LOCUS       NM_001108045            3604 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus transmembrane protein 63c (Tmem63c), mRNA.
ACCESSION   NM_001108045 XM_001061327 XM_234431
VERSION     NM_001108045.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3604)
  AUTHORS   Schulz,A., Muller,N.V., van de Lest,N.A., Eisenreich,A.,
            Schmidbauer,M., Barysenka,A., Purfurst,B., Sporbert,A.,
            Lorenzen,T., Meyer,A.M., Herlan,L., Witten,A., Ruhle,F., Zhou,W.,
            de Heer,E., Scharpfenecker,M., Panakova,D., Stoll,M. and Kreutz,R.
  TITLE     Analysis of the genomic architecture of a complex trait locus in
            hypertensive rat models links Tmem63c to kidney damage
  JOURNAL   Elife 8, e42068 (2019)
   PUBMED   30900988
  REMARK    GeneRIF: Tmem63c is differentially expressed in glomeruli of
            allele-specific rat models during onset of albuminuria.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3604)
  AUTHORS   Zhao,X., Yan,X., Liu,Y., Zhang,P. and Ni,X.
  TITLE     Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers
            hyperosmolarity activated ion currents in HEK293 cells
  JOURNAL   Cell Biochem Funct 34 (4), 238-241 (2016)
   PUBMED   27045885
REFERENCE   3  (bases 1 to 3604)
  AUTHORS   Hou,C., Tian,W., Kleist,T., He,K., Garcia,V., Bai,F., Hao,Y.,
            Luan,S. and Li,L.
  TITLE     DUF221 proteins are a family of osmosensitive calcium-permeable
            cation channels conserved across eukaryotes
  JOURNAL   Cell Res 24 (5), 632-635 (2014)
   PUBMED   24503647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001061327.1, XM_234431.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3604
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3604
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /note="transmembrane protein 63c"
                     /db_xref="GeneID:314332"
                     /db_xref="RGD:1310207"
     exon            1..297
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            298..445
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            446..507
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            508..717
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..2982
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /codon_start=1
                     /product="calcium permeable stress-gated cation channel 1"
                     /protein_id="NP_001101515.1"
                     /db_xref="GeneID:314332"
                     /db_xref="RGD:1310207"
                     /translation="MTASPESMGQKFRNMTANECFQSRSTVLQGQPFGGIPTVLLLNI
                     ILWVCVVLVYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKSSPSEVYLEAERRDK
                     GFSTWFFNSLTMRDRDLINKCGEDARIYIMFQYHLIIFVLILCIPSLGIILPVNYIGS
                     ALDWSSHFGRTTIVNVSTESQFLWLHSIFAFMYFLTNFAFMGHHCLGFVPKKNLHFTR
                     TLMITYVPTEIQDPETISKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLY
                     YTAKAKKTGKVMIKVHPCSHLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVQ
                     LKRLDLIFVTFQDARTVKRIHNDYKYINCGRHPMQSSVTTIVKNNHWRVARAPHPKDI
                     IWKHLSIRRFSWWARFIAINTSLFFLFFFLTTPAIIINTIDMYNVTRPIEKLQSPVVT
                     QFFPSVLLWAFTVIMPLLVYFSAFLEAHWTRSNQNLIIMYKCYIFLVFMVVILPSMGL
                     TSLDVFLRWLFDIYYLEHATIRFQCVFLPDNGAFFINYVITSALFGTGMELMRLGSLC
                     TYCTRLFLSRSEPERVHIRKNLAMDFQFGREYAWMLNVFSVVMAYSITCPIIVPFGLL
                     YLCMKHITDRYNMYYSYAPTKLNAQIHMAAVYQAIFAPLLGLFWMLFFSILRVGSLHS
                     ITLFSLSSIIISVIIAFSGVFLGKFRIAQQYEQPEEETETVFDVEPSSTTSTPTSLLY
                     VATVLQEPELNLTPASSPARHTYGTMNSQPEEGEEESGLRGFARELDPAQFQEGLELE
                     GQSH"
     exon            718..797
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            798..879
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            880..917
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1060
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1109
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1218
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1292
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1373
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1497
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1631
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1754
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1908
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2015
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2102
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2168
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2331
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2437
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2605
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2715
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2787
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..3604
                     /gene="Tmem63c"
                     /gene_synonym="RGD1310207"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagttgttgc aaaccgcagc cagggagcgg cagccttgtg cattcgggat ggtcatggtt
       61 tctggtaact acaggacttc cagggcagag ccttggtctc tgcttatcta gtccgggttc
      121 ccccacaggt caaagcagcg ttgggcgggg ccaaggttgc ctcctactgg gaggagccgg
      181 gatgccactc ccgtggtgat gcagagagga atttgctgac agtcccttgc taggtggagc
      241 tggctttacc aggccgctaa aaagaaggag gaggacccac ccgcaatctt ctctcagatc
      301 tctgaaggaa ccactttagt cgtcaagaat cggtgagacg ctgtagggtc acttggaagc
      361 atttcttccc agagactggt cgagaactgg aaagcttggg gacatagcct ttcagcctga
      421 gctctcacca acacctgtgc cccagcaaac tgtagctgag tggatgccta agatctgacg
      481 tggaccttcc ttggagagct gcctcagagt ggggagtagt cccagagtcc aactgagacc
      541 ttctacctgg cggggagcct acgtgtgccc aggatgactg cttctccaga aagcatgggc
      601 caaaagtttc gaaacatgac ggcaaatgag tgtttccagt cccggagcac tgtccttcag
      661 gggcagccct ttggggggat ccccactgtg ctcttactca acatcatctt atgggtgtgc
      721 gttgtcttgg tttactcctt cctccggaaa gctgcgtggg actacgggcg cctggctctg
      781 ctgatacaca atgacagcct aacctcgctg atctacggag agcaaagtga gaagtcatcc
      841 ccctcagagg tttacttgga ggcagaacgc agggacaagg gcttctctac ctggttcttc
      901 aacagcctaa ctatgaggga ccgggacctg atcaacaagt gcggggaaga tgctcgaatt
      961 tacatcatgt tccagtatca cctcatcatc tttgtgctca tcctctgcat cccctccctg
     1021 ggcatcattt tgcctgttaa ctacattgga agtgctctgg actggagtag tcactttggt
     1081 cggaccacca ttgtcaatgt ctctacagag agccagttcc tgtggctgca cagcatcttt
     1141 gccttcatgt acttcctcac caacttcgcc ttcatgggtc atcactgctt gggatttgtg
     1201 ccaaagaaga acctccattt cacgaggacg ctgatgatca cctacgttcc cactgaaatc
     1261 caggatcccg agaccatcag caagcacttc catgaggcct atcctgggtg tgtggtgacc
     1321 agagtccatt tctgctatga tgtcaggaac ctgattgact tggatgatca aagacgccat
     1381 gccatgaggg gcaggctcta ctacacagcc aaggctaaga agactgggaa ggtgatgatc
     1441 aaggttcatc cctgttccca cctgtgcttc tgcaagtgtt ggacctgctt taaggaggta
     1501 gatgcggagc agtactacag tgagttggaa gagcagctga cagatgagtt caatgctgag
     1561 ctcaatcgtg tccagctgaa gaggctcgac ctgatctttg tcaccttcca ggatgccagg
     1621 acagtgaaaa gaatccataa tgattacaag tacatcaatt gtggtagaca ccccatgcag
     1681 tcttcagtaa cgaccattgt caaaaacaac cactggaggg ttgctcgtgc ccctcacccc
     1741 aaagacatca tctggaaaca cctgtccatc cgccgcttca gttggtgggc tcgatttatc
     1801 gccatcaaca cctccctgtt cttcctcttc ttctttctca ccacgcctgc catcatcatc
     1861 aacaccatcg acatgtacaa tgtcacccgc cccattgaga aattgcagag ccccgtcgtg
     1921 actcagttct tcccctctgt gctgctctgg gccttcactg tgataatgcc tctgctggtc
     1981 tacttctccg ctttcctaga ggcccactgg acgagatcga atcagaacct gatcataatg
     2041 tacaaatgct acatcttcct ggtgtttatg gtggtcattc tgccctccat ggggctgact
     2101 agtctggatg tgtttttgcg ctggctcttt gacatctact atctcgaaca tgcaaccatc
     2161 aggttccagt gcgtgttcct tccagacaat ggtgcgttct ttatcaacta cgtgatcaca
     2221 tcagctctgt ttggcacagg catggagctg atgcgcctgg ggtcactctg cacatactgc
     2281 acccgcctct tcttatccag atcagagcca gagagagttc acatcagaaa gaatctggcc
     2341 atggatttcc aatttggacg agagtatgca tggatgttga acgtcttcag cgtggtgatg
     2401 gcatatagca tcacttgccc tataatcgtc ccgtttgggc tgctgtatct gtgcatgaag
     2461 cacatcacag accgctataa catgtactac tcctatgcgc ccaccaaact gaacgcgcag
     2521 atccacatgg ccgctgtcta ccaggccata tttgccccac tgttgggact cttctggatg
     2581 ctcttcttct caatcctgag agtaggttcc ctccacagca tcactttgtt ttccttgtcg
     2641 tcgatcatca tctccgtgat catcgccttt tctggcgttt ttctggggaa gttccggatt
     2701 gcccaacagt atgagcagcc tgaggaagaa acagagactg tgtttgatgt ggaaccaagc
     2761 agcaccacct ccactcccac ctcccttctg tacgtggcca ccgtgctaca ggaaccggag
     2821 ctgaacctga cccccgcctc ctccccagcc cggcacacct atggcaccat gaacagccag
     2881 ccagaagagg gagaagaaga gagtggtctg agaggctttg caagggagct ggacccagcc
     2941 cagttccagg aagggctgga actagagggc cagagccact gattaggact ccagctgagg
     3001 ggtcagggga gagcctggtg agggaaggca ggcaggagct ccctcccaca gactttggga
     3061 agctcctgac agacatctgc caccctgtgg ccctttgaag agccaaatct gctgaccagt
     3121 cagaaagggt gggctggagt ggaggaggct taggccatgt ttctgggact ggtagctgaa
     3181 gtccaggacc caagagacta tatgctgtgt gtcgtgctgg ggtcaagctg gtacgagtgt
     3241 gcataaggaa gaggtaggaa gaagcccact gacagctttc tggggggttc atcatcccct
     3301 acccaactcc agctgcccac caaggattgc tccagacccc catcctccac tgcagtctga
     3361 gcagagaaag gtatgtgtac tgggccttgt gaacaagata ccggtggctg tctcatcaca
     3421 ggtttcccta cagagcatct agaaactctg tacctcatcc tctgagcaag aggcagctgg
     3481 gacaagcctg gggagtgact gaggccttcc ctgtttctct gctctgctat ctacttataa
     3541 tggtagctgg gacacctact cgggctcatt aaaggagacc tacatgcatg tggtaaagga
     3601 aact
//
