LOCUS       NM_153311               2366 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 5 (Tmprss5), mRNA.
ACCESSION   NM_153311
VERSION     NM_153311.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Guipponi,M., Toh,M.Y., Tan,J., Park,D., Hanson,K., Ballana,E.,
            Kwong,D., Cannon,P.Z., Wu,Q., Gout,A., Delorenzi,M., Speed,T.P.,
            Smith,R.J., Dahl,H.H., Petersen,M., Teasdale,R.D., Estivill,X.,
            Park,W.J. and Scott,H.S.
  TITLE     An integrated genetic and functional analysis of the role of type
            II transmembrane serine proteases (TMPRSSs) in hearing loss
  JOURNAL   Hum Mutat 29 (1), 130-141 (2008)
   PUBMED   17918732
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Omer,S., Lomthaisong,K. and Bicknell,A.B.
  TITLE     Identification of two alternate splice variants of a novel serine
            protease expressed in steroidogenic tissues
  JOURNAL   Endocr Res 28 (4), 339-348 (2002)
   PUBMED   12530635
  REMARK    GeneRIF: AmP-Long has no effect on steroidogenesis nor cleaves StAR
            as was shown by western blot analysis using StAR antibody.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153311.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF537098.1, SRR26643288.33662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000008.1  58338455-58338527
            74-176              JAXUCZ010000008.1  58344416-58344518
            177-275             JAXUCZ010000008.1  58344803-58344901
            276-398             JAXUCZ010000008.1  58345523-58345645
            399-534             JAXUCZ010000008.1  58347554-58347689
            535-648             JAXUCZ010000008.1  58347889-58348002
            649-692             JAXUCZ010000008.1  58350137-58350180
            693-855             JAXUCZ010000008.1  58350856-58351018
            856-1034            JAXUCZ010000008.1  58351899-58352077
            1035-1133           JAXUCZ010000008.1  58353001-58353099
            1134-1276           JAXUCZ010000008.1  58353548-58353690
            1277-1429           JAXUCZ010000008.1  58353984-58354136
            1430-2366           JAXUCZ010000008.1  58355625-58356561
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2366
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /note="transmembrane serine protease 5"
                     /db_xref="GeneID:266681"
                     /db_xref="RGD:628625"
     exon            1..73
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            74..176
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1438
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /note="adrenal mitochondrial protease; transmembrane
                     protease, serine 5 (spinesin)"
                     /codon_start=1
                     /product="transmembrane protease serine 5"
                     /protein_id="NP_695223.2"
                     /db_xref="GeneID:266681"
                     /db_xref="RGD:628625"
                     /translation="MEIRCTEEGPGPGIFRAELGDQQQPISQSQRWCCLQRGCVILGA
                     LGLLAGAGVGSWLLVLYLWPAASPPVSVTLQEEEVTLSCPGVSSEEKLLPSLPKAVSF
                     RINGEDLLLEVQVRARPDWLLVCHEGWNPALGMHICQSLGYFRLTQHKAVNLSDIKLN
                     RSQEFAQLSARPGSLVEEAWQPSTNCPSGRIVSLKCSECGARPLASRIVGGQAVASGR
                     WPWQASVMLGSRHTCGASVLAPYWVVTAAHCMYSFRLSRLSSWRVHAGLVSHSAVRQH
                     QGTMVEKIIPHPLYSAQNHDYDVALLQLRTPINFSDTVSAVCLPAKEQHFPQGSQCWV
                     SGWGHTDPSHTHSSDTLQDTMVPLLSTDLCNSSCMYSGALTHRMLCAGYLDGRADACQ
                     GDSGGPLVCPSGDTWHLVGVVSWGRGCAEPNRPGVYAKVAEFLDWIHDTVQVR"
     exon            177..275
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            276..398
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            399..534
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            535..648
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            649..692
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            693..855
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1034
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1133
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1276
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1429
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..2366
                     /gene="Tmprss5"
                     /gene_synonym="Amp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacatgag gacaggagcc acaccctgcc cagcagacct tactgcctta catcagtgca
       61 actgactcac ctgagttcaa cattggatga ccaatgccca atggagatcc ggtgcacaga
      121 agagggtcct gggcctggga tcttcagagc agagttggga gaccagcagc aacccatctc
      181 tcagtcccag cgttggtgct gcctgcaacg tggctgtgta atactgggag ccctggggct
      241 gctggctgga gcaggtgttg gttcctggct cttagtgttg tatctctggc cggctgcctc
      301 tccacccgtc tcggtgacgt tgcaggagga ggaggtaacg ctgagctgcc caggagtgag
      361 cagtgaggaa aaactccttc catctcttcc caaagcagta tctttcagaa taaatggtga
      421 ggatcttctg cttgaagtgc aagtaagggc tcggccagac tggctcctgg tctgccatga
      481 gggctggaac cctgccctgg ggatgcacat ctgccagagt cttggatatt tcaggctcac
      541 tcaacacaag gcagtgaatc tgtctgacat caagctcaac agatcccagg agtttgctca
      601 gctctctgct agaccgggaa gccttgtaga ggaggcatgg cagcccagca ctaactgtcc
      661 ttctggccga attgtttctc tcaaatgttc tgagtgtggg gcaagacctc tggcttctcg
      721 aatagttggc ggtcaagctg tggcttctgg gcgctggccg tggcaagcta gtgtgatgct
      781 cggctcccga cacacatgtg gggcctctgt gctggcaccc tactgggtag tgactgccgc
      841 ccactgcatg tacagtttca ggctgtcccg tctatccagc tggcgggttc atgcagggct
      901 ggtcagccac agtgctgtcc gacaacacca gggaactatg gtggagaaga tcattcccca
      961 ccctttgtac agcgcccaga accatgacta tgatgtggct ctgctgcagc tccggacacc
     1021 aatcaacttc tcagacactg tgagcgctgt gtgtttgccg gccaaggagc agcactttcc
     1081 acaagggtcg cagtgctggg tgtctggctg gggccacacc gaccccagcc atactcatag
     1141 ctcagataca ctgcaggaca caatggtacc cctgcttagc accgatctct gcaacagctc
     1201 atgcatgtac agtggggcac tcacacaccg catgctgtgt gccggctacc tggatggaag
     1261 ggcagatgcg tgccagggag acagtggggg acccctggtg tgtcccagtg gtgacacgtg
     1321 gcaccttgta ggggtggtca gctggggtcg tggctgtgca gagcccaatc gcccaggtgt
     1381 ctatgccaaa gtagcagagt tcctggactg gatccatgac actgtgcagg tccgctagct
     1441 gaagaagaag cagctgctgc ctgcgacaca gaactgtgga tctcccatgg atcatcccag
     1501 actgaggact agcatctggg tcactgggcc tttccccaaa ggctctgact tctagtttgt
     1561 ctttctcatc tgagaacctc cacaacagag aagagtctgg ggctgggttg ggaatgatga
     1621 tgagaggaag ggataagaag acagaggaga cagaagaggc ttctggaagc atctgggaga
     1681 ctgccctctg ctctccacac accccatgtg catccactgg gaggatgctg gaggtgcccc
     1741 agccctgttt tcttctgagg ccagggaagg cctaagttca actttagaag atgccctgtc
     1801 tcaagggtct taggcagata atgttaaggt tggaccagct caggtaaagg catcgaaatc
     1861 aagatccccc ccatgctggt cctgttttga ggtaactcta agtagccctc cgtgaagcag
     1921 aggtctacaa ggtaagaagg atggagttgg gttaggatgc tgtttttcac acgacagttc
     1981 tgtaaattgc ttgatattaa gtggagatta tatataatct tggttgaggt cctccctctc
     2041 tgtattagct aatgtgatga aatacacggt caagagaact tactttggct cagagacaaa
     2101 agatccagtc tactgtgctg aggaatgtga ggtgctactc tgtcaggaag cagggagagg
     2161 aggtgctggg gctttggtcg tagacctcgg ccattgctta gaggccctaa catacagggc
     2221 aagtctcagt tacacctctc aggaaagtcc ctcacagatg tacttagagg tgtgtctccc
     2281 aggtgattca aaatccagca tacttgtcag caaagactag ccatcactgt cacacgtgtt
     2341 actgaataga aatacaaatt tcctcc
//
