LOCUS       NM_001107916            4035 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus transmembrane protein 67 (Tmem67), mRNA.
ACCESSION   NM_001107916 XM_001053339 XM_232818
VERSION     NM_001107916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4035)
  AUTHORS   Shim,J.W., Territo,P.R., Simpson,S., Watson,J.C., Jiang,L.,
            Riley,A.A., McCarthy,B., Persohn,S., Fulkerson,D. and
            Blazer-Yost,B.L.
  TITLE     Hydrocephalus in a rat model of Meckel Gruber syndrome with a
            TMEM67 mutation
  JOURNAL   Sci Rep 9 (1), 1069 (2019)
   PUBMED   30705305
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4035)
  AUTHORS   Szabo,T., Orosz,P., Balogh,E., Javorszky,E., Mattyus,I.,
            Bereczki,C., Maroti,Z., Kalmar,T., Szabo,A.J., Reusz,G.,
            Varkonyi,I., Marian,E., Gombos,E., Orosz,O., Madar,L., Balla,G.,
            Kappelmayer,J., Tory,K. and Balogh,I.
  TITLE     Comprehensive genetic testing in children with a clinical diagnosis
            of ARPKD identifies phenocopies
  JOURNAL   Pediatr Nephrol 33 (10), 1713-1721 (2018)
   PUBMED   29956005
REFERENCE   3  (bases 1 to 4035)
  AUTHORS   Strongin,A., Heller,T., Doherty,D., Glass,I.A., Parisi,M.A.,
            Bryant,J., Choyke,P., Turkbey,B., Daryanani,K., Yildirimli,D.,
            Vemulapalli,M., Mullikin,J.C., Malicdan,M.C., Vilboux,T., Gahl,W.A.
            and Gunay-Aygun,M.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Characteristics of Liver Disease in 100 Individuals With Joubert
            Syndrome Prospectively Evaluated at a Single Center
  JOURNAL   J Pediatr Gastroenterol Nutr 66 (3), 428-435 (2018)
   PUBMED   29112083
REFERENCE   4  (bases 1 to 4035)
  AUTHORS   Fleming,L.R., Doherty,D.A., Parisi,M.A., Glass,I.A., Bryant,J.,
            Fischer,R., Turkbey,B., Choyke,P., Daryanani,K., Vemulapalli,M.,
            Mullikin,J.C., Malicdan,M.C., Vilboux,T., Sayer,J.A., Gahl,W.A. and
            Gunay-Aygun,M.
  TITLE     Prospective Evaluation of Kidney Disease in Joubert Syndrome
  JOURNAL   Clin J Am Soc Nephrol 12 (12), 1962-1973 (2017)
   PUBMED   29146704
REFERENCE   5  (bases 1 to 4035)
  AUTHORS   Lambacher,N.J., Bruel,A.L., van Dam,T.J., Szymanska,K.,
            Slaats,G.G., Kuhns,S., McManus,G.J., Kennedy,J.E., Gaff,K.,
            Wu,K.M., van der Lee,R., Burglen,L., Doummar,D., Riviere,J.B.,
            Faivre,L., Attie-Bitach,T., Saunier,S., Curd,A., Peckham,M.,
            Giles,R.H., Johnson,C.A., Huynen,M.A., Thauvin-Robinet,C. and
            Blacque,O.E.
  TITLE     TMEM107 recruits ciliopathy proteins to subdomains of the ciliary
            transition zone and causes Joubert syndrome
  JOURNAL   Nat Cell Biol 18 (1), 122-131 (2016)
   PUBMED   26595381
REFERENCE   6  (bases 1 to 4035)
  AUTHORS   Dawe,H.R., Smith,U.M., Cullinane,A.R., Gerrelli,D., Cox,P.,
            Badano,J.L., Blair-Reid,S., Sriram,N., Katsanis,N.,
            Attie-Bitach,T., Afford,S.C., Copp,A.J., Kelly,D.A., Gull,K. and
            Johnson,C.A.
  TITLE     The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and
            are required for primary cilium formation
  JOURNAL   Hum Mol Genet 16 (2), 173-186 (2007)
   PUBMED   17185389
REFERENCE   7  (bases 1 to 4035)
  AUTHORS   Baala,L., Romano,S., Khaddour,R., Saunier,S., Smith,U.M.,
            Audollent,S., Ozilou,C., Faivre,L., Laurent,N., Foliguet,B.,
            Munnich,A., Lyonnet,S., Salomon,R., Encha-Razavi,F., Gubler,M.C.,
            Boddaert,N., de Lonlay,P., Johnson,C.A., Vekemans,M., Antignac,C.
            and Attie-Bitach,T.
  TITLE     The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert
            syndrome
  JOURNAL   Am J Hum Genet 80 (1), 186-194 (2007)
   PUBMED   17160906
REFERENCE   8  (bases 1 to 4035)
  AUTHORS   Smith,U.M., Consugar,M., Tee,L.J., McKee,B.M., Maina,E.N.,
            Whelan,S., Morgan,N.V., Goranson,E., Gissen,P., Lilliquist,S.,
            Aligianis,I.A., Ward,C.J., Pasha,S., Punyashthiti,R., Malik
            Sharif,S., Batman,P.A., Bennett,C.P., Woods,C.G., McKeown,C.,
            Bucourt,M., Miller,C.A., Cox,P., Algazali,L., Trembath,R.C.,
            Torres,V.E., Attie-Bitach,T., Kelly,D.A., Maher,E.R., Gattone,V.H.
            2nd, Harris,P.C. and Johnson,C.A.
  TITLE     The transmembrane protein meckelin (MKS3) is mutated in
            Meckel-Gruber syndrome and the wpk rat
  JOURNAL   Nat Genet 38 (2), 191-196 (2006)
   PUBMED   16415887
  REMARK    GeneRIF: We have refined MKS3 mapping to a 12.67-Mb interval
            (8q21.13-q22.1) that is syntenic to the Wpk locus in rat, which is
            a model with polycystic kidney disease, agenesis of the corpus
            callosum and hydrocephalus.
REFERENCE   9  (bases 1 to 4035)
  AUTHORS   Gattone,V.H. 2nd, Tourkow,B.A., Trambaugh,C.M., Yu,A.C., Whelan,S.,
            Phillips,C.L., Harris,P.C. and Peterson,R.G.
  TITLE     Development of multiorgan pathology in the wpk rat model of
            polycystic kidney disease
  JOURNAL   Anat Rec A Discov Mol Cell Evol Biol 277 (2), 384-395 (2004)
   PUBMED   15052665
REFERENCE   10 (bases 1 to 4035)
  AUTHORS   Nauta,J., Goedbloed,M.A., Herck,H.V., Hesselink,D.A., Visser,P.,
            Willemsen,R., Dokkum,R.P.E.V., Wright,C.J. and Guay-Woodford,L.M.
  TITLE     New rat model that phenotypically resembles autosomal recessive
            polycystic kidney disease
  JOURNAL   J Am Soc Nephrol 11 (12), 2272-2284 (2000)
   PUBMED   11095650
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On May 30, 2008 this sequence version replaced NM_001107916.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1094014.1,
                                           SRR26360194.202952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000005.1  30386424-30386666   c
            244-332             JAXUCZ010000005.1  30384857-30384945   c
            333-426             JAXUCZ010000005.1  30377453-30377546   c
            427-526             JAXUCZ010000005.1  30374847-30374946   c
            527-596             JAXUCZ010000005.1  30373041-30373110   c
            597-671             JAXUCZ010000005.1  30372874-30372948   c
            672-734             JAXUCZ010000005.1  30370952-30371014   c
            735-889             JAXUCZ010000005.1  30368933-30369087   c
            890-998             JAXUCZ010000005.1  30368711-30368819   c
            999-1076            JAXUCZ010000005.1  30367857-30367934   c
            1077-1142           JAXUCZ010000005.1  30367309-30367374   c
            1143-1299           JAXUCZ010000005.1  30364900-30365056   c
            1300-1423           JAXUCZ010000005.1  30364087-30364210   c
            1424-1529           JAXUCZ010000005.1  30362754-30362859   c
            1530-1586           JAXUCZ010000005.1  30359473-30359529   c
            1587-1685           JAXUCZ010000005.1  30358454-30358552   c
            1686-1784           JAXUCZ010000005.1  30347831-30347929   c
            1785-1871           JAXUCZ010000005.1  30347533-30347619   c
            1872-1971           JAXUCZ010000005.1  30346437-30346536   c
            1972-2111           JAXUCZ010000005.1  30346204-30346343   c
            2112-2252           JAXUCZ010000005.1  30344128-30344268   c
            2253-2333           JAXUCZ010000005.1  30340937-30341017   c
            2334-2450           JAXUCZ010000005.1  30340348-30340464   c
            2451-2567           JAXUCZ010000005.1  30337502-30337618   c
            2568-2672           JAXUCZ010000005.1  30337299-30337403   c
            2673-2775           JAXUCZ010000005.1  30336540-30336642   c
            2776-2918           JAXUCZ010000005.1  30335674-30335816   c
            2919-4035           JAXUCZ010000005.1  30333793-30334909   c
FEATURES             Location/Qualifiers
     source          1..4035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..4035
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /note="transmembrane protein 67"
                     /db_xref="GeneID:313067"
                     /db_xref="RGD:1586167"
     exon            1..243
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2999
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /note="meckelin; Meckel syndrome type 3 protein homolog;
                     Wistar polycystic kidney"
                     /codon_start=1
                     /product="meckelin precursor"
                     /protein_id="NP_001101386.3"
                     /db_xref="GeneID:313067"
                     /db_xref="RGD:1586167"
                     /translation="MGMGTMVMRTRPLAAMAVRSCFSALTGTVYLLLVLCEVSWAQIF
                     SFPFQRPETCDLNQYFDISALSCAPCGANQRRDALGTSCICLPGYHMISNNGGPSIIC
                     KKCPENMKGVTKDGWDCISCPNGLTAEGKCHCPSGHILVERNVSGSLLSQATCELCDG
                     NENSFTKPNALGVRCVRCEPTFVNTSRSCSCSEPHISTGGLCFSNTGNFPQRLISTER
                     YGELGMSSNSEWFTKYLQATAAACWTHSNLTSCQALGNMCVMNMNSYDSTTFDACRLF
                     HYVFEGAAGLTGVHSVPFWRQNLPWLFYGDQPGLASQVLSTTPLPTNFSFKGQNQLKF
                     VAASYDIRGNFIRWQTVKGGVLQLCPDTERRLDAAYSFGTTYQQNCEISLSKLLADFP
                     SPVFYDIYLEYTDEVQHHYLWAIPVLNLNLQHNKLFVNQDSSSSKWLLTRRIFLVDAV
                     SGRENDLGNQPRVIRVATQISLSIRLVPNTKNGNIYTPLLTIAYSDIDIKNAYSQSVK
                     ISFSVKYEMNQGDAFVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVMKFL
                     LYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPVQEERFVTYVGCAFAMKAL
                     QFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEI
                     QTVRKINPLFQVLTTLFFLEVVGFKNLALMDPSSSLSRSLSDYAAPYSRILRYAVATT
                     IWLVIGIVQAVFFAAFYERFIEDKIRQFVDLCSMSNVSVFLLSHRCFGYYIHGRSVHG
                     HADTNMEDMNMNLRREAENLCSQRGLVPNTDGQTFQIAVSSQMRQHYDRIHETLTRRN
                     GPARLLSSSGSTLEQSIKAYHAMNKFLGSFIDHVHKEMDYFIKDKLLLEKILGMEFME
                     PLEKSIFYNDESHSFSSVLYYGNEATLLIFDLLFFCVVDLACQNFVLASFLTYLQQEI
                     FRFIRNTVGQKNLATKTLVDERFLI"
     exon            244..332
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            333..426
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            427..526
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            527..596
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            597..671
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            672..734
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            735..889
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            890..998
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1076
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1142
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1299
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1423
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1529
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1586
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1685
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1784
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1871
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1971
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2111
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2252
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2333
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2450
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2567
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2672
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2775
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2918
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..4035
                     /gene="Tmem67"
                     /gene_synonym="Mks3; Wpk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaccatggg tatgggtacc atggtgatgc gtacaaggcc tttggcggcc atggcggtca
       61 ggtcctgttt ttcagctctg actggcactg tgtaccttct cttggttctt tgcgaagtct
      121 catgggccca aatcttctcc ttccctttcc agcggccgga gacttgcgat ctcaaccagt
      181 acttcgacat ctcggcgctc tcctgtgccc cctgtggagc caaccagcgg agggacgcac
      241 tgggaacttc ctgtatatgt ctaccaggat atcatatgat ttctaataat ggaggacctt
      301 ccattatttg taaaaagtgt ccagaaaaca tgaaaggtgt taccaaagat ggctgggact
      361 gcatttcttg ccctaatggt ttaactgctg aggggaagtg ccactgtccc agtggccata
      421 tattagtgga aagaaatgtt agcgggtctt tgttatccca agcaacttgt gagctttgtg
      481 atggaaatga aaactcgttt acaaaaccca atgctttagg agtcaggtgt gtccgctgcg
      541 aaccaacatt cgtgaataca agccggtcgt gttcatgttc agagcctcac atttcgacag
      601 gtggattatg tttcagcaac acagggaatt ttcctcaacg tttaatttcc actgaacgtt
      661 atggcgagct tggcatgtca tcaaactcag aatggtttac aaagtatttg caggcaacag
      721 cagctgcatg ctggactcac agcaacctga catcttgcca agctctcggg aatatgtgcg
      781 tgatgaacat gaactcttac gactcgacta cattcgatgc ttgccgactg ttccactacg
      841 tcttcgaagg cgctgctggg ctgaccggcg tgcattctgt cccgttctgg agacagaacc
      901 ttccttggct gttttacgga gaccagccag gattggcttc tcaagttctc agtactaccc
      961 ctcttcctac aaatttcagt tttaaaggac aaaaccagct gaagtttgtt gctgcttcct
     1021 acgatatacg aggaaacttc atcagatggc aaactgtaaa aggtggtgtt ctacagcttt
     1081 gtccagacac cgagagaaga ctagatgctg catattcttt tggaacaacg taccagcaaa
     1141 actgtgaaat ctctctctct aaactcctgg ctgactttcc cagtcctgtg ttttatgata
     1201 tttacctgga atatactgat gaagtgcaac atcattacct ttgggctatc ccagtgttaa
     1261 acctcaatct tcaacataat aaactgtttg tgaaccaaga cagtagctcc agcaagtggc
     1321 ttctgactcg gcgcattttc ttagtggatg cagtaagtgg acgagaaaat gacctaggaa
     1381 atcagccaag agtaattcga gttgctaccc agatatcact gagcatacgc cttgtaccca
     1441 acacaaagaa tggaaacatc tacactccct tactcaccat tgcctacagt gacattgaca
     1501 tcaaaaatgc ttatagccag tctgtgaaga tttccttctc agtgaaatat gagatgaatc
     1561 aaggagatgc atttgtccag acagatattg ctttgggtgt gttgggcggg ctggctgtgc
     1621 tatcatctct cttgaagacg gcagggtgga agagacgcat tgggagcccc atgattgacc
     1681 tacagacagt tatgaaattc ctgctgtact acgctggtga cctggccaat gtgtttttca
     1741 tcatcactgt ggggacaggg ctttattggc ttattttctt caaagcacag aagtctgtct
     1801 ctgttttgct gccgatgccg gttcaggaag aacgtttcgt tacttatgtg gggtgtgcct
     1861 ttgctatgaa ggctctacaa tttttgcaca agctcatatc ccagattacc atagatatat
     1921 tctttattga ttgggaacgg ccgaaaggaa aagttctcaa agctgtcgaa ggtgagggtg
     1981 gtgtgcggag tgccactgtt cctgtgagca tatggagaac gtattttgtg gcaaatgaat
     2041 ggaacgagat tcagactgtg agaaaaatca atccactctt tcaagtactt accacgctct
     2101 tcttcttgga ggtggtggga ttcaaaaact tagcgttaat ggatccatcc tcgagccttt
     2161 ctagaagcct gtcagactac gcagctcctt acagtcgcat tttgagatac gctgtggcta
     2221 ccactatctg gctggtgatc ggaatagtcc aggctgtttt ctttgctgcc ttttatgaga
     2281 gattcataga agacaaaatc cggcagttcg ttgacctgtg ctccatgagt aacgtgtcag
     2341 tgttcctgct gtcccacaga tgttttggat attacattca cggcaggtca gtccacggcc
     2401 atgcggacac caacatggag gacatgaaca tgaacctgag gcgagaggcg gaaaatttgt
     2461 gcagtcaaag aggtttggtg cccaacacag atgggcagac gtttcagatt gccgtttcca
     2521 gtcagatgag acagcactat gacagaattc acgagacatt aacaaggaga aatggccctg
     2581 ccagactgct gagctcatca gggagtacct tggaacaaag tataaaggca taccacgcaa
     2641 tgaataagtt cctcggctct ttcattgacc acgttcataa ggaaatggat tacttcataa
     2701 aagacaagtt gcttctcgaa aagatcctcg ggatggagtt catggagccc ctggagaaga
     2761 gcatcttcta caatgatgaa agtcattctt tcagcagtgt gctgtattat gggaacgagg
     2821 ccactctcct tatctttgat ctgttgttct tctgtgtcgt ggacttggct tgccagaact
     2881 ttgttttagc atccttcctc acctacctgc agcaagagat ttttcgattt atccgaaata
     2941 cagtaggaca aaagaattta gcaaccaaaa cactagtgga tgaaagattt ctgatctaat
     3001 ctgtgatgca aaacctgagg actcagtata atggggccaa gccgtgatgt caggctatct
     3061 tttgtaaaac tcgtaataca tattattctt ccttttttta tctacagaaa gatttatttt
     3121 tatagcttgt aaaatataag atatagtaga aatactattt ccccattatg tgttgtattt
     3181 aatttactaa ataatgcatt aacgctgacc aggaggcgaa caaataaaca acacaaaaca
     3241 aagccaaccc ctcccaatcc cactttccat gctttcccag gccttgatgg caagctaacc
     3301 ccagcactgt cgtttcagaa caggacctgc ctgcttttcc tcacagctta aatctatttt
     3361 tctaggctca aaactactgt tctgttcagt attttcacat tttattaata ttcgtggtta
     3421 aataaatttt aagaggtatt ttcagattta atttggttcg cgttactgat gactctaata
     3481 gctcaccctg tctgtcagta ggtgggtccg tccccactag acaaagcatc cagtcctttt
     3541 atgtacctgg ttcctgatgt cattacattt gttaaactgg gtgatatttt tcacaatata
     3601 ggattttttc acgtactttg atattttaag agtacttctc caaagtgttg cttttcaatt
     3661 atgactaaat attacaaata atagaccata aatatatcac cttatgttga ccaatttatt
     3721 ggaagcaaac ttcgacttca tgaggcagta gcttattttc tactaaggaa aataaatgga
     3781 ttcaagatac ttttacagta aatcctgaac catatagtcg atctttttct attttcccct
     3841 cagtacactc ttaagtgtgt cttttcatgg tgtgtcatag acttggagag ccctggtgct
     3901 gctgatgatt gccacacccc cagacaacgt gtctgcttct cacaatgatg ctgtgtaaca
     3961 tgtaaacgca gtgctgtgta catactgtat atacctgtga attgaaaata gataataaaa
     4021 tattttacat tgcta
//
