LOCUS       NM_013044               2615 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus tropomodulin 1 (Tmod1), mRNA.
ACCESSION   NM_013044
VERSION     NM_013044.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2615)
  AUTHORS   Omotade,O.F., Rui,Y., Lei,W., Yu,K., Hartzell,H.C., Fowler,V.M. and
            Zheng,J.Q.
  TITLE     Tropomodulin Isoform-Specific Regulation of Dendrite Development
            and Synapse Formation
  JOURNAL   J Neurosci 38 (48), 10271-10285 (2018)
   PUBMED   30301754
  REMARK    GeneRIF: Tmod1 is required for dendritic spine development and
            synapse formation.
REFERENCE   2  (bases 1 to 2615)
  AUTHORS   Gray,K.T., Suchowerska,A.K., Bland,T., Colpan,M., Wayman,G.,
            Fath,T. and Kostyukova,A.S.
  TITLE     Tropomodulin isoforms utilize specific binding functions to
            modulate dendrite development
  JOURNAL   Cytoskeleton (Hoboken) 73 (6), 316-328 (2016)
   PUBMED   27126680
  REMARK    GeneRIF: Tmod1 increases dendritic branching distal from the cell
            body and the number of filopodia/thin spines. Tmod2 increases
            dendritic branching proximal to the cell body and the number of
            mature dendritic spines.
REFERENCE   3  (bases 1 to 2615)
  AUTHORS   Boczkowska,M., Rebowski,G., Kremneva,E., Lappalainen,P. and
            Dominguez,R.
  TITLE     How Leiomodin and Tropomodulin use a common fold for different
            actin assembly functions
  JOURNAL   Nat Commun 6, 8314 (2015)
   PUBMED   26370058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2615)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. doi:
            10.1172/JCI80057. PMID: 25654555]
REFERENCE   5  (bases 1 to 2615)
  AUTHORS   Yuan,B., Wan,P., Chu,D., Nie,J., Cao,Y., Luo,W., Lu,S., Chen,J. and
            Yang,Z.
  TITLE     A cardiomyocyte-specific Wdr1 knockout demonstrates essential
            functional roles for actin disassembly during myocardial growth and
            maintenance in mice
  JOURNAL   Am J Pathol 184 (7), 1967-1980 (2014)
   PUBMED   24840128
REFERENCE   6  (bases 1 to 2615)
  AUTHORS   Robledo,R.F., Ciciotte,S.L., Gwynn,B., Sahr,K.E., Gilligan,D.M.,
            Mohandas,N. and Peters,L.L.
  TITLE     Targeted deletion of alpha-adducin results in absent beta- and
            gamma-adducin, compensated hemolytic anemia, and lethal
            hydrocephalus in mice
  JOURNAL   Blood 112 (10), 4298-4307 (2008)
   PUBMED   18723693
REFERENCE   7  (bases 1 to 2615)
  AUTHORS   Kong,K.Y. and Kedes,L.
  TITLE     Cytoplasmic nuclear transfer of the actin-capping protein
            tropomodulin
  JOURNAL   J Biol Chem 279 (29), 30856-30864 (2004)
   PUBMED   15123707
  REMARK    GeneRIF: Tmod may be involved in the differentiation process in
            myogenic cells
REFERENCE   8  (bases 1 to 2615)
  AUTHORS   Rho,S.B., Chun,T., Lee,S.H., Park,K. and Lee,J.H.
  TITLE     The interaction between E-tropomodulin and thymosin beta-10 rescues
            tumor cells from thymosin beta-10 mediated apoptosis by restoring
            actin architecture
  JOURNAL   FEBS Lett 557 (1-3), 57-63 (2004)
   PUBMED   14741341
  REMARK    GeneRIF: Introduction of E-Tmod cDNA into a tumor cell line
            reverses TB10 mediated apoptosis and restored actin architectures.
REFERENCE   9  (bases 1 to 2615)
  AUTHORS   Fritz-Six,K.L., Cox,P.R., Fischer,R.S., Xu,B., Gregorio,C.C.,
            Zoghbi,H.Y. and Fowler,V.M.
  TITLE     Aberrant myofibril assembly in tropomodulin1 null mice leads to
            aborted heart development and embryonic lethality
  JOURNAL   J Cell Biol 163 (5), 1033-1044 (2003)
   PUBMED   14657235
REFERENCE   10 (bases 1 to 2615)
  AUTHORS   Watakabe,A., Kobayashi,R. and Helfman,D.M.
  TITLE     N-tropomodulin: a novel isoform of tropomodulin identified as the
            major binding protein to brain tropomyosin
  JOURNAL   J Cell Sci 109 (Pt 9), 2299-2310 (1996)
   PUBMED   8886980
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072521.1.
            
            On Jun 13, 2004 this sequence version replaced NM_013044.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2615
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="tropomodulin 1"
                     /db_xref="GeneID:25566"
                     /db_xref="RGD:3874"
     exon            1..56
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            57..213
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1173
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="erythrocyte tropomodulin; E-Tropomodulin"
                     /codon_start=1
                     /product="tropomodulin-1"
                     /protein_id="NP_037176.2"
                     /db_xref="GeneID:25566"
                     /db_xref="RGD:3874"
                     /translation="MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALL
                     PAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKIWVPKQKP
                     MDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKEG
                     LNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAE
                     ALKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILCLVEAL
                     PHNTSLVELKIDNQSQPLGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMMN
                     NNDLVRKRRLADLTGPIIPKCRSGV"
     exon            214..370
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            371..490
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            491..580
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            581..711
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            712..819
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            820..963
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1108
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..2592
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagccccgc gttccgctcg ttgccgccgc ccgcgctcgc gccgccccgc atcccggtca
       61 ccagttcagg agacaaagac acagcctccc acaatgtcct acagacgaga gctggagaaa
      121 tatcgagacc tggatgagga tgaaatcctg ggggccctca cagaggagga gctcaggaca
      181 ctggaaaacg agctggatga gctagaccct gataatgcac tgctccctgc aggcctgagg
      241 cagaaggatc agaccaccaa ggcacccaca ggccccttta aaagagagga gcttttggac
      301 cacttggaaa agcaagcgaa ggaatttaag gaccgagaag acctggttcc ctacacaggg
      361 gagaaacgag gaaagatctg ggttcccaag cagaagccaa tggatcccgt gctggagagc
      421 gtgacgctgg agccggaact ggaggaggcc ctagcaaatg cctcagatgc cgaactatgt
      481 gacattgcag ctattctggg catgcacacg ctcatgagca accagcagta ctaccaagcc
      541 ttgggcagca gctccatcgt gaacaaggag gggctcaaca gtgtgatcaa acccacacag
      601 tacaagcctg tgcctgatga agaaccaaat tcaacagatg tagaggaaac gctggagcga
      661 ataaagaaca atgacccaga acttgaagag gttaatctta acaacatccg gaatattccc
      721 atacccactc tcaaggcgta cgcggaagcc ctgaaagaga actcctacgt gaagaagttc
      781 agcatcgtgg ggacccgcag caatgaccct gtggcatttg ctcttgctga aatgctgaag
      841 gtgaacaagg tgttgaagac gctgaatgtc gagtccaact tcatctccgg agctgggatc
      901 ctgtgcctgg tggaagctct cccccacaac acttctctgg tcgaactgaa aatcgacaac
      961 cagagccagc ctttgggcaa caaagtggaa atggagatcg tgaacatgtt ggagaaaaac
     1021 acaacactcc tcaaatttgg ctaccacttt acccagcagg ggccccggct gcgggcatcc
     1081 aacgccatga tgaacaacaa cgaccttgtg aggaagagga ggctcgcaga cctgacgggg
     1141 cctattattc ccaagtgccg cagcggtgtc tagtgcgcaa agggacgccc acgcctatga
     1201 actggacgtg ttctaccgat aatgtgtgtt ccccagtgga gaccaggagg caaatgttgg
     1261 cgtgaactct tgtggttcag ttctttgtgc actaaggttt agggtaacta gtgactgtag
     1321 ttggaccttt tataaaatat ggttaatgtg aaggttttct ttagtcacag aagttcagtc
     1381 tgataattat ttaaaaatgc agaagccctc aagctggcag gccttgctgc agacagcgtg
     1441 acactggcag agacagccca ggggcccttg gcggccgtgc tttggtgctt aggtgcactt
     1501 acaacatgaa tgcatcagca cacaacactt cccacctagt ttggaagcat ggtgaaacaa
     1561 tttatttcag atttgagcat agcagctcag taaaagaaca tagattcatg atttttcaac
     1621 cccacttgaa acgttaaaat caagattaaa gctgccaaat tgattccagg atcaagtccc
     1681 caccccctaa gaatgaaaga caagccccag aattttctaa gaatcagaaa gacacaggat
     1741 tccttctgcc aggtaagaga aagggggaga aaaaggcaat agtggaattg agtttcaaaa
     1801 cctaccacgc caagcaacag acatgagtgc tgtgtgaaca cctgggaggt tctcatctgt
     1861 agtcagaaat catttcttct ttattgaatg ccaacttcat gatggatgaa aacttacaac
     1921 cacataaaaa catcttccaa taccgcagtg agccaacggc ttatgtgaga tcaacaccat
     1981 tgggtgaatt tccagtccac catgcctgtg gtatttagca tggccctgct tacagacacc
     2041 aagtgcctgc ccggtcactt aggagacaaa tcaaatcaca cacgaagcct ctgaaggaca
     2101 gcagagtaca acatcccaat ggtaaggaat taggagatcc tggacataca acacaaggaa
     2161 ttattctgaa acctaatctt ggcattccta ctggatccct ttaacaccat gggagccagt
     2221 aaaaatgtta aaatacactg ttcttgtgcc ttttaataga ccacagtgcc agttaaacta
     2281 gtacttttgt tgctttgggg agtgttttcc ttagggattc agccgatatg acagtgatgg
     2341 ctcaaaagct gcagagcaca gccaggggct tctgacctaa gacctgcaca ccggactgta
     2401 aggccatgga cagcacaggg taactagagt ggcatcgggg cctcagcact gtgagtggtc
     2461 actgaggccc aggagtggca ccaagctgca gggacagcca gctccactca gcttctcctt
     2521 gaaacacaac tgcagctgca ttctgcatca ctggaaactg caaaataata ttaaagccat
     2581 ttggtgtatg taaaaaaaaa aaaaaaaaaa aaaaa
//
