LOCUS       NM_001100995            2946 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus transmembrane protein 65 (Tmem65), mRNA.
ACCESSION   NM_001100995 XM_001068872
VERSION     NM_001100995.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2946)
  AUTHORS   Nazli,A., Safdar,A., Saleem,A., Akhtar,M., Brady,L.I.,
            Schwartzentruber,J. and Tarnopolsky,M.A.
  TITLE     A mutation in the TMEM65 gene results in mitochondrial myopathy
            with severe neurological manifestations
  JOURNAL   Eur J Hum Genet 25 (6), 744-751 (2017)
   PUBMED   28295037
REFERENCE   3  (bases 1 to 2946)
  AUTHORS   Sharma,P., Abbasi,C., Lazic,S., Teng,A.C.T., Wang,D., Dubois,N.,
            Ignatchenko,V., Wong,V., Liu,J., Araki,T., Tiburcy,M., Ackerley,C.,
            Zimmermann,W.H., Hamilton,R., Sun,Y., Liu,P.P., Keller,G.,
            Stagljar,I., Scott,I.C., Kislinger,T. and Gramolini,A.O.
  TITLE     Evolutionarily conserved intercalated disc protein Tmem65 regulates
            cardiac conduction and connexin 43 function
  JOURNAL   Nat Commun 6, 8391 (2015)
   PUBMED   26403541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2946)
  AUTHORS   Nishimura,N., Gotoh,T., Oike,Y. and Yano,M.
  TITLE     TMEM65 is a mitochondrial inner-membrane protein
  JOURNAL   PeerJ 2, e349 (2014)
   PUBMED   24765583
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129127.1.
            
            On Aug 13, 2007 this sequence version replaced XM_001068872.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129127.1, FQ224194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2946
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /note="transmembrane protein 65"
                     /db_xref="GeneID:500874"
                     /db_xref="RGD:1563224"
     exon            1..556
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1056
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /codon_start=1
                     /product="transmembrane protein 65"
                     /protein_id="NP_001094465.1"
                     /db_xref="GeneID:500874"
                     /db_xref="RGD:1563224"
                     /translation="MSRLLPLLGSRTARSLRPGPVAAHRPPSWCSCGRGLLALGVPSG
                     PRLLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQACRFPKP
                     EMVLAKRAKEVSAAETPDSFEKLEALPPTPGQLRYVFFHNAIPFVGFGFLDNAIMIVA
                     GTQIELSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVD
                     MWQTRVSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETSN"
     exon            557..637
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
     exon            638..682
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
     exon            683..750
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
     exon            751..805
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
     exon            806..848
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
     exon            849..954
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
     exon            955..2922
                     /gene="Tmem65"
                     /gene_synonym="RGD1563224"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccgccgg taccgcccgc ccgctctgag ctcccggccc ggccgcggca cagaaagttt
       61 tcctgggctc acggcctgcg ggaagcggag cgggcacggc tgagaggcgg tcgctgcgcg
      121 ggcccgcaga gtgcatggtg ccgggcgccc gggccgctcg tctggaggac ccggggcggg
      181 gccgggctga gcccagctcc tgagcctctg tccagctgcg tccatagcga tcttcccttg
      241 ggactgccgc gggggtcgcg ctccagcgtc atgtcccggc tgctgccgct gctggggagc
      301 cggacggcgc gcagcctgag gccgggccct gtcgccgcgc accgcccgcc gtcctggtgc
      361 agctgcggcc ggggactgct ggctctcggg gtccccagtg gtccccggct tctgggcact
      421 caccccaaga aggagcccat ggaggcgctg aacacggcgc agggcgcgcg cgacttcatc
      481 tacagcctgc actccaccga aaggagctgc ttgctcaaag agctgcaccg cttcgagtcc
      541 attgccatcg cacaagcatg cagatttccc aaacctgaga tggtccttgc gaagcgtgcg
      601 aaggaggtgt cggcagcaga gacccctgat agttttgaaa aattggaagc tctaccaccc
      661 actccaggac agctgagata tgtattcttc cacaatgcga tacctttcgt agggtttggc
      721 tttttggata acgcaattat gattgttgca ggaacccaaa ttgaattgtc tattggaatt
      781 attttgggaa tttcaacaat ggcagctgct gctttgggaa atcttgtttc agatttagct
      841 ggacttggcc ttgcaggtta tgttgaggcc ttggcgtcca ggttaggcct ctcaattcct
      901 gatcttacac caaagcaagt tgacatgtgg caaacacgtg ttagcacaca tttgggcaag
      961 gctgttgggg tgacgatcgg ctgcattcta ggaatgttcc ctttgatttt ctttggagga
     1021 ggtgaagaag atgaaaaact ggaaacatca aattaatcat cttagaatac ctataaaaga
     1081 tgtaaactaa tgtacctcag tcattaaatc tactgtcaca acatttagca gacagtacca
     1141 gtgcatagat acgggatcaa ataattcagc atgtacttcg gaaacactaa cttattgtgg
     1201 cttggtcttc ttaagacatc tttttaacaa ctacttagta tcattttatg taaattattg
     1261 agatgctttt catcaatggc tgtcaacatg ttatcttttc cttctatgta tcaacatatt
     1321 atttaacttt cagtcattga tactgtactg tactgacttg gggtttgctt tcttacataa
     1381 cctgcacggg atacctattt atgtctttat tttttttccc tgatggacat aattcaatgc
     1441 tgaggtttct ccaaattatt taagatgttt aatatcagtt aaaaattgta actccctgcc
     1501 tggtggcatc ccttttgtgg tattttacgg taaacattta caatcatata aattcattca
     1561 atttttaaag ttccacatct tttcaaaaat gaaacagtgt tttaagtata tctgactatt
     1621 ttaattttga cccacactgt ctttaaaggt cagaggttaa tcagaaagaa caattgtctg
     1681 gccctccttt tacatacacc atacacgcta acaagtgtac ttatttctga ttggcttttt
     1741 acctttcatt tcccaacttt gagcaatcac agtgaattct ggtttgagag agaaggcagc
     1801 gcttggacac ttcctgtgtc ttagagtagg gttaagagag cagggtaact aagaaaccca
     1861 taatgatatt tggaaattag gctaaaaaaa ttttttttac agaaatagaa aatggaaatc
     1921 ttcaaggagg tctagggagt ggatgaccaa gttcaagtgg tatttgggaa gttcatgaag
     1981 catcggttct acgactttgg aaagattaat gtgttatttt ctcatggaat ggaatgagtc
     2041 tatgctcaga gtcccaatcg cattagatct tgctttgtga cttttttctg gaagagtgtt
     2101 ttagaaacaa catgtatttt ctgttgctct ttgctatcta gtcaaatgta acatgaggag
     2161 tgatcctttc tcctattttt gaactttttt cttctctcgt ggcgatcata gcacagctgg
     2221 tgaaagctgc ttgtgtctgt gttgtatgtc tgacctacac ggtcctgaga atcctgagta
     2281 tcctgagttt tagcttttga accctttccc gcatttgcta aaaagttaca tgtagcagaa
     2341 taagtgaaca taaggaaggg agagactgaa gttagaattt aatcctgggg aattaaaatt
     2401 attcatgtct gctgagtaga tggcaagaca aatgtcacat gaccatgctt tttaaatctt
     2461 acttgggagt tttgtttgca caaactttct ttgggctcct tttaaagatt tcttttccgt
     2521 aagaaatcac gtcacatatt gttccttttt gttctttggg gtaacttagt cctgtccttt
     2581 atcatagaat ttaaggaaag ataacataaa ggtaaaaaga catcaaattc tcatatacac
     2641 aagtaacatt ctcctttggt cacattagca tcacgtgact tgaggtcgca gacagactct
     2701 tctgtatctt tgtccacgtg tcacacagac agcaagcaca gggttcagga tgatagacta
     2761 gaaggcacct tttactttct gtgtaaacac gtgtgtgctg gtttccttac cttgcgtatt
     2821 ggtggttttc ctgtctttgt ttttaagtgt tgtattgtgg tgcttaactt ttctccttat
     2881 taaataccat ctccagaaac tcgtcttgga gtttagaaaa caaaaaaaaa aaaaaaaaaa
     2941 aaaaaa
//
