LOCUS       NM_001106449            1301 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus tropomodulin 4 (Tmod4), transcript variant 2,
            mRNA.
ACCESSION   NM_001106449 XM_001054854 XM_215641
VERSION     NM_001106449.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1301)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. PMID: 25654555]
REFERENCE   2  (bases 1 to 1301)
  AUTHORS   Gokhin,D.S., Lewis,R.A., McKeown,C.R., Nowak,R.B., Kim,N.E.,
            Littlefield,R.S., Lieber,R.L. and Fowler,V.M.
  TITLE     Tropomodulin isoforms regulate thin filament pointed-end capping
            and skeletal muscle physiology
  JOURNAL   J Cell Biol 189 (1), 95-109 (2010)
   PUBMED   20368620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, FN800735.1 and FM111895.1.
            
            On Jul 24, 2012 this sequence version replaced NM_001106449.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217203.1, FQ214903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000002.1  185384719-185384760
            43-636              FN800735.1         1-594
            637-1190            FM111895.1         93-646
            1191-1301           JAXUCZ010000002.1  185389439-185389549
FEATURES             Location/Qualifiers
     source          1..1301
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1301
                     /gene="Tmod4"
                     /note="tropomodulin 4"
                     /db_xref="GeneID:295261"
                     /db_xref="RGD:1308940"
     exon            1..126
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            127..289
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1204
                     /gene="Tmod4"
                     /codon_start=1
                     /product="tropomodulin-4"
                     /protein_id="NP_001099919.1"
                     /db_xref="GeneID:295261"
                     /db_xref="RGD:1308940"
                     /translation="MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENML
                     LPAGLRQRDQTKKSPTGPLDRDALLQYLEQQALEVKERDDLVPFTGEKKGKPFIQPKR
                     EIPAQEQITLEPELEEALSHATDAEMCDIAAILGMYTLMSNKQYYDAICSGEICNTEG
                     ISSVVQPDKYKPVPDEPPNPTNIEEMLKRVRSNDKELEEVNLNNIQDIPIPVLSDLCE
                     AMKTNTYVRSFSLVATKSGDPIANAVADMLRENRSLLSLNIESNFISSTGLMAVLKAV
                     RENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAANAMTR
                     NNELRRQQKKR"
     exon            290..446
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            447..563
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            564..653
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            654..784
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            785..892
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1036
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1181
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1301
                     /gene="Tmod4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgctgagc tcactgttcc cccactctct cccccggcac caggctcctc ctgctgaccg
       61 gacagtgccc cagtagaaca gacggaccaa ctgacaaggg gaggtgagag gtgaccactg
      121 ggactggctg tgagtgtcac accgtgggga gggggtaggg gccaccatgt catcctatca
      181 gaaggaactg gagaagtaca gagacataga tgaagacgag atcctaagga ccttgagccc
      241 tgaggagcta gaacagctgg actgtgagct acaagaaatg gatcctgaga acatgctgct
      301 gccagctgga ctgagacaac gtgaccagac aaagaagagt ccaacagggc cactagacag
      361 agacgcccta ttgcagtacc tggaacaaca ggcgctagaa gtcaaagagc gtgacgactt
      421 ggtgcccttc actggcgaga agaagggaaa accctttatt cagcctaaga gagaaattcc
      481 agcacaggaa cagatcacac tggagcctga actggaggaa gcactgtccc atgccacaga
      541 tgctgaaatg tgtgacattg cagcgatcct gggcatgtac acactgatga gcaacaagca
      601 atactatgat gctatctgca gcggagagat ctgcaacacc gaaggcatta gcagtgtagt
      661 gcagcctgac aagtataagc cagtaccaga tgaaccccca aaccccacca acattgagga
      721 gatgctaaag agggtgcgga gcaatgacaa agagctggag gaggtgaacc tcaataacat
      781 ccaggacatc ccgatacccg tgctaagcga cttgtgtgaa gcaatgaaga ctaataccta
      841 tgtccggagc ttcagtctgg tggccacaaa gagtggtgac cccatcgcca atgcggtggc
      901 tgacatgttg cgtgagaacc gcagtctcct gagcctgaac atcgaatcca acttcatcag
      961 cagcacaggg ctcatggctg tgctgaaggc agttcgagaa aacgctactc tcactgagct
     1021 ccgagtagat aaccagcgcc agtggcctgg agatgctgta gagatggaga tggccactgt
     1081 gctagagcag tgtccgtcta ttgtccgctt cgggtaccac ttcacacaac aaggaccgcg
     1141 agctcgggca gccaacgcca tgacccgcaa caatgagctg cggcgtcagc aaaagaagag
     1201 ataacatcac ccttcctttt accacaagag atgagagcct gggacacgta gatcctcatc
     1261 tctctctcct tccctgtaaa taaaatccct tttgttcacg c
//
