LOCUS       NM_001395516            3454 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 9 (Tmprss9), mRNA.
ACCESSION   NM_001395516 NM_001047100 XM_006240931
VERSION     NM_001395516.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3454)
  AUTHORS   Okumura,Y., Hayama,M., Takahashi,E., Fujiuchi,M., Shimabukuro,A.,
            Yano,M. and Kido,H.
  TITLE     Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates
            urokinase-type plasminogen activator and the proteolytic activation
            is negatively regulated by glycosaminoglycans
  JOURNAL   Biochem J 400 (3), 551-561 (2006)
   PUBMED   16872279
  REMARK    GeneRIF: The isolation and characterization of serase-1B, a splice
            variant of polyserase-1, is reported.[Serase-1B]
REFERENCE   2  (bases 1 to 3454)
  AUTHORS   Cal,S., Quesada,V., Garabaya,C. and Lopez-Otin,C.
  TITLE     Polyserase-I, a human polyprotease with the ability to generate
            independent serine protease domains from a single translation
            product
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9185-9190 (2003)
   PUBMED   12886014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jul 15, 2021 this sequence version replaced
            NM_001047100.2, XM_006240931.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000007.1  9481695-9481854     c
            161-288             JAXUCZ010000007.1  9479207-9479334     c
            289-356             JAXUCZ010000007.1  9478187-9478254     c
            357-532             JAXUCZ010000007.1  9477885-9478060     c
            533-574             JAXUCZ010000007.1  9475752-9475793     c
            575-688             JAXUCZ010000007.1  9474827-9474940     c
            689-860             JAXUCZ010000007.1  9473763-9473934     c
            861-1135            JAXUCZ010000007.1  9472426-9472700     c
            1136-1272           JAXUCZ010000007.1  9471451-9471587     c
            1273-1591           JAXUCZ010000007.1  9470363-9470681     c
            1592-1763           JAXUCZ010000007.1  9467795-9467966     c
            1764-2035           JAXUCZ010000007.1  9467139-9467410     c
            2036-2172           JAXUCZ010000007.1  9466089-9466225     c
            2173-2566           JAXUCZ010000007.1  9465255-9465648     c
            2567-2738           JAXUCZ010000007.1  9463086-9463257     c
            2739-3001           JAXUCZ010000007.1  9462347-9462609     c
            3002-3138           JAXUCZ010000007.1  9462127-9462263     c
            3139-3454           JAXUCZ010000007.1  9460998-9461313     c
FEATURES             Location/Qualifiers
     source          1..3454
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3454
                     /gene="Tmprss9"
                     /note="transmembrane serine protease 9"
                     /db_xref="GeneID:314636"
                     /db_xref="RGD:1309581"
     exon            1..160
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..3300
                     /gene="Tmprss9"
                     /note="polyserase-1; polyserase-I; polyserine protease 1;
                     serase-1b; transmembrane protease, serine 9"
                     /codon_start=1
                     /product="transmembrane protease serine 9"
                     /protein_id="NP_001382445.1"
                     /db_xref="GeneID:314636"
                     /db_xref="RGD:1309581"
                     /translation="MEPAAPDLQPVPEVTKGVPVPTPDSGCCRAAVTTVVAISVASLT
                     LGVLSAFLSAQGVQVEHTAQLHGVRFTSLLQQENSDFYRLLTPALQTLFVRSFQKTEL
                     ESSCTGCTVLSYRDGNSSVIVHFRLHFLLRALQPLSLDQEADILQKGIQARLQGQGLS
                     LAAYGTITSVELTGRCEGPVTERDLKSGHCPGNAFSCQNSQCVSKENPECDDRVDCSD
                     GSDEAQCDCGWQPAWRSAGRIVGGAEAAPGEFPWQVSLRENHEHFCGATIIGARWLVS
                     AAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRARVLRIAKHPAYNADTADFDVAVLEL
                     ARPLPFGRYVQPACLPAATHVFPPRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQN
                     LCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGVVSWGIGCAE
                     ARRPGVYTRVTRLRDWILEVTSSADTPVVPTEAPAPITPSTPWPTSPESRVPNTTAKP
                     TVAPTPAPLHPSTAAKPQECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGSRHFCG
                     ATVVGDRWLLSAAHCFNHTKLEQVQAHLGTVSLLGVGGSPVKLGLRSVALHPRYNPGI
                     LDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQ
                     KASVGIIEQKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFYLAG
                     IVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDPSSTAHPHTSSTRLIPSQPPTTTA
                     AGLIPEASTGRPATLRATIRVTTRPLNTTLSARSTTTRRQTPAPGTTVFSHLPDCGLA
                     PPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPM
                     QWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPIC
                     LPGPTRPPEGARCVITGWGSLREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSRMLC
                     AGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGW
                     IGQNIRE"
     exon            161..288
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            289..356
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            357..532
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            533..574
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            575..688
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            689..860
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1135
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1272
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1591
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1763
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2035
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2172
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2566
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2738
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..3001
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3138
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3454
                     /gene="Tmprss9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtttctgag ccatggagcc agcggcacca gacttacaac ctgtgccaga ggtgacgaag
       61 ggtgtccccg tccccactcc tgactctggc tgttgtcgag ccgctgtcac cacagtggtg
      121 gccatcagcg tggccagcct caccctagga gtcctttcag ccttcctctc tgcacagggt
      181 gtccaggtgg agcacacggc gcagctacat ggggtccgtt tcaccagcct tttgcagcag
      241 gagaactccg acttctaccg cctgcttacg cctgctctgc agacgctgtt cgtgaggagt
      301 ttccagaaaa cagagttaga atcgagctgc acgggctgca cagtgctgag ttacagagat
      361 ggcaattcca gcgtgattgt gcatttccgg ctacactttc tgctccgagc cctccagcca
      421 ctgagcctgg accaggaagc agacatcttg cagaaaggaa tccaggcaag gttacaagga
      481 caaggtcttt ccctggctgc ctacggcacc atcacatccg tggagctgac aggaaggtgt
      541 gaaggtccgg tgaccgagag ggacttaaag tcaggccact gccccgggaa tgccttctcc
      601 tgtcagaaca gtcaatgcgt gagcaaagaa aacccggagt gtgacgacag agtggactgc
      661 tctgatgggt ctgacgaggc tcagtgtgac tgcggctggc agcctgcctg gagatcagct
      721 ggaaggatcg tgggcggagc ggaggcggct ccgggagagt tcccctggca ggtcagcctc
      781 cgagagaatc acgaacactt ctgcggcgcc accatcatcg gtgcccggtg gctggtgtct
      841 gctgcccact gcttcaacga attccaggac cctgcgcaat gggccgccca ggcaggcagc
      901 gtgcacctga gcggttcaga ggccagcgct gtgcgtgcgc gcgtgctccg tatcgccaag
      961 catcctgcct acaacgcgga cacggcggac tttgacgtgg cggtgctgga actggctcgc
     1021 ccgctgccct tcggccgcta tgtgcagcct gcctgccttc ccgcggccac tcacgtcttc
     1081 ccaccgcgca agaagtgcct gatctcgggc tggggttacc tgaaggagga cttcctggtg
     1141 aagccagagg tccttcagaa agccacagtg gaattgctgg accagaacct gtgttccagc
     1201 ctgtatggcc actcgctcac ggacaggatg gtgtgtgccg gctacctgga cgggaaggtg
     1261 gactcctgcc agggtgactc cgggggaccc ctggtctgcg aggagccttc cggaaggttc
     1321 ttcctggctg gtgtcgtgag ctggggaatc ggctgtgcag aagcacggcg cccaggggtc
     1381 tacacccgag tcaccaggct gcgggattgg atcttggagg tgaccagctc ggctgacacg
     1441 cccgtggtcc ccaccgaggc tccagcaccc atcaccccca gcactccctg gcctaccagc
     1501 cccgagagcc gggtgcccaa caccactgct aaacccaccg ttgcccccac ccctgcgcca
     1561 ctgcacccca gcactgcggc caagccacaa gagtgtgggg ccaggcccgc gatggacaag
     1621 cccactcgca ttgtgggcgg gatcagcgcc gtgtccgggg aggtgccctg gcaggccagc
     1681 ctgaaggaag gatccagaca tttctgcgga gccaccgtgg tgggtgaccg ctggctgctg
     1741 tccgctgccc actgtttcaa ccacaccaaa ctggaacagg tgcaggcgca cttgggcacc
     1801 gtgtccctgc tgggtgtcgg cgggagcccc gtgaagctgg ggctgcgaag cgtggccctg
     1861 cacccccgct acaacccagg aatcctggac tttgacgtgg ccttgctgga gttggcccag
     1921 ccattggtct tcaacaagta catccagcca gtctgtctcc cgctggccat ccacaagttc
     1981 cccgtgggcc ggaagtgtat gatctcggga tggggcaaca tgcaggaggg aaacgccacc
     2041 aagcccgaca tcttgcagaa ggcgtctgtg ggcatcatag agcagaagat gtgtggtgcc
     2101 ctctacaact tctccctcac cgaccgcatg ctctgcgccg gcttcctgga gggtagagtc
     2161 gactcctgcc agggtgattc tggtggcccc ctggcatgtg aggagacacc tggtgtcttt
     2221 tacctggctg gcatcgtgag ctggggcatt ggctgtgccc aagctaagaa gcctggtgta
     2281 tatgcacgaa tcacgcgcct caaggactgg atcctgaaag ccatgtcctc agaccccagc
     2341 tctacggctc acccccacac ctccagcaca cggctcatcc ctagccagcc cccaacaacc
     2401 acagctgctg gcctcatccc agaggccagc acaggcagac ctgctaccct cagagccacc
     2461 atcagagtga ctactagacc actcaacaca acgttgtctg ccaggagtac caccaccagg
     2521 agacagacac cagcaccggg caccactgtg ttctctcatc tgccagactg cggcctggca
     2581 cccccagggg ccctgacccg gatagtgggc ggcagcgcag cctcgcttgg agaatggccc
     2641 tggcaagtga gcctgtggct gcggcgcagg gagcaccgct gtggggcggt actggtggcc
     2701 gagaggtggc ttctgtctgc agcacactgt ttcgacgtct atggggaccc tatgcagtgg
     2761 gcagccttcc tggggacccc gttcctgagc agcacggagg gccagttgga gcgtgtggca
     2821 cgcatctatc gccacccgtt ctacaacatc tacacgctgg actatgacgt ggcgctgctg
     2881 gagctggcgg ggcctgtgcg ccgtagccgc ttggtgcgac ccatctgcct accaggtccc
     2941 actcgtcctc ctgaaggcgc gcgctgtgtc atcactggct ggggttcgct gcgagaagga
     3001 ggctccatgg cgaggcagct gcagaaggct gcggtgaggg tcctcagtga acagacatgt
     3061 cgccgcttct acccggtaca gatcagcagt cgtatgttgt gcgcaggctt cccgcagggt
     3121 ggcgtggaca gctgctcggg tgatgcaggg ggacccctgg cctgcaggga gccatctggc
     3181 caatgggtgc taactggggt caccagttgg ggctacggct gtggcaggcc gcacttccca
     3241 ggtgtctaca ctcgagtggc tgctgtacta ggatggatag gccagaatat ccgggaatga
     3301 cacccccgtg gccagcgacc caggcatgga ctacaaacac aactgctggc cacccaaccc
     3361 acggtgggga gtcggtggcg gaacacacat gggggtccga caagaactag ctgtgaccgt
     3421 gtatattgtt ccaataaaca gagtcccttc tcct
//
