LOCUS       NM_053671               3458 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TATA element modulatory factor 1 (Tmf1), mRNA.
ACCESSION   NM_053671 XM_346710
VERSION     NM_053671.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3458)
  AUTHORS   Elkis,Y., Bel,S., Lerer-Goldstein,T., Nyska,A., Creasy,D.M.,
            Shpungin,S. and Nir,U.
  TITLE     Testosterone deficiency accompanied by testicular and epididymal
            abnormalities in TMF(-/-) mice
  JOURNAL   Mol Cell Endocrinol 365 (1), 52-63 (2013)
   PUBMED   23000399
REFERENCE   2  (bases 1 to 3458)
  AUTHORS   Bel,S., Elkis,Y., Lerer-Goldstein,T., Nyska,A., Shpungin,S. and
            Nir,U.
  TITLE     Loss of TMF/ARA160 protein renders colonic mucus refractory to
            bacterial colonization and diminishes intestinal susceptibility to
            acute colitis
  JOURNAL   J Biol Chem 287 (30), 25631-25639 (2012)
   PUBMED   22553199
REFERENCE   3  (bases 1 to 3458)
  AUTHORS   Gu,P., Min,J.N., Wang,Y., Huang,C., Peng,T., Chai,W. and Chang,S.
  TITLE     CTC1 deletion results in defective telomere replication, leading to
            catastrophic telomere loss and stem cell exhaustion
  JOURNAL   EMBO J 31 (10), 2309-2321 (2012)
   PUBMED   22531781
REFERENCE   4  (bases 1 to 3458)
  AUTHORS   Lerer-Goldshtein,T., Bel,S., Shpungin,S., Pery,E., Motro,B.,
            Goldstein,R.S., Bar-Sheshet,S.I., Breitbart,H. and Nir,U.
  TITLE     TMF/ARA160: A key regulator of sperm development
  JOURNAL   Dev Biol 348 (1), 12-21 (2010)
   PUBMED   20691678
REFERENCE   5  (bases 1 to 3458)
  AUTHORS   Volpe,M., Shpungin,S., Barbi,C., Abrham,G., Malovani,H., Wides,R.
            and Nir,U.
  TITLE     trnp: A conserved mammalian gene encoding a nuclear protein that
            accelerates cell-cycle progression
  JOURNAL   DNA Cell Biol 25 (6), 331-339 (2006)
   PUBMED   16792503
REFERENCE   6  (bases 1 to 3458)
  AUTHORS   Hsiao,P.W. and Chang,C.
  TITLE     Isolation and characterization of ARA160 as the first androgen
            receptor N-terminal-associated coactivator in human prostate cells
  JOURNAL   J Biol Chem 274 (32), 22373-22379 (1999)
   PUBMED   10428808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF415257.1, CK470592.1, AF107843.1, CK473511.1, DY564782.1,
            CK602135.1, BQ780433.1 and BM390672.1.
            
            On Oct 12, 2007 this sequence version replaced NM_053671.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               BF415257.1         1-400
            401-1058            CK470592.1         77-734
            1059-1213           AF107843.1         982-1136
            1214-1826           CK473511.1         66-678
            1827-2408           DY564782.1         108-689
            2409-2987           CK602135.1         116-694
            2988-3382           BQ780433.1         73-467              c
            3383-3458           BM390672.1         1-76                c
FEATURES             Location/Qualifiers
     source          1..3458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3458
                     /gene="Tmf1"
                     /note="TATA element modulatory factor 1"
                     /db_xref="GeneID:114206"
                     /db_xref="RGD:620551"
     exon            1..219
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..3359
                     /gene="Tmf1"
                     /codon_start=1
                     /product="TATA element modulatory factor"
                     /protein_id="NP_446123.2"
                     /db_xref="GeneID:114206"
                     /db_xref="RGD:620551"
                     /translation="MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSAWAEAIPY
                     GEPGISPSVSGGWDTSTWGLNSSSEPQSSPTASQAITKPVRRTVVDESENFFSAFLSP
                     SDVQTIQKSPVVSKPPAKSQRPEEEVKSSLQEPSSPGQSRTSETAESEATDSACVSGE
                     TPAVGTPSPVPEGKREETASEESEGKVPTVRAKASESVVKVNTAEDVSPTSTQSLTTE
                     TKDMALEPKEQKHEDRQSNTPSPPVSSFSSGTSTTSDIEVLDHESVISESSASSRQET
                     SDAKSSLHLMQTSFQLLSASACPEYGRLDDFQKLSESCCSSDAFERIDSFSVQSLDSR
                     SVSEINSDDELPGRGYALVPIVVSPSAPKTKVVESTEENVEEEEGNETLIAPSEEAEL
                     EESGRSATPVNCDQPDTLASPTPVNVGPSASGPAAEDGEAAENHPKAPQLEQEDVGKT
                     VEFLNEKLEKRETQLLSLSKEKALLEEAYDNLKDEMFRVKEESSSISSLKDEFTQRIA
                     EAERKAQLACKERDTAKKEMKTMKEELASRLNSSQTADLLKEKDEQIQGLMEEGEKLS
                     KQQLHNSNMIKKLRAKDKDNESVIAKLKKKAKELEEELQHLRQVLDGKEEVEKQHREN
                     IKKLNSVVERQEKDLGRLQVDMNELEEKSRSTQAALDSAYRELTDLHKANAAKDSEVQ
                     EAALRREMKAKEELSGALEKAQEEARQQQETLALQVGDLRLALQRAEQAAARKEDYLR
                     HEISELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEMLEKNLSD
                     RLGESQTLLAAAVERERAATEELLANKIQMSSVESQNALLRQENSRLQAQLESEKNKL
                     RKLEDENSRYQVELENLKDEYVRTLEEARKEKTLLSSQLEMERMKVEQERKKTIFTQE
                     TLKEKEHKPFSVSSTPTMSRSSSLSGVDMAGLQTSFLSQDESHDHSFGPMSTSASGSN
                     LYEAVRMGAGSSIIENLQSQLKLREGEISHLQLEISNLEKTRSIMSEELVKLTNQNDE
                     LEEKVKEIPKLRVQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELL
                     RQRLS"
     exon            220..1424
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1528
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1655
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1761
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1904
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2071
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2228
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2321
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2478
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2671
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2741
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2834
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2936
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3089
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3215
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3445
                     /gene="Tmf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcgg gaggcggtgg gccggggcca ccgctgaggc cgccggtgcc ggccggaccc
       61 ggcgctgagg aggggccatg agctggttca atgcctcgca gttgtccagc ttcgccaagc
      121 aggccctgtc ccaggcccag aagtccatcg acagggtcct ggacatccag gaggaagagc
      181 cgagcgcctg ggccgaggcc atcccgtacg gtgagccagg aataagtccc tctgtgagtg
      241 gaggatggga tacttcaacc tggggattga actcaagctc tgaacctcag agttcaccaa
      301 cagcctctca agcaattaca aagccagttc ggaggactgt agtagatgaa tctgaaaatt
      361 tcttcagtgc ctttctctct ccatcggatg tgcagaccat tcagaagagt ccagtggtct
      421 caaagcctcc tgctaaatca cagcgaccag aagaagaagt gaaaagcagt ttacaagaac
      481 catcgtctcc tggccagtcc agaacctctg agacagcgga gtctgaagcg acagactctg
      541 cctgtgtttc gggagagact ccagccgtgg gcactccctc acctgtccct gaaggcaagc
      601 gtgaagaaac tgctagtgaa gagtctgagg ggaaggtgcc caccgtgaga gcgaaggcgt
      661 ctgaaagcgt agttaaggta aacacagcag aagatgtatc tcccacatcc actcagtctc
      721 ttacgaccga aacgaaggat atggctttgg agcctaaaga acaaaaacac gaagacagac
      781 aaagcaacac accttctcct cctgttagct ccttctcgtc aggcacttcc accaccagtg
      841 acattgaagt tttagatcat gaaagtgtaa taagtgagag ctcagctagt tcaaggcaag
      901 agacttcaga tgcaaagtca agtcttcacc tcatgcagac ctcatttcag cttctctctg
      961 catctgcttg tcctgagtat ggccgcttag atgacttcca aaagctcagt gagagttgct
     1021 gctcttcgga tgcttttgag agaatagact cgtttagcgt gcagtctctg gatagccgga
     1081 gtgtgagtga aatcaactcg gacgacgaac tgccgggtag aggctatgct ttagtaccta
     1141 tagtcgtgag tccttcagcc ccgaagacaa aagtagtaga atctactgag gaaaacgttg
     1201 aagaagagga aggaaacgag acattaattg caccttctga ggaagcagaa ttagaggaaa
     1261 gtggccgaag tgctactcca gttaactgtg accagccaga tacattggct tctcctacac
     1321 cagtaaatgt tgggccctct gcctctggac cggccgctga ggatggtgaa gctgctgaaa
     1381 accacccaaa agcaccacag ctggagcaag aagatgttgg caagacagtt gaatttctga
     1441 atgagaagct agaaaagagg gagactcaat tattgtcact tagtaaggaa aaggcacttc
     1501 tagaggaagc ttatgataac ctgaaggatg aaatgttcag agtaaaagaa gaaagtagta
     1561 gcatttcttc cctgaaagat gagtttaccc agaggatcgc agaagcagaa aggaaagctc
     1621 aactcgcctg caaagagaga gacactgcga agaaggaaat gaaaaccatg aaggaagaac
     1681 ttgcctctag attaaatagt agtcagactg cagaccttct gaaggaaaag gatgaacaga
     1741 ttcaaggctt aatggaagaa ggagaaaaac tttcgaagca gcagctgcat aattccaaca
     1801 tgattaagaa attaagagct aaggataaag acaatgaaag tgttattgca aagctgaaga
     1861 aaaaagctaa ggagctggaa gaggagctac agcatttaag acaggtcctt gatggcaaag
     1921 aagaggttga gaaacaacat agagaaaaca ttaaaaaact aaattctgta gtagaacgcc
     1981 aggaaaaaga tcttggccga cttcaggtag acatgaatga acttgaagaa aagagccgaa
     2041 gtactcaggc tgccctagac agtgcctaca gagaacttac tgatcttcac aaagccaacg
     2101 ctgctaagga cagtgaggta caagaagctg ctctgaggcg tgagatgaaa gctaaagaag
     2161 aactttctgg ggcactggag aaggcccagg aagaagcccg tcagcagcaa gagactttag
     2221 cacttcaggt tggggacctt aggctagcgc tgcaacgggc agagcaagca gctgccagga
     2281 aagaggatta cttacgccat gagatcagtg aacttcagca gagactccaa gaagcagaga
     2341 atcgaaacca ggagctgagt caaagtgttt catcaacaac aagacctttg cttcgacaga
     2401 tagaaaattt acaagcaact ctaggatccc agacatcgtc atgggagatg ctagagaaga
     2461 atctttctga tcggctcggt gaatcacaga ccttgttggc tgcagcagtt gaaagagaac
     2521 gtgcagctac ggaagaactc ctagccaaca aaatccagat gtcttcagtg gagtcgcaga
     2581 atgcattact acgacaggaa aacagtagac tgcaggccca gctagagtca gagaaaaata
     2641 aattaagaaa actagaggat gaaaatagcc ggtaccaggt tgaattagaa aatctaaaag
     2701 atgaatatgt aagaacactt gaagaggcaa ggaaagaaaa gacacttttg agcagtcagt
     2761 tagaaatgga aagaatgaaa gttgaacaag aaaggaagaa aaccattttc actcaagaaa
     2821 cactaaaaga aaaggagcac aagccgtttt ccgtttctag tactcccacc atgtcacgat
     2881 ccagttctct aagtggagta gatatggcag ggctgcagac atccttccta tctcaggatg
     2941 agtctcacga ccattcattt gggccaatgt ctacgtcagc cagtggaagc aatctttatg
     3001 aagctgtaag gatgggagcc ggatcaagca ttatcgaaaa tcttcagtct cagctaaagc
     3061 tgagggaagg agaaattagt catttacagc tagaaattag taacctagaa aaaactcgat
     3121 ccataatgtc cgaagagcta gttaaattaa caaatcagaa tgatgaactt gaggagaaag
     3181 tgaaagagat acccaagctt cgagttcagc tgcgagattt ggatcaaaga tacaacacta
     3241 ttctgcagat gtatggagaa aaagcagaag aagcagagga acttcgcctg gatcttgaag
     3301 atgtaaaaaa tatgtataaa actcaaatag atgaacttct aagacaaaga ctcagctaac
     3361 ttgtgaagtt tgtgttccat cacactaatg taaacactta tatataaatg cagacgtaca
     3421 ataaattctt ctacagaatt agaaaaaaaa aaaaaaaa
//
