LOCUS       NM_001398901            6568 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transmembrane protein 74 (Tmem74), mRNA.
ACCESSION   NM_001398901 XM_576263
VERSION     NM_001398901.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6568)
  AUTHORS   Yu,C., Wang,L., Lv,B., Lu,Y., Zeng,L., Chen,Y., Ma,D., Shi,T. and
            Wang,L.
  TITLE     TMEM74, a lysosome and autophagosome protein, regulates autophagy
  JOURNAL   Biochem Biophys Res Commun 369 (2), 622-629 (2008)
   PUBMED   18294959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 28, 2021 this sequence version replaced XM_576263.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1074679.1,
                                           SRR26643298.39890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000007.1  76822508-76822633   c
            127-6568            JAXUCZ010000007.1  76814000-76820441   c
FEATURES             Location/Qualifiers
     source          1..6568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..6568
                     /gene="Tmem74"
                     /gene_synonym="RGD1566279"
                     /note="transmembrane protein 74"
                     /db_xref="GeneID:500864"
                     /db_xref="RGD:1566279"
     exon            1..126
                     /gene="Tmem74"
                     /gene_synonym="RGD1566279"
                     /inference="alignment:Splign:2.1.0"
     exon            127..6568
                     /gene="Tmem74"
                     /gene_synonym="RGD1566279"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..1447
                     /gene="Tmem74"
                     /gene_synonym="RGD1566279"
                     /codon_start=1
                     /product="transmembrane protein 74"
                     /protein_id="NP_001385830.1"
                     /db_xref="GeneID:500864"
                     /db_xref="RGD:1566279"
                     /translation="MELHSLPKRNSPVGPCNAVEWSSGETSGDHTEEAALRASLCYEK
                     NLTSTPRADVIEVCGLSTSPTSPTSLFQDNAIQTGFFPSGPPDSGNNQVLADRKVCNC
                     CSQELETSFTYVDENVNLEQRSQRSPSAKDNNHPGDLGWGNPNEWSHEAAISLMSEDD
                     DDTSSEATSSGKSVDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLE
                     KESAMLGAHLDRCVIAGLCLLTLGGVVLSCLLMMSMWKGELYRRNRFASSKESAKLYG
                     SFNFRMKTSTNEDTLELSLVEEDAFAVQS"
ORIGIN      
        1 acccagccga acccagcgga gaacacaggc tacaagtgct caggctggga ataacggact
       61 ttctccgggt gccacgcgga cgcgagtgct gcgggcttca gctttactga gtggccaaag
      121 cagaaggaaa cttgccttct catttgaggg attctgtcac aggaatgtgt gagtctctgg
      181 ataaatttgg cttggtgacg gcagtgtgct gtccccagag attctgctac atcctccttg
      241 ctccttttct accctgaccc gagtttctca ctgctaaccc ctgtgacaag tcagaagatt
      301 tggctcttcc gtgatcttct gcccccaggt tccctttccc gtttttgcca ctctgatgag
      361 aaactgaggc caaggtgtcc tcaaccagtc atggctgtaa agggaatgcg gaccagagga
      421 gcaggcctcc ttactgtatg aaagtagatt ctgccaggtc cttcttatca cattgtgttg
      481 ctgctagcaa aatttctgga aatctcgggg aaaaatctaa ctagccccca tggaactcca
      541 ctctctgcct aagaggaaca gcccagttgg cccatgcaat gctgtggagt ggagttcagg
      601 agagacttcc ggtgaccaca cagaagaggc ggccctcaga gcttctcttt gctatgagaa
      661 aaacttgaca tcgacaccaa gggcagatgt catagaagtg tgtggactta gcacttctcc
      721 aacatcccca acctccttgt tccaagacaa tgctattcaa acaggcttct tcccctcagg
      781 acctcctgac tcagggaaca accaagtact ggctgatcgt aaggtctgta attgttgcag
      841 ccaggaacta gaaacttctt ttacctacgt ggatgagaat gtcaacttgg aacagagaag
      901 tcagaggtca ccatcagcaa aagacaataa tcaccctgga gatcttggat ggggaaaccc
      961 taacgaatgg tctcatgagg ctgccatatc tttgatgtct gaagatgatg acgacacaag
     1021 ttcagaagcc acatcttcag ggaagtctgt agactatggc ttcatcagcg ctatcttgtt
     1081 cttggtcact ggtattttgc tagtgatcat ttcttatatt gtccctcggg aggtcacagt
     1141 ggatcccaac actgtggcag cccgggagat ggaacgccta gaaaaagaga gtgcaatgtt
     1201 aggtgcacac ctggaccgtt gtgtgatcgc tgggctctgc ctcctcaccc ttgggggagt
     1261 tgttctgtct tgcttgctga tgatgtctat gtggaagggg gagctctatc gtagaaatag
     1321 atttgcatct tccaaagagt ctgcaaaact ctatggttct ttcaacttca ggatgaaaac
     1381 tagtactaat gaagatactc tggaactgtc cttggtagag gaagatgcct ttgctgtaca
     1441 gagttagttc taaaatcctt gagagaacag ccatgtattt tatatgaaaa aaaaaaaagt
     1501 caagtgtgtc ctttatttgt ttgtcaagaa aagtgtttct ccccacaaac taaaagccac
     1561 tgagtgtttt gtttccatga atcttgtgta agaaagccta tgtaagttgt aaaaaaaaac
     1621 atggccagct aacccctact tgctgcaaac tgaaaactaa ttcacctgca atcaccatgg
     1681 gtttctactt caaaatactt ctgctgacct aaaattaagt tgtcttatac atcaacatag
     1741 acactattac aagggactag aagggcttct gcagaatttg agcacttggc aatctattcc
     1801 gtgaaacata agcactaatt aaatagtaag gcttacattt aattcccaaa ggtgctttcc
     1861 cattttcttg ttgaattttc ttcctctaat ttgactaaac tctaaaatgt aaactttggc
     1921 agtgtgaata ttttgaaatc taaggatgtt ggttattttt taaagcctat aagatattat
     1981 attttaaatt attactgtat ttagaagtga caactatgtc attaatatgg accatctact
     2041 aaagataaga atacaaatct tcagacccat gtgaggtcaa caaactgtta tcacaaggta
     2101 ttttccttaa gccttctttc ccaatgaact agaagtgttt gctgatacat tgtttcctgc
     2161 ttgtggattt gtactcagct tgatgagttg tgcccttgaa atctttacca cttctcatat
     2221 atgtgtggag aagtgttaga cttttaaaac ctatctcctg gcagccacac atccagacaa
     2281 gtttgaacca tgagtgggct tggcatttgc tcaggtgaca tttgtgatga tggtttggag
     2341 aaaatgtcca ggatccttgc agctagactg gaactgtgcc tagcagaagc catgacttaa
     2401 agagtcctta accaaatctt acactgaaga gaggaaaagg aaacccactt atttagtggg
     2461 agttgtgttc attacaagtc ctgactcatc ttgtgatctc taaacatctt tcagagaaca
     2521 ttctacttca ggtccttaaa gaccatgctc ttgcctcata aagtgaaatg tctagcttat
     2581 gggaaatact gtgggaaaag tggtcaggaa agggatggga attcagccta agaaaggcct
     2641 tgaattccac tgatgtccct taaagtggcc ccaccctccc acttagtttt tttgttagta
     2701 tgttacaaaa accagtgagt tcattttcaa ggaagacgaa agccaggaat tcatgggagt
     2761 gaaagtatga gctaatgaga aagctatttc attgtagatt cttaagatca cctaagtcta
     2821 atgtagactt ctgtgttgtc attgaggagg tggggttaac tgtacgcata tctattatat
     2881 gaatgggctc ttgtggatat cagaaccatt tgttgagtta gctttgttaa gagttaaagg
     2941 aaaattaagt aagggaggga gaggtagaga tgacagcatg tcacagaatt cttaggcaaa
     3001 taatatatat atatatatat atatatatat atatatatat atatatcttc tctctgtaga
     3061 ataaagaact tgataatgaa gtactggttt actggccata aaggactaga aagaacttgc
     3121 attttgtgct ttctttttct gcaattctcc tgtcatctgt gctaaaggca cattcccaga
     3181 aggttacact ttacctttta gaggtatatt cagttttgac cgctgctaga ctgtttgagg
     3241 aactactttg gaaatattga ataaggtggg agaaatctac ttccatgggt ggatagatat
     3301 aagccaggtt caaactgtga cgacaaaatg taaaatcaaa tttaaactaa tttaaatcta
     3361 ggtctggtgg atcatgcctg gatcccaaca cttaggagac taaattgaga tcaacaaagc
     3421 catcttgatc tacatagtga gttccagaac agaatacaga gtgggactct gtttcacaac
     3481 atcaaaatat aataaaatat tcatgattat ttatatgaga tctctgaatt ctgtttttat
     3541 ttatttgtat cataattaaa tggttgcata gcaaataaga caggactcat ttgtggtcca
     3601 attttcagtt cttcatgact ttgaaagtta aacatgaaag ctgtattttc aatcctgtaa
     3661 aactgatgat aaaggaagaa aacagagttc ctcatatagg aaaagttagt gaacttacca
     3721 tgttgctaaa ttatacagat atgcccaaaa tgaagacagt actttttatt actattatta
     3781 tataattgtt ttttgcagtc cagtcattat ctgccctcta acagttcctc atcctattcc
     3841 tcccccatgc ctggactcca ggaggatgtt ccaccccaca ccccacacca cacctcacca
     3901 gaccttccca ctctctgggg cctcaagtct atcaaggttt aggagtgtct tctctcactg
     3961 aggccagacc aggcagtcct ctgctgtata tgtgtcaggg gcctcatatc agctggtgtg
     4021 tgctgcctgg ttggtacttt aaaaaaaacc catttcagaa aagaatttaa atgaagagtg
     4081 agcaaatgcc catttctgcc ttctctaaaa cgtctcaaac acagagagca tgacatttaa
     4141 cttctgccga cctgagggaa gatgcttata cccaatggga ccaattcaga aaatcacccg
     4201 gatgctttct ggaggctgtg ctgatgtaat tctaataatt gccttaactg actctcctcc
     4261 cggtattcta tttgtattgc cctcacccat tctgttagtg cctgactttg agatgattgc
     4321 ttgaatttaa aatgaagcta aggaatatgg acatgattca taggtacagt gtttgccttg
     4381 tgtatgggag gccctgagtg gagccctcag cactgcaaga aaataaaagt aaaggtaata
     4441 caggcaaaga aaaactctga accttctgca ctttttgcgt catattgatt tcagtacaat
     4501 gtagagtggt ttgggtacta gaattacctt ggcctgacca tgtgagaaac cagaaactgg
     4561 acagactcag gcagtgctct gaccttggat ctttctctgg cttcctgggt cgtcttccat
     4621 aagatgcctg ttgttatctg tggaagtttc cttagggtgt ggaagcttca ggcattacta
     4681 aacaaaccgt cccctttgcg agcattggaa actactgcag tgcttgttcg gttctctttg
     4741 cagtgccact gcctggccag tcatttggaa ttccggacgt gtccatgcag tgggatatgc
     4801 tggcccttta tgatgtgaat ctttcttggg tctcctgcta ggtatctaat ttgtgattta
     4861 gaagactaga aggctccaag ggatcaccaa actctctctg acctggggtg ttttcagcca
     4921 tgtgactaag ttcctcaaaa acttaaaata tacgagccca tcctctccct ttttttaaaa
     4981 aaatgtggat tgaggcccag tttgaccagg tctagcacat atatctttta ggtagaaatg
     5041 agactaaaca aactgccaca ccagatgttc tgggccttct tttcctttac ccctagagtg
     5101 aaatcaaata attaaatatg caccataata atcgaatata aagaatgaag gatctgagtg
     5161 tgtatatatt cctgttttct tttaaatttc tttagaataa gcatcttaaa taattacatc
     5221 tgaacattct gaatttaatc tgttaaatgt atatgcatat gattaatggt cagagcaaaa
     5281 gaagaaatac ctctgtatct atttgaagct tttcaatcca aaatttgatt ccactgcagc
     5341 aactcaggct accacagaaa tgtggcctga caaaagggat tcacaatgct tgtcaatgct
     5401 tccctggtgg cagcaagata taatatcatt ggctggatct gactgcccca aagaacaagt
     5461 cccatccttc cagctatctg gaatggcttt agcttttatg agacagggca gaaacaatca
     5521 ccatgatgag gagaattaaa atgaagtccc agtaggcttc tctcagcacg ggagaactca
     5581 gaagacataa ttaacagttt tgactgtcgg cctctttttg gctatatctt tttatggtac
     5641 acacagtatt ctataaaata tctctttcag tttttatggg tgtacaactt tggaactaat
     5701 ttggctgagt gatagtaata ctatcaactg caagatgttc ctgcaaatgc agaattgctt
     5761 ttaaaaacac tcatgacttt aattgctttt gtttttaagt atgcaggttg atgtgtacaa
     5821 gcctgcatat atgctagggt gtgtctcata agtacataac tttaatattc ctaagctatt
     5881 cttagtttaa agccttattg gaatttgtct tgccttaagg tcaattctgt gaacaagaag
     5941 tctttcacag gtaactataa agagtttgga ataaacctca gaatgaaata ctataaatat
     6001 acaaaccttc tttgctgttg ttgttcaaag tctcccaatg ctttctgatt tcttttcaac
     6061 cttgcaatta taagctcata agtatgcaga atatttataa atgatcttac cttgagttac
     6121 agttttctta ctgagaaatg tggataacaa tgtccttggc tccaatgttg agtgactcct
     6181 ctgtggttca gaaatagctt gtcttacttc tcatctctgt ctgaatgctt cctatacaga
     6241 atgcaagcaa gtttgagtat gaaggcaaag atggattctc cctctgctgt gtatttctct
     6301 gagattctct tctgactttt cattctactt tccttgccaa atcgaagtaa ttgatgttgg
     6361 tttgtatttt ctgatattat gaaggcaatc ataaacatga tgggctttcc cctcctggca
     6421 cttatactat ataaaatata aatctttatt gagaagtttt cagtgtgttt aacttttatt
     6481 gacctctaat ataatgcata tttgaccttt taaaattatc ttctaaaatt attcatgtac
     6541 aagaaaaaaa taaaaggaat atttactc
//
