LOCUS       NM_001033652            1658 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus transmembrane serine protease 11D (Tmprss11d),
            transcript variant 1, mRNA.
ACCESSION   NM_001033652
VERSION     NM_001033652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1658)
  AUTHORS   Heurich,A., Hofmann-Winkler,H., Gierer,S., Liepold,T., Jahn,O. and
            Pohlmann,S.
  TITLE     TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis
            by TMPRSS2 augments entry driven by the severe acute respiratory
            syndrome coronavirus spike protein
  JOURNAL   J Virol 88 (2), 1293-1307 (2014)
   PUBMED   24227843
REFERENCE   2  (bases 1 to 1658)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1658)
  AUTHORS   Hansen,I.A., Fassnacht,M., Hahner,S., Hammer,F., Schammann,M.,
            Meyer,S.R., Bicknell,A.B. and Allolio,B.
  TITLE     The adrenal secretory serine protease AsP is a short secretory
            isoform of the transmembrane airway trypsin-like protease
  JOURNAL   Endocrinology 145 (4), 1898-1905 (2004)
   PUBMED   14691009
  REMARK    GeneRIF: Predominantly expressed in upper gastrointestinal and
            respiratory tract-but also in adrenal gland. Complex expression
            pattern. Multifunctional role beyond adrenal proliferation.
REFERENCE   4  (bases 1 to 1658)
  AUTHORS   Bicknell,A.B.
  TITLE     Identification of a serine protease involved with the regulation of
            adrenal growth
  JOURNAL   Ann N Y Acad Sci 994, 118-122 (2003)
   PUBMED   12851306
  REMARK    GeneRIF: Results identify a secreted serine protease (adrenal
            secretory protease) expressed by the adrenal gland, which plays a
            role in adrenal growth.
REFERENCE   5  (bases 1 to 1658)
  AUTHORS   Bicknell,A.B., Lomthaisong,K., Woods,R.J., Hutchinson,E.G.,
            Bennett,H.P., Gladwell,R.T. and Lowry,P.J.
  TITLE     Characterization of a serine protease that cleaves
            pro-gamma-melanotropin at the adrenal to stimulate growth
  JOURNAL   Cell 105 (7), 903-912 (2001)
   PUBMED   11439186
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033652.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF453776.1, SRR22582416.988955.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JAXUCZ010000014.1  22062129-22062375
            248-369             JAXUCZ010000014.1  22094097-22094218
            370-488             JAXUCZ010000014.1  22096374-22096492
            489-556             JAXUCZ010000014.1  22098048-22098115
            557-711             JAXUCZ010000014.1  22104841-22104995
            712-750             JAXUCZ010000014.1  22108618-22108656
            751-928             JAXUCZ010000014.1  22109844-22110021
            929-1188            JAXUCZ010000014.1  22118449-22118708
            1189-1331           JAXUCZ010000014.1  22120648-22120790
            1332-1658           JAXUCZ010000014.1  22123863-22124189
FEATURES             Location/Qualifiers
     source          1..1658
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..1658
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /note="transmembrane serine protease 11D"
                     /db_xref="GeneID:64565"
                     /db_xref="RGD:620654"
     exon            1..247
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1493
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /note="isoform a is encoded by transcript variant 1;
                     airway trypsin-like protease; AT; adrenal secretory serine
                     protease; transmembrane protease, serine 11d"
                     /codon_start=1
                     /product="transmembrane protease serine 11D isoform a"
                     /protein_id="NP_001028824.2"
                     /db_xref="GeneID:64565"
                     /db_xref="RGD:620654"
                     /translation="MYRPRSMVSPSRFFNPFMVALIVIITVGLLAMTAGLLIHFLAFD
                     KRAYFYHSNFHILNVDYTEALNSPATHEYRTLSERIESMITDAFRESNLRSEFIRTHV
                     VKLRKEGSGVVADVVMKFRSSKRNNKKAMKTRIQSVLQRLSSSGNLEIAPSNEITSLT
                     DQDTENVLTQECGARPDLITLSEERIIGGTQAETGDWPWQVSLQLNNVHHCGGTLISN
                     LWVLTAAHCFRSYSNPQQWTATFGVSTISPRLRVRVRAILAHAEYNSITRDNDIAVVQ
                     LDRPVTFTRNIHRVCLPAATQNIIPDSVAYVTGWGSLTYGGNTVTNLQQGEVRIVSSE
                     VCNEPAGYGGSVLPGMLCAGVRSGAVDACQGDSGGPLVQEDTRRLWFVVGIVSWGYQC
                     GLPNKPGVYTRVTAYRNWIRQQTGI"
     exon            248..369
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            370..488
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            489..556
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            557..711
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            712..750
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            751..928
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1188
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1331
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1658
                     /gene="Tmprss11d"
                     /gene_synonym="Asp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatgaatgg gattgtttct gatttgtaag gtgtctccat ctctgattct ggcccacaag
       61 tcacaccatt ggctcaagct gattctttca gacttgtttt acaagttggg ttttaattac
      121 acgggatttc ctcctttggc ttcaggtaca cagaacacga aagagtcatt cagttgagag
      181 ggaatctcaa agcagtagga cggacagaac caaggacctc ttcattattc aagagtaaaa
      241 tgtataggcc aagatcaatg gtatcacctt caagattctt caatcccttt atggtagctc
      301 tcattgtcat aataacagta gggctcctgg ccatgaccgc aggtctactt attcactttt
      361 tagcttttga caagagagct tacttttatc atagcaactt tcatatccta aatgttgact
      421 atactgaagc tttaaactca ccagctacgc atgaatacag aaccttgagt gaaagaatcg
      481 agtctatgat tactgatgca tttcgagaat caaatctacg aagtgagttt atcaggacac
      541 atgttgtcaa actgagaaaa gaagggagtg gtgtggttgc ggatgttgtc atgaaatttc
      601 gatctagtaa gcgtaacaac aaaaaggcaa tgaaaaccag aatccaatct gtgctacaaa
      661 gactcagcag ctctgggaac ttggaaatag ccccttcgaa tgagataaca tcactcactg
      721 accaggatac agaaaatgtt ttgactcaag aatgtggagc acgtccagac cttataacac
      781 tgtcagaaga gagaatcatt ggaggcactc aagctgagac aggtgactgg ccctggcaag
      841 tcagtctaca gctcaacaat gtccaccact gtggaggtac cctgatcagt aacttgtggg
      901 tcctgacagc cgctcactgc ttcagaagct actcgaatcc tcaacaatgg acagccacct
      961 ttggtgtttc tacaataagt cctaggttaa gagtgagagt aagggctatt ttagcccatg
     1021 ctgagtacaa ctccataact cgtgataatg atattgcagt tgtacaactt gacagacctg
     1081 tcacctttac cagaaatatc catagggtat gtctcccagc agcaacccaa aatatcatac
     1141 ctgattccgt cgcatatgtc acaggatggg gatctctcac ttatggaggc aacacggtca
     1201 caaatctaca gcaaggagag gtcagaatag taagttcgga ggtgtgcaac gagccagctg
     1261 gctacggtgg gagtgtcttg ccaggaatgc tctgtgctgg agtccgttca ggggccgtgg
     1321 atgcatgcca gggtgattct ggtggcccac tagtacaaga agacacaagg cggctttggt
     1381 ttgtcgtggg gattgtgagc tggggatatc aatgtggcct gccaaataag ccaggagtgt
     1441 atacgcgagt gacagcctac cgcaactgga ttaggcagca gactggaatc tagggcgacc
     1501 gaggaaaacg cgccgcctcc cgtgaagtct gtacccaagt gcgcctgatt caaatgccgc
     1561 agcctcgctt ttcaactgcc aaggaaactg gaaacgtccc atttcaacat cccattacat
     1621 aaatatggtt taacagttta gcatttcttt gtcgatat
//
