LOCUS       NM_133387               1517 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus trimethyllysine hydroxylase, epsilon (Tmlhe),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_133387
VERSION     NM_133387.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1517)
  AUTHORS   Nava,C., Lamari,F., Heron,D., Mignot,C., Rastetter,A., Keren,B.,
            Cohen,D., Faudet,A., Bouteiller,D., Gilleron,M., Jacquette,A.,
            Whalen,S., Afenjar,A., Perisse,D., Laurent,C., Dupuits,C.,
            Gautier,C., Gerard,M., Huguet,G., Caillet,S., Leheup,B.,
            Leboyer,M., Gillberg,C., Delorme,R., Bourgeron,T., Brice,A. and
            Depienne,C.
  TITLE     Analysis of the chromosome X exome in patients with autism spectrum
            disorders identified novel candidate genes, including TMLHE
  JOURNAL   Transl Psychiatry 2 (10), e179 (2012)
   PUBMED   23092983
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1517)
  AUTHORS   Monfregola,J., Cevenini,A., Terracciano,A., van Vlies,N.,
            Arbucci,S., Wanders,R.J., D'Urso,M., Vaz,F.M. and Ursini,M.V.
  TITLE     Functional analysis of TMLH variants and definition of domains
            required for catalytic activity and mitochondrial targeting
  JOURNAL   J Cell Physiol 204 (3), 839-847 (2005)
   PUBMED   15754339
REFERENCE   3  (bases 1 to 1517)
  AUTHORS   Vaz,F.M., Ofman,R., Westinga,K., Back,J.W. and Wanders,R.J.
  TITLE     Molecular and Biochemical Characterization of Rat epsilon
            -N-Trimethyllysine Hydroxylase, the First Enzyme of Carnitine
            Biosynthesis
  JOURNAL   J Biol Chem 276 (36), 33512-33517 (2001)
   PUBMED   11431483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085923.1.
            
            [WARNING] On Nov 14, 2024 this sequence was replaced by
            NM_133387.3.
            
            On Oct 27, 2005 this sequence version replaced NM_133387.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1517
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /note="trimethyllysine hydroxylase, epsilon"
                     /db_xref="GeneID:170898"
                     /db_xref="RGD:620629"
     exon            1..78
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     exon            79..260
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1381
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /EC_number="1.14.11.8"
                     /note="TMLD; TML dioxygenase; TML hydroxylase;
                     TML-alpha-ketoglutarate dioxygenase;
                     epsilon-trimethyllysine 2-oxoglutarate dioxygenase;
                     epsilon-trimethyllysine hydroxylase"
                     /codon_start=1
                     /product="trimethyllysine dioxygenase, mitochondrial"
                     /protein_id="NP_596878.2"
                     /db_xref="GeneID:170898"
                     /db_xref="RGD:620629"
                     /translation="MWYHKLLHQQSRLQNLMKRGDIAHGLRLSGFKSLFPFSLHWCHT
                     ASKSVNCTWHQHEDHLELGTKPRALRLLELQYASTVMRFDYVWLRDHCRSASCYNSKT
                     HQRSLDTASVDLCIKPKTIRLDESTLFFTWPDGHVTRYDLDWLVKNSYEGQKQEVIQP
                     RVLWNAKLYQDAQLPSVDFQGFLETKEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLA
                     RRVSLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEG
                     TGGRTLLVDGFYAAQQVLQRAPEEFDLLSQVPLKHEYIENVGQCHNHMIGVGPILNIY
                     PWNKELYLIRYNNYDRAVINTVPYDVVRRWYAAHRTLTTELRRPENELWVKLKPGKVL
                     FIDNWRVLHGRESFTGYRQLCGCYLTRDDVLNTARILGLHA"
     exon            261..296
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     exon            297..473
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     exon            474..753
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     exon            754..873
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1110
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1249
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1492
                     /gene="Tmlhe"
                     /gene_synonym="Tmlh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgaggag gctgcaccgc accgagtctc tgcttgcgtt ttcctccgca gacctccgag
       61 ccgtgacttc cagcgcagga tgtggtacca taagttgttg caccaacaaa gcaggctcca
      121 gaacttgatg aagagaggag acatagctca cggtcttcgt ctgtccggct ttaaaagttt
      181 atttccattt tcgctccatt ggtgccatac ggcttccaag tctgtgaatt gtacttggca
      241 ccaacatgaa gatcatttgg agctggggac caaacccagg gccttgcgct tgctagaact
      301 gcaatatgcc agcactgtga tgcgcttcga ttatgtctgg cttcgagacc actgccgctc
      361 agcctcgtgc tataattcta agactcacca gcggagcctg gacactgcca gtgtggattt
      421 atgcattaag ccaaagacga ttcgtctgga tgaaagtaca ctctttttca cttggccaga
      481 tggtcatgtg actagatacg acctggattg gctggtgaaa aacagctacg aagggcagaa
      541 gcaggaggtc atccaaccca gggtgctgtg gaacgccaag ctctaccagg acgcccagct
      601 tccgtctgtt gatttccagg gtttcttgga aacaaaggaa ggactgaaga agtttctgca
      661 gaactttctg ctctacggaa ttgcgtttgt agaaaatgtc cctcccactc aggagcacac
      721 ggaaaagctg gcacgaaggg tcagcctaat cagagaaacc atttatggaa ggatgtggta
      781 tttcacgtca gacttttcca gaggtgacac tgcgtacacc aagctagccc tagatcgcca
      841 taccgatacc acctactttc aagagccctg tggcattcaa gtatttcatt gtcttaagca
      901 cgaaggaaca ggtggcagga cactgttggt ggatggattc tatgcagcgc aacaagtact
      961 ccaaagagca cctgaggaat ttgacctcct cagccaagta ccattgaagc atgaatatat
     1021 tgaaaatgtt ggacaatgtc acaatcacat gataggggtt ggacccatct taaatatcta
     1081 cccatggaat aaggagctgt atttgatcag gtacaacaac tacgacaggg ctgtcatcaa
     1141 cactgtgcct tacgacgttg tccgtcgttg gtatgcagca caccgaaccc taacgactga
     1201 actgagaagg cctgagaatg aactttgggt caaactgaag cctggaaagg tactatttat
     1261 agacaactgg cgagtccttc acggcaggga gtcattcact ggctaccgtc aactgtgtgg
     1321 ctgctatttg actagagatg atgtactgaa tactgctcga attctaggtc ttcatgccta
     1381 aaatttaaag cactaggatt atgaatacac tcggtaccct actacgagaa ttttatatca
     1441 acagaacaat attgtattaa aaattgtttc agattgtcta ttttccattc taaaaaaaaa
     1501 aaaaaaaaaa aaaaaaa
//
