LOCUS       NM_001025014            2289 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus transmembrane protein 50B (Tmem50b), mRNA.
ACCESSION   NM_001025014 XM_340968
VERSION     NM_001025014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Moldrich RX, Laine J, Visel A, Beart PM, Laffaire J, Rossier J and
            Potier MC.
  TITLE     Transmembrane protein 50b (C21orf4), a candidate for Down syndrome
            neurophenotypes, encodes an intracellular membrane protein
            expressed in the rodent brain
  JOURNAL   Neuroscience 154 (4), 1255-1266 (2008)
   PUBMED   18541381
  REMARK    GeneRIF: Tmem50b is a developmentally-regulated intracellular ER
            and Golgi apparatus membrane protein that may prove important for
            correct brain development through functions associated with
            precursor cells and glia.
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem
            P, Lehrach H, Yaspo ML and Janitz M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091349.1.
            
            On Jun 25, 2005 this sequence version replaced XM_340968.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091349.1, CK476801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663608, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2289
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /note="transmembrane protein 50B"
                     /db_xref="GeneID:360698"
                     /db_xref="RGD:1307561"
     exon            1..117
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /inference="alignment:Splign:2.1.0"
     exon            118..257
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..635
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /codon_start=1
                     /product="transmembrane protein 50B"
                     /protein_id="NP_001020185.1"
                     /db_xref="GeneID:360698"
                     /db_xref="RGD:1307561"
                     /translation="MAGFLDNFRWPECECIDWSERRNTVASVVAGILFFTGWWIMIDA
                     AVVYPKPEQLNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYESGCLGRTGARVWLFIG
                     FMLMFGSLIASMWILFGAYVTQNIDVYPGLAVFFQNALIFFSTLIYKFGRTEELWA"
     exon            258..370
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /inference="alignment:Splign:2.1.0"
     exon            371..438
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /inference="alignment:Splign:2.1.0"
     exon            439..531
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /inference="alignment:Splign:2.1.0"
     exon            532..589
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /inference="alignment:Splign:2.1.0"
     exon            590..2266
                     /gene="Tmem50b"
                     /gene_synonym="RGD1307561"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacgggcc tcgggctcca ccgctgaggt tgagccggct gctgctgccc gggccgacgc
       61 gcgccctgga cgtccctgct ccagcttggg ctcggcgagg acgttgcagg tagccgggaa
      121 gcgctgttga atgagaaacc cacgcgtacg gagttcatat ggcaggcttc ctggataact
      181 tccgatggcc ggagtgcgag tgtattgact ggagtgagcg caggaacacg gtagcctccg
      241 tggttgcagg aatcttgttc tttacaggct ggtggataat gatcgatgcg gccgtggtgt
      301 atcctaagcc tgagcaacta aaccacgcct tccacacgtg tggtgtcttc tccacgctgg
      361 ccttcttcat gataaatgct gtatccaatg cccaggtgcg aggtgacagc tatgagagcg
      421 gctgcttagg aagaactgga gctcgggtct ggctcttcat tggtttcatg ctgatgttcg
      481 gatcgcttat cgcctccatg tggatccttt ttggtgcata tgttactcaa aatattgatg
      541 tttaccctgg actagctgtg ttctttcaaa atgcacttat attttttagc actctgatct
      601 acaaattcgg aagaactgaa gagctctggg cctgagatca cctcacacac acctcacctt
      661 cctcttgttc cacgcctagc ttcctttttc tctggtatag tctacatatt gccaaatgaa
      721 gcacatcatg tgctcagagg tttctgtctt catagttttg tgccctgagt tttgaattgc
      781 ttttgaaaat gtctatcttg gtttttcatc aactagacaa gttaatatga tagaatatat
      841 catcactaca tgtacatgat actgaatgtc aggtttttat tcccaagact aagattggtg
      901 agtcctgagc cagggttata ttgtcttggt gttagaggta aatactctga cttggtgtct
      961 ctgaggtttg aaaacgtgca aaatacacag ctctgtgtct ctggaggccc tgagctgtta
     1021 atgaaggcat ttctgccagg tgtaacttac tttggcttag aaatgagttg ttgttttttt
     1081 ttaaaggaaa aatgtttgtg catatgtttt aaagagctgg actttttata tgaagatttt
     1141 ttaaatgccc aaaggactag tttgaaagcc ccctttacaa agaattcctc taacttgact
     1201 tttgcttgag aagggataac acagagataa actccatttt gtggaaagat ggtaggcagc
     1261 tgagccatgt gtccccatct taccaagcta cttcgatgcc cgggtgtcaa ggacggcttg
     1321 ccacaatctg gcattacaca cggcaaggga ccctgctgca ggtgctgtgt agacatggcc
     1381 aagtggaata actagctaag accatcccga agggcgctgt gacctacaga aggtcagacg
     1441 ctcgactcac ttcattctgg actccctctg ctgtctcagg ctctcaggct ctcaggctct
     1501 gggtgacact ccacaccaga cgctccttcc ctgtgtttga cgctgcgctc gcaccgtgta
     1561 tatttctgtg ggcctttccc tggggtcagg attttgtgtt gcacttttaa ccccagagga
     1621 cctttctaag accttgtgct gtaaacagta gtgaggatgg cagtggtgca ccttctgact
     1681 ctggcctcac cttacttagc agttctcaga gaggcccctc caagcacagc gtgtgaagca
     1741 gctgctgatc gctgtgccca ttctgatgca tcttgcttca ctgttttccc gtcagtccct
     1801 caaaaggcca gctttgtctt gcttccagca aactacagag ctaacgacac gtttccattc
     1861 atagaacatg cagtgagtgt ccctctcaca ctgctgaagt taggtgtgtg ggggacgtgg
     1921 acctctcaca cacgctgcag ttaggtgtgg gggacgcaaa acacagcctg gctctgtcca
     1981 ttctcactgt ccaagatgcg ctcataaaca aggagaggac gcactggacc acagcatgcg
     2041 catgcagagg tttatgacgg gtagccctga ggaccgactg gaaatgctgg tggcttcctc
     2101 tctattcatg aattttgttt taattgtgag caaatctgtt gatttcctgt ttgttgtttc
     2161 attaaacaag agagatgaca ttagtatcct catagatatt atgagtcaga attcttggta
     2221 atcatctaaa ttcacacagt tctcttaata aagctctcaa gctcaaaaaa aaaaaaaaaa
     2281 aaaaaaaaa
//
