LOCUS       NM_130424               3135 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 2 (Tmprss2), mRNA.
ACCESSION   NM_130424
VERSION     NM_130424.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   Park,G.C., Bang,S.Y., Lee,H.W., Choi,K.U., Kim,J.M., Shin,S.C.,
            Cheon,Y.I., Sung,E.S., Lee,M., Lee,J.C., Kim,H.S. and Lee,B.J.
  TITLE     ACE2 and TMPRSS2 immunolocalization and oral manifestations of
            COVID-19
  JOURNAL   Oral Dis 28 Suppl 2, 2456-2464 (2022)
   PUBMED   35000261
  REMARK    GeneRIF: ACE2 and TMPRSS2 immunolocalization and oral
            manifestations of COVID-19.
REFERENCE   2  (bases 1 to 3135)
  AUTHORS   Da Eira,D., Jani,S. and Ceddia,R.B.
  TITLE     Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2
            Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in
            Rat Lung and Heart Tissues
  JOURNAL   Nutrients 13 (10), 3357 (2021)
   PUBMED   34684358
  REMARK    GeneRIF: Obesogenic and Ketogenic Diets Distinctly Regulate the
            SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the
            Renin-Angiotensin System in Rat Lung and Heart Tissues.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3135)
  AUTHORS   Khoury,E.E., Knaney,Y., Fokra,A., Kinaneh,S., Azzam,Z., Heyman,S.N.
            and Abassi,Z.
  TITLE     Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2
            and ADAM17 in rats with heart failure: Potential implication for
            COVID-19 disease
  JOURNAL   J Cell Mol Med 25 (8), 3840-3855 (2021)
   PUBMED   33660945
  REMARK    GeneRIF: Pulmonary, cardiac and renal distribution of ACE2, furin,
            TMPRSS2 and ADAM17 in rats with heart failure: Potential
            implication for COVID-19 disease.
REFERENCE   4  (bases 1 to 3135)
  AUTHORS   Sato,T., Ueha,R., Goto,T., Yamauchi,A., Kondo,K. and Yamasoba,T.
  TITLE     Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower
            Aerodigestive Tracts of Rats: Implications on COVID 19 Infections
  JOURNAL   Laryngoscope 131 (3), E932-E939 (2021)
   PUBMED   32940922
  REMARK    GeneRIF: Expression of ACE2 and TMPRSS2 Proteins in the Upper and
            Lower Aerodigestive Tracts of Rats: Implications on COVID 19
            Infections.
REFERENCE   5  (bases 1 to 3135)
  AUTHORS   Zang,R., Gomez Castro,M.F., McCune,B.T., Zeng,Q., Rothlauf,P.W.,
            Sonnek,N.M., Liu,Z., Brulois,K.F., Wang,X., Greenberg,H.B.,
            Diamond,M.S., Ciorba,M.A., Whelan,S.P.J. and Ding,S.
  TITLE     TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small
            intestinal enterocytes
  JOURNAL   Sci Immunol 5 (47) (2020)
   PUBMED   32404436
REFERENCE   6  (bases 1 to 3135)
  AUTHORS   Shulla,A., Heald-Sargent,T., Subramanya,G., Zhao,J., Perlman,S. and
            Gallagher,T.
  TITLE     A transmembrane serine protease is linked to the severe acute
            respiratory syndrome coronavirus receptor and activates virus entry
  JOURNAL   J Virol 85 (2), 873-882 (2011)
   PUBMED   21068237
REFERENCE   7  (bases 1 to 3135)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (bases 1 to 3135)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 3135)
  AUTHORS   Lucas,J.M., True,L., Hawley,S., Matsumura,M., Morrissey,C.,
            Vessella,R. and Nelson,P.S.
  TITLE     The androgen-regulated type II serine protease TMPRSS2 is
            differentially expressed and mislocalized in prostate
            adenocarcinoma
  JOURNAL   J Pathol 215 (2), 118-125 (2008)
   PUBMED   18338334
REFERENCE   10 (bases 1 to 3135)
  AUTHORS   Vaarala,M.H., Porvari,K.S., Kellokumpu,S., Kyllonen,A.P. and
            Vihko,P.T.
  TITLE     Expression of transmembrane serine protease TMPRSS2 in mouse and
            human tissues
  JOURNAL   J Pathol 193 (1), 134-140 (2001)
   PUBMED   11169526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 10, 2015 this sequence version replaced NM_130424.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061712.1, SRR26643295.43001.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000011.1  50443035-50443114   c
            81-148              JAXUCZ010000011.1  50430805-50430872   c
            149-368             JAXUCZ010000011.1  50428327-50428546   c
            369-455             JAXUCZ010000011.1  50423090-50423176   c
            456-575             JAXUCZ010000011.1  50422488-50422607   c
            576-702             JAXUCZ010000011.1  50417102-50417228   c
            703-813             JAXUCZ010000011.1  50414975-50415085   c
            814-857             JAXUCZ010000011.1  50410920-50410963   c
            858-1026            JAXUCZ010000011.1  50409229-50409397   c
            1027-1202           JAXUCZ010000011.1  50408337-50408512   c
            1203-1298           JAXUCZ010000011.1  50407784-50407879   c
            1299-1441           JAXUCZ010000011.1  50406966-50407108   c
            1442-1594           JAXUCZ010000011.1  50406387-50406539   c
            1595-3135           JAXUCZ010000011.1  50403707-50405247   c
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..3135
                     /gene="Tmprss2"
                     /note="transmembrane serine protease 2"
                     /db_xref="GeneID:156435"
                     /db_xref="RGD:620766"
     exon            1..80
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            81..148
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1606
                     /gene="Tmprss2"
                     /EC_number="3.4.21.-"
                     /note="transmembrane protease, serine 2"
                     /codon_start=1
                     /product="transmembrane protease serine 2"
                     /protein_id="NP_569108.2"
                     /db_xref="GeneID:156435"
                     /db_xref="RGD:620766"
                     /translation="MALNSGSPPGIGPYYENHGYQSEHVYSPRPPVSPSGYNLYPAQS
                     CPSPVPQYAPRVTTQASTPAIHIQPRSSGTLCTSKSKKSMLVALALGTVLAGAAVAAG
                     LLWKFWDSKCSSSEMECGSSGTCISSSLWCDGVSQCPNGEDENRCVRLYGTSFTLQVY
                     SSQRKAWYPVCQDDWNESYGRAACKDMGYKNSFYSSQGIPDQSGATSFMKLNVSAGNV
                     DLYKKLYHSDSCSSRMVVSLRCIECGVRSVRRQSRIVGGSTASPGDWPWQVSLHVQGI
                     HVCGGSIITPEWIVTAAHCVEEPLSSPRYWTAFAGILKQSLMFYGSRHQVEKVISHPN
                     YDSKTKNNDIALMKLQTPLAFNDVVKPVCLPNPGMMLDLAQECWISGWGATYEKGKTS
                     DVLNAAMVPLIEPSKCNSKYIYNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLKNEI
                     WWLIGDTSWGSGCAKAYRPGVYGNVTVFTDWIYQQMRANS"
     exon            149..368
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..455
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..575
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..702
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..813
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..857
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1026
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1202
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1298
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1441
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1594
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..3135
                     /gene="Tmprss2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagtagg tcgtgtactt ggagtggaca aggaaaccga gagccccggc ggaggcggag
       61 aggggcgggg agcacagcag gtcacctgga ggaagccaca tactgacctc ctcatgctgc
      121 tgacacaggc aggatggcat tgaactcagg gtcacctcca ggaattggac cttactatga
      181 gaaccacggg tatcagtctg agcacgtcta ttccccgagg ccacctgtgt ctcccagtgg
      241 ctacaacttg tatccagccc agagctgccc atctccagtg ccccagtatg ctccgagagt
      301 cacaactcaa gcctcaacac ctgccatcca catacagccc cgatcctcag gaacactgtg
      361 cacctcaaaa tctaagaaat ccatgcttgt cgccctggcc ctgggcactg tcctcgccgg
      421 tgctgctgtg gctgctggct tgctttggaa gttctgggac agcaagtgct cttcatcaga
      481 gatggagtgt gggtcttcag ggacatgtat cagctcctcc ctctggtgtg acggagtgtc
      541 acagtgtccc aacggggaag acgagaaccg gtgtgttcgc ctctatggaa caagcttcac
      601 cctccaggtt tactcatctc agaggaaagc ctggtatccc gtctgccagg atgattggaa
      661 tgagagctac gggagagcag catgtaaaga catgggatac aagaacagct tttattctag
      721 ccaagggata ccagaccaga gcggggcaac gagctttatg aagctgaatg tgagcgcagg
      781 caacgtcgac ctctataaaa aactctacca cagtgactcg tgctcatccc gcatggtggt
      841 ttctttgcgc tgtatagaat gcggggttcg ctcagtaaga cgtcagagca ggattgtggg
      901 tgggtcgacc gcctcaccag gagactggcc ctggcaggtc agcctgcacg tccaaggtat
      961 ccatgtctgc ggaggctcca tcatcacccc cgagtggatt gtgacagccg cccactgtgt
     1021 ggaagaaccc ctcagcagcc ctaggtactg gacggcattt gcgggaattt tgaaacagtc
     1081 tctcatgttc tatggaagta gacaccaggt agaaaaagtg atttcccatc caaattacga
     1141 ctctaagacc aagaataatg acattgctct catgaagctg cagacaccct tggcttttaa
     1201 tgatgtagtg aagccagtgt gtctgccgaa cccaggcatg atgctggacc tagcccagga
     1261 gtgctggatt tcagggtggg gggccaccta tgagaaaggg aagacctcag atgtgctgaa
     1321 tgctgccatg gtacccttga tcgagccctc caaatgtaat agcaaataca tatacaacaa
     1381 cttaatcaca ccagccatga tctgcgccgg gttcctccag ggctctgtcg actcttgtca
     1441 gggagacagt ggagggcccc tggttacttt gaagaatgaa atctggtggc tgattgggga
     1501 cacgagctgg ggctcgggct gtgccaaggc atacagacct ggagtatacg ggaatgtgac
     1561 agtatttaca gattggatct accagcaaat gagggcgaac agctaatcca cgtggctttg
     1621 tccccgactt cctttgtctt caacaacctt ctgcaagaaa accaaggggc ggattttcaa
     1681 cttcctgtgc acaatgtacc ttttgagatg attcaaaggg cctttcactt ttattaaaca
     1741 gtgacttatc tgactgtgct ccctggtcct gtgagggctt cagtgcccca ccctccaggc
     1801 tacttcagca gctcctacca gaaaggatga ccagatcctg ttgggtttgg gcacataggg
     1861 ccaaatacag aagaaggtgg cactctcatg ttgagacttc tttttggctt atgctcaggc
     1921 ctcttttgga tgagtaagga ctatgacctc tgagtagtct gatgacctga gaagagtagg
     1981 gaagccaggc agggccttgg gccaaggtac aggtacagag agagaaagag agagagagag
     2041 agagagagag agagagagag agagagagag agagagagag agagagaaca ctacccattg
     2101 cctgtggcct agctctgctg tgtagttttg ggctggtcat actataatga cttcatgaac
     2161 aacagcccag gagtaaagga cttattctcc tgcatgttga catgacagtc atttccaagg
     2221 ttgatggaac ctttgccagg ctgagggcct aggcagggcc ttcagagcaa gaaactaatg
     2281 tctgcatgtc ccttgggtga gctctatatg gtatcattca gtctggttct tggctcccca
     2341 ccgctatttc tgtcagcctt tcacagcctg aaacttacct ctttggtttg gctccaggta
     2401 aggcctggta cttgatggag cctgtatagc tcagctagtc atctagaggc tgaggtccat
     2461 tagaatcagg gacttgtgaa tccagtcacc ttgcttctgg gttgtgttta ttcccttact
     2521 acctcactgc acctgcacac tagtctggat gaatgtctgt agttcacctg catttggact
     2581 gtgtgcttgt gcctcagata ttagacctct tccagatggt taggttgttc tgtagactga
     2641 cgatgggatt agtagtccca agctttggac aaagatgaaa aagaggagct cgttgtcttc
     2701 tatccttttc tggccctggg tttataccag gaaagccatg ccacaatcac caaatatgaa
     2761 gtatgaatgt cttacctatg gtgaggctct gcctcctcct ctgtgcctgg ctcttcagaa
     2821 ggcagtgaat gggtcacagc tgggactccg tctttgctgg ggagggtctc ccaccaagga
     2881 aatagttgcc actccatgta aagagttccc tcatgcttcc tctgggaaca acactctagg
     2941 gaccttctta gatgccataa ggtacctact tacaagacta aatgtacaag caccttgaag
     3001 tgtgagaaca tgttccctcc ttagctctcc ctgtctttgc tgttggttgg ttatttcctg
     3061 ttttgtgtct gttctgagct gtgagattcc actgtgaaat gtatgaataa agtatgtaat
     3121 tctgtccatt gttca
//
