LOCUS       NM_031136                605 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus thymosin beta 4, X-linked (Tmsb4x), mRNA.
ACCESSION   NM_031136 XM_001053027
VERSION     NM_031136.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 605)
  AUTHORS   Li,H.W. and Zhang,H.H.
  TITLE     [Effect and mechanism of thymosin beta 4 on spinal cord-derived
            neural stem /progenitor cell injury induced by oxidative stress]
  JOURNAL   Zhongguo Gu Shang 35 (8), 763-771 (2022)
   PUBMED   35979771
  REMARK    GeneRIF: [Effect and mechanism of thymosin beta 4 on spinal
            cord-derived neural stem /progenitor cell injury induced by
            oxidative stress].
REFERENCE   2  (bases 1 to 605)
  AUTHORS   Li,H., Wang,Y., Hu,X., Ma,B. and Zhang,H.
  TITLE     Thymosin beta 4 attenuates oxidative stress-induced injury of
            spinal cord-derived neural stem/progenitor cells through the
            TLR4/MyD88 pathway
  JOURNAL   Gene 707, 136-142 (2019)
   PUBMED   31054361
  REMARK    GeneRIF: Results show that Tbeta4 increased cell viability and
            decreased apoptosis of H2O2-injured neural stem/progenitor cells.
            Also, Tbeta4 attenuated oxidative stress injury in H2O2-injured
            neural stem/ progenitor cells via the TLR4/MyD88 pathway.
REFERENCE   3  (bases 1 to 605)
  AUTHORS   Zhao,Y., Song,J., Bi,X., Gao,J., Shen,Z., Zhu,J. and Fu,G.
  TITLE     Thymosin beta4 promotes endothelial progenitor cell angiogenesis
            via a vascular endothelial growth factor-dependent mechanism
  JOURNAL   Mol Med Rep 18 (2), 2314-2320 (2018)
   PUBMED   29956769
  REMARK    GeneRIF: In conclusion, Thymosin beta4 significantly increased
            angiogenesis by enhancing the paracrine effects of Endothelial
            progenitor cells (EPCs), evidenced by the increased expression of
            VEGF
REFERENCE   4  (bases 1 to 605)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 605)
  AUTHORS   Zhou,T., Huang,Y.X., Song,J.W. and Ma,Q.M.
  TITLE     Thymosin beta4 inhibits microglia activation through microRNA 146a
            in neonatal rats following hypoxia injury
  JOURNAL   Neuroreport 26 (17), 1032-1038 (2015)
   PUBMED   26457369
  REMARK    GeneRIF: Data reveal, that Thymosin beta4 (Tbeta4) inhibits
            microglia activation in vitro.
REFERENCE   6  (bases 1 to 605)
  AUTHORS   Cassimeris,L., Safer,D., Nachmias,V.T. and Zigmond,S.H.
  TITLE     Thymosin beta 4 sequesters the majority of G-actin in resting human
            polymorphonuclear leukocytes
  JOURNAL   J Cell Biol 119 (5), 1261-1270 (1992)
   PUBMED   1447300
REFERENCE   7  (bases 1 to 605)
  AUTHORS   Safer,D., Elzinga,M. and Nachmias,V.T.
  TITLE     Thymosin beta 4 and Fx, an actin-sequestering peptide, are
            indistinguishable
  JOURNAL   J Biol Chem 266 (7), 4029-4032 (1991)
   PUBMED   1999398
REFERENCE   8  (bases 1 to 605)
  AUTHORS   Atkinson,M.J., Freeman,M.W. and Kronenberg,H.M.
  TITLE     Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a
            regulated manner
  JOURNAL   Mol Endocrinol 4 (1), 69-74 (1990)
   PUBMED   2325669
REFERENCE   9  (bases 1 to 605)
  AUTHORS   Leonard,D.G., Ziff,E.B. and Greene,L.A.
  TITLE     Identification and characterization of mRNAs regulated by nerve
            growth factor in PC12 cells
  JOURNAL   Mol Cell Biol 7 (9), 3156-3167 (1987)
   PUBMED   3670309
REFERENCE   10 (bases 1 to 605)
  AUTHORS   Goodall,G.J., Richardson,M., Furuichi,Y., Wodnar-Filipowicz,A. and
            Horecker,B.L.
  TITLE     Sequence of a cloned 523-bp cDNA for thymosin beta 4
  JOURNAL   Arch Biochem Biophys 236 (1), 445-447 (1985)
   PUBMED   3838131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1 and M34043.1.
            
            On Mar 15, 2021 this sequence version replaced NM_031136.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF249194.1, FQ094755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                JAXUCZ010000021.1  30761611-30761621
            12-605              M34043.1           1-594
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..605
                     /gene="Tmsb4x"
                     /note="thymosin beta 4, X-linked"
                     /db_xref="GeneID:81814"
                     /db_xref="RGD:621622"
     exon            1..58
                     /gene="Tmsb4x"
                     /inference="alignment:Splign:2.1.0"
     exon            59..173
                     /gene="Tmsb4x"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..208
                     /gene="Tmsb4x"
                     /note="t beta 4; thymosin, beta 4, X chromosome"
                     /codon_start=1
                     /product="thymosin beta-4"
                     /protein_id="NP_112398.1"
                     /db_xref="GeneID:81814"
                     /db_xref="RGD:621622"
                     /translation="MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
                     "
     exon            174..605
                     /gene="Tmsb4x"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagtcggc agcggcctct gagcagatcg tctctccttg ttcgcccagc tcgctcagct
       61 ccttccagca accatgtctg acaaacccga tatggctgag atcgagaaat tcgataagtc
      121 gaagttgaag aagacagaaa cacaagagaa aaatcctctg ccttcaaaag aaacaattga
      181 acaagagaag caagctggcg aatcgtaatg aggcgagcgc cgccaatatg cactgtacat
      241 tccacgagca ttgccttctt attttacttc ttttagctgt ttaacttcgt aagatgcaaa
      301 gaggttggat caagtttaaa tgactgtgct gcccctttca catcaaagaa tcagaactac
      361 tgaccaggaa ggcctccccc cgcctctccc gcccacctgc tggcctggct ggcagagagg
      421 gaaaagaact tgcatgttgg tgaaggaaaa agctgggtgg gagatggtgg aattgagagt
      481 aaaataaaga tgtcttgcag gatataaaat gcagtttaat cagagtgcca tttttttttg
      541 ttcaaacgat tttaattatt ggaatgcaca atttttttaa tatgcaaata aagttttaaa
      601 acctg
//
