LOCUS       NM_198781               1284 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus transmembrane and ubiquitin-like domain
            containing 1 (Tmub1), transcript variant 1, mRNA.
ACCESSION   NM_198781 XM_342613
VERSION     NM_198781.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Lan,X., Li,G., Liu,H., Fu,H., Chen,P. and Liu,M.
  TITLE     MiR-27a/b Regulates Liver Regeneration by Posttranscriptional
            Modification of Tmub1
  JOURNAL   Dig Dis Sci 63 (9), 2362-2372 (2018)
   PUBMED   29777440
  REMARK    GeneRIF: MiR-27a/b regulates hepatocyte proliferation by
            controlling posttranscriptional modification of Tmub1 during liver
            regeneration.
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Lan,X., Fu,H., Li,G., Zeng,W., Lin,X., Zhu,Y., Liu,M. and Chen,P.
  TITLE     TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with
            the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic
            Domain
  JOURNAL   Sci Rep 8 (1), 9917 (2018)
   PUBMED   29967478
  REMARK    GeneRIF: TMUB1 regulates hepatocyte proliferation by interacting
            with CAML and further interferes with the binding of CAML to
            cyclophilin B.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Fu,H., Xu,J., Chen,J., Li,G., Zhao,X. and Chen,P.
  TITLE     Microarray analysis reveals Tmub1 as a cell cycle-associated
            protein in rat hepatocytes
  JOURNAL   Mol Med Rep 17 (3), 4337-4344 (2018)
   PUBMED   29344642
  REMARK    GeneRIF: The transcriptional profile and potential biological
            processes affected by Tmub1 expression in hepatocytes have been
            reported.
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Liu,M., Yuan,T., Liu,H. and Chen,P.
  TITLE     CCAAT/enhancer-binding protein beta regulates interleukin-6-induced
            transmembrane and ubiquitin-like domain containing 1 gene
            expression in hepatocytes
  JOURNAL   Mol Med Rep 10 (4), 2177-2183 (2014)
   PUBMED   25109894
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Castelli,M., Piobbico,D., Bartoli,D., Pieroni,S., Brunacci,C.,
            Bellet,M.M., Chiacchiaretta,M., Della Fazia,M.A. and Servillo,G.
  TITLE     Different functions of HOPS isoforms in the cell: HOPS shuttling
            isoform is determined by RIP cleavage system
  JOURNAL   Cell Cycle 13 (2), 293-302 (2014)
   PUBMED   24240191
  REMARK    GeneRIF: HOPS has distinct, isoform-specific functions in the
            nucleolus, nucleus, and cytoplasm.
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Liu,M., Liu,H., Wang,X., Chen,P. and Chen,H.
  TITLE     IL-6 induction of hepatocyte proliferation through the
            Tmub1-regulated gene pathway
  JOURNAL   Int J Mol Med 29 (6), 1106-1112 (2012)
   PUBMED   22426572
  REMARK    GeneRIF: Tmub1 plays a negative role in IL-6-induced hepatocyte
            proliferation.
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Jo,Y., Sguigna,P.V. and DeBose-Boyd,R.A.
  TITLE     Membrane-associated ubiquitin ligase complex containing gp78
            mediates sterol-accelerated degradation of
            3-hydroxy-3-methylglutaryl-coenzyme A reductase
  JOURNAL   J Biol Chem 286 (17), 15022-15031 (2011)
   PUBMED   21343306
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Zhang,W., Savelieva,K.V., Suwanichkul,A., Small,D.L.,
            Kirkpatrick,L.L., Xu,N., Lanthorn,T.H. and Ye,G.L.
  TITLE     Transmembrane and ubiquitin-like domain containing 1 (Tmub1)
            regulates locomotor activity and wakefulness in mice and interacts
            with CAMLG
  JOURNAL   PLoS One 5 (6), e11261 (2010)
   PUBMED   20582322
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Yang,H., Takagi,H., Konishi,Y., Ageta,H., Ikegami,K., Yao,I.,
            Sato,S., Hatanaka,K., Inokuchi,K., Seog,D.H. and Setou,M.
  TITLE     Transmembrane and ubiquitin-like domain-containing protein 1
            (Tmub1/HOPS) facilitates surface expression of GluR2-containing
            AMPA receptors
  JOURNAL   PLoS One 3 (7), e2809 (2008)
   PUBMED   18665261
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Della Fazia,M.A., Castelli,M., Bartoli,D., Pieroni,S.,
            Pettirossi,V., Piobbico,D., Viola-Magni,M. and Servillo,G.
  TITLE     HOPS: a novel cAMP-dependent shuttling protein involved in protein
            synthesis regulation
  JOURNAL   J Cell Sci 118 (Pt 14), 3185-3194 (2005)
   PUBMED   16014383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DY313123.1 and
            JAXUCZ010000004.1.
            
            On Mar 30, 2015 this sequence version replaced NM_198781.2.
            
            Summary: The protein encoded by this gene belongs to a group of
            integral ubiquitin-like domain containing proteins that are
            involved in a range of cellular processes. In mouse, the protein
            exists in uncleaved transmembrane forms as well as a cleaved form
            that shuttles between the nucleus and cytoplasm. During liver
            regeneration in rat, it has been shown that the protein shuttles
            from the cytoplasm to the nucleus to inhibit hepatocyte
            proliferation. Homozygous null mutant mice display normal
            development and physiology but exhibit a strong increase in
            locomoter activity during the dark phase of the light:dark cycle,
            indicating a function in behavioral regulation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) uses an alternate exon in the
            5' UTR compared to variant 2. Variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY313123.1, BC059162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-741               DY313123.1         1-741
            742-1284            JAXUCZ010000004.1  11623955-11624497
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1284
                     /gene="Tmub1"
                     /gene_synonym="Hops"
                     /note="transmembrane and ubiquitin-like domain containing
                     1"
                     /db_xref="GeneID:362301"
                     /db_xref="RGD:735120"
     exon            1..52
                     /gene="Tmub1"
                     /gene_synonym="Hops"
                     /inference="alignment:Splign:2.1.0"
     exon            53..468
                     /gene="Tmub1"
                     /gene_synonym="Hops"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..820
                     /gene="Tmub1"
                     /gene_synonym="Hops"
                     /note="hepatocyte odd protein shuttling protein"
                     /codon_start=1
                     /product="transmembrane and ubiquitin-like
                     domain-containing protein 1"
                     /protein_id="NP_942076.2"
                     /db_xref="GeneID:362301"
                     /db_xref="RGD:735120"
                     /translation="MALIEGVGDEVTVLFSVLACLLVLALAWVSTHTTESTDPLPQSS
                     GTTTPAQPSEAMTAIDSIREEAPGAESPSLRHRGPSAQPEPEAGVTASTPPDSPQEPL
                     LLRLKFLNDSEQVARAWPQDTIGSLKRTQFPGREQQVRLIYQGQLLGDDTQTLGSLHL
                     PPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRP
                     FFPLTATLGLAGFTLLLSLLAFAMYRP"
     exon            469..1284
                     /gene="Tmub1"
                     /gene_synonym="Hops"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcggcccg gaagtgcccg aggagccgaa atggagctgg tggagctggg cgctccttag
       61 cacctctggc aacacaggtg ccatggcctt gattgaaggc gtaggggatg aggtgactgt
      121 ccttttttcg gtgcttgcct gccttctggt gctggccctc gcctgggtct caacacatac
      181 gactgagagt acagatcccc taccacagtc gtcagggacc acaacaccag cacagcccag
      241 tgaagccatg acagccattg atagcatcag agaggaggcc ccaggagctg agagtcccag
      301 cctgaggcac agaggtccat ctgcacagcc agagcctgag gcaggggtca cagcatcaac
      361 acctccagac tctccacagg aacccttact gctacggttg aaatttctca atgactctga
      421 acaggtggcc agggcctggc ctcaggacac cattggctcc ttgaaaagaa cccagtttcc
      481 aggccgggaa cagcaggttc gactcatcta ccaaggccaa ctgctaggag acgacaccca
      541 gacactgggc agtctccacc ttccccccaa ctgcgttctc cactgccacg tgtccacaag
      601 agtcggtccc ccgcatcctc cctgcccacc ggggtcagag cccggcccct ccgggctgga
      661 aatcggcagc cttctgttgc ccctgctgct tctgctgctg ctcctgctct ggtactgcca
      721 gatccagtac cggcccttct ttcccctgac cgctaccttg ggcctggccg gcttcaccct
      781 gctcctcagt ctcctggcct ttgccatgta tcgcccgtag tgcctccacg ggcttttggc
      841 agtgtcgacg gcccctctgg acctcattcc ccaaggcgca aagggagctg ctgtctgccc
      901 aggcccacct cacccgctgc ctgtcttttc ccactaccct ggagcccagc cttgcgcaac
      961 agaggactcc aggtgttagc ggaggccacc ccatgtgatc ttcatagctc tgggccatct
     1021 cctggggctg ctggccctca gccttctctg acagtgggct cttctgaatc aggcacctgc
     1081 tgccgctgcc ttggcctggc acagagccag accaccccaa tgggcccatc ttagtgtgct
     1141 gacagaggat caagatacat ctagtttcaa agagatgcct aggctgaatt ggaaactggt
     1201 gaagactggc gaaggggaat tgaggggggg gagagttgtt tttctggaat ttgtggagat
     1261 taaagaaact gtgatgtttt caca
//
