LOCUS       NP_001129330             920 aa            linear   ROD 03-APR-2024
DEFINITION  protein O-mannosyl-transferase TMTC3 [Rattus norvegicus].
ACCESSION   NP_001129330 XP_001080635 XP_008763538 XP_235093
VERSION     NP_001129330.1
DBSOURCE    REFSEQ: accession NM_001135858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 920)
  AUTHORS   Larsen,I.S.B., Narimatsu,Y., Joshi,H.J., Siukstaite,L.,
            Harrison,O.J., Brasch,J., Goodman,K.M., Hansen,L., Shapiro,L.,
            Honig,B., Vakhrushev,S.Y., Clausen,H. and Halim,A.
  TITLE     Discovery of an O-mannosylation pathway selectively serving
            cadherins and protocadherins
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11163-11168 (2017)
   PUBMED   28973932
REFERENCE   2  (residues 1 to 920)
  AUTHORS   Yun,E.J. and Vu,T.H.
  TITLE     mSmile is necessary for bronchial smooth muscle and alveolar
            myofibroblast development
  JOURNAL   Anat Rec (Hoboken) 295 (1), 167-176 (2012)
   PUBMED   21956870
REFERENCE   3  (residues 1 to 920)
  AUTHORS   Racape,M., Duong Van Huyen,J.P., Danger,R., Giral,M., Bleicher,F.,
            Foucher,Y., Pallier,A., Pilet,P., Tafelmeyer,P., Ashton-Chess,J.,
            Dugast,E., Pettre,S., Charreau,B., Soulillou,J.P. and Brouard,S.
  TITLE     The involvement of SMILE/TMTC3 in endoplasmic reticulum stress
            response
  JOURNAL   PLoS One 6 (5), e19321 (2011)
   PUBMED   21603654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jul 20, 2021 this sequence version replaced
            XP_008763538.1, XP_235093.4, XP_001080635.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.26580.1,
                                           SRR26643296.19515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     Protein         1..920
                     /product="protein O-mannosyl-transferase TMTC3"
                     /EC_number="2.4.1.109"
                     /note="transmembrane and TPR repeat-containing protein 3;
                     transmembrane and tetratricopeptide repeat containing 3"
                     /calculated_mol_wt=103933
     Region          77..>375
                     /region_name="Stt3"
                     /note="Asparagine N-glycosylation enzyme, membrane subunit
                     Stt3 [Posttranslational modification, protein turnover,
                     chaperones]; COG1287"
                     /db_xref="CDD:440898"
     Region          263..336
                     /region_name="TMTC_DUF1736"
                     /note="Protein O-mannosyl-transferase TMTC, DUF1736;
                     pfam08409"
                     /db_xref="CDD:462468"
     Region          444..673
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          451..479
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          484..528
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          535..562
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(537..538,541,543,545,569,572..573,576..577,579..580,
                     603,606..607,610..611,614)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          549..804
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          567..597
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          602..630
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          673..701
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          706..736
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          741..770
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          776..799
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          799..>841
                     /region_name="ParB_N_Srx"
                     /note="ParB N-terminal domain and sulfiredoxin
                     protein-related families; cl28891"
                     /db_xref="CDD:452888"
     CDS             1..920
                     /gene="Tmtc3"
                     /gene_synonym="RGD1306351"
                     /coded_by="NM_001135858.2:188..2950"
                     /db_xref="GeneID:314785"
                     /db_xref="RGD:1306351"
ORIGIN      
        1 mmegkmadin fkevtlivgv vaacywnslf cgfvfddvsa ildnkdlhps tplktlfqnd
       61 fwgtpmseer shksyrpltv ltfrlnylls elkpmsyhll ntvfhavvsv iflkvcrlfl
      121 dkrgsviaal lfavhpihte avtgvvgrae llssvfflaa flsytkskgp dnsivwtpia
      181 ltvllvavat lckeqgitvv giccvyevfv aqgytlpllc avagqflrgk gsipfsmlqt
      241 liklivlmfs tlllvvirvq viqsqlpvft rfdnpaavsp tptrqltfny llpvnawlll
      301 npselccdwt mgtipliesf ldvrnlatfa ffcflgalgi fslrypgdss ktvlmalslm
      361 alpfipasnl ffpvgfvvae rvlyvpsmgf cilvahgwqk isnksvlkkl swvclsmvil
      421 thalktlhrn wdweseytlf msalkvnknn aklwnnvgha leneknfeka lkyflqathv
      481 qpddigahmn vgrtyknlnr tkeaeesyml akslmpqiip gkkyaariap nhlnvyinla
      541 nliranesrl eeadqlyrqa ismrpdfkqa yisrgelllk mnkplkakea ylkaleldrn
      601 nadlwynlai vyielkepde alknfnrale lnsrhklalf nsailmqesg evklrpeark
      661 rllnyineep qdangyfnlg mlamddkkds eaetwmkrai klqpdfrsal fnlallysqt
      721 akelkalpil eellryypdh tkglilkgdi lmnqkkdiag akkcfekile mdpsnvqgkh
      781 nlcvvyfeek dllkaerclv etlalaphee yiqrhlsivr dkiassgivd qplspvdkts
      841 gteekdevps edvkeiises rpaqiiktnd nrksqsnkqs tgnadqdaph kttkdikeie
      901 kkrvaalkrl eeierilnge
//
