LOCUS       NM_001395714            3723 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus thymopoietin (Tmpo), transcript variant 1, mRNA.
ACCESSION   NM_001395714 XM_008765218
VERSION     NM_001395714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Hebbar,S., Mesngon,M.T., Guillotte,A.M., Desai,B., Ayala,R. and
            Smith,D.S.
  TITLE     Lis1 and Ndel1 influence the timing of nuclear envelope breakdown
            in neural stem cells
  JOURNAL   J Cell Biol 182 (6), 1063-1071 (2008)
   PUBMED   18809722
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Bradley,C.M., Jones,S., Huang,Y., Suzuki,Y., Kvaratskhelia,M.,
            Hickman,A.B., Craigie,R. and Dyda,F.
  TITLE     Structural basis for dimerization of LAP2alpha, a component of the
            nuclear lamina
  JOURNAL   Structure 15 (6), 643-653 (2007)
   PUBMED   17562312
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Naetar,N., Hutter,S., Dorner,D., Dechat,T., Korbei,B., Gotzmann,J.,
            Beug,H. and Foisner,R.
  TITLE     LAP2alpha-binding protein LINT-25 is a novel chromatin-associated
            protein involved in cell cycle exit
  JOURNAL   J Cell Sci 120 (Pt 5), 737-747 (2007)
   PUBMED   17284516
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Parise,P., Finocchiaro,G., Masciadri,B., Quarto,M., Francois,S.,
            Mancuso,F. and Muller,H.
  TITLE     Lap2alpha expression is controlled by E2F and deregulated in
            various human tumors
  JOURNAL   Cell Cycle 5 (12), 1331-1341 (2006)
   PUBMED   16760672
  REMARK    GeneRIF: In agreement with its regulation by E2F, LAP2alpha over
            expression in primary tumors was found to be correlated with tumor
            proliferation rate
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Dechat,T., Gajewski,A., Korbei,B., Gerlich,D., Daigle,N.,
            Haraguchi,T., Furukawa,K., Ellenberg,J. and Foisner,R.
  TITLE     LAP2alpha and BAF transiently localize to telomeres and specific
            regions on chromatin during nuclear assembly
  JOURNAL   J Cell Sci 117 (Pt 25), 6117-6128 (2004)
   PUBMED   15546916
  REMARK    GeneRIF: LAP2alpha and BAF transiently localize to telomeres and
            specific regions on chromatin during nuclear assembly
REFERENCE   8  (bases 1 to 3723)
  AUTHORS   Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
            Brok-Simoni,F., Simon,A.J. and Rechavi,G.
  TITLE     Nuclear membrane protein LAP2beta mediates transcriptional
            repression alone and together with its binding partner GCL
            (germ-cell-less)
  JOURNAL   J Cell Sci 114 (Pt 18), 3297-3307 (2001)
   PUBMED   11591818
REFERENCE   9  (bases 1 to 3723)
  AUTHORS   Yang,L., Guan,T. and Gerace,L.
  TITLE     Integral membrane proteins of the nuclear envelope are dispersed
            throughout the endoplasmic reticulum during mitosis
  JOURNAL   J Cell Biol 137 (6), 1199-1210 (1997)
   PUBMED   9182656
REFERENCE   10 (bases 1 to 3723)
  AUTHORS   Furukawa,K., Pante,N., Aebi,U. and Gerace,L.
  TITLE     Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and
            identification of regions that specify targeting to the nuclear
            envelope
  JOURNAL   EMBO J 14 (8), 1626-1636 (1995)
   PUBMED   7737115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Aug 2, 2021 this sequence version replaced XM_008765218.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.27152.1,
                                           SRR26360186.2557243.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840109,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               JAXUCZ010000007.1  27554417-27554935   c
            520-646             JAXUCZ010000007.1  27548136-27548262   c
            647-805             JAXUCZ010000007.1  27546421-27546579   c
            806-3723            JAXUCZ010000007.1  27542777-27545694   c
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..3723
                     /gene="Tmpo"
                     /gene_synonym="LAP2"
                     /note="thymopoietin"
                     /db_xref="GeneID:25359"
                     /db_xref="RGD:3875"
     exon            1..519
                     /gene="Tmpo"
                     /gene_synonym="LAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2322
                     /gene="Tmpo"
                     /gene_synonym="LAP2"
                     /note="isoform 1 is encoded by transcript variant 1; TP
                     beta; Thymopoietin (lamina associated polypeptide 2);
                     lamina-associated polypeptide 2"
                     /codon_start=1
                     /product="lamina-associated polypeptide 2, isoform beta
                     isoform 1"
                     /protein_id="NP_001382643.1"
                     /db_xref="GeneID:25359"
                     /db_xref="RGD:3875"
                     /translation="MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQH
                     LTARNRPPLAAGANSKGPPDFSSDEEREPTPVLGSGASVGRGRGAVGRKATKKTDKPR
                     PEDKDDLDVTELSNEELLEQLVRYGVNPGPIVGTTRKLYEKKLLKLREQGAESRSSTP
                     LPTVSSSAENTRQNGSNDSDRYSDNDEGKKKEHKKVKSARDCVPFSELASTPSGAFFQ
                     GISFPEISARPPLGRTELQAAKKVHTAKGDPPRDTHADTALPGKGQTQKLAPGRSLFI
                     PSESSYDRCVEKSSSPSSQRQFAARLVSAAASPSLIRETTTTYCKDVVENICRGGKSR
                     AQPSRAEEPHVSDQSVFSSEREVLQESERSQVISPPLAQAIREYVNSLLVQGGVSSLP
                     GTSDSVPTLDVENICKRLSQSSHPESESLSPPRKVPRLSEKPVKGGDSGSCVAFQNTP
                     GSEHRSSLGKSVVSHSLTTLGIEVSEQPRRDKIDASEPSFPLHESIVKVIEEEWQQID
                     RQLPMVACKYPVSSSEATRILSVPKVDDEILGFISEATPRAATQASSTESCDKQLDLA
                     LCRSYEAAASALQIAAHTAFVAKSLQADISQAAQMINSDPNDALQALEILSRAYDAAS
                     YLCDAAFDEARMCACTMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGALFGGEVH
                     KVIKKRGNKQ"
     exon            520..646
                     /gene="Tmpo"
                     /gene_synonym="LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..805
                     /gene="Tmpo"
                     /gene_synonym="LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..3723
                     /gene="Tmpo"
                     /gene_synonym="LAP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctcgctg cgggctccag gcttggccgc acttgctcac cagtggtgcg cccggggctt
       61 ttgtggctta gccggcctgg gctttgtgtc cgagttctgc tccgtgcctg cggcgcttct
      121 cccggtcagg gattcccgag gcggcgtgcg cagcccccgg gaccagcgag cgatcgagcg
      181 agcgcgccgg cttgagcggt ggcgactgcg aggggccgag gaggagagaa ggagggggac
      241 gagatgccgg agttcctaga ggacccttcg gtcctgacca aagacaagtt gaagagcgag
      301 ttggtcgcca acaacgtgac gctcccggcc ggcgagcagc gcaaggacgt gtacgtgcag
      361 ctctacctgc agcacctcac ggcgcgcaac cggccgccgc tcgccgcggg agccaacagc
      421 aaagggccgc ccgacttctc gagcgacgag gagcgcgagc ccaccccagt gcttggctcc
      481 ggggcctccg tgggtcgcgg ccgcggcgcc gtcggcagga aagccacaaa gaaaactgat
      541 aagcccaggc cagaagataa agatgatctg gatgtgacag agctctctaa cgaagaactt
      601 ctggaacagc ttgtgagata tggagtgaat cctggtccca ttgtgggaac caccaggaag
      661 ctgtatgaga agaagctgtt gaagctgagg gaacagggag cagaatcgag atcctctact
      721 cctctcccaa cagtctcttc ctctgcagaa aacacgaggc agaatggaag taatgactct
      781 gacagataca gtgacaatga cgaaggaaag aagaaagaac acaagaaagt gaagtccgct
      841 agggattgtg ttcctttttc tgaacttgca tctactccct ctggtgcatt ttttcagggt
      901 atttctttcc ctgaaatctc cgcccgtcct cctttgggca ggactgaact gcaggcagct
      961 aaaaaagtac atactgctaa gggagaccca cctagggaca ctcatgctga tacagccttg
     1021 cctggaaagg gacagacgca gaagttagcc cctggacgga gcttatttat tccttcagag
     1081 tctagctatg atagatgtgt agagaaaagc tcttcaccat cttctcagcg tcaatttgct
     1141 gccaggctgg tctctgctgc agcgtctcct tcactgatca gagaaaccac tactacttac
     1201 tgtaaggacg tagtagaaaa tatttgccgt ggagggaaga gtagagctca gccatcgcgt
     1261 gctgaggagc ctcatgtttc agatcagtca gttttctcta gtgaaagaga agtgctgcaa
     1321 gagtcggaga ggtcccaggt catttctcct ccacttgctc aggcaatccg agagtatgtc
     1381 aattctctgt tggtccaggg tggggtcagc agtttgcctg ggacttctga ttctgtacct
     1441 acactggatg tagaaaacat atgtaagaga cttagccagt ccagccatcc agaatctgaa
     1501 tccctgtccc ctccccgaaa agtccctagg ctcagtgaga agccagtaaa gggaggggac
     1561 tctggctcct gtgtggcatt ccagaataca cctggatccg aacataggtc ttctttgggc
     1621 aaaagtgttg tctctcattc tcttactact ctgggaatag aagtgtctga acagccacgg
     1681 cgggataaaa tagatgcctc agaaccgtcg ttccctctcc atgagtctat cgtaaaggtc
     1741 attgaagagg agtggcagca aattgatagg cagctgccga tggtggcatg caaatatcca
     1801 gtttcttcca gcgaggcaac ccggatatta tcagttccaa aagtagatga tgagatcctg
     1861 gggtttattt ctgaagccac cccaagagca gccactcagg catcctccac tgagtcttgt
     1921 gataaacagt tggacttggc tctctgtagg tcttacgaag ctgcagcatc agcattgcag
     1981 atcgcagccc ataccgcctt cgtggctaag tctctgcaag ctgacataag tcaggctgca
     2041 cagatgatta attccgatcc taatgatgca ctgcaggccc tggagattct gagcagagcc
     2101 tatgatgcag catcctatct ttgtgacgct gcatttgatg aagcgaggat gtgtgcctgc
     2161 accatggggt cttctaccat gggtcggcgg tatctgtggt tgaaggactg taagatcagt
     2221 ccagcttcta agaataaact aactgttgcc ccctttaagg gtggagcgtt atttggaggg
     2281 gaagtacaca aagtgattaa aaagcgtgga aataagcagt aataagatta aggacaaaga
     2341 cagaaatgtt gacttggaga attcgtggac ctttctatgg atttagtctc ctaatggagc
     2401 cgatttcaag gtgttaagct cccactcatc aagttatagt ataacggcac atatcaagac
     2461 ctagtaccat tgaagcttga tagatcacat cacacttgtc tcacaagaat gtacagcttc
     2521 ctattttata tgacactctg ggtttacacg gagtcccagc aactgaaata atcagtagaa
     2581 ccctcacttg ctttagtatg ccattcacat ccttccttat gtgtaggtcg gagttaaaca
     2641 ttgttagtcc ttttgttttt tattttccct gctcacagga gtttggtttt gggaagtcta
     2701 gtgcataggc atgatttcag tctgctctgc tttgtgccgc ctgccttcat tacgtacatc
     2761 tgttttgcta atagtcattt tgttgtccac tcagtacatt gccagacatc ttacagctga
     2821 cctttgtacc agaattttta gccaagcatc tatctacaca ctccacatct gtctgcactc
     2881 ttgttcatac ttctgtctgc agagaacttt tataattcta gaccagtgca acaaacttac
     2941 tgattgattc agacacgtgt gtgcctgtat cagagggaaa ggcactgctc ctcagtggtg
     3001 agatgcataa gcttcacatg catgtgactc tgagttcagt tcacagccac ttaaaacagt
     3061 ttaatgagca tttagatcta gagatacttt gtaagcaact gataagaggt agattgcata
     3121 tctgtataac acatttatgc acatttttag taaaggaata gaaagcaatg tagcttcatg
     3181 tctgatagag gaggtagtca gtccctggtt acacaagtac atgggccaca tttgaggaac
     3241 acggggatga taaataagta gaatctgctg tacctcatgg tcgctcaaca tgacactaca
     3301 aagatggggc ttttattttc tacatgtatt taaagatatt tttgtatgtc ctgcatagtt
     3361 aaattacata tctggatgct aaaaccaatg aggtattttc taaaaacctt gagaattttt
     3421 actctccccc aatgtctgtg tctgtatgaa gcaatgtatt gccctgctgt cacttgtatg
     3481 gctgtaaggt aaggttccag ttgcagagcc agtctggaag atagtctgca gtataatcaa
     3541 atgcagccct ggtgtgcatg tccagcaccc cgtgttgtta ggctactcac tccatccctg
     3601 cagctgttat gtcttctaaa atgtacatgc atacatgtac ctgttaagtg ctgtgtgatt
     3661 tctttaaaac aatgtatgcc tgtagaatgc ctctacgaat tcaataaagt tgttaaattt
     3721 gaa
//
