LOCUS       NM_031613               1191 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus tropomodulin 2 (Tmod2), mRNA.
ACCESSION   NM_031613
VERSION     NM_031613.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Omotade,O.F., Rui,Y., Lei,W., Yu,K., Hartzell,H.C., Fowler,V.M. and
            Zheng,J.Q.
  TITLE     Tropomodulin Isoform-Specific Regulation of Dendrite Development
            and Synapse Formation
  JOURNAL   J Neurosci 38 (48), 10271-10285 (2018)
   PUBMED   30301754
  REMARK    GeneRIF: In hippocampal neurons, TMOD2 regulates dendritic
            arborization.
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Gray,K.T., Suchowerska,A.K., Bland,T., Colpan,M., Wayman,G.,
            Fath,T. and Kostyukova,A.S.
  TITLE     Tropomodulin isoforms utilize specific binding functions to
            modulate dendrite development
  JOURNAL   Cytoskeleton (Hoboken) 73 (6), 316-328 (2016)
   PUBMED   27126680
  REMARK    GeneRIF: Tmod1 increases dendritic branching distal from the cell
            body and the number of filopodia/thin spines. Tmod2 increases
            dendritic branching proximal to the cell body and the number of
            mature dendritic spines.
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Cox,P.R., Fowler,V., Xu,B., Sweatt,J.D., Paylor,R. and Zoghbi,H.Y.
  TITLE     Mice lacking Tropomodulin-2 show enhanced long-term potentiation,
            hyperactivity, and deficits in learning and memory
  JOURNAL   Mol Cell Neurosci 23 (1), 1-12 (2003)
   PUBMED   12799133
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Watakabe,A., Kobayashi,R. and Helfman,D.M.
  TITLE     N-tropomodulin: a novel isoform of tropomodulin identified as the
            major binding protein to brain tropomyosin
  JOURNAL   J Cell Sci 109 (Pt 9), 2299-2310 (1996)
   PUBMED   8886980
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031613.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U59240.1, SRR26643298.45415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000008.1  85232554-85232736   c
            184-340             JAXUCZ010000008.1  85229700-85229856   c
            341-463             JAXUCZ010000008.1  85227245-85227367   c
            464-550             JAXUCZ010000008.1  85221716-85221802   c
            551-681             JAXUCZ010000008.1  85219935-85220065   c
            682-789             JAXUCZ010000008.1  85216203-85216310   c
            790-933             JAXUCZ010000008.1  85210805-85210948   c
            934-1078            JAXUCZ010000008.1  85208665-85208809   c
            1079-1191           JAXUCZ010000008.1  85206153-85206265   c
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1191
                     /gene="Tmod2"
                     /note="tropomodulin 2"
                     /db_xref="GeneID:58814"
                     /db_xref="RGD:61948"
     exon            1..183
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1113
                     /gene="Tmod2"
                     /note="N-Tmod; neuronal tropomodulin"
                     /codon_start=1
                     /product="tropomodulin-2"
                     /protein_id="NP_113801.1"
                     /db_xref="GeneID:58814"
                     /db_xref="RGD:61948"
                     /translation="MALPFQKGLEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESA
                     TLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKE
                     KPVETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGQGRK
                     GPVRNVVKGEKAKPVFEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEF
                     AKALETNTHVRKFSLAATRSNDPVALAFAEMLKVNKTLKSLNVESNFITGAGILALVE
                     ALRENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAI
                     TKNNDLVRKKRVEGDRR"
     exon            184..340
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..463
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..550
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..681
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..789
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..933
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1078
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1191
                     /gene="Tmod2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcaggaag ctggcccact tgaaggtgtg agaggaaggt gagaggaagg tgtaaccatg
       61 gcgctcccct ttcagaaagg gctggagaaa tacaagaaca tcgacgagga cgagcttctt
      121 ggcaaactct cagaagagga actgaaacag ttggaaaatg ttctagatga cctagatccc
      181 gagagtgcaa cactaccggc tggattccga cagaaagacc agacccagaa agcagccact
      241 ggcccatttg accgtgagca tctgctcatg tatctggaga aagaggcttt ggaacagaaa
      301 gacagggagg atttcgtacc cttcacagga gaaaagaaag ggagagtctt tattcccaag
      361 gaaaagcctg tagaaactcg taaagaagag aaagtgactc tggacccaga actggaggaa
      421 gccttggcca gcgcctcaga cactgaactc tacgaccttg cagctgtcct tggagtccac
      481 aatttgctca acaatccgaa gtttgatgaa gaaacaacca atggccaagg ccgcaagggg
      541 ccggtgagga atgtcgtcaa aggtgaaaag gccaagccgg tgtttgagga gccaccgaac
      601 cccacaaatg tggaagcaag cctgcagcag atgaaagcca acgaccccag cctgcaggag
      661 gtcaacctca acaacattaa gaacattcca attccaaccc tgaaggagtt tgcaaaggct
      721 ctggagacca acacccacgt gaggaagttc agcctggccg caacccgaag caatgaccct
      781 gtggccctgg cctttgcaga gatgctgaag gtcaacaaga ccttgaaaag tctgaatgta
      841 gagtccaatt ttatcaccgg cgctgggatc ctggccctgg tggaagcgct gcgggagaat
      901 gacaccttga cagagatcaa gatcgacaac cagaggcagc agttgggaac agccgtggag
      961 atggagatcg cccagatgct ggaggagaac tcaaggatcc tcaagtttgg gtaccagttt
     1021 accaagcaag ggccacggac aagagtggca gctgccatca caaaaaataa tgacctagtt
     1081 cgcaagaaga gagttgaagg agacaggagg taaacctcca ctaaaagagg tgacgtctca
     1141 ccatgcggcc atccagaaaa acatacacac aatcttcctc ttctccacgg g
//
