LOCUS       NM_001134414            2586 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus transmembrane O-mannosyltransferase targeting
            cadherins 4 (Tmtc4), mRNA.
ACCESSION   NM_001134414 XM_001079115 XM_224552
VERSION     NM_001134414.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Li,J., Akil,O., Rouse,S.L., McLaughlin,C.W., Matthews,I.R.,
            Lustig,L.R., Chan,D.K. and Sherr,E.H.
  TITLE     Deletion of Tmtc4 activates the unfolded protein response and
            causes postnatal hearing loss
  JOURNAL   J Clin Invest 128 (11), 5150-5162 (2018)
   PUBMED   30188326
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Larsen,I.S.B., Narimatsu,Y., Joshi,H.J., Siukstaite,L.,
            Harrison,O.J., Brasch,J., Goodman,K.M., Hansen,L., Shapiro,L.,
            Honig,B., Vakhrushev,S.Y., Clausen,H. and Halim,A.
  TITLE     Discovery of an O-mannosylation pathway selectively serving
            cadherins and protocadherins
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11163-11168 (2017)
   PUBMED   28973932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jul 7, 2012 this sequence version replaced NM_001134414.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.46068.1,
                                           SRR26643288.54773.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000015.1  106463082-106463143 c
            63-275              JAXUCZ010000015.1  106458053-106458265 c
            276-391             JAXUCZ010000015.1  106453975-106454090 c
            392-608             JAXUCZ010000015.1  106452800-106453016 c
            609-696             JAXUCZ010000015.1  106445169-106445256 c
            697-800             JAXUCZ010000015.1  106433091-106433194 c
            801-893             JAXUCZ010000015.1  106428802-106428894 c
            894-1058            JAXUCZ010000015.1  106428252-106428416 c
            1059-1261           JAXUCZ010000015.1  106426358-106426560 c
            1262-1433           JAXUCZ010000015.1  106425048-106425219 c
            1434-1565           JAXUCZ010000015.1  106424521-106424652 c
            1566-1645           JAXUCZ010000015.1  106419698-106419777 c
            1646-1753           JAXUCZ010000015.1  106419467-106419574 c
            1754-1895           JAXUCZ010000015.1  106419206-106419347 c
            1896-2010           JAXUCZ010000015.1  106415327-106415441 c
            2011-2123           JAXUCZ010000015.1  106413705-106413817 c
            2124-2193           JAXUCZ010000015.1  106408917-106408986 c
            2194-2586           JAXUCZ010000015.1  106407597-106407989 c
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q25"
     gene            1..2586
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /note="transmembrane O-mannosyltransferase targeting
                     cadherins 4"
                     /db_xref="GeneID:290501"
                     /db_xref="RGD:1560183"
     exon            1..62
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            63..275
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2342
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /EC_number="2.4.1.109"
                     /note="transmembrane and TPR repeat-containing protein 4;
                     transmembrane and tetratricopeptide repeat containing 4"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase TMTC4"
                     /protein_id="NP_001127886.1"
                     /db_xref="GeneID:290501"
                     /db_xref="RGD:1560183"
                     /translation="MAELDADLDHIIPSVLPPFWAKLVVGFVSLLCFARSYDGDFVFD
                     DSEAIVNNKDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLTVLTFRVNYYLSGGFH
                     PVGFHVVNILLHGGISILMLDVFSVLFGGLQYSSKGRRVHLAPRASLLAALLFAVHPV
                     HTECVAGVVGRADLLCALFFLLSFLGYCRAFKETGNKEGTHSSTFWVLLSIFLGAVAM
                     LCKEQGVTVLGLNAVFDILVIGRLDILVAVRKVLRKDKSLESTGMLKNGGLLFRMALL
                     TIGGSTMLYIRWKIMGTGPPAFTEVDNPASFADSVLVRAINYNYYYSLNAWLLLCPWW
                     LCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLGFLV
                     IPFLPASNLFFRVGFVVAERVLYLPSAGYCMLLTFGFGTLSRHTKKKKPVAAIILGIL
                     LINALRCVIRSGEWRSEDRLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREA
                     VRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRF
                     EEAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVMKPEHSLAWNNM
                     VILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKAN
                     PNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDPVAVGTKENYSLLRRKLEQMQKKD
                     V"
     exon            276..391
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            392..608
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            609..696
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            697..800
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            801..893
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1058
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1261
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1433
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1565
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1645
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1753
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1895
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2010
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2123
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2193
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2586
                     /gene="Tmtc4"
                     /gene_synonym="RGD1560183"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagctgct ggagtttaag cacgcgggag ggagatgaga tcgcagctcg tgctccttgc
       61 agatttctaa ccagcataat gctggagcag gaggctggcg gcctgcagtt ttcaagatgg
      121 ctgaactgga tgctgacttg gatcacatca tcccatccgt ccttccccct ttctgggcta
      181 agttagtagt gggatttgtt tcccttctgt gttttgcaag gagctatgat ggagattttg
      241 tctttgatga ctctgaagct attgttaaca ataaggacct ccaatcagac acaccccttg
      301 cggacctgtg gcatcatgac ttctggggca gtagactgag cagtaacacc agccacaagt
      361 cctacaggcc acttactgtc ctgactttca gggttaacta ctacctgtct ggaggctttc
      421 accccgtggg tttccacgtg gtcaacatcc tcctgcacgg cggcatctcc atcctcatgc
      481 tagatgtctt ctcggtactg tttggtggcc tgcagtacag cagtaaaggc cggagggttc
      541 acctggcccc cagggcttcc ctgctggcgg cattgctgtt tgctgtccat ccagtccaca
      601 ccgagtgtgt tgctggtgtt gttggccgtg cagacctcct gtgtgccctg ttcttcttgt
      661 tgtctttcct tggctactgt cgagcattta aagaaacagg taacaaggag ggaacacact
      721 cttccacctt ctgggtattg ctgagtatct ttctgggagc agtggccatg ctgtgcaaag
      781 agcaaggagt caccgtgctg ggcttgaatg ctgtgttcga tatcctggtg ataggcagac
      841 tcgacattct ggtagctgtc cggaaagtcc tgcgtaagga caagtcacta gagagcaccg
      901 gcatgctcaa gaatggaggc ctcctcttcc gaatggccct gctcaccatt ggaggctcca
      961 ctatgcttta tatacgctgg aaaatcatgg gaacaggccc accggcattt actgaggtgg
     1021 acaacccagc atcctttgct gacagtgtgt tggttagggc cataaactat aattactact
     1081 attcattgaa tgcctggctg ctgctgtgtc cctggtggct gtgttttgat tggtcaatgg
     1141 gctgcatccc cctcattaag tcagttggtg actggagggt aattgctcta gcagcacttt
     1201 ggctctgcct aattggccta atattccaag ccctgtgctc tgaggatagc tgcaagagaa
     1261 gaatcctcac tctgggtttg ggatttctcg tgatcccctt tcttcctgca agcaacttgt
     1321 ttttccgagt gggctttgtg gtcgcagagc gtgtcctcta cctcccaagc gctgggtact
     1381 gcatgctgct gacctttgga tttggaactc taagcagaca cactaagaaa aagaaaccgg
     1441 tcgccgccat catcctgggc atccttctca tcaatgcact gagatgtgtg attcgcagtg
     1501 gcgagtggcg gagtgaagac cggctctttc gaagcgccct gtctgtgtgt cccctcaatg
     1561 ctaaggttca ctacaacatt ggcaaaaacc tggctgatca aggcaaccaa acagcagcca
     1621 tcaaatatta ccgggaagca gtcagactaa atcccaagta tgttcatgcc atgaataacc
     1681 ttgggaatat cttaaaggaa aggaatgagc tccaggaagc tgaagagctg ctgtcattgg
     1741 ctgtccaaat acagccagac tttgcagccg catggatgaa tttgggcata gttcagaaca
     1801 gcctgaaacg gtttgaggag gcagagcaaa gctaccgcac agcaattaag cacaggcgga
     1861 aatacccaga ctgctactac aacctcgggc ggctgtatgc agatctaaat cgccacgtgg
     1921 atgcattgaa tgcttggaga aatgccaccg taatgaagcc ggagcacagc ctggcatgga
     1981 ataacatggt catacttctg gacaacacag gtaacttagc ccaagctgaa gccgtgggaa
     2041 gagaggcact gcagttaatt cctaatgatc actcccttat gttctcattg gcaaacgtgc
     2101 tggggaaatc ccagaaatac aaggagtctg aagctttatt cctcaaggca attaaagcaa
     2161 atccaaatgt tgcaagttac catggtaatt tggctgtgct ttatcatcgc tggggacatc
     2221 tcgactcggc caagaaacac tatgagatct ccttgcagct tgaccctgtg gcagtaggca
     2281 ccaaggagaa ttacagtctc ctgagaagaa agctagaaca aatgcagaag aaagatgtct
     2341 gatctgccct tcatgttggg agtttgtgag tgtgtgcatg aggcctctgt tcagatcgtg
     2401 tgcttatgtt tagccattta aaagtctcgg acatttatct tactctactg ttgttttttt
     2461 tttctatgaa aacaaacaca tgcaaaaaga ctatagcacc agcaatactc tcttgaatga
     2521 ctgataggat ttttgcattg aagttgtatt ttttcacaca acccaaatgt aattctaaaa
     2581 tctcaa
//
