LOCUS       NM_001270651            1348 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus tropomodulin 4 (Tmod4), transcript variant 3,
            mRNA.
ACCESSION   NM_001270651
VERSION     NM_001270651.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. PMID: 25654555]
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Gokhin,D.S., Lewis,R.A., McKeown,C.R., Nowak,R.B., Kim,N.E.,
            Littlefield,R.S., Lieber,R.L. and Fowler,V.M.
  TITLE     Tropomodulin isoforms regulate thin filament pointed-end capping
            and skeletal muscle physiology
  JOURNAL   J Cell Biol 189 (1), 95-109 (2010)
   PUBMED   20368620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, FN800735.1 and FM111895.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216249.1, SRR26643289.6852.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000002.1  185384719-185384821
            104-173             JAXUCZ010000002.1  185385428-185385497
            174-683             FN800735.1         85-594
            684-1237            FM111895.1         93-646
            1238-1348           JAXUCZ010000002.1  185389439-185389549
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1348
                     /gene="Tmod4"
                     /note="tropomodulin 4"
                     /db_xref="GeneID:295261"
                     /db_xref="RGD:1308940"
     exon            1..103
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            104..173
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            174..336
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1251
                     /gene="Tmod4"
                     /codon_start=1
                     /product="tropomodulin-4"
                     /protein_id="NP_001257580.1"
                     /db_xref="GeneID:295261"
                     /db_xref="RGD:1308940"
                     /translation="MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENML
                     LPAGLRQRDQTKKSPTGPLDRDALLQYLEQQALEVKERDDLVPFTGEKKGKPFIQPKR
                     EIPAQEQITLEPELEEALSHATDAEMCDIAAILGMYTLMSNKQYYDAICSGEICNTEG
                     ISSVVQPDKYKPVPDEPPNPTNIEEMLKRVRSNDKELEEVNLNNIQDIPIPVLSDLCE
                     AMKTNTYVRSFSLVATKSGDPIANAVADMLRENRSLLSLNIESNFISSTGLMAVLKAV
                     RENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAANAMTR
                     NNELRRQQKKR"
     exon            337..493
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            494..610
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..700
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            701..831
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            832..939
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1083
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1228
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1348
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgctgagc tcactgttcc cccactctct cccccggcac caggctcctc ctgctgaccg
       61 gacagtgccc cagtagaaca gacggaccaa ctgacaaggg gaggaactgg gcatggagcc
      121 agctgtgctg gcagggcctc cagcagctgt gtcagggcaa gagccgttgc cgggctgtga
      181 gtgtcacacc gtggggaggg ggtaggggcc accatgtcat cctatcagaa ggaactggag
      241 aagtacagag acatagatga agacgagatc ctaaggacct tgagccctga ggagctagaa
      301 cagctggact gtgagctaca agaaatggat cctgagaaca tgctgctgcc agctggactg
      361 agacaacgtg accagacaaa gaagagtcca acagggccac tagacagaga cgccctattg
      421 cagtacctgg aacaacaggc gctagaagtc aaagagcgtg acgacttggt gcccttcact
      481 ggcgagaaga agggaaaacc ctttattcag cctaagagag aaattccagc acaggaacag
      541 atcacactgg agcctgaact ggaggaagca ctgtcccatg ccacagatgc tgaaatgtgt
      601 gacattgcag cgatcctggg catgtacaca ctgatgagca acaagcaata ctatgatgct
      661 atctgcagcg gagagatctg caacaccgaa ggcattagca gtgtagtgca gcctgacaag
      721 tataagccag taccagatga acccccaaac cccaccaaca ttgaggagat gctaaagagg
      781 gtgcggagca atgacaaaga gctggaggag gtgaacctca ataacatcca ggacatcccg
      841 atacccgtgc taagcgactt gtgtgaagca atgaagacta atacctatgt ccggagcttc
      901 agtctggtgg ccacaaagag tggtgacccc atcgccaatg cggtggctga catgttgcgt
      961 gagaaccgca gtctcctgag cctgaacatc gaatccaact tcatcagcag cacagggctc
     1021 atggctgtgc tgaaggcagt tcgagaaaac gctactctca ctgagctccg agtagataac
     1081 cagcgccagt ggcctggaga tgctgtagag atggagatgg ccactgtgct agagcagtgt
     1141 ccgtctattg tccgcttcgg gtaccacttc acacaacaag gaccgcgagc tcgggcagcc
     1201 aacgccatga cccgcaacaa tgagctgcgg cgtcagcaaa agaagagata acatcaccct
     1261 tccttttacc acaagagatg agagcctggg acacgtagat cctcatctct ctctccttcc
     1321 ctgtaaataa aatccctttt gttcacgc
//
