LOCUS       NM_001171177            3050 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transmembrane O-mannosyltransferase targeting
            cadherins 2 (Tmtc2), mRNA.
ACCESSION   NM_001171177 XM_001080732 XM_235136
VERSION     NM_001171177.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Larsen,I.S.B., Narimatsu,Y., Joshi,H.J., Siukstaite,L.,
            Harrison,O.J., Brasch,J., Goodman,K.M., Hansen,L., Shapiro,L.,
            Honig,B., Vakhrushev,S.Y., Clausen,H. and Halim,A.
  TITLE     Discovery of an O-mannosylation pathway selectively serving
            cadherins and protocadherins
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11163-11168 (2017)
   PUBMED   28973932
REFERENCE   2  (bases 1 to 3050)
  AUTHORS   Runge,C.L., Indap,A., Zhou,Y., Kent,J.W. Jr., King,E., Erbe,C.B.,
            Cole,R., Littrell,J., Merath,K., James,R., Ruschendorf,F.,
            Kerschner,J.E., Marth,G., Hubner,N., Goring,H.H., Friedland,D.R.,
            Kwok,W.M. and Olivier,M.
  TITLE     Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing
            Loss
  JOURNAL   JAMA Otolaryngol Head Neck Surg 142 (9), 866-872 (2016)
   PUBMED   27311106
REFERENCE   3  (bases 1 to 3050)
  AUTHORS   Sunryd,J.C., Cheon,B., Graham,J.B., Giorda,K.M., Fissore,R.A. and
            Hebert,D.N.
  TITLE     TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide
            repeat-containing adapter proteins involved in calcium homeostasis
  JOURNAL   J Biol Chem 289 (23), 16085-16099 (2014)
   PUBMED   24764305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 24, 2011 this sequence version replaced
            XM_235136.5, XM_001080732.2, NM_001171177.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.20359.1,
                                           SRR26643429.26590.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000007.1  42693069-42693151   c
            84-654              JAXUCZ010000007.1  42524606-42525176   c
            655-1483            JAXUCZ010000007.1  42483260-42484088   c
            1484-1598           JAXUCZ010000007.1  42463112-42463226   c
            1599-1684           JAXUCZ010000007.1  42432773-42432858   c
            1685-1869           JAXUCZ010000007.1  42432059-42432243   c
            1870-1948           JAXUCZ010000007.1  42430428-42430506   c
            1949-2070           JAXUCZ010000007.1  42413705-42413826   c
            2071-2152           JAXUCZ010000007.1  42375946-42376027   c
            2153-2267           JAXUCZ010000007.1  42356330-42356444   c
            2268-2331           JAXUCZ010000007.1  42341920-42341983   c
            2332-3050           JAXUCZ010000007.1  42280746-42281464   c
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..3050
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /note="transmembrane O-mannosyltransferase targeting
                     cadherins 2"
                     /db_xref="GeneID:299762"
                     /db_xref="RGD:1309848"
     CDS             1..2511
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /EC_number="2.4.1.109"
                     /note="transmembrane and TPR repeat-containing protein 2;
                     transmembrane and tetratricopeptide repeat containing 2"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase TMTC2 precursor"
                     /protein_id="NP_001164648.2"
                     /db_xref="GeneID:299762"
                     /db_xref="RGD:1309848"
                     /translation="MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWT
                     HIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLF
                     TRFSKALLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYTKHCS
                     TRGYSARTWGWFLGTGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKMRQILPTIYK
                     RKNLSLFLSISLLTFWGTSLLGARLYWMGNKPPSFSNSDNPAADSDSLLARTLTFFYL
                     PTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYSGLLLLAYCGLKSPSLE
                     GECNGKAVTNGKQNANGHSCYSDVEYRNSEIKPSFASKVENGIKSCVSQRPQLPSTEN
                     IVILSLSLLIIPFIPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRF
                     LKSLVFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSK
                     ISEAEIAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAVGSRPTLASAYLN
                     TGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGRYEE
                     ALSVYREAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLT
                     YGKLLALTGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAEL
                     DSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKA
                     EANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT"
     exon            1..83
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            84..654
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            655..1483
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1598
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1684
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1869
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1948
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2070
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2152
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2267
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2331
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..3050
                     /gene="Tmtc2"
                     /gene_synonym="RGD1309848"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgattgcag agttggtgag cagcgctctg gggctcgcct tgtatctcaa caccctgagt
       61 gcggatttct gctacgatga cagccgtgct atcaagacta atcaggacct gctgccagaa
      121 accccctgga cccacatttt ctataatgat ttctggggga ctcttctaac ccacagtggt
      181 agccacaaat cctaccggcc gctctgcact ctttcttttc gactgaatca tgccatcgga
      241 gggctgaatc cctggagtta tcaccttgtc aatgtcctgt tgcacgcggc cgtcaccggc
      301 ctcttcacac gcttctccaa ggccctgctt ggggacggat actggacttt catggcgggc
      361 ttgatgtttg cctcgcaccc cattcacacg gaggcagtgg cgggcatcgt gggccgggca
      421 gacgtgggcg ccagtctctt tttcctcctg tccttgctct gctacaccaa gcactgttct
      481 acaagaggct actcagccag aacttggggc tggttcctgg ggacaggact gtgcgctgga
      541 tgcagcatgc tgtggaagga gcaaggagtg accgtcctcg cagtttcagc cgtttatgac
      601 gtctttgtct tccacaggct gaagatgagg cagattcttc ctaccattta caaaaggaag
      661 aacttgtctc tctttctcag cattagcttg ttaacattct gggggaccag ccttttgggt
      721 gcccggttat actggatggg caataaacca ccaagctttt ccaactccga caaccccgct
      781 gctgactcgg acagcctttt ggctcgcacg ctcactttct tctatttacc taccaagaac
      841 ctctggctat tgctctgccc ggacaccctg agctttgatt ggtccatgga cgccgtgcct
      901 cttctcaaaa cagtttgtga ttggagaaat ctacacactg tggccttcta ttctggactt
      961 ctcctgctcg cctactgtgg tttgaagagc ccaagtttag aaggagagtg caacgggaaa
     1021 gctgtgacaa acggcaagca gaacgccaat ggccatagtt gctactcaga cgtggagtac
     1081 cggaactcag aaattaagcc cagctttgca tccaaagtag agaatggaat taaaagttgc
     1141 gtatcacaga gacctcagct cccttccact gagaacattg tcatcctgtc tttatctttg
     1201 ttgataatac cttttattcc tgccacgaac ctgtttttct atgtcggctt tgtaatcgca
     1261 gagcgagtct tatatattcc cagtatgggc ttctgccttc tgatcacagt gggcgccaga
     1321 gccctttatg tcaaagtaca aaagaggttt ctcaagagcc tggtttttta tgctacagca
     1381 acgttaattg tcttctacgg actcaagact gcgatcagga acggagactg gcagaatgag
     1441 gagatgctgt atagatcagg gatcaaagtg aaccccgcca aagcatgggg taaccttgga
     1501 aatgttctga agagtcagag taaaatctct gaagctgaaa tcgcctatag aaatgctctg
     1561 tactaccgca gcaacatggc tgacatgctg tataatttag ggttgctgct ccaagagaac
     1621 agcaggtttg cagaagctct ccattattac aaactggctg tcggcagcag gcctaccctg
     1681 gcttctgcct atttaaacac cggcatcatt ctcatgaacc aagggaagac agaagaagcc
     1741 cgacgtacat tcctcaagtg ttctgagatt ccagatgaga atctgaagga tcctcatgca
     1801 cataagagtt ctgttaccag ctgcctgtac aacctcggga aactctatca tgagcaagga
     1861 cgctatgagg aagccctgag tgtttatagg gaagcaattc agaagatgcc aaggcagttt
     1921 gcccctcaga gcttatacaa catgatgggc gaagcctaca tgagactgag taagcttcct
     1981 gaagctgagc attggtacat ggaatcattg agatccaaga cggaccacat ccctgctcat
     2041 cttacctatg ggaagctgct ggcgctaaca ggtcgtaaga gtgaggctga aaagttcttc
     2101 ttgaaggcta ttgagctgga tcctaccaaa ggaaactgtt acatgcacta tggtcagttt
     2161 ctcctggagg aatctcgcct cacagaagca gccgagatgg caaaaaaagc agctgagctg
     2221 gacagcacag agttcgatgt cgtcttcaat gctgcccaca tgctcagaca agctagcctc
     2281 aatgaagctg cggagaagta ttacgatctt gcagcaagac tgagacctaa ttaccctgct
     2341 gctctcatga acctaggggc catcctacat ctcaatgggc gactccagaa ggctgaggcc
     2401 aactacctga gggctctgca gctcaagccg gatgatgtca tcactcagtc caatctccgc
     2461 aagctgtgga acatcatgga aaagcaaggc ttgaagacct ccaagacctg acactcgaga
     2521 actagcctcc ttctcctacg cttgtcaaag ctggcttcat taacggacag atcttcccag
     2581 cagtgcagcg gtgataaaac ctcactggag ataacaagcc caggacagag gtcatcatgg
     2641 ttaccgccac tgctaggaga atccactttg ctatgggcac agcccttaac accaaaaagg
     2701 ggaacattga gaacctctgg gagggtgtaa ttgttaccca tagactgtaa accagagcac
     2761 ttaacaggac tttggggcgt tcttagaagg gagtgggatc tcagctgcag atgttgttca
     2821 cttttgaggg agaatttgaa attatattgt tccttaaaca ctgtgagagg aagtcagaga
     2881 gcccatccag ccacagtgaa ctcttaaggg ggtgattaac acacagtgtg aatcccagtg
     2941 agccaccggt tgtccttatg ctgcttgatt gctgaagcta atcaaacatt ggttttaaca
     3001 gtgtgtcagg atctgtcaga atctccagtt gtctcttgac ttgctcataa
//
