LOCUS       NM_001139465            1513 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus transmembrane protein 59 (Tmem59), mRNA.
ACCESSION   NM_001139465
VERSION     NM_001139465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   Boada-Romero E, Letek M, Fleischer A, Pallauf K, Ramon-Barros C and
            Pimentel-Muinos FX.
  TITLE     TMEM59 defines a novel ATG16L1-binding motif that promotes local
            activation of LC3
  JOURNAL   EMBO J 32 (4), 566-582 (2013)
   PUBMED   23376921
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Ullrich S, Munch A, Neumann S, Kremmer E, Tatzelt J and
            Lichtenthaler SF.
  TITLE     The novel membrane protein TMEM59 modulates complex glycosylation,
            cell surface expression, and secretion of the amyloid precursor
            protein
  JOURNAL   J Biol Chem 285 (27), 20664-20674 (2010)
   PUBMED   20427278
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1513)
  AUTHORS   Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA and Weinmaster G.
  TITLE     Fringe glycosyltransferases differentially modulate Notch1
            proteolysis induced by Delta1 and Jagged1
  JOURNAL   Mol Biol Cell 16 (2), 927-942 (2005)
   PUBMED   15574878
REFERENCE   5  (bases 1 to 1513)
  AUTHORS   Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske
            WA, Morin D, Penn SG, Jovanovich SB, Plopper CG and Buckpitt AR.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   6  (bases 1 to 1513)
  AUTHORS   Wen T, Gu P and Chen F.
  TITLE     Discovery of two novel functional genes from differentiation of
            neural stem cells in the striatum of the fetal rat
  JOURNAL   Neurosci Lett 329 (1), 101-105 (2002)
   PUBMED   12161272
  REMARK    GeneRIF: Sequencing analyses showed that SHD10 shared a 94%
            (547/581) homology with mouse EST BI687817, but its biological
            function has not been reported. SHD11 shared a 91% (512/562)
            homology with mouse EST BG172336.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB704217.1, FM094601.1, FM091711.1 and CV126271.1.
            
            On Sep 19, 2012 this sequence version replaced NM_001139465.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214069.1, FQ231829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               CB704217.1         11-349
            340-847             FM094601.1         72-579
            848-891             FM091711.1         268-311
            892-1513            CV126271.1         69-690
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..1513
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /note="transmembrane protein 59"
                     /db_xref="GeneID:100196907"
                     /db_xref="RGD:1310313"
     exon            1..239
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1022
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /codon_start=1
                     /product="transmembrane protein 59 precursor"
                     /protein_id="NP_001132937.1"
                     /db_xref="GeneID:100196907"
                     /db_xref="RGD:1310313"
                     /translation="MAAPKGKLWVQAQVGLPPLLLLTMALAGGSGTAAAEAFDSVLGD
                     TASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTE
                     AYSQPDEQYACHLGCQDQLPFAELRQEQLMSLMPRMHLLFPLTLVRSFWSDMMDSAQS
                     FITSSWTFYLQADDGKIVIFQSKPEIQYAPQLEQEPADLRQSSLSKMSYLQMRNSQAH
                     RNYLEDEESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCAAVATAVEQYVPPEKLSI
                     YGDLEFMNEQKLSRYPAPSLVVVRSQTEEHEEAGPLPTKVNLAHSEI"
     exon            240..345
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
     exon            346..440
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
     exon            441..593
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
     exon            594..675
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
     exon            676..757
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
     exon            758..866
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1493
                     /gene="Tmem59"
                     /gene_synonym="Orf18; RGD1310313; Shd11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaaaagaa aacagcaaca attcgggctg ctgtgacaga ggggaacaag atggcggcgc
       61 caaaggggaa gctttgggtc caggcccagg tggggctccc gccgctgctg ctgctgacca
      121 tggcgctggc cggaggctcc ggaactgcag cggccgaagc gtttgactcg gtcctgggag
      181 acacggcgtc ctgtcaccga gcctgtcagc tgacctatcc tttgcacacc tacccgaagg
      241 aagaggagtt atacgcatgt cagagaggct gcaggctgtt ttcaatttgc cagttcgtgg
      301 atgatggaat tgatttaaat cgaaccaaac tggaatgtga atctgcgtgc acagaagcgt
      361 attcccagcc tgacgagcag tatgcgtgcc atctcggctg ccaggaccag ttgccatttg
      421 ctgaactgag acaagaacaa ctcatgtccc tgatgccaag gatgcacctc ctcttccctc
      481 tgactctggt gaggtccttc tggagcgaca tgatggactc tgcacagagc ttcataacct
      541 cttcatggac tttttatctt caagctgatg atggaaaaat agtcatattc cagtctaagc
      601 cggaaattca gtatgcaccg cagttggagc aggagcctgc agacttaaga cagtcatcgt
      661 taagcaaaat gtcctatcta cagatgagaa actcccaagc acacaggaac tacctggaag
      721 atgaagaaag cgatggcttt ttaagatgtc tgtctcttaa ctctgggtgg attttaacta
      781 cgactctggt gctctcggtg atggtgttgc tctggatctg ctgtgcagct gtggctacag
      841 ccgtggagca atacgtgccc cctgagaagc tgagtatcta tggtgacttg gagtttatga
      901 atgaacaaaa gctgagcaga tatccagctc cttccctcgt ggttgtcagg tctcagactg
      961 aagagcacga ggaggcgggg cccctgccca ccaaggtgaa tcttgctcac tcagaaatct
     1021 aagctttttt aaaaagtgtt gtcaacacat aaacttccat tcctcataga gctttttaaa
     1081 attgtttcat tggacatagg ccttaagaaa tcactatgag atgcaaataa aatgacccga
     1141 ccctgggaag actttatttg ctgtgacttt acctgtattt ttctagtcgt ttgagatgga
     1201 cattgggttg tatttcattt tactaatacc tgtagctact ttgttagttg ccttggtttt
     1261 ggttttttcc tctcttagcc aaattctatg agctgatcat tgttgccccg cccctgccat
     1321 gaccccgtca gtcacctcac ttaagctgaa aacttaggat gtgatgcttc tgcccggaaa
     1381 tggcctccaa actgtactct gaattatagc agaaaatgtt atttaatgac actacatttt
     1441 cagttgtatt gaattgaaat cattaaaatt tatttgaata attatgtact gaaaaaaaaa
     1501 aaaaaaaaaa aaa
//
