LOCUS       NM_001130556            2999 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 6 (Tmprss6), mRNA.
ACCESSION   NM_001130556 XM_001074604 XM_001074630 XM_235768
VERSION     NM_001130556.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2999)
  AUTHORS   Gurieva,I., Frydlova,J., Rychtarcikova,Z., Vokurka,M., Truksa,J.
            and Krijt,J.
  TITLE     Erythropoietin administration increases splenic erythroferrone
            protein content and liver TMPRSS6 protein content in rats
  JOURNAL   Blood Cells Mol Dis 64, 1-7 (2017)
   PUBMED   28282554
  REMARK    GeneRIF: EPO administration increased TMPRSS6 content in the plasma
            membrane-enriched fraction of liver homogenate; in iron-pretreated
            rats, this increase was abolished. The results confirm that iron
            pretreatment prevents the EPO-induced decrease in liver Hamp
            expression.
REFERENCE   2  (bases 1 to 2999)
  AUTHORS   Rausa,M., Pagani,A., Nai,A., Campanella,A., Gilberti,M.E.,
            Apostoli,P., Camaschella,C. and Silvestri,L.
  TITLE     Bmp6 expression in murine liver non parenchymal cells: a mechanism
            to control their high iron exporter activity and protect
            hepatocytes from iron overload?
  JOURNAL   PLoS One 10 (4), e0122696 (2015)
   PUBMED   25860887
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2999)
  AUTHORS   De Falco,L., Silvestri,L., Kannengiesser,C., Moran,E., Oudin,C.,
            Rausa,M., Bruno,M., Aranda,J., Argiles,B., Yenicesu,I.,
            Falcon-Rodriguez,M., Yilmaz-Keskin,E., Kocak,U., Beaumont,C.,
            Camaschella,C., Iolascon,A., Grandchamp,B. and Sanchez,M.
  TITLE     Functional and clinical impact of novel TMPRSS6 variants in
            iron-refractory iron-deficiency anemia patients and
            genotype-phenotype studies
  JOURNAL   Hum Mutat 35 (11), 1321-1329 (2014)
   PUBMED   25156943
REFERENCE   4  (bases 1 to 2999)
  AUTHORS   Maxson,J.E., Chen,J., Enns,C.A. and Zhang,A.S.
  TITLE     Matriptase-2- and proprotein convertase-cleaved forms of
            hemojuvelin have different roles in the down-regulation of hepcidin
            expression
  JOURNAL   J Biol Chem 285 (50), 39021-39028 (2010)
   PUBMED   20937842
  REMARK    GeneRIF: Matriptase-2- and proprotein convertase-cleaved forms of
            hemojuvelin have different roles in the down-regulation of hepcidin
            expression
REFERENCE   5  (bases 1 to 2999)
  AUTHORS   Truksa,J., Gelbart,T., Peng,H., Beutler,E., Beutler,B. and Lee,P.
  TITLE     Suppression of the hepcidin-encoding gene Hamp permits iron
            overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6
  JOURNAL   Br J Haematol 147 (4), 571-581 (2009)
   PUBMED   19751239
REFERENCE   6  (bases 1 to 2999)
  AUTHORS   Silvestri,L., Guillem,F., Pagani,A., Nai,A., Oudin,C., Silva,M.,
            Toutain,F., Kannengiesser,C., Beaumont,C., Camaschella,C. and
            Grandchamp,B.
  TITLE     Molecular mechanisms of the defective hepcidin inhibition in
            TMPRSS6 mutations associated with iron-refractory iron deficiency
            anemia
  JOURNAL   Blood 113 (22), 5605-5608 (2009)
   PUBMED   19357398
REFERENCE   7  (bases 1 to 2999)
  AUTHORS   Finberg,K.E., Heeney,M.M., Campagna,D.R., Aydinok,Y., Pearson,H.A.,
            Hartman,K.R., Mayo,M.M., Samuel,S.M., Strouse,J.J., Markianos,K.,
            Andrews,N.C. and Fleming,M.D.
  TITLE     Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia
            (IRIDA)
  JOURNAL   Nat Genet 40 (5), 569-571 (2008)
   PUBMED   18408718
REFERENCE   8  (bases 1 to 2999)
  AUTHORS   Ramsay,A.J., Reid,J.C., Velasco,G., Quigley,J.P. and Hooper,J.D.
  TITLE     The type II transmembrane serine protease
            matriptase-2--identification, structural features, enzymology,
            expression pattern and potential roles
  JOURNAL   Front Biosci 13, 569-579 (2008)
   PUBMED   17981570
  REMARK    GeneRIF: identification, structural features, enzymology,
            expression pattern and potential roles of TMPRSS6 [review]
            Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2999)
  AUTHORS   Hooper,J.D., Campagnolo,L., Goodarzi,G., Truong,T.N., Stuhlmann,H.
            and Quigley,J.P.
  TITLE     Mouse matriptase-2: identification, characterization and
            comparative mRNA expression analysis with mouse hepsin in adult and
            embryonic tissues
  JOURNAL   Biochem J 373 (Pt 3), 689-702 (2003)
   PUBMED   12744720
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_235768.4, XM_001074604.1, XM_001074630.1.
FEATURES             Location/Qualifiers
     source          1..2999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2999
                     /gene="Tmprss6"
                     /note="transmembrane serine protease 6"
                     /db_xref="GeneID:315388"
                     /db_xref="RGD:1307138"
     exon            1..202
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2521
                     /gene="Tmprss6"
                     /note="transmembrane protease, serine 6"
                     /codon_start=1
                     /product="transmembrane protease serine 6"
                     /protein_id="NP_001124028.1"
                     /db_xref="GeneID:315388"
                     /db_xref="RGD:1307138"
                     /translation="MPRCFQLPCSTRMPTAEVPQAAGGQGDGGDGEEAAEPEGVFKAP
                     RNAKRKDRDYVRFTPLLLVLAALASAGVMLWYFLGYKAEVTISQVYSGSLRVLNRHFS
                     QDLARRESIAFRTETAKAQKMFQELVASTRLGTYYNSSSIYAFGEGPLICFFWFILDI
                     PEYQRLTLSPEVVRELLVGELLSNSSALASYRTEYEVDPEGLVILEASVNDIVVLNST
                     LGCYRYSYVNPGQVLRLRGPDQQTTSCLWHLQGPEDLMLKVQLEWTRVDCRDRVAMYD
                     AAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGLHSFYDPFLLSVKSVAFQD
                     CQVNLTLEGRLDPQGFLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQK
                     YNLLCTQGQWMIQNRRLCGFRTLQPYAERIPVVASDGITINFTSQISLTGPGVQVYYS
                     LYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPR
                     VCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHC
                     DCGLQGPSSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSM
                     ASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSA
                     TVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAYRYQ
                     VTPRMLCAGYRKGKKDACQGDSGGPLVCKEPR"
     exon            203..437
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            438..571
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            572..639
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            640..818
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            819..860
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1065
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1202
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1315
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1425
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1571
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1670
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1784
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1901
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2070
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2342
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2479
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2516
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2999
                     /gene="Tmprss6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtccgtc ctggacctga caggaggccc atggaacttg gggccacagg ccacgaggga
       61 caagggccag acaccccagt catggttcca ggctattgat ccaacctaag ctggccagtt
      121 gtgggtggag agaccttggc ctggataaac agaggcctcc aggcctgtgt tcaggcccag
      181 cacctacctt ccactcttga agatgccaag atgtttccag ctcccctgtt ctaccaggat
      241 gcccaccgct gaggttcccc aagcagctgg tggtcagggt gatggaggtg atggagagga
      301 agctgcagag ccagaggggg tgttcaaggc ccccagaaac gccaagagaa aagacaggga
      361 ctacgtccgc ttcacaccac tgttgctggt cttggctgcg ttggcttcgg caggagtcat
      421 gctctggtat ttcctagggt acaaggcgga agtgaccata agccaggtgt actctggcag
      481 cctccgggtg ctcaaccgcc atttttcaca ggacttggcc cgacgggagt ctattgcttt
      541 ccgcactgaa actgccaaag cccagaagat gttccaagag ctggttgcca gcacccgctt
      601 gggtacttac tacaactcca gttccatcta cgcctttggg gagggacccc ttatctgctt
      661 cttctggttc atccttgaca tccccgagta ccagcgactg accctgagcc ctgaggtggt
      721 gcgcgagctc ctggtgggtg agctactgtc caacagctca gccttggctt cctataggac
      781 cgaatatgag gtggacccgg aaggcctggt gatactagaa gccagcgtga acgacatagt
      841 cgtactgaat tccacgctgg gctgttaccg ctacagctac gtgaacccgg gccaggtcct
      901 ccggttgagg gggcccgacc agcagaccac tagctgcctg tggcacctgc aggggcccga
      961 ggacctcatg ctcaaagtgc agctagagtg gactcgggtt gattgcagag acagggtggc
     1021 gatgtacgac gcagctgggc ccctggagaa gagacttatc acctcggtct atgggtgcag
     1081 ccgccaggaa cccgtgatgg aggtgctggc gtcgggctct gtcatggccg tggtgtggaa
     1141 gaagggcttg catagcttct atgacccttt tctgctctca gtgaagtctg tggccttcca
     1201 ggactgccag gtgaacctga ccctggaagg ccggctggat ccacagggct tcctccgtac
     1261 accctactac cccagttact actcgcccag tacccactgc tcctggcatc tcacggttcc
     1321 ctctctggac tatggcttgg cactctggtt tgacgcctat gcactgagga ggcagaagta
     1381 caacctacta tgtactcagg gccagtggat gatccagaac aggaggctat gtggcttccg
     1441 taccctgcag ccatatgctg agaggatccc cgtggtggcc tcggatggta tcaccatcaa
     1501 cttcacctcc cagatctccc tcacaggccc gggtgtgcaa gtgtactaca gcttgtacaa
     1561 ccaatcagac ccctgccctg gagagttcct ctgctctgtg aatggattgt gtgtccctgc
     1621 ttgtgacgga atcaaggact gccccaacgg cctggatgag aggaactgtg tctgcagagc
     1681 catgttccag tgccaagagg acagcacgtg catctcactg ccgagagtct gtgaccggca
     1741 gcccgactgt ctcaatggta gcgacgaaga gcagtgccaa gaaggagtgc cctgtgggac
     1801 attcactttc cagtgtgagg accggagctg tgtgaagaag cccaaccccg agtgtgacgg
     1861 gcaggcagac tgcagggatg gctcggatga ggagcactgt gactgtggcc tccagggccc
     1921 ctccagccgc attgtgggcg gggccatgtc ctcggagggt gagtggccct ggcaggccag
     1981 tctccagatt cggggtcgac acatctgtgg gggggctctc atcgctgacc gctgggtcat
     2041 aacagccgct cactgcttcc aggaggacag catggcctcc ccgaggctgt ggaccgtgtt
     2101 tctgggaaag atgcggcaga attcacgctg gccgggcgag gtgtccttca aggtgagccg
     2161 cctgttcctg cacccgtatc atgaggagga cagccatgac tacgacgtgg ccctgctgca
     2221 gctggaccac cctgtggtgt actcggccac cgtgcgcccc gtctgcctgc ccgcacgctc
     2281 tcacttcttt gagccaggcc agcactgctg gatcacaggc tggggagccc agcgagaggg
     2341 tggtcctggt agcagcaccc ttcagaaggt ggatgtgcaa ctgatccctc aggacctgtg
     2401 caatgaggcc taccgttacc aggtgacccc acgcatgctc tgtgctggtt atcgcaaggg
     2461 caagaaagat gcctgccagg gcgactctgg aggcccactg gtttgcaagg agcccaggtg
     2521 accacccagc cagggcacaa gtattctggg gcgagcgacc ctgctaaggc ctgtcccctc
     2581 atgcctaccc cagggacagt acagagaagg atgtcagctg gtggttagga tgcctccagg
     2641 ggctagcctc agctcggctt cacttccaac cctttcttat tctagtcctt tcccctctcc
     2701 cctcctactg ctgttttggg gtggggtctg gtggcaatga tgctggttcc aaggtctgtg
     2761 ggaaagtaag attccttccc cttgcaaaag cctctagggg gaactggatc cgagaaagaa
     2821 ggtgcctcta tcaaggctct gtcagagccc ttgagactgc caagtagggc cataccgtaa
     2881 gccaaatcat ggggcagcct cagctgcggg tgcctgctgt gctctgcctg ctacagggcc
     2941 ctccctgcca ttcactggag gcccactgtc tgttccggaa ataaagcagt tggccaagc
//
