LOCUS       NM_001270650            1375 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tropomodulin 4 (Tmod4), transcript variant 1,
            mRNA.
ACCESSION   NM_001270650
VERSION     NM_001270650.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1375)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. PMID: 25654555]
REFERENCE   2  (bases 1 to 1375)
  AUTHORS   Gokhin,D.S., Lewis,R.A., McKeown,C.R., Nowak,R.B., Kim,N.E.,
            Littlefield,R.S., Lieber,R.L. and Fowler,V.M.
  TITLE     Tropomodulin isoforms regulate thin filament pointed-end capping
            and skeletal muscle physiology
  JOURNAL   J Cell Biol 189 (1), 95-109 (2010)
   PUBMED   20368620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, FN800735.1 and FM111895.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000002.1  185384719-185384848
            131-200             JAXUCZ010000002.1  185385428-185385497
            201-710             FN800735.1         85-594
            711-1264            FM111895.1         93-646
            1265-1375           JAXUCZ010000002.1  185389439-185389549
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1375
                     /gene="Tmod4"
                     /note="tropomodulin 4"
                     /db_xref="GeneID:295261"
                     /db_xref="RGD:1308940"
     exon            1..130
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            131..200
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            201..363
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1278
                     /gene="Tmod4"
                     /codon_start=1
                     /product="tropomodulin-4"
                     /protein_id="NP_001257579.1"
                     /db_xref="GeneID:295261"
                     /db_xref="RGD:1308940"
                     /translation="MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENML
                     LPAGLRQRDQTKKSPTGPLDRDALLQYLEQQALEVKERDDLVPFTGEKKGKPFIQPKR
                     EIPAQEQITLEPELEEALSHATDAEMCDIAAILGMYTLMSNKQYYDAICSGEICNTEG
                     ISSVVQPDKYKPVPDEPPNPTNIEEMLKRVRSNDKELEEVNLNNIQDIPIPVLSDLCE
                     AMKTNTYVRSFSLVATKSGDPIANAVADMLRENRSLLSLNIESNFISSTGLMAVLKAV
                     RENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAANAMTR
                     NNELRRQQKKR"
     exon            364..520
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            521..637
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            638..727
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            728..858
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            859..966
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1110
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1255
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1375
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgctgagc tcactgttcc cccactctct cccccggcac caggctcctc ctgctgaccg
       61 gacagtgccc cagtagaaca gacggaccaa ctgacaaggg gaggtgagag gtgaccactg
      121 ggactggtag gaactgggca tggagccagc tgtgctggca gggcctccag cagctgtgtc
      181 agggcaagag ccgttgccgg gctgtgagtg tcacaccgtg gggagggggt aggggccacc
      241 atgtcatcct atcagaagga actggagaag tacagagaca tagatgaaga cgagatccta
      301 aggaccttga gccctgagga gctagaacag ctggactgtg agctacaaga aatggatcct
      361 gagaacatgc tgctgccagc tggactgaga caacgtgacc agacaaagaa gagtccaaca
      421 gggccactag acagagacgc cctattgcag tacctggaac aacaggcgct agaagtcaaa
      481 gagcgtgacg acttggtgcc cttcactggc gagaagaagg gaaaaccctt tattcagcct
      541 aagagagaaa ttccagcaca ggaacagatc acactggagc ctgaactgga ggaagcactg
      601 tcccatgcca cagatgctga aatgtgtgac attgcagcga tcctgggcat gtacacactg
      661 atgagcaaca agcaatacta tgatgctatc tgcagcggag agatctgcaa caccgaaggc
      721 attagcagtg tagtgcagcc tgacaagtat aagccagtac cagatgaacc cccaaacccc
      781 accaacattg aggagatgct aaagagggtg cggagcaatg acaaagagct ggaggaggtg
      841 aacctcaata acatccagga catcccgata cccgtgctaa gcgacttgtg tgaagcaatg
      901 aagactaata cctatgtccg gagcttcagt ctggtggcca caaagagtgg tgaccccatc
      961 gccaatgcgg tggctgacat gttgcgtgag aaccgcagtc tcctgagcct gaacatcgaa
     1021 tccaacttca tcagcagcac agggctcatg gctgtgctga aggcagttcg agaaaacgct
     1081 actctcactg agctccgagt agataaccag cgccagtggc ctggagatgc tgtagagatg
     1141 gagatggcca ctgtgctaga gcagtgtccg tctattgtcc gcttcgggta ccacttcaca
     1201 caacaaggac cgcgagctcg ggcagccaac gccatgaccc gcaacaatga gctgcggcgt
     1261 cagcaaaaga agagataaca tcacccttcc ttttaccaca agagatgaga gcctgggaca
     1321 cgtagatcct catctctctc tccttccctg taaataaaat cccttttgtt cacgc
//
