LOCUS       NM_001109299            2599 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transmembrane inner ear (Tmie), mRNA.
ACCESSION   NM_001109299 XM_001076090 XM_576477
VERSION     NM_001109299.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2599)
  AUTHORS   Shin,M.J., Lee,J.H., Yu,D.H., Kim,H.J., Bae,K.B., Yuh,H.S.,
            Kim,M.O., Hyun,B.H., Lee,S., Park,R. and Ryoo,Z.Y.
  TITLE     Spatiotemporal expression of tmie in the inner ear of rats during
            postnatal development
  JOURNAL   Comp Med 60 (4), 288-294 (2010)
   PUBMED   20819378
  REMARK    GeneRIF: Tmie exists in the cytoplasm and may have a key role in
            the maturation and structure of stereocilia bundles in developing
            hair cells. After hair cell maturation, Tmie is thought to be
            involved in the maintenance of organ of Corti cells.
REFERENCE   2  (bases 1 to 2599)
  AUTHORS   Su,M.C., Yang,J.J., Chou,M.Y., Hsin,C.H., Su,C.C. and Li,S.Y.
  TITLE     Expression and localization of Tmie in adult rat cochlea
  JOURNAL   Histochem Cell Biol 130 (1), 119-126 (2008)
   PUBMED   18327602
  REMARK    GeneRIF: Our results point out the presence and localization of
            Tmie products in the cochlea of rat.
REFERENCE   3  (bases 1 to 2599)
  AUTHORS   Naz,S., Giguere,C.M., Kohrman,D.C., Mitchem,K.L., Riazuddin,S.,
            Morell,R.J., Ramesh,A., Srisailpathy,S., Deshmukh,D., Riazuddin,S.,
            Griffith,A.J., Friedman,T.B., Smith,R.J. and Wilcox,E.R.
  TITLE     Mutations in a novel gene, TMIE, are associated with hearing loss
            linked to the DFNB6 locus
  JOURNAL   Am J Hum Genet 71 (3), 632-636 (2002)
   PUBMED   12145746
REFERENCE   4  (bases 1 to 2599)
  AUTHORS   Mitchem,K.L., Hibbard,E., Beyer,L.A., Bosom,K., Dootz,G.A.,
            Dolan,D.F., Johnson,K.R., Raphael,Y. and Kohrman,D.C.
  TITLE     Mutation of the novel gene Tmie results in sensory cell defects in
            the inner ear of spinner, a mouse model of human hearing loss DFNB6
  JOURNAL   Hum Mol Genet 11 (16), 1887-1898 (2002)
   PUBMED   12140191
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_576477.1, XM_001076090.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMN06680413
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2599
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="transmembrane inner ear"
                     /db_xref="GeneID:501061"
                     /db_xref="RGD:1562523"
     exon            1..808
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1024
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1407
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     CDS             1312..1773
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /codon_start=1
                     /product="transmembrane inner ear expressed protein"
                     /protein_id="NP_001102769.1"
                     /db_xref="GeneID:501061"
                     /db_xref="RGD:1562523"
                     /translation="MAGRQRGSGRLWALGGAALGACLAGVASQLVEPSTAPPKPKPPP
                     LTKETVVFWDMRLWHVVGIFSLFVLSIIITLCCVFNCRVPRTRKEIEARYLQRKAAKM
                     YTDKLETVPPLNELTEIPGEDKKKKKKDSVDTVAIKVEEDEKNEAKKKGEK"
     exon            1408..1525
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1675
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..2599
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggcctc ggaatgtccc taagcaaaca actctctccc ccgagcctct cccgccagac
       61 ttcgaaaact cccctccggt ccgcgagcac cccgggatcg cacccaggct gtcttttcgc
      121 ctcttacctc cctctcccga tccgagaccg caggcagtgc cttacccacc gactctgagc
      181 aggctgtacc tctgagacct tgccgacccc cattgggtca cccggccctt tcacccctac
      241 acaccggcga aggagccctg ggtagattcg ggaaacttgt ttaaggcagt cggccatgat
      301 gaccccgcaa cccctggact gggggcgctt cggtagcagc cactgctgcg tgtgaccttg
      361 aaagaggccc cctgcattca ttccgggtac agcctgaatc tggccagttt cctgtgccaa
      421 agccttcgac cttggaaaga gcagcgcagt tccaaaccaa actcttggaa ggaggaggga
      481 cgatggttca aacctgtaac aaagatgcct gctgtccagc tgccgggctc ccgtttggcc
      541 agaagcaagt cacccctccg cctgcagtgg caccaggcct ctgggagctg actagcctgg
      601 ctgaattgct tctaaccctt ccaagtctga gcacagagag aagcctgggg aagaggcagc
      661 tgtgaaagag caagaatggt ccacctgccc cttacccaag ttttggacgg cctccatgcg
      721 tcctgccaga gagaagagag acttctaaga gtctctgaga aggggcctgc caacttcaac
      781 agccctggct cccttaggtc gctttttgga gaaagtgtca aatcttctgg aactggagtt
      841 actgatggtt gagagccacc ccgtggatgc tgggaatcaa acatgggacc ttcgcaagag
      901 caacaaatgc tccaaaacac cgagcctctt ccaagagagc gaactttgaa catcagtgcc
      961 ctccctgggc tgagcagcaa gggaagtcct gtgagcagca gtccagtgac tgtgtcctga
     1021 taagtgccct tgggatggag tagaaggtct aaaagtctga tagcctaggc ggggtgccac
     1081 ccacacctac cctcacccca gtagtgatgg cgcaggtggc gtcccgggaa cctgacaccc
     1141 aagatgaata aatgatgcgg actcaaccgc ccgcagccag aactctccgc ggccgctgcc
     1201 actaccaccg tcaccgcctg ccggtggcca ggggcagtca cctggtagct ctgtgcatca
     1261 gccccctctg ctctcaggac ctgtagcgga gcccgcggca aacaggagaa catggccggg
     1321 aggcagcgtg gctcggggcg gctctgggcg ctgggcggcg ccgcgctggg ggcttgcctg
     1381 gcgggtgtcg cctcgcagct ggtagagccc agcacggccc cgcccaagcc caagccgccc
     1441 ccactgacca aggagaccgt ggtgttctgg gacatgcgcc tgtggcatgt ggtgggcatc
     1501 ttttccctct tcgtgctgtc catcatcatc acgctgtgct gtgtgttcaa ctgccgtgta
     1561 ccgcggacac ggaaggagat cgaggctcgg tatctacagc gaaaagcagc caagatgtac
     1621 acagacaagc tggagaccgt gcctcccctc aacgaactca cagaaatccc tggagaggac
     1681 aagaagaaaa agaagaagga cagtgtggac accgtggcta tcaaggtaga ggaggacgag
     1741 aagaatgagg caaagaagaa aggagagaag tgagggcggc gtcctggaga tggcagccgg
     1801 ggctggcagg ccctgaagcg taagttcagg ccgggatcca ggcatcaaga ctccgagttc
     1861 atacatggac ggcagaggct gtggtccaag ggaaagccaa ggtcgtgggc attacctcac
     1921 ggcccaaaag atgtagggac aagactggac tctgttcatt tcacatggtc agtctgggca
     1981 cttctcacgg gccactgtcc ctctatagat atagagtggc ctcaaactcc tctccccatc
     2041 caggcaagct tctgtcccac ccttcttgcc aggggcagaa gtggctatga aggagtcagg
     2101 gattggtcga tgaggatggc aggattgaac agattgttca acaacacaga tggaggactg
     2161 gaaggggact tgtgacatgg gagattctct gacatagcta gatagccacc ccaaagagca
     2221 aggagattgc cccaagtttg acggtgatct gtccttggct tctagggtgt ccccattatc
     2281 aggagaatcc ctgatctggc aaatgccaag ctctgaaaac aaggtaacag cgtgacaggg
     2341 cggagaccac tgaggggctg gcaggaggcc tagggcctaa gggcttctgg ctcaggggtg
     2401 gggtctgaaa catagaagaa tgagttgcgt gggccgagtg agaaaacctg ggtctcctca
     2461 cgggaaccaa gaactactca agacgcagtg catggggtac ggactactgc ggttgccttt
     2521 tctctggcca ggactctgtc agaccaccag tctgccgaac acagtggtat gcaggtcctc
     2581 ttctgccatg tcccttact
//
