LOCUS       NM_001109258            1766 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus transmembrane protein 70 (Tmem70), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001109258 XM_001062611 XM_575742
VERSION     NM_001109258.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1766)
  AUTHORS   Mizukami S, Yafune A, Watanabe Y, Nakajima K, Jin M, Yoshida T and
            Shibutani M.
  TITLE     Identification of epigenetically downregulated Tmem70 and Ube2e2 in
            rat liver after 28-day treatment with hepatocarcinogenic
            thioacetamide showing gene product downregulation in hepatocellular
            preneoplastic and neoplastic lesions produced by tumor promotion
  JOURNAL   Toxicol Lett 266, 13-22 (2017)
   PUBMED   27914986
  REMARK    GeneRIF: The effect of thioacetamide on neoplastic liver changes
            and hypermethylation and downregulation of proteins, especially
            Tmem70 and Ube2e2, are reported.
REFERENCE   2  (bases 1 to 1766)
  AUTHORS   Cizkova A, Stranecky V, Mayr JA, Tesarova M, Havlickova V, Paul J,
            Ivanek R, Kuss AW, Hansikova H, Kaplanova V, Vrbacky M, Hartmannova
            H, Noskova L, Honzik T, Drahota Z, Magner M, Hejzlarova K, Sperl W,
            Zeman J, Houstek J and Kmoch S.
  TITLE     TMEM70 mutations cause isolated ATP synthase deficiency and
            neonatal mitochondrial encephalocardiomyopathy
  JOURNAL   Nat Genet 40 (11), 1288-1290 (2008)
   PUBMED   18953340
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062611.1, XM_575742.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213707.1, BE113141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..1766
                     /gene="Tmem70"
                     /gene_synonym="RGD1566224"
                     /note="transmembrane protein 70"
                     /db_xref="GeneID:500384"
                     /db_xref="RGD:1566224"
     exon            1..318
                     /gene="Tmem70"
                     /gene_synonym="RGD1566224"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..882
                     /gene="Tmem70"
                     /gene_synonym="RGD1566224"
                     /codon_start=1
                     /product="transmembrane protein 70, mitochondrial"
                     /protein_id="NP_001102728.1"
                     /db_xref="GeneID:500384"
                     /db_xref="RGD:1566224"
                     /translation="MLLPMVSRWTAGLWHGRTRTSWCAAAALRDSRVVLRRAALRTEP
                     ARLRSGVLLPLAEPLGSPGRAQIPVCWRPCVCLLHTQVGKPEDGRLIYTGNLARTVFG
                     VKCFSYSTSVVSLAFLPYLLSQSNMMFGSLPLQVLFYGVMGSFTVITPTLLHFLTKGY
                     VIRLYHEATTDTYRAITYNVVLSESSTVFHQGDVTVPESAHIFTTFYAKTKSLLVNPA
                     LFVNPEDYNHLMGYDKPFTFDMEEVNEKKLHEGEK"
     exon            319..424
                     /gene="Tmem70"
                     /gene_synonym="RGD1566224"
                     /inference="alignment:Splign:2.1.0"
     exon            425..1766
                     /gene="Tmem70"
                     /gene_synonym="RGD1566224"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taccgcgtgt tcaacttaag gggcggagcc tcacctctct gactgctact gtagtgtaaa
       61 gtcgcttttt ggcgtctttg gccgctgctg caaaccgaca gcctccatcc aacccgcagc
      121 atgttgttgc ctatggtcag ccggtggaca gcaggcctat ggcacggccg gactaggacg
      181 tcgtggtgtg cggccgccgc gctccgagat tccagggtcg tcctccggcg tgcggccttg
      241 cgcactgagc ccgcgcgact gcggagcggc gtgctcctgc cgctagccga gcctttgggg
      301 tcacccgggc gagcgcagat acctgtttgt tggagaccat gtgtctgcct cttacataca
      361 caagttggta aaccagaaga tggcaggctg atttatactg ggaacctggc ccggacagta
      421 tttggtgtga aatgtttctc ttattctaca agtgtggtca gccttgcatt cttaccgtac
      481 cttctctcac aaagtaacat gatgtttgga agtctgcctt tgcaagtctt attttatgga
      541 gtcatgggga gcttcacggt gatcactccc acgctgcttc actttcttac aaaaggctat
      601 gtcattcggt tgtaccatga agccacaaca gatacttaca gagccattac ttacaatgtt
      661 gtgctttcag aaagcagcac agtgtttcac cagggtgacg tgacagttcc agagagtgca
      721 cacatattta ccacttttta tgctaaaaca aaatcgctat tggttaatcc agcactcttt
      781 gtaaaccctg aagactataa ccatctaatg ggttatgaca aaccattcac ttttgatatg
      841 gaagaagtca atgaaaagaa actgcacgag ggtgagaaat gaacctgttc tttgtctgtg
      901 cttaaatgtc atgcattttt agctaacaat aataataata ttgcctttac tttgttattg
      961 ttttctagtg agtgattgtt aaaaacataa aacaagtgta agtaagggct gaggacgcag
     1021 tagttggtac tgtgtttgcc atatgtgagg ccctaggatc ggccttcatt tacccagtgt
     1081 gcttttgtac agctataatg ccagcacagc ggacatggag ggaggaagat cagaaatttg
     1141 aggtcatctt ggttatgtag taggtctgag gtcaacctgg accttgtctt aaaaacagaa
     1201 attgaaatta tcgagtagaa ttttgaataa tttttacatg acaatgttcc tatgtaataa
     1261 aatatgttta attaagaaca agttgtcttt gtttaaaatg tgggtggtca tgtgtattct
     1321 ggtatatgta tggctacatt tatttgctga tattgttttt agagagaatc tcactatgta
     1381 agctgaatgt ctggaactta ctgtgaatta atagagacca gagatctatc ctcttctgtg
     1441 tgtgccaata catctgggcc atgaatggat agagtaagag taggtgccta ggactggaga
     1501 gatggctcag cggttaagag cactgtctgc tcttccagag gtcctgagct caattcccag
     1561 caaccacatg gtggctcgca accaactata ctggggtctg atgtcctctt ctggtgtgtc
     1621 tgaagacagc tacagtgtac tctacataaa ataaatatta aaaaaggtat gccaccacta
     1681 cccagtatgt gtttgagttt ttgtttgttt gtttttggct ctggtttttt tatttgtttt
     1741 gtttttagtt ttttaattat taaaat
//
