LOCUS       NM_001108998            2235 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 4 (Tmprss4), mRNA.
ACCESSION   NM_001108998 XM_345932
VERSION     NM_001108998.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Zang R, Gomez Castro MF, McCune BT, Zeng Q, Rothlauf PW, Sonnek NM,
            Liu Z, Brulois KF, Wang X, Greenberg HB, Diamond MS, Ciorba MA,
            Whelan SPJ and Ding S.
  TITLE     TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small
            intestinal enterocytes
  JOURNAL   Sci Immunol 5 (47) (2020)
   PUBMED   32404436
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Valero-Jimenez A, Zuniga J, Cisneros J, Becerril C, Salgado A,
            Checa M, Buendia-Roldan I, Mendoza-Milla C, Gaxiola M, Pardo A and
            Selman M.
  TITLE     Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF
            lungs and increases the fibrotic response in bleomycin-induced lung
            injury
  JOURNAL   PLoS One 13 (3), e0192963 (2018)
   PUBMED   29529050
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On Oct 4, 2007 this sequence version replaced XM_345932.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132282, SAMEA5756307
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2235
                     /gene="Tmprss4"
                     /note="transmembrane serine protease 4"
                     /db_xref="GeneID:367074"
                     /db_xref="RGD:1305033"
     exon            1..268
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1573
                     /gene="Tmprss4"
                     /note="transmembrane protease, serine 4"
                     /codon_start=1
                     /product="transmembrane protease serine 4"
                     /protein_id="NP_001102468.1"
                     /db_xref="GeneID:367074"
                     /db_xref="RGD:1305033"
                     /translation="MEPDSGQPLNNHDVPPFRKPRSPLETFKKVGIPIIAVILSLIAL
                     GIVALLIKVVLDKYYFICGNPLTFIPRGQMCDGHLDCASGEDEEHCVKNFPEKPGVTV
                     RLSKDRSTLQVLDAARGTWASVCFDNFTEALAKTACRQMGYNSQPAFGPVEMGPNQTL
                     LVTPVTGNSQELQMQNGSRSCLSGSLVSLRCLDCGKSLKTTRVVGGVEASADSWPWQV
                     SIQYNKQHVCGGSILDHHWILTAAHCFRKYLDVSSWKVRAGSNKLGNSPSLPVAKIFI
                     AEPNPLQPKEKDIALVKLKMPLTFSGSVRPICLPFSDEELIPTMPVWVIGWGFTEENG
                     GKMSDTLLQASVQVIDSARCNAEDAYQGEVTAGMLCAGTPQGGKDTCQGDSGGPLMYH
                     YDKWQVVGIVSWGYGCGSPSTPGVYTKVTAYLDWIYNVRRSEM"
     exon            269..302
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            303..416
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..569
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            570..699
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            700..801
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            802..842
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1002
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1169
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1268
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1411
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1561
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..2235
                     /gene="Tmprss4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttataggact tgaccaaccc catagtcctc aagtcactcc tagatagtgg caggtggtag
       61 ctggcttgcg gaaggaggag gaagaagaga atgctggaaa tcaaggagca agtccagctt
      121 tgcacttggg ccccctctgc ccagtgctga ccacagcttt ctgagctgct tcctaatgag
      181 gctcatttga ggaccctctc ctgctgtctt gggtgacaga tctagctcca ggctgtaaga
      241 aaactaggag gattaccaaa gcaatatgga gccagacagt ggccaacccc tgaacaacca
      301 tgatgtccct ccctttcgca aaccccgaag tcccctggag accttcaaaa aggtggggat
      361 ccccatcatc gcggtgattc tgagcctgat agccctcggg attgtggccc tcctcatcaa
      421 agtggttctg gataaatact acttcatctg cggaaatccc ctgaccttca ttccgagggg
      481 ccagatgtgt gatggccacc ttgactgtgc ctcgggggag gatgaggaac actgtgtcaa
      541 gaacttccct gaaaagcctg gagtgacagt ccgactctcc aaggacagat ccaccctgca
      601 ggtactggat gcagccagag ggacctgggc ctcagtctgt tttgacaact tcacagaagc
      661 gctggccaag acagcctgca ggcagatggg ctataacagc caacccgctt ttggaccagt
      721 ggagatgggc ccaaaccaga ctctcctcgt caccccagtc acaggaaaca gccaggaact
      781 tcagatgcag aatggaagca gatcctgcct ctcaggctcc ctggtttccc tgcgctgcct
      841 tgactgtgga aagagcctga agactactcg tgtggtgggt ggggtggagg cctctgcgga
      901 ttcttggccg tggcaagtca gcatccagta caacaagcag catgtctgtg gtgggagcat
      961 tctggaccac cactggattc tcacagcagc ccactgcttc aggaaatatc ttgacgtgtc
     1021 cagctggaag gtgagggccg gctcaaacaa gctgggtaac tctccgtcct tgcctgtggc
     1081 caagatcttc attgctgaac ccaatcccct gcaacccaaa gagaaggaca ttgccctcgt
     1141 taagctgaag atgccgctca cattctcagg ctcggtcagg cccatctgcc tgcctttctc
     1201 tgatgaagag ctcatcccaa ccatgccagt ctgggtcatt ggatggggct ttacagagga
     1261 aaacggaggg aagatgtctg acacgctgct gcaggcgtca gtccaggtca tcgacagcgc
     1321 acggtgcaat gcggaggatg cctaccaggg ggaggtgact gctggcatgc tgtgtgcagg
     1381 taccccacag ggtggcaagg acacctgcca gggtgacagt ggtgggcctt tgatgtacca
     1441 ttatgacaag tggcaggttg taggcatcgt gagctggggc tatggctgtg ggagcccaag
     1501 tacccctgga gtgtacacca aggtcactgc ctatcttgac tggatctaca atgttcggag
     1561 gtctgagatg taatgttgct atctgccacc ccagaggctg cttcccctca gacctgccta
     1621 ctgtgtgatc cctcaaagtc agacatggga caagagcctc cttgaacaaa ctctggtatt
     1681 tcctgcagca gccaaggact cagacatacg cattgcagag gtgcctggag tggactcagg
     1741 tggactggct cagccactcc tgcctctccc aaaccctggg agacatgcgg tccataggag
     1801 tgaagccatt gacacaattc tcagaagtgt tattcagtca aggtggctct ctcttccact
     1861 gaaggaaggg aggtcagctt tctcctgaga gcccagacca gtgaggactg agtagatgag
     1921 acaagggtca gaaaagcttt ctttgcctcg tcgtgaaagc actgggttaa gaggtcagtc
     1981 tcttctaagg tgaggtgtat attttaatgt cagggtatta ttgtccctcc tgtggtcaat
     2041 atcattaaac gggtatgaga aatcgctggc atagactttt tggactgcat gataagaatc
     2101 caactaggac tgtcacacct ttagtctttg tgctggtact gcatgactgg tcccagagca
     2161 caaaggacaa gccacagaaa ttattccacc tgagtcttga ttgctgaacc aatacgtttg
     2221 ctgggccgtc tggca
//
