LOCUS       NM_001107619            2691 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 3 (Tmprss3), mRNA.
ACCESSION   NM_001107619 XM_001079126 XM_228059
VERSION     NM_001107619.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2691)
  AUTHORS   Peng A, Ge S, Wang Q, Xie D, Wu W and Xiao Z.
  TITLE     [Expression of TMPRSS3 in the rat cochlea following kanamycin
            ototoxicity]
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 36 (10), 987-991 (2011)
   PUBMED   22086001
  REMARK    GeneRIF: TMPRSS3 may play an important role in normal cochlea
            function and is involved in kanamycin-induced deafness.
REFERENCE   2  (bases 1 to 2691)
  AUTHORS   Fasquelle L, Scott HS, Lenoir M, Wang J, Rebillard G, Gaboyard S,
            Venteo S, Francois F, Mausset-Bonnefont AL, Antonarakis SE,
            Neidhart E, Chabbert C, Puel JL, Guipponi M and Delprat B.
  TITLE     Tmprss3, a transmembrane serine protease deficient in human
            DFNB8/10 deafness, is critical for cochlear hair cell survival at
            the onset of hearing
  JOURNAL   J Biol Chem 286 (19), 17383-17397 (2011)
   PUBMED   21454591
REFERENCE   3  (bases 1 to 2691)
  AUTHORS   Guipponi M, Toh MY, Tan J, Park D, Hanson K, Ballana E, Kwong D,
            Cannon PZ, Wu Q, Gout A, Delorenzi M, Speed TP, Smith RJ, Dahl HH,
            Petersen M, Teasdale RD, Estivill X, Park WJ and Scott HS.
  TITLE     An integrated genetic and functional analysis of the role of type
            II transmembrane serine proteases (TMPRSSs) in hearing loss
  JOURNAL   Hum Mutat 29 (1), 130-141 (2008)
   PUBMED   17918732
REFERENCE   4  (bases 1 to 2691)
  AUTHORS   Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem
            P, Lehrach H, Yaspo ML and Janitz M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2691)
  AUTHORS   Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL,
            Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M
            and Hruban RH.
  TITLE     Highly expressed genes in pancreatic ductal adenocarcinomas: a
            comprehensive characterization and comparison of the transcription
            profiles obtained from three major technologies
  JOURNAL   Cancer Res 63 (24), 8614-8622 (2003)
   PUBMED   14695172
REFERENCE   6  (bases 1 to 2691)
  AUTHORS   Guipponi M, Vuagniaux G, Wattenhofer M, Shibuya K, Vazquez M,
            Dougherty L, Scamuffa N, Guida E, Okui M, Rossier C, Hancock M,
            Buchet K, Reymond A, Hummler E, Marzella PL, Kudoh J, Shimizu N,
            Scott HS, Antonarakis SE and Rossier BC.
  TITLE     The transmembrane serine protease (TMPRSS3) mutated in deafness
            DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro
  JOURNAL   Hum Mol Genet 11 (23), 2829-2836 (2002)
   PUBMED   12393794
REFERENCE   7  (bases 1 to 2691)
  AUTHORS   Scott HS, Kudoh J, Wattenhofer M, Shibuya K, Berry A, Chrast R,
            Guipponi M, Wang J, Kawasaki K, Asakawa S, Minoshima S, Younus F,
            Mehdi SQ, Radhakrishna U, Papasavvas MP, Gehrig C, Rossier C,
            Korostishevsky M, Gal A, Shimizu N, Bonne-Tamir B and Antonarakis
            SE.
  TITLE     Insertion of beta-satellite repeats identifies a transmembrane
            protease causing both congenital and childhood onset autosomal
            recessive deafness
  JOURNAL   Nat Genet 27 (1), 59-63 (2001)
   PUBMED   11137999
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473988.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_228059.4, XM_001079126.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132291, SAMEA5760476
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2691
                     /gene="Tmprss3"
                     /note="transmembrane serine protease 3"
                     /db_xref="GeneID:309665"
                     /db_xref="RGD:1310135"
     exon            1..149
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1417
                     /gene="Tmprss3"
                     /EC_number="3.4.21.-"
                     /note="transmembrane protease, serine 3"
                     /codon_start=1
                     /product="transmembrane protease serine 3"
                     /protein_id="NP_001101089.1"
                     /db_xref="GeneID:309665"
                     /db_xref="RGD:1310135"
                     /translation="MGENDPPAAEAPFSFRSLFGLDDLKISSVAPDGDAVAAQILSLL
                     PLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCHSSFKCIELTARCDGVPNCKDGE
                     DEYRCVRVSGQRAALQVFTAAAWRTMCSDDWKSHYAKIACAQLGFPSYVSSDHLRVDA
                     LEEQFQGDFVSINHLLPDDKVTALHHSVYMREGCTSGHVVTLKCSACGMRTGYSPRIV
                     GGNVSSLTQWPWQVSLQFQGYHLCGGSVITPLWIVTAAHCVYDLYHPKSWTVQVGLVS
                     LMDSPVPSHLVEKIIYHSKYKPKRLGNDIALMKLSEPLTFDETIQPICLPNSEENFPD
                     GKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLKGG
                     VDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWIHEQLERD
                     LKT"
     exon            150..260
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            261..377
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            378..501
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..627
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..671
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..837
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1007
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1103
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1246
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1399
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2691
                     /gene="Tmprss3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taagcaggtg gaggtggaac cggaacccaa catcagaggc cctgagatag tcaccatggg
       61 ggaaaacgac cctccagcag ccgaagcccc cttctccttc cggtcactct ttggcttgga
      121 cgatttgaaa ataagttctg tggcaccaga tggagatgca gtggccgcgc agatcttgtc
      181 ccttctgccc ttgaagtttt ttccgatcat cgtcattggg atcatagcct tgatactggc
      241 gttggctatc ggcctgggca tccacttcga ctgctctggg aagtacaggt gccattcatc
      301 tttcaagtgt attgaactaa cagcccgatg tgacggggtc cccaattgca aggacgggga
      361 ggatgagtac cgttgcgtgc gggtgagcgg ccaaagagca gcgctccaag tgttcacggc
      421 tgctgcatgg aggaccatgt gttcagatga ctggaaaagc cactatgcca agattgcctg
      481 tgcccagctg gggtttccca gctatgtgag ctcagaccac ctcagagtgg atgcacttga
      541 ggagcagttc cagggcgact tcgtgtccat caatcacctc ttgccagatg acaaggtgac
      601 cgcattacac cactctgtgt acatgaggga aggctgcacc tcaggccatg tggtcacctt
      661 gaagtgctca gcctgtggca tgagaactgg ctacagtccc cgcattgtgg gtggaaacgt
      721 gtcctcgctc actcagtggc cctggcaggt cagcctccag ttccaggggt accacctatg
      781 tgggggctcc gtcatcaccc ctctgtggat tgtcaccgct gcgcactgtg tttacgacct
      841 gtaccacccc aagtcctgga ctgtccaggt gggtctcgtg tccctgatgg acagtcctgt
      901 gccctcccac ctggtggaga aaatcatcta ccacagcaag tacaaaccaa agcgactggg
      961 caatgacatc gccctcatga agctgtccga gccactcacc tttgacgaga ccatccagcc
     1021 catctgcctg cccaactctg aagagaactt tccagacggg aaattgtgct ggacctcagg
     1081 atggggagcc acagaggacg gaggtgacgc ctcccctgtc ctgaaccacg cggccgtccc
     1141 tttaatttca aacaagatct gcaaccacag ggatgtgtat ggcggtatca tttcaccctc
     1201 catgctctgt gcgggctatc tgaaaggcgg tgtggacagc tgccagggag acagcggggg
     1261 acccctggtg tgccaggaga ggagactgtg gaagttagtg ggtgcgacaa gctttggaat
     1321 tggctgtgct gaggtgaaca agcctggagt ctacacacga atcacctcct tcctggactg
     1381 gattcacgaa cagttggaga gagatctgaa gacttgaaga agagggaaca agccagcacc
     1441 tgagctcctg aggggtggac acagcacggg ccttccctgg actcctgagt ggacatgttg
     1501 gatgggagta ccagctctta ccaccctgcc catggcgttg aagcatatcc atccactggg
     1561 atgagaaccc ttccaacccc gacacccgga gttgcttgct gctaaagccc ctggctttga
     1621 ggctgaaaca accttggact catgtacaca agcggcacct ttcccggtca ccccccaccc
     1681 accctagatt ttctccttat agttgctgcc aacactggca agctctcatg cacaccaatc
     1741 gaacaccagt tggtgcagga actgctggtg tggattgttg aagacgcagt cacctattcg
     1801 ttctagcccc gggctccaga tctcaaccca actgcctact tccaggagct ggttttggga
     1861 gtgaggaact tagtctttga ctgattcagt ctgaggtttt ttgttttttg ttttgttttg
     1921 ttttggctcc gctgttttct cacaggattt ggtgcttgac gaatttctcg cttctgaaag
     1981 gcgtcccttt gcttagcttg gcctgtcctt gggcttgagt gaatgcgtgg ccatgggcca
     2041 cggacactga aatcacgggc tcacctcaaa agccgaccat gctacacatg tcgggagttt
     2101 gcattttcct gttaaggttt cccagcatat cagaagtgta ccatattgta ttgtgggact
     2161 cataaacaga gtaagggaca caggccaggt gaagacaaga ctggacacta aaagcaagtt
     2221 gaatagaggg gttctaagtt acagggtctg ccccacttgt cctccatgaa ctctgctaat
     2281 ggaccacagc cgatggtgtc cacagcccct cttacatggc ttacagtcct gtggtccctg
     2341 tattacccag taacagagga gggtttcgtg agacacaggc attggtcatt taagcttgtc
     2401 acagatgaag tcttcagagt atgaatcagt tgctttgtgg ctgcaataga aaatgtgtgt
     2461 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgcgc gcgcatacgt gtgtatgtgg
     2521 tgtgtagtat gtgtagtgtg ggtggggccc atcaccaaga caaactgcca catagtcatt
     2581 gagctttgac ccaaccctgt ccaaattaga gcccccctct atggatgtaa tttatctatt
     2641 agtcacggga agaaatgata aacacaactg gaaataaagc acagaagtta t
//
