LOCUS       NM_001105895            4070 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 15 (Tmprss15),
            mRNA.
ACCESSION   NM_001105895 XM_001065169 XM_001065222 XM_001065283 XM_001065342
            XM_213668
VERSION     NM_001105895.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Holzinger,A., Maier,E.M., Buck,C., Mayerhofer,P.U., Kappler,M.,
            Haworth,J.C., Moroz,S.P., Hadorn,H.B., Sadler,J.E. and Roscher,A.A.
  TITLE     Mutations in the proenteropeptidase gene are the molecular cause of
            congenital enteropeptidase deficiency
  JOURNAL   Am J Hum Genet 70 (1), 20-25 (2002)
   PUBMED   11719902
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473989.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213668.4, XM_001065283.1, XM_001065169.1, XM_001065342.1,
            XM_001065222.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..4070
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /note="transmembrane serine protease 15"
                     /db_xref="GeneID:288291"
                     /db_xref="RGD:1311046"
     exon            1..332
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            333..400
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            401..552
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            553..597
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            598..632
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            633..677
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            678..721
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     CDS             682..3261
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /EC_number="3.4.21.9"
                     /note="protease, serine, 7 (enterokinase); transmembrane
                     protease, serine 15"
                     /codon_start=1
                     /product="enteropeptidase"
                     /protein_id="NP_001099365.1"
                     /db_xref="GeneID:288291"
                     /db_xref="RGD:1311046"
                     /translation="MGEFSIVIVSPTSGNVSVECQPGSRPCANAWDCVATDLFCDGEV
                     NCPDGVDEDTGLCATACDGRFLLTGDSGVFQANRYPRPDESGVVCRWIIRVNQGLSVR
                     MSFGKFISHYTDVLDIYEGIGPSKILRGSFWETDPGTIRIFSNQVTVTFLIKSDEYDY
                     IGFNATYSTFNSSEINNYEKINCTFDDGFCFWTQDLDDDNEWERNQMARFPCYTGPFS
                     DHTFGNESGFYISTPAEQAWKSERVGLSSLSLGFTSEPVCLHFWYYMCCENVYNLNIH
                     VSSTETTDKIVFQRQGNYGRNWNYGQVTLNETVEFKVVFNAFRNRGCSTIALDDISLT
                     NGICSESPYPEPTLVPTPPPEHPTDCGGPFELWEPNTTFSSPNFPDNYPNQAFCIWNL
                     NAQSGKNIQLHFQEFDLENINDVVEVRDGVKFDSLLLAVYTGRGPVKDLFSTTNRMTV
                     IFDTDMKNGGKGFKANFTSGYYLGIPQPCQDDEFQCKDGNCIPMGNLCDSYQHCSDGS
                     DEAHCVRFLNGTQSNNGLVQFNIHNIWHIACAEPWTTQISNEVCHLLGLGSANSSMPI
                     LSTGGGPFVRLNEAPNGSLILTPSLQCSQDSLILLQCNHKSCGEKMVTQKVGPKIVGG
                     SDTQAGAWPWVVALYYRDRSGDRLLCGASLVSSDWLVSAAHCVYRRNLDPTRWTAVLG
                     LHMQSNLTSPQVVRRVVDRIVINPHYDKRRKVNDIAMMHLEFKVNYTDYIQPICLPEE
                     NQTFTPGRMCSIAGWGYNKINGSTVDVLKEADVPLVSNEKCQQQLPEYDITESMLCAG
                     YEEGGTDSCQGDSGGPLMCQENNRWFLVGVTSFGVQCALPNHPGVYARVSQFIEWIHS
                     FLH"
     exon            722..853
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            854..962
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1069
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1210
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1360
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1466
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1617
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1753
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1843
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1969
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2110
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2221
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2354
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2500
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2687
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2869
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2965
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3105
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..4070
                     /gene="Tmprss15"
                     /gene_synonym="Prss7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaagaca cacacagcac actcacagtg aagattgtca acgttagctt gaatggctga
       61 tgactgtaga gtcctcagga acttgagagg tttcactcta aagtcagtat tagagtattc
      121 gtcttgttga tgtggaaaac cgcattggct cacagttcct aaattatcca gccttgaaaa
      181 agcaaaaatg aaatctatca gaaatgtggc tgcaggacat cgttctatca gctctttcga
      241 agtgatggtc tcagctctct tcatggtgct catggtcctc tctgttgggt taattgtggt
      301 gtcctggctg gcagttaagg aatcagaaac agatagatga gatctttgag tcaagtaatc
      361 tgaagaatga atataaaaaa tcaagagttt ttcaatttga aaatggcagc gttattgtcc
      421 tctttgacct tttttttgct cagtgggtat cagatgaaaa tgtaaaagaa gaactgattc
      481 agggcattga agcaaatata tccagccaac tggtcactct ccatattgat ttgaacagca
      541 ttgatatcgc agcatctttg agcaacttct caacaccatt ccctctgaca acttcagata
      601 agtaatagct agcagtttaa tgacaacttc aggatcgttg gataacttct caacaccaat
      661 tggtacaaca acctcagcac aatgggtgag ttctcaatag taattgtttc accaacttct
      721 ggcaatgtct cagtggagtg ccaacctggt tcacggccct gtgctaatgc ttgggactgc
      781 gtagcaactg atttgttttg tgatggagaa gtgaattgtc cagatggtgt tgatgaagac
      841 actgggctat gtgccacagc ttgtgatgga agatttttgt tgacgggaga ttctggggtt
      901 ttccaagcca atcgttatcc acggccagat gaatcaggtg ttgtttgccg ctggatcatc
      961 cgtgtaaacc aaggactttc cgttagaatg agctttggaa aatttatttc acattataca
     1021 gatgtgttag atatttatga aggtatagga cctagcaaaa ttctaagagg ctctttttgg
     1081 gaaactgatc ctggaaccat tcgaattttt tctaaccaag ttactgtcac ctttctgata
     1141 aaatcagatg aatatgatta cattggcttt aacgcaacat acagcacttt caacagcagc
     1201 gagattaaca attatgaaaa aatcaactgt acatttgatg atggtttttg cttctggacc
     1261 caggatcttg atgatgataa tgagtgggaa aggaaccaaa tggccaggtt tccttgttac
     1321 actggcccat tttctgacca tacatttgga aacgaatcag gattttacat ttctacacca
     1381 gctgagcagg catggaaaag tgaaagagtg ggcctctcaa gcctttcttt aggcttcact
     1441 tcagagcctg tctgccttca tttctggtat tacatgtgct gtgaaaatgt ctacaactta
     1501 aacattcatg tcagcagcac tgaaaccaca gacaaaatag tttttcaaag gcaaggaaac
     1561 tatgggagga attggaacta tggtcaagtc acattaaacg aaacagtaga atttaaggtt
     1621 gtgttcaatg cttttagaaa ccgaggttgc agtacaatag ccctggatga tataagtcta
     1681 acaaatggga tctgtagtga gagtccttat ccagaaccaa ccttggtccc cacccctcca
     1741 ccagagcatc ctactgactg cggaggacct tttgaactat gggagccaaa tacaacgttc
     1801 agttctccaa attttccaga caattacccc aaccaagctt tctgtatatg gaacttaaat
     1861 gcacagagtg ggaaaaatat tcaacttcac tttcaagaat tcgacttaga aaatatcaat
     1921 gatgtagttg aagttagaga tggggtaaaa tttgactccc tgctcttagc cgtgtataca
     1981 ggacgtggtc ctgtgaagga cttgttctct accacaaata gaatgactgt gattttcgac
     2041 acagacatga agaacggagg caagggcttc aaagcaaatt tcacttctgg ctattacttg
     2101 gggattccac agccctgcca ggatgacgaa tttcagtgca aagatggaaa ctgcattcca
     2161 atggggaatc tctgtgacag ctaccaacac tgcagtgatg gctcggatga agcacattgt
     2221 gtgcgctttc tcaatggcac acagagcaac aatgggttgg tacagttcaa tattcataac
     2281 atatggcata ttgcttgtgc tgagccctgg accacacaaa tttcaaatga agtttgtcac
     2341 cttctgggac tagggagtgc aaactcatca atgccaatac tatctactgg aggtggacca
     2401 tttgtgagat taaacgaagc ccctaatggc agcttgatac taacacccag tctacagtgc
     2461 tcccaagatt ccttgattct gttgcaatgt aaccataaat catgtggaga aaaaatggtg
     2521 actcagaaag ttggcccaaa gatcgttggt ggaagtgaca cccaggcagg ggcatggccg
     2581 tgggttgtgg ctttgtatta cagagacagg tctggagacc ggctgctgtg cggtgcctct
     2641 cttgtcagca gtgactggct ggtgtctgct gcacactgtg tgtacagaag aaatctagat
     2701 ccaaccagat ggacagcagt cctgggcctg catatgcaat cgaatctgac ttctcctcaa
     2761 gtagtaagac gggtggtcga tcgaattgtc ataaaccctc attatgacaa acgaagaaag
     2821 gttaatgaca ttgctatgat gcaccttgag tttaaagtaa attatacaga ttatatacag
     2881 cctatttgtt taccagaaga aaatcaaaca tttactccag gaagaatgtg ttcaattgct
     2941 ggctggggat ataataaaat aaatggttct actgtggatg tgctgaaaga agctgatgtt
     3001 cctcttgtat ccaatgaaaa gtgccagcag cagctgccag aatacgacat cactgaaagt
     3061 atgctatgtg cgggatatga agaaggaggg acagattctt gtcagggtga ttctggagga
     3121 ccattaatgt gccaagaaaa caacagatgg tttcttgttg gtgtgacatc atttggagtc
     3181 cagtgtgcac tgcctaatca ccctggggta tatgcccggg tctcacagtt tatagaatgg
     3241 atccatagct ttctacatta ggcattttcc tgacccaaac ataaatgagg ggcatgtttt
     3301 cctttttcct tcatttttac ttaaactagt atggcgactg agagtttcat gagaagaaaa
     3361 agatcatatt tttagctaaa tcatttaaat gctgaaatgg ggatggtagg cagacaataa
     3421 attaaaataa atctttgaaa cataaagtaa tcatgaaatg catttctgtt tcataataaa
     3481 caattactct tctatagaca ttatcatttc ctttgtctca aaccaatttt taccattttc
     3541 tattgtgaga agggctatta ttttaagaca ttttccatac atttaagttc aaatgggtgg
     3601 agaagtgaaa tgaagtagtt tgcctaacgt atgtcattgt ttgaaatgag atgttgtaac
     3661 tcatctaatt tcaatttagt gttaccacca gagtcattgc tgttttcctg cttctccatt
     3721 cacaagcatt tctatttaaa tataatgttt ccctgctcat aaaagtacat ttattatgag
     3781 cccatatcac agacactatc aaatcataac tgtgcctttc ttcgaagtaa acagaacata
     3841 caaaggtctc tctcttgacc tagcatcaac acaaaagtaa actactttcc acccttattc
     3901 tccacaaatg atctttacat ttactttatc ttttttattt aaaaaaataa aaaacagttt
     3961 aaaaatgtac agtttttaga ctttcctgaa catgtgaaaa atttgttcag acacagttga
     4021 attgccttct aaaggcaaaa aatgtgtaat aaatgaattt gcttcagtcc
//
