LOCUS       NM_001012358            2382 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transmembrane protein 41B (Tmem41b), mRNA.
ACCESSION   NM_001012358 XM_341904
VERSION     NM_001012358.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2382)
  AUTHORS   Trimarco,J.D., Heaton,B.E., Chaparian,R.R., Burke,K.N.,
            Binder,R.A., Gray,G.C., Smith,C.M., Menachery,V.D. and Heaton,N.S.
  TITLE     TMEM41B is a host factor required for the replication of diverse
            coronaviruses including SARS-CoV-2
  JOURNAL   PLoS Pathog 17 (5), e1009599 (2021)
   PUBMED   34043740
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2382)
  AUTHORS   Shoemaker,C.J., Huang,T.Q., Weir,N.R., Polyakov,N.J., Schultz,S.W.
            and Denic,V.
  TITLE     CRISPR screening using an expanded toolkit of autophagy reporters
            identifies TMEM41B as a novel autophagy factor
  JOURNAL   PLoS Biol 17 (4), e2007044 (2019)
   PUBMED   30933966
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2382)
  AUTHORS   Van Alstyne,M., Lotti,F., Dal Mas,A., Area-Gomez,E. and
            Pellizzoni,L.
  TITLE     Stasimon/Tmem41b localizes to mitochondria-associated ER membranes
            and is essential for mouse embryonic development
  JOURNAL   Biochem Biophys Res Commun 506 (3), 463-470 (2018)
   PUBMED   30352685
REFERENCE   4  (bases 1 to 2382)
  AUTHORS   Morita,K., Hama,Y., Izume,T., Tamura,N., Ueno,T., Yamashita,Y.,
            Sakamaki,Y., Mimura,K., Morishita,H., Shihoya,W., Nureki,O.,
            Mano,H. and Mizushima,N.
  TITLE     Genome-wide CRISPR screen identifies TMEM41B as a gene required for
            autophagosome formation
  JOURNAL   J Cell Biol 217 (11), 3817-3828 (2018)
   PUBMED   30093494
REFERENCE   5  (bases 1 to 2382)
  AUTHORS   Moretti,F., Bergman,P., Dodgson,S., Marcellin,D., Claerr,I.,
            Goodwin,J.M., DeJesus,R., Kang,Z., Antczak,C., Begue,D.,
            Bonenfant,D., Graff,A., Genoud,C., Reece-Hoyes,J.S., Russ,C.,
            Yang,Z., Hoffman,G.R., Mueller,M., Murphy,L.O., Xavier,R.J. and
            Nyfeler,B.
  TITLE     TMEM41B is a novel regulator of autophagy and lipid mobilization
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30126924
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089866.1.
            
            On Feb 18, 2005 this sequence version replaced XM_341904.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089866.1, FQ228941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..2382
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /note="transmembrane protein 41B"
                     /db_xref="GeneID:361626"
                     /db_xref="RGD:1310870"
     exon            1..243
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..998
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /note="protein stasimon"
                     /codon_start=1
                     /product="transmembrane protein 41B"
                     /protein_id="NP_001012358.1"
                     /db_xref="GeneID:361626"
                     /db_xref="RGD:1310870"
                     /translation="MAKGRVAERSQTEMLHSTPAGDRAVGTQGSAAPGNKDHLKEKPC
                     VEAGSARTSLLILVSIFSCAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVL
                     SKYKDTFYVQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGA
                     SFCYMLSYLVGRPVVYKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINIT
                     SPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLYQLTTAGEAVSWNSVFILMILALLS
                     ILPAIFQKKLKQKFE"
     exon            244..361
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /inference="alignment:Splign:2.1.0"
     exon            362..490
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /inference="alignment:Splign:2.1.0"
     exon            491..584
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /inference="alignment:Splign:2.1.0"
     exon            585..689
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /inference="alignment:Splign:2.1.0"
     exon            690..828
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /inference="alignment:Splign:2.1.0"
     exon            829..2358
                     /gene="Tmem41b"
                     /gene_synonym="RGD1310870"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgtgccg gaagtggctg tgcggtgcgc ccgggtgttg aaaaggaagc tgcgggagga
       61 gctttaatcg ttcaaggggg tgcggcaccg ctgggagctc tttacggccc cctgcagcag
      121 ccatggcgaa aggcagagtc gccgagcgat cgcagaccga gatgctgcac tcgaccccag
      181 cgggggaccg ggcagtgggg acgcagggtt ccgctgctcc aggcaacaaa gatcatctga
      241 aagaaaagcc ttgtgtggaa gctgggtcag caagaacgtc actccttata ctggtgtcca
      301 ttttttcatg tgcagctttt gttatgtttt tggtgtataa aaatttccct cagcttagtg
      361 aggaagagag agtgaatatg aaggttccga gagatatgga tgacgccaag gctctaggaa
      421 aagttctttc caaatataag gacacctttt atgtacaagt attggttgct tattttgcta
      481 catatatttt tctgcaaaca tttgctatcc caggttccat attcctcagt atactctccg
      541 ggtttcttta tcccttccca cttgccttat tccttgtttg cttgtgctct ggacttggtg
      601 cctcattctg ctacatgctc tcctacttag ttggaagacc cgttgtatac aagtacctaa
      661 cagagaaggc agtgaagtgg tcacagcagg tagagcgtca tagagaacat cttattaact
      721 atattatatt tttgagaatc acaccgtttc tgcctaattg gtttattaat attacatctc
      781 ctgtgataaa tgtaccattg aaagtgtttt ttattggcac ttttctaggt gttgcacctc
      841 cctcttttgt agcaattaag gcgggaacaa ctctttatca gctcacaaca gcaggggaag
      901 ctgtatcctg gaactcggta tttattctga tgattttggc tcttctttct attctgccag
      961 ccatcttcca aaaaaaacta aagcagaagt ttgagtgaaa aatcatggct ttttgttcac
     1021 caccaccatc accccagctg ccgacaccac caccatcatc tcaggatcgg caggtgtatt
     1081 cattttatgt tggaaatcat ctcttcagta actgaaagaa ggatttgtaa agtaaaatat
     1141 cccatgagat agataatgca tgtatgtggc acgggagaac agaaattggc atgctatgag
     1201 aagtgctgtc atctgacctg tgagagatac cttccacatc actgttccag gattggctct
     1261 gagacatcat tcatagtggc gtggtttgga attcttactc taaacgattc atttaaagtg
     1321 tttttctcct ttttgtttaa ctaatgacta aaatagtgaa ctcaggtaca gtggaacata
     1381 cttataaccc cagctgctca ggacacttaa ggccagagta ttgctagttt aagaacgtca
     1441 caagacaccc tgtattaaaa taaggaacag tggaattaaa ttaaataaaa attcagagca
     1501 caaactgaat acttgaagca aaaatgagtt tttcattttc tttctctttt cagacagcac
     1561 tttccatagg ccagcgaatg tagcaaggat gggttattta agttttcctt agaaatttgc
     1621 atcatggatt agtctgataa tttgaattct ggccagtctg tttttatcct ttttttttct
     1681 aggttttaca gtatttccac catacatata gaaaaggaga attatatatc tgtatcatat
     1741 tggtgttgat aatgtatatt aagataatga tattttgtta cagtgtcttt attatctcaa
     1801 aaggggttct aaaagtaaat actcaaagca tatacttttt agacattaat tattttatac
     1861 tgaaacaact gacagtagga cattagtgat taaatctagt ttctttgttc caatgactgt
     1921 aaaatttgcc tcagtttttg tctgctcatt aaagaatgta ttgtaattac ctttcatgca
     1981 tgatacatct tcagttgctt tgttgccttt cctctgatgg cctcctttgg ggcagcactt
     2041 gattagtaca ctttcccaac tgcaaagctt ctaccctctc acctcgacat ggtgattggt
     2101 gtctccaccg ttccttggaa gagacttagc tgcttacgta tgtctcctgt tccgtgccag
     2161 gacaaaccac ctgaagcata aagcactatg atcccagttg gcatgtcgaa caattgcttt
     2221 agtggagtgg gaagtcctag tgtttattca aagtctgatc atctcaaagc ctgtttctcc
     2281 tgcaaaatgt ggactaatcc ttttttgtca cagtattaac atgtggatat attacaaata
     2341 caaggaagac aatactgaaa aaaaaaaaaa aaaaaaaaaa aa
//
