LOCUS       NM_001007643            1640 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus thioredoxin-related transmembrane protein 2
            (Tmx2), mRNA.
ACCESSION   NM_001007643 XM_230274
VERSION     NM_001007643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Vandervore,L.V., Schot,R., Milanese,C., Smits,D.J., Kasteleijn,E.,
            Fry,A.E., Pilz,D.T., Brock,S., Borklu-Yucel,E., Post,M.,
            Bahi-Buisson,N., Sanchez-Soler,M.J., van Slegtenhorst,M., Keren,B.,
            Afenjar,A., Coury,S.A., Tan,W.H., Oegema,R., de Vries,L.S.,
            Fawcett,K.A., Nikkels,P.G.J., Bertoli-Avella,A., Al Hashem,A.,
            Alwabel,A.A., Tlili-Graiess,K., Efthymiou,S., Zafar,F., Rana,N.,
            Bibi,F., Houlden,H., Maroofian,R., Person,R.E., Crunk,A.,
            Savatt,J.M., Turner,L., Doosti,M., Karimiani,E.G., Saadi,N.W.,
            Akhondian,J., Lequin,M.H., Kayserili,H., van der Spek,P.J.,
            Jansen,A.C., Kros,J.M., Verdijk,R.M., Milosevic,N.J., Fornerod,M.,
            Mastroberardino,P.G. and Mancini,G.M.S.
  TITLE     TMX2 Is a Crucial Regulator of Cellular Redox State, and Its
            Dysfunction Causes Severe Brain Developmental Abnormalities
  JOURNAL   Am J Hum Genet 105 (6), 1126-1147 (2019)
   PUBMED   31735293
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Meng,X., Zhang,C., Chen,J., Peng,S., Cao,Y., Ying,K., Xie,Y. and
            Mao,Y.
  TITLE     Cloning and identification of a novel cDNA coding
            thioredoxin-related transmembrane protein 2
  JOURNAL   Biochem Genet 41 (3-4), 99-106 (2003)
   PUBMED   12670024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083678.1.
            
            On Nov 29, 2004 this sequence version replaced XM_230274.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083678.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1640
                     /gene="Tmx2"
                     /note="thioredoxin-related transmembrane protein 2"
                     /db_xref="GeneID:295701"
                     /db_xref="RGD:1359456"
     exon            1..208
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..286
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..610
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1309
                     /gene="Tmx2"
                     /note="thioredoxin domain-containing protein 14"
                     /codon_start=1
                     /product="thioredoxin-related transmembrane protein 2
                     precursor"
                     /protein_id="NP_001007644.1"
                     /db_xref="GeneID:295701"
                     /db_xref="RGD:1359456"
                     /translation="MAVLAPLIALVYSVPRLSRWLARPYCLLSALLSIAFLLVRKLPP
                     ICNGLPTQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHVGNIFMFSKVANA
                     ILFFRLDIRMGLLYLTLCIVFLMTCKPPLYMGPEYIKYFNDKTIDEELERDKRVTWIV
                     EFFANWSNDCQSFAPIYADLSLKYNCSGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLP
                     TLILFQGGKEVMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQRAKKLSKGGDMSEE
                     KPGNPTPTAVPDGENKKDK"
     exon            611..671
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..785
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..862
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..969
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1035
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1165
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1612
                     /gene="Tmx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacccaac ccaaacccac cccgggaaat caagttatct tttagagttg tgaatcgcca
       61 aagggcttct gacactgttg cccactggcc acccgtagcc ctgttatctt acaccttgcg
      121 ctgcaggatg ctagccacaa cggtcaccta aactattatc tgattggcta cttttggccc
      181 actactcacc tggcaattcc cgcataagct tcccatcatt ggatacgcta agctccgccc
      241 accatcttcc ggcaacttac ttcctttgcc ctgagagatt gttcagcacc caataagaga
      301 tctacatccg ggtctggagg cgttgcatct gatatttggc ccaatagaag ccttgctgtt
      361 gggggcggag gacgacgatt tggggagcgg gagtgagcct gcaagagtgt aggcagggaa
      421 gatggctgtc ctcgcgcctc tgattgcctt ggtgtactcg gtgccgcggc tttctcgatg
      481 gctggccaga ccttattgcc ttctgtctgc cctgctttcc attgctttcc tcctcgtgag
      541 gaagctgccg ccgatttgca acggtctccc cacgcagcgc gaagatggca acccgtgtga
      601 ctttgactgg agagaggtgg agatcctgat gtttctcagt gctattgtga tgatgaagaa
      661 ccgcagatcc atcactgtgg agcaacatgt gggcaacatc ttcatgttta gcaaagtggc
      721 caacgcaatt cttttcttcc gattggatat tcgaatgggc ctgctgtacc tcacactctg
      781 catagtgttc ctgatgacct gcaagccccc cctgtacatg ggtcctgaat atatcaagta
      841 cttcaatgat aaaaccattg atgaagaact ggaacgagac aagagggtca cttggattgt
      901 ggagttcttt gccaattggt ctaatgattg ccagtctttt gctcccatct atgctgactt
      961 gtctctcaag tacaactgtt cagggctaaa ttttgggaag gtagatgttg gacgttacac
     1021 tgacgttagc acacggtaca aagtgagcac atcacccctc accaaacaac tccctaccct
     1081 gatcctcttc caaggtggca aggaggtaat gcgtcggcca cagattgaca agaaaggacg
     1141 agctgtctct tggacctttt ctgaggagaa tgtgattcga gaattcaact tgaatgagct
     1201 gtaccaacga gccaagaagc tctcaaaggg tggagacatg tcagaggaga agcctgggaa
     1261 ccctacgccc actgccgtgc cagatgggga gaacaagaaa gacaaatagg accctgcatt
     1321 gtttttgctt cctctcctgt ccatttcagg aaccttcgag gcccagttcc agctgtaacc
     1381 acaatccttg cctgaggcct tttgatttct cctgtttggc tgtgcctagg tggggcactg
     1441 tgtctgcttc tgatttttaa agaagcatct tgggaaccat gaagcattct attacgaagg
     1501 gctgttctgc cctggccaac tgttcctcga agggagtaat ctcatggata gaggtagaaa
     1561 tggtttccct ccaaggttgg gtcagtgtgt aaactgctgt tcaacacttg aaaaaaaaaa
     1621 aaaaaaaaaa aaaaaaaaaa
//
