LOCUS       NM_001135858            5994 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transmembrane O-mannosyltransferase targeting
            cadherins 3 (Tmtc3), mRNA.
ACCESSION   NM_001135858 XM_001080635 XM_008765316 XM_235093
VERSION     NM_001135858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5994)
  AUTHORS   Larsen,I.S.B., Narimatsu,Y., Joshi,H.J., Siukstaite,L.,
            Harrison,O.J., Brasch,J., Goodman,K.M., Hansen,L., Shapiro,L.,
            Honig,B., Vakhrushev,S.Y., Clausen,H. and Halim,A.
  TITLE     Discovery of an O-mannosylation pathway selectively serving
            cadherins and protocadherins
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11163-11168 (2017)
   PUBMED   28973932
REFERENCE   2  (bases 1 to 5994)
  AUTHORS   Yun,E.J. and Vu,T.H.
  TITLE     mSmile is necessary for bronchial smooth muscle and alveolar
            myofibroblast development
  JOURNAL   Anat Rec (Hoboken) 295 (1), 167-176 (2012)
   PUBMED   21956870
REFERENCE   3  (bases 1 to 5994)
  AUTHORS   Racape,M., Duong Van Huyen,J.P., Danger,R., Giral,M., Bleicher,F.,
            Foucher,Y., Pallier,A., Pilet,P., Tafelmeyer,P., Ashton-Chess,J.,
            Dugast,E., Pettre,S., Charreau,B., Soulillou,J.P. and Brouard,S.
  TITLE     The involvement of SMILE/TMTC3 in endoplasmic reticulum stress
            response
  JOURNAL   PLoS One 6 (5), e19321 (2011)
   PUBMED   21603654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jul 20, 2021 this sequence version replaced
            XM_008765316.3, NM_001135858.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.26580.1,
                                           SRR26643296.19515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000007.1  37196366-37196540   c
            176-391             JAXUCZ010000007.1  37188136-37188351   c
            392-610             JAXUCZ010000007.1  37186883-37187101   c
            611-710             JAXUCZ010000007.1  37185296-37185395   c
            711-826             JAXUCZ010000007.1  37183700-37183815   c
            827-999             JAXUCZ010000007.1  37183112-37183284   c
            1000-1252           JAXUCZ010000007.1  37177604-37177856   c
            1253-1401           JAXUCZ010000007.1  37171980-37172128   c
            1402-1522           JAXUCZ010000007.1  37169896-37170016   c
            1523-1634           JAXUCZ010000007.1  37165174-37165285   c
            1635-1738           JAXUCZ010000007.1  37159245-37159348   c
            1739-1908           JAXUCZ010000007.1  37158056-37158225   c
            1909-2135           JAXUCZ010000007.1  37156532-37156758   c
            2136-5994           JAXUCZ010000007.1  37151456-37155314   c
FEATURES             Location/Qualifiers
     source          1..5994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..5994
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /note="transmembrane O-mannosyltransferase targeting
                     cadherins 3"
                     /db_xref="GeneID:314785"
                     /db_xref="RGD:1306351"
     exon            1..175
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            176..391
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2950
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /EC_number="2.4.1.109"
                     /note="transmembrane and TPR repeat-containing protein 3;
                     transmembrane and tetratricopeptide repeat containing 3"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase TMTC3"
                     /protein_id="NP_001129330.1"
                     /db_xref="GeneID:314785"
                     /db_xref="RGD:1306351"
                     /translation="MMEGKMADINFKEVTLIVGVVAACYWNSLFCGFVFDDVSAILDN
                     KDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNT
                     VFHAVVSVIFLKVCRLFLDKRGSVIAALLFAVHPIHTEAVTGVVGRAELLSSVFFLAA
                     FLSYTKSKGPDNSIVWTPIALTVLLVAVATLCKEQGITVVGICCVYEVFVAQGYTLPL
                     LCAVAGQFLRGKGSIPFSMLQTLIKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPA
                     AVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFAFFCF
                     LGALGIFSLRYPGDSSKTVLMALSLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCI
                     LVAHGWQKISNKSVLKKLSWVCLSMVILTHALKTLHRNWDWESEYTLFMSALKVNKNN
                     AKLWNNVGHALENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESY
                     MLAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPD
                     FKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVYIELKEPDEALKN
                     FNRALELNSRHKLALFNSAILMQESGEVKLRPEARKRLLNYINEEPQDANGYFNLGML
                     AMDDKKDSEAETWMKRAIKLQPDFRSALFNLALLYSQTAKELKALPILEELLRYYPDH
                     TKGLILKGDILMNQKKDIAGAKKCFEKILEMDPSNVQGKHNLCVVYFEEKDLLKAERC
                     LVETLALAPHEEYIQRHLSIVRDKIASSGIVDQPLSPVDKTSGTEEKDEVPSEDVKEI
                     ISESRPAQIIKTNDNRKSQSNKQSTGNADQDAPHKTTKDIKEIEKKRVAALKRLEEIE
                     RILNGE"
     exon            392..610
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            611..710
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            711..826
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            827..999
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1252
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1401
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1522
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1634
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1738
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1908
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2135
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..5994
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgccc tggaagagct ggggaaggat cgggaggcgg gaggagcggc tgctaaggtg
       61 cggccgccca ggagccggag cgtggcggac tatgacagtg ttttctgcag agtccttctc
      121 cggtccaccg tctccgaagc tttcctgaac catctcttgg cggagccgcc ctcagtttgc
      181 ctggttaatg atggaaggga agatggctga tattaacttc aaagaagtga ctttgatagt
      241 cggcgtggtt gctgcctgct actggaacag tctgttctgt gggtttgttt ttgatgatgt
      301 ttcagcaata ctggataaca aagacctgca cccatctaca cctttaaaaa ctttatttca
      361 gaatgacttc tggggaactc ctatgtctga ggagagaagc cacaagtcat acaggccctt
      421 aacagtgttg acatttcgct taaattacct cctcagtgaa ctaaagccca tgtcttacca
      481 cctcctgaat acggtgttcc atgctgtggt cagtgtgatc tttctcaagg tctgcagact
      541 ttttctggat aagaggggca gtgtgattgc ggctctgctc tttgcagtgc acccaatcca
      601 tacggaagca gtcacaggtg ttgtaggaag agctgaactc ttatcctctg tctttttcct
      661 agctgcattc ctgtcgtata ctaaatccaa aggaccagac aattccatag tgtggactcc
      721 gattgcattg acagtgctct tagtggctgt tgcaacattg tgtaaagaac aagggataac
      781 agttgtcgga atctgttgtg tatatgaagt atttgtggcc caagggtaca ctttgccatt
      841 gttatgtgcc gttgctggac agtttctccg cgggaagggt agcattccat tttctatgct
      901 acagacatta ataaaactca ttgtcttgat gttcagtact ttactacttg tcgtgatcag
      961 agtccaagtt attcagtcac aacttccagt gtttacgagg tttgataatc cagccgctgt
     1021 aagcccaacc cctacaaggc agctgacttt taactacctc cttcctgtga atgcttggct
     1081 tctattgaat ccttcagaac tctgctgtga ttggaccatg ggaacaatac cactgataga
     1141 atcatttcta gatgttcgaa atcttgccac ttttgctttc ttttgctttc tgggtgcttt
     1201 gggaatattc agtctcagat accctggtga ctcctccaag actgtcctaa tggcgctttc
     1261 tttaatggcg ttaccattta ttcccgcatc aaacctcttc tttcctgttg gatttgttgt
     1321 tgcagagcga gtactatatg ttcctagcat ggggttctgt attttagtag cccatggatg
     1381 gcaaaaaatt tcaaacaaaa gtgtcctgaa aaagctctcc tgggtttgtc tgtccatggt
     1441 gatattaacc catgccttga aaacactcca tagaaattgg gactgggagt cagaatatac
     1501 attgtttatg tcagccttaa aggtgaataa aaacaatgcc aaattatgga ataatgtggg
     1561 tcatgctctg gaaaatgaga agaactttga gaaagctttg aaatactttt tgcaggctac
     1621 ccatgttcag ccagatgaca ttggtgccca catgaatgta ggaagaacgt ataaaaactt
     1681 aaacagaact aaagaagctg aagaatctta catgttggct aaatcactaa tgcctcagat
     1741 tattcctggt aaaaaatatg cagccagaat tgcccctaat cacctaaatg tttatatcaa
     1801 tttggccaac ctcattcgag caaatgagtc ccgcctggag gaagcggacc agctgtaccg
     1861 acaggcaatc agcatgaggc cagacttcaa gcaggcttac attagcaggg gagaattgct
     1921 tttaaaaatg aataagcctc tcaaagcaaa agaagcatat cttaaagcac tggagctgga
     1981 cagaaataat gcagacctgt ggtacaactt ggcaattgtt tatattgaac ttaaagaacc
     2041 agatgaagct ctgaagaact ttaatcgggc tttggaactg aactccagac ataagctagc
     2101 actgtttaat tctgctattt taatgcagga atcaggtgaa gttaaactca gaccagaagc
     2161 tagaaaacgg cttctaaatt acataaatga ggagccgcaa gatgctaatg gctatttcaa
     2221 tttggggatg cttgccatgg atgacaaaaa ggactctgaa gctgagactt ggatgaagag
     2281 ggctatcaag ttacagcctg acttcagaag tgctttgttc aacctggcac tcctgtactc
     2341 acagactgct aaggagttaa aggcattgcc aatcttagaa gagctgctca gatactatcc
     2401 tgatcatacc aagggcctca ttttaaaagg agatattctg atgaaccaga agaaggatat
     2461 agctggagct aagaaatgtt ttgaaaagat cctggaaatg gatccaagca atgtgcaagg
     2521 aaagcacaat ctctgtgtcg tgtactttga agagaaggac ttgctgaaag cggagagatg
     2581 cctagttgaa accttggcat tagcacctca tgaggaatat attcaacgcc atttgagtat
     2641 agtcagggat aaaatcgcct cttctggtat tgtggatcag ccactgtccc cagttgataa
     2701 gacttcaggt acagaagaaa aagatgaagt cccttccgag gatgtaaaag aaatcatcag
     2761 tgagtccagg ccagcacaaa tcataaaaac aaatgataac agaaagtctc agtctaacaa
     2821 gcagtcaaca ggaaatgcag accaagatgc cccccataaa acaacaaaag acatcaaaga
     2881 aattgagaag aaaagagttg ctgctttgaa aaggctagaa gagattgaac ggattttaaa
     2941 tggagaataa cactaattct gtatcatgta acaatgtagc caagaccttc agtctctatc
     3001 atgtgtttgc ttgtactgga aactgaaaaa tgttgagact atatactggt ttttcaaaaa
     3061 ctgcataaga ttctctatat aggatcaaaa tgagattttt attgaagacc tatctgtccc
     3121 aggatatatg ttttataaga gaggacacaa attttaattt ggaagaatat tggagaaatc
     3181 acaaattcca agtcacaact tgaaacattt attatagaaa gagaaagatg tgggtttatt
     3241 atagaaagaa aagggtgggg aagtactgat atgtctttct actaatctga attgaaataa
     3301 tatggggcat caaagatgaa cccttggaga taaatccaga atgtactggg gtttgtgaat
     3361 tcccatttat taactgtttt tcatttttca ttacctcttt ggattcagga atggactgat
     3421 actcattgaa gacattcagt aactcttctc ataaaccaag ggacattata ctgcatagtc
     3481 atactgtgtt tttttaatgt gttctttgat tggaatttag aaggaatggt agaaaaaaca
     3541 ttttaaagta aatcatacat catgtagatg acaagttagc ttaggaatgc cttttgtctt
     3601 tcatgctaat atgtaagcat taagcaggta aagtgttatg catatacact agtggtgctc
     3661 gctgatactg tattctctca cactgaggac tcccacataa gctacataac catgactact
     3721 cattggcact tgttccccaa agtcttctgc ttcttggcag aaaagtccca gtcattcttc
     3781 tttaagcttt agagtaattg tagtaatctc tttcatcttt aatctctctg gtctgagctt
     3841 aaaatcagtt tcctgtttcc aaactcatac cttaacaatt cttagatacc taaaccacta
     3901 cagtcagttt tgtttaactg aaggcaaaac aatgtgacat ttatttttaa atactagatt
     3961 cctcttatcg tatatatttt attaagtatt tattttaact actgatcttt cataaaaatt
     4021 ttaaactttt agtttaaatt gctagttccc ttgagttaac taatctctat gtcttagaaa
     4081 ccatcctttt ctaatgtttt ctaagaaatc ttttataaat aggtcataag aaacatgttc
     4141 tgcattaaag acccattcct tttagcttcc cagaggacct gacatagttg ttttcttttt
     4201 tttttttttt tttttttttt aagataattt aactccagca ctaaagccaa tgggtgttag
     4261 ttcttgaccc aagagatttg ttaaccatca aagcagtatc ttgtttcagt tcttagagtg
     4321 tatctttgtg acttcagatc tagagtggag aatacctcat gtactataac ttgaagttat
     4381 tgttctctct gtttatctct agaaaagttt ttgctgataa tcactacaat ttaaattcta
     4441 agtggaggac agtgcagtaa gtaagtcaaa ggaaaccttt tatgatagca cacctaataa
     4501 aagtttgaag actattttag taaatttata tagctagtca agtgatgagg ataaatatta
     4561 atatccaata atttttatac aagaaatctt ttattagcac tcataattat gcctgtcaca
     4621 aagaaagtac tcatacttga attttaattt atttaaatca aattcatctt gaatatctat
     4681 tattaattat taccagtcag tgatacccaa cttcatttcg tagtagaatc atatgggagc
     4741 tttcctgaaa ttgagtcatg cttcagtctt tccaaaacct cttccagtga gtctcactgt
     4801 agttagagtt cagggcaact gctctaaatt agttcagtaa aggtcctttt ctctcctctg
     4861 ttaaatttgt aaattagtaa tacaacccaa ttaagttttg atggcttaaa tcccactaag
     4921 gaatatatcc tattgaaaat ataaatagta aattctatca accttgctta tggtcaaatt
     4981 aatatttctt aagtgcatga aattgtattg gaacgattca gatgagaagc tatagtaaat
     5041 atctccacac ccccagctgc ctcagctctt gttttgaaga agtgagaaca gaaacacttt
     5101 aagcccaggt tactatctta cgatttaaca ctttggatat atgaatttaa aaaaaaaaaa
     5161 aagacatatc acaggattgt gtgcagataa aaagatacag gtttaatttt caacatttaa
     5221 aaaatctact tgtcatgact tctagcaaag ctttgacaat cttcaaggag ccatgttaca
     5281 tttccccttc actactcctc agaaagtgga gttaaattct aaattgctac tatagttttt
     5341 gtttccctat taacatttga aattgggaat tttcaaattt tcctagtgag tagtcttact
     5401 caccaaccct cctcttgagg ctaggccttg tagtgttgcc catgcaggtc ttgaactcaa
     5461 aggctcaagt gatcctgtcg cagctccctg tgtgcctggg agtaccggca tgtgcatcct
     5521 cgcccagtcc cagggtgtga ttttccgaca ccagtgacgt caagaataaa ataactagat
     5581 atatcatttt gtttaacctt ttgtgtatac tcttatgtat ttgatgtgtg aattacacag
     5641 ttctaataaa acatgccttt ctttacatct gagttttcaa cttcatgtta tagaatgctt
     5701 caaagatgct ttaatgaaaa ctattaagaa tatatagatt tgtatgtcga tttatacttc
     5761 aaaaatccat atatttgtca tatttatttt tttatttgca tggccaaatg atatttaaaa
     5821 tgagtccccc ccccccaaat atctggtaac tgttaaaact cttgtcacct atccatattc
     5881 agggttcctt aaaaagtagt ttaaaattgt atgcattttt atattactat gctgtttgtg
     5941 tgtatcacat ttctaaatat tcattattaa attgttactt tttaaaactt tcaa
//
