LOCUS       NP_001099919             345 aa            linear   ROD 30-MAR-2024
DEFINITION  tropomodulin-4 [Rattus norvegicus].
ACCESSION   NP_001099919 XP_001054854 XP_215641
VERSION     NP_001099919.1
DBSOURCE    REFSEQ: accession NM_001106449.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 345)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. PMID: 25654555]
REFERENCE   2  (residues 1 to 345)
  AUTHORS   Gokhin,D.S., Lewis,R.A., McKeown,C.R., Nowak,R.B., Kim,N.E.,
            Littlefield,R.S., Lieber,R.L. and Fowler,V.M.
  TITLE     Tropomodulin isoforms regulate thin filament pointed-end capping
            and skeletal muscle physiology
  JOURNAL   J Cell Biol 189 (1), 95-109 (2010)
   PUBMED   20368620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, FN800735.1 and FM111895.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001054854.1, XP_215641.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217203.1, FQ214903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..345
                     /product="tropomodulin-4"
                     /calculated_mol_wt=39076
     Region          4..143
                     /region_name="Tropomodulin"
                     /note="pfam03250"
                     /db_xref="CDD:460862"
     Region          <194..>285
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     CDS             1..345
                     /gene="Tmod4"
                     /coded_by="NM_001106449.2:167..1204"
                     /db_xref="GeneID:295261"
                     /db_xref="RGD:1308940"
ORIGIN      
        1 mssyqkelek yrdidedeil rtlspeeleq ldcelqemdp enmllpaglr qrdqtkkspt
       61 gpldrdallq yleqqalevk erddlvpftg ekkgkpfiqp kreipaqeqi tlepeleeal
      121 shatdaemcd iaailgmytl msnkqyydai csgeicnteg issvvqpdky kpvpdeppnp
      181 tnieemlkrv rsndkeleev nlnniqdipi pvlsdlceam ktntyvrsfs lvatksgdpi
      241 anavadmlre nrsllslnie snfisstglm avlkavrena tltelrvdnq rqwpgdavem
      301 ematvleqcp sivrfgyhft qqgpraraan amtrnnelrr qqkkr
//
