg cttcacgggc gaagactgca gcgagctcat ttgccccaat gactgcttcg
     1261 accgaggtcg ctgcatcaac ggcacctgct actgtgaaga aggtttcaca ggtgaagact
     1321 gtggtgagct cacctgcccc aacaactgtc agggccatgg ccagtgtgaa gagggacagt
     1381 gtgtttgcaa cgagggcttt gcaggggcag actgcagtga aaagcggtgt cccgcagact
     1441 gtcaccacca tggccgctgt ctcaacggac agtgtgagtg tgacgatggg ttcacagggg
     1501 ctgactgtgg ggaactccag tgccccaatg gctgcagtgg gcatggccgc tgtgtcaatg
     1561 ggcagtgtgt gtgtgacgag ggctacaccg gagaagactg tagccaacgg cgatgcccca
     1621 atgactgcca caaccggggt cactgtgtac agggcaaatg catatgtgag caaggcttca
     1681 aaggctttga ctgtagtgag atgagctgtc ccaatgactg ccaccagcat ggccgctgtg
     1741 tgaatggcat gtgcatctgt gatgatgact acactgggga agactgcaga gaccgccgct
     1801 gtccccggga ctgtagccag agggggcgct gtgtggacgg acagtgcatt tgtgaggatg
     1861 gtttcactgg ttctgactgt gctgagctct cctgccctgg tgactgccac ggccatggcc
     1921 gctgtgtgaa tggccaatgc atctgccacg agggcttcac cggcaaagac tgcaaagagc
     1981 aaaggtgccc cagtgactgc cacggccaag gccgctgtga ggacggccaa tgtatctgtc
     2041 atgagggctt cacaggcctg gactgtgggc agcgctcctg tcccaatgac tgcagcaacc
     2101 agggacaatg tgtggcaggc cgctgcatct gcaatgaagg ctacacaggg gtagactgct
     2161 ctgaggtgtc ccctcccaaa gaccttattg tgacagaagt aacagaggag actgtaaatc
     2221 tggcatggga caatgagatg cgggtcactg agtacctcat tatgtacaca cccacccatg
     2281 ctgatggcct ggagatgcag ttccgtgtgc ctggggacca gacatctacc accatccggg
     2341 agctggagcc aggagtggag tacttcattc atgtgttcgc catcttggag aacaagagga
     2401 gcatccctgt cagtgccaga gttgccacct acttgcctgc acctgaaggc ctaaaattca
     2461 agtctatcaa ggagacatct gtggaagtag agtgggatcc tctggacatc gcttttgaaa
     2521 cgtgggagat cattttcaga aatatgaaca aagaagatga gggagagatc acaaaaagct
     2581 tgaggaggcc agagacctcc taccgccaaa ctggcctggc tcctggccaa gaatatgaaa
     2641 tatctcttca cattgtgaaa aacaacaccc gaggccctgg cttgaagaaa gtgaccacaa
     2701 ctcgcctgga tgcccccagc caaattgagg tgagagacat cacagacact acagcactga
     2761 tcacctggtc caagcccttg gctgaaattg atagcattga gctctcctat ggcatcaagg
     2821 atgtgcctgg agaccggacc accatcgacc tcacacatga agacaaccag tactccatcg
     2881 ggaacctgaa acctgacacg gagtatgagg tgtccctcat ctcccgcaga gtggacatgg
     2941 caagcaaccc tgccaaggag accttcatca caggcctgga tgctcccagg aatctccgtc
     3001 gcgtctcaca gacagacaac agcatcacct tggagtggag gaatgtcaag gcagacattg
     3061 atagttatag aattaagtat gcacctatct ctggaggtga ccatgctgag atagatgttc
     3121 caaagagcca gcaagccaca accaaaacca cactcacagg tctaaggcca ggaactgaat
     3181 atggagtggg cgtctctgct gttaagggag acaaggaggg cgatccagca accatcaatg
     3241 cagccacaga aattgatgca cccagggact tacaggtgtc tgagaccaca caagacagtc
     3301 tgactttatt ctggaagaca cctctggcca agtttgatcg ttaccgcctc aactacagcc
     3361 tccccacagg ccagtcaata gagattcagc tgccaaagga tgccacctcc catgtcctga
     3421 cagacctgga gccagggcaa gaatacactg ttctcctcac cgctgagaag ggcagacata
     3481 agagcaagcc tgcgcgtgtg aaggcatcca cagaagaagt accttctctg gaaaatctca
     3541 ccgtgaccga ggccggctgg gatggcctca gactcaactg gactgcagat gacctggcct
     3601 atgagtactt tgttattcag gtacaggaag ccaacaaggt ggagactgct cacaacttca
     3661 cagtacttgg taacctccgg actgcagaca tcccgggcct caaggctgcc actccttata
     3721 gagtctccat ttatggggta gctcggggct ataaaacacc cgtgctctct gctgagacct
     3781 tcacagggaa aactcccagt ttgggagagg tgactgtggc tgaggtgggc tgggatgccc
     3841 tcaagctcaa ctggactgct ccagaaggag cctatacgaa ctttttcatt caggtgctag
     3901 aggctgacat gacccagact gtccagaacc tcacagtccc agggggactg aggtcagtgg
     3961 acctacctgg gctcaaagca gccacccgct attacatcac cgttcgaggg gtcacccagg
     4021 acttcagcac agcccctctc tctgttgagg tcttgacaga ggagatccct caactgggag
     4081 gcttgtccgt gactgaggtc agctgggaca gccttacact caactggacc acagatgatc
     4141 tggcctataa acactttatc attcaggtgc aggaggccaa caatgtagag gctgctcaga
     4201 acctcacagt atctggtagc ctcagagttg tggacatccc aggcctcaag gctgataccc
     4261 cttatagagt ctccatctat ggggtgatcc agggctatag aacaccaatg ctctctgctg
     4321 atgtctccac agccaaagaa cctgaaattg gaaacttaaa tatttctgat gtaactcctg
     4381 agagcttcaa tctctcctgg acagctaccg acgggatctt cgacatgttt actatcgaaa
     4441 ttattgattc taataggttg ctgcagacag cagaacataa tatatctggt gctgaacgaa
     4501 ctgcccacat ctcgggcctt ccacctagta ctgatttcat tgtctacctc tctggaattg
     4561 ctcccagcat ccgtaccaaa accatcagta ccacagccac cacagaagct gaaccggaag
     4621 ttgacaacct tctagtttca gatgctactc cagacggttt ccgtctgtcc tggactgctg
     4681 atgaagggat attcgacagt tttgttatca ggatcagaga taccaaaaag caatctgaac
     4741 cacaagaaat aaccctccct tcccccgacc gtaccaggga cataacaggt ctcagagagg
     4801 ccactgagta cgaaattgaa ctctatggaa taagccgtgg aaggcgatcc cagccagtca
     4861 gtgccatagc aacaacagcc atgggttctc cgaaggaaat catgttctca gacatcactg
     4921 aaaatgcagc cacagtcagc tggagagcac cgactgctca agtggagagt ttccggatta
     4981 cttatgtgcc tgtaacagga ggtcccccat ccatggtgac cgtggatggg acggatactg
     5041 agacccgact ggtgaggctc acccctggag tggagtacca cgtcagtgtg attgccatga
     5101 agggatttga agaaagtgat ccggtctcgg ggtctctaat cacagctctc gatggtccat
     5161 ctggccttct gacagccaac atcacagact cagaagcctt ggccatgtgg cagccagcca
     5221 ttgccactgt agacagttat gtcatctcct acacagggga gagagtgcca gaaattaccc
     5281 gcacagtgtc tgggaataca gtggagtttg aactacatga cctggagcct gccacagagt
     5341 acacactgag tgtctttgca gagaaaggtc accagaagag ttctaccatc gctacgaaat
     5401 ttaccacaga cctggattcc ccaagagaat tgactgctac tgaggttcag tcagaaactg
     5461 ccctcctcac ctggagacct ccccgggcat cggtcactgg atacctcctg gtctatgagt
     5521 ctgtggatgg tacagtcaag gaagtcattg tggggcctga caccacctcc tacagcctgg
     5581 cagacctgag cccatccacc cactacacag caagaatcca ggcattgagt gggtccctga
     5641 ggagcaaact gatccaaacc atcttcacca caattggact cctatatcca ttccctaggg
     5701 attgctctca agcaatgttg aatggcgaca ccacctctgg cctctatacc atctatataa
     5761 atggtgacaa gactcaagca ctggaagtct actgtgatat gacctctgat ggaggtggat
     5821 ggatcgtttt cctgagacgc aaaaatggac gtgaggactt ctatcgaaac tggaaggcct
     5881 atgccgctgg gtttggagac cgcagagaag aattctggct tggactggat aacctgagca
     5941 aaatcacagc ccaagggcaa tatgagctcc gggtggacct acaagaccat ggggagtcag
     6001 cctatgctgt gtatgacagg ttcagtgttg gagatgccaa gagtcgctac aagctgaagg
     6061 tagaaggata cagtggaacg gcaggtgact ccatgaacta tcacaatggt agatccttct
     6121 ctacctatga caaggacaca gactcagcca tcaccaactg tgccctgtcc tacaaaggag
     6181 ctttctggta taagaactgt catcgtgtca acctgatggg cagatatggg gacaataatc
     6241 acagtcaggg tgttaactgg ttccactgga agggccatga gtactcaatc cagtttgcgg
     6301 agatgaaact aagacccagc aacttccgaa atctggaagg caggcgtaag cgggcataaa
     6361 tcccagggac aatttggtga gagaggaatg gggcccagag aaaacaggat ttttaccaaa
     6421 gcatcaatac aaccagtcca acggtgaagc tatccttggg catttgatgg gcatccaagc
     6481 agaccatgga tcactgaggc actgacgtag gcccctctgc aattacttcc tttgcaccaa
     6541 agacaacagt ctgcaactag tttctgcttt tttgtttgat tgagcaaagt ctcctagcga
     6601 cagcaacacc gtgattttta cttctactgg gtggttctgg gaatgggaga ggggcgagct
     6661 ggctatccag cggacatagt cattttcaga gccagctata ttctacacaa agctgttcaa
     6721 ttgttattgg ttgggtcgca aagataaaac atacgtcatt ggaggttacc ccttgccctg
     6781 cgccccactg atgttttgta catttcctac aactgaagcc agaaaaatga tattgtttaa
     6841 atttcaagga cattaatatt attaatataa taatggtgat ggtgatgatg atgttgaaaa
     6901 ctgaggactt ttaaagagac attcccttcc caaatgtgtc tggacagtac ctgattgtat
     6961 ttttttgttg ttgtttttta ataaaaagca cagtactttt ca
//
