LOCUS       NM_001400798            4934 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus thioredoxin-related transmembrane protein 3
            (Tmx3), mRNA.
ACCESSION   NM_001400798 XM_039097375
VERSION     NM_001400798.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4934)
  AUTHORS   Holbrook,L.M., Watkins,N.A., Simmonds,A.D., Jones,C.I.,
            Ouwehand,W.H. and Gibbins,J.M.
  TITLE     Platelets release novel thiol isomerase enzymes which are recruited
            to the cell surface following activation
  JOURNAL   Br J Haematol 148 (4), 627-637 (2010)
   PUBMED   19995400
REFERENCE   2  (bases 1 to 4934)
  AUTHORS   Haugstetter,J., Blicher,T. and Ellgaard,L.
  TITLE     Identification and characterization of a novel thioredoxin-related
            transmembrane protein of the endoplasmic reticulum
  JOURNAL   J Biol Chem 280 (9), 8371-8380 (2005)
   PUBMED   15623505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jan 27, 2022 this sequence version replaced XM_039097375.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74947.1,
                                           SRR26643297.50767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000018.1  86021137-86021315
            180-234             JAXUCZ010000018.1  86022187-86022241
            235-274             JAXUCZ010000018.1  86025214-86025253
            275-398             JAXUCZ010000018.1  86027187-86027310
            399-444             JAXUCZ010000018.1  86028757-86028802
            445-525             JAXUCZ010000018.1  86030057-86030137
            526-625             JAXUCZ010000018.1  86032669-86032768
            626-703             JAXUCZ010000018.1  86033419-86033496
            704-770             JAXUCZ010000018.1  86035883-86035949
            771-869             JAXUCZ010000018.1  86039250-86039348
            870-927             JAXUCZ010000018.1  86041156-86041213
            928-981             JAXUCZ010000018.1  86041388-86041441
            982-1038            JAXUCZ010000018.1  86042677-86042733
            1039-1168           JAXUCZ010000018.1  86047805-86047934
            1169-1237           JAXUCZ010000018.1  86049247-86049315
            1238-4934           JAXUCZ010000018.1  86050329-86054025
FEATURES             Location/Qualifiers
     source          1..4934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q13"
     gene            1..4934
                     /gene="Tmx3"
                     /note="thioredoxin-related transmembrane protein 3"
                     /db_xref="GeneID:682967"
                     /db_xref="RGD:1592777"
     exon            1..179
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1495
                     /gene="Tmx3"
                     /EC_number="5.3.4.1"
                     /codon_start=1
                     /product="protein disulfide-isomerase TMX3 precursor"
                     /protein_id="NP_001387727.1"
                     /db_xref="GeneID:682967"
                     /db_xref="RGD:1592777"
                     /translation="MSLRALITGFTPRSMANAAGRRSWAALRLCAAVILLDLAVCKGF
                     VEDLNESFKDNRKDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDAT
                     SYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMF
                     DHVRKRHRVFFVYIGGESPLKEKYIDAASELIVYTYFFSASEDVVPEYVTLKEMPAVL
                     VFKDDTYFVYDEYEDGDLSSWISRERFQNYLTMDGFLLYELGDTGKLVAIAVIDEKNT
                     SLEHTRLKSIIQEVARDFRDHFHRDFQFGHMDGNDYINTLLMDELTVPTIVVLNTSNQ
                     QYFLLDRHIKDASDMVQFINSILDGTVPAQGGDSIFQRLKRIVFDAKSTIVSIFKSSP
                     LMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSEMENQEQIEESKEQESSS
                     GGSLVPTVQESKDVLEKKKD"
     exon            180..234
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            235..274
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            275..398
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..444
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            445..525
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            526..625
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..703
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..770
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            771..869
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            870..927
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            928..981
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1038
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1168
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1237
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..4934
                     /gene="Tmx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtccgggtg ggagctgtcc tgcgtccccg gtcttcctca ctttcctttc cggagaggcg
       61 ggcgcctggc gcgggcgatt ctatgtctct gcgcgcgctc atcacgggat tcacgccgcg
      121 ctccatggcg aatgcagcgg ggcggaggag ctgggcggcc ctccggctct gcgctgccgt
      181 tattttactt gatctggctg tctgtaaagg atttgtagaa gatctaaatg aatcatttaa
      241 agataatcga aaagatgaca tttggcttgt tgatttttat gcaccctggt gtggccattg
      301 taaaaaactg gaaccaattt ggaatgaagt tgggcttgaa atgaaaagta ttggttctcc
      361 agttaaagtt ggaaagatgg atgctacttc gtattctagc attgcttcag agtttggagt
      421 tcgaggttat ccaacaatta agctattaaa gggagacttg gcatataatt acagaggacc
      481 acggaccaaa gatgatataa ttgagtttgc tcacagagtg tctggggctc taattcggcc
      541 tcttccaagt caacaaatgt tcgaccatgt acggaagagg caccgtgtat tttttgttta
      601 tattggtgga gaatcaccct tgaaagagaa atacatagat gctgcttcag agttaattgt
      661 atatacgtac ttcttttctg cctcagaaga tgtggttcct gagtacgtga cactgaagga
      721 gatgcctgct gtgcttgttt tcaaagatga cacttacttt gtttacgatg agtatgaaga
      781 tggagatctg tcctcatgga tcagcaggga gaggtttcag aactatctta ctatggatgg
      841 tttccttttg tatgaacttg gagacacagg aaagcttgtg gccattgcag ttattgatga
      901 gaaaaacaca tcactcgagc ataccagatt aaagtcaatt attcaggaag ttgctagaga
      961 tttcagagac cacttccata gagattttca gtttggccat atggatggaa atgactatat
     1021 aaacaccttg ctgatggacg agttgacggt cccaaccata gttgtactga atacttcaaa
     1081 ccaacagtac tttttgctag atagacatat taaggatgcc agcgacatgg tccagttcat
     1141 taacagcatt ttggatggta cagtaccagc ccaaggaggt gatagcattt ttcagagatt
     1201 gaaaagaata gtatttgatg ccaaatctac aattgtgtct atattcaaga gctctccact
     1261 tatgggctgc tttcttttcg ggctgccact gggtgtcatc agtatcatgt gctatggaat
     1321 ctatacagct gacacagatg gaggctatat agaagaacga tatgaagtgt ccaaaagtga
     1381 aatggaaaac caggaacaga tagaagagag caaagagcag gaatccagca gtggagggtc
     1441 tctagtgcct actgtgcaag agtccaaaga tgtattagaa aagaagaaag attgagactt
     1501 cacagataaa aaatatttga tagaatttca agttattaaa gagtatttat tgaacttaga
     1561 gatttaatca tgatctattt acagaagaga acatattctt tgtattttgc taataacaac
     1621 tgcatgaatt aaaataatct ttccataagt aggaagctgt ttggaacaaa gtgatgaaca
     1681 gtttgttcaa aacaaagcca gatcattgta tcacttacct tacagatccg ttctgtgcac
     1741 acttctctat gtgcatgttc tatgacaaag ttaagaagct cggacagaat attaaattgc
     1801 ccgttaatgt ggaagatgtg ttttttgcaa agagaaatag tactttcacc tactatatta
     1861 attctcctat attttggata aaatttatat aaacaaataa agtctttaaa atttagacat
     1921 tttaagaact gttaactttt tccgtgtatc aaatttaagg ttctgagttt gaaactagta
     1981 attttatata tagcatagtg attttatttt actagttgtt tttaaaggag aaatgttact
     2041 tttttactta tactctgttg cattattatg atattggcat atggtcccat gaagtggggg
     2101 aagaatcttg taattgacct tttaaaatga ccgctggtat gcggggagtg atggcttcag
     2161 cttttaccta tgctgtttag aagagtgcac tgtccaccac tggaggaagg agtggccctc
     2221 ctaatatatc ttgattttag ccaaagcagc ctagtatttt gttttgtttt tattttatag
     2281 cttctagtat ttctattaat tcagaatgtt ttcggaagta atagaaatca tgtttttatg
     2341 atatgtaaac taataattaa aatttactgc cacacctcta ttgtggaagg ccataacatg
     2401 ttcacagtac aatcaacatg ttcaactcag atgtcacaaa caaagggaga gatcctaatt
     2461 cccttctcta gacccagcct tgcctctttg acagtcacaa cctctgtctt tcatcagaat
     2521 gcagtcatgc ctcacagtgg gtgtttgtga taatatgttt actacagatc agtttgttaa
     2581 ttttgaagct ttcacgttat ctaatctcag aatttttatt agctaatgtt taggtcctat
     2641 tctttgagta ttctagagtt tgttgaaagg atccgctgaa catttacaaa catggtttgt
     2701 agcactaact ctgaagttac ttggggcttc tgctttggtt gccaagggag cttctggttt
     2761 ctgatgcaat actaatcaac attgcatcat attaatgaat taaaacatgt atatctatag
     2821 agcaagagaa ttgctaatca tagtctgtgt ccaaatattc tttttatatt taaaagcaac
     2881 catttttaat atttaatcac ccatcattaa ctttatggat aatggtgtac gtatgtagtc
     2941 atggggaatg ttcagaaaat aaaagaatat tttcaggtgg aaactggaga taagcactgt
     3001 taaaattact gtaacaaact cctccataga ataaagatga ctctttggga aagttcatgg
     3061 taatggtccc aatggtcaag cctttttgca ggagaaaagc ctgaagtcca tatggatgcc
     3121 tcattaatga taatatgtgg tgaagagaga gacataaaga aataggaagt accactatta
     3181 catttattac tgtttatcac taccaaatgt taaatgtatt ttgtcttgtc aatcatcctt
     3241 gtaaataagt tctcagtagg aaaaaagagt aaagcacagc tttgcattaa taaacatatg
     3301 cacagaggta attcattgta tcctgtaata gttttctttt tgaatgagtg ctttggttct
     3361 ctgttgtgaa acaactttat attgatcctc atattctatt tgtactttta aaatgtgcat
     3421 caggggaaag aacgtgtaag tggtttgtaa gtaaatagtt ttatttcttt ttgaattaaa
     3481 cttttaattt ttacatgttt cttcttgagg atattatttg cattattaga ttgctcacat
     3541 aaaaaaaaac ttaaaatttg ttcactcatg tacttttctt ttcagtgtgt tatcagagta
     3601 ccgtttgctt atcaggagaa catactttag aatcaaggca gctctattca taatctagga
     3661 aaaggtcgat cctctaattc ccttggttaa ataccagaaa tagaatcctt tcaggaaatt
     3721 gggattctac ctttcctttc atgtgtcaag ttctgatttc tgaaattcaa aattatagct
     3781 cattggtgct ctaccaacat ttaagagtat ttcagagaat gtgcatttaa acatgcccaa
     3841 catcctcagc acctctgtcc cgaaatctct ctttgttgtg tttatcaata tttttgtagt
     3901 ttcttttgtt tgaaatgtct ttgaaattaa ttagatctag aggtttttac tcaaaggact
     3961 tctgaaacct ggtttagaaa taatgtaaaa gatgccaaat gagtaaaggt gatggaaagg
     4021 tctcttgaag agctgaagca gtcatgaatg ttgtttctgt ttactcagtt ttattgccca
     4081 tgatgtttct aatgttgact tggtaggtag ctctaaattt taagaaaaga ataattccag
     4141 cattggtatc acagaggcag gcagatctct gtgagttcga ggccagcctg aaatgcagag
     4201 tgagttccag gacagccagg gctacagaga aaccctttct tggggaaaaa aatatataca
     4261 tttttcatca gtctttcatg atgaaatgaa cagaggggaa aaaaaatcac tcagctattc
     4321 ttacgtagaa attgttaaac aagtgtaaga tattaacact taaacgactg agtttgcaat
     4381 tttattttta caaatatata ttttttctga atgtataagt cccaagaatg aggagaataa
     4441 taataatgac gataataaat tttctagttt ggactaagtt ataatggttt ttgaaagttt
     4501 ttattactac taacttgttt aattgtgata ctctgcctta tacaccaatt ggaaaccttt
     4561 gtttttctaa aataaaataa ttaaaaacat cattgcataa ttgctacctt taatatgttt
     4621 ttcagaagtt tgccacatga ccaatctcta aacaaactca gaagctacaa ctattattcc
     4681 acacagtact ttccttttat taaggcatag tttatttata attacagaaa cacaatttta
     4741 gattttaagc aggcttggaa gtgaattgta gcttagttcc ttatacccaa aacatctctt
     4801 ggtctagttt taattgtata aaacctaata tgttttttaa acatttcttt ttaaaaggat
     4861 acctcaactt ttctacaaaa tttaaagtgt ggtggatttg aattttgtat taataaatta
     4921 tgatcctgga cacc
//
