LOCUS       NM_021671               3553 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus transmembrane protein 33 (Tmem33), transcript
            variant 1, mRNA.
ACCESSION   NM_021671
VERSION     NM_021671.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3553)
  AUTHORS   Sakabe,I., Hu,R., Jin,L., Clarke,R. and Kasid,U.N.
  TITLE     TMEM33: a new stress-inducible endoplasmic reticulum transmembrane
            protein and modulator of the unfolded protein response signaling
  JOURNAL   Breast Cancer Res Treat 153 (2), 285-297 (2015)
   PUBMED   26268696
REFERENCE   2  (bases 1 to 3553)
  AUTHORS   Urade,T., Yamamoto,Y., Zhang,X., Ku,Y. and Sakisaka,T.
  TITLE     Identification and characterization of TMEM33 as a
            reticulon-binding protein
  JOURNAL   Kobe J Med Sci 60 (3), E57-E65 (2014)
   PUBMED   25612671
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3553)
  AUTHORS   Chi,A., Valencia,J.C., Hu,Z.Z., Watabe,H., Yamaguchi,H.,
            Mangini,N.J., Huang,H., Canfield,V.A., Cheng,K.C., Yang,F., Abe,R.,
            Yamagishi,S., Shabanowitz,J., Hearing,V.J., Wu,C., Appella,E. and
            Hunt,D.F.
  TITLE     Proteomic and bioinformatic characterization of the biogenesis and
            function of melanosomes
  JOURNAL   J Proteome Res 5 (11), 3135-3144 (2006)
   PUBMED   17081065
REFERENCE   4  (bases 1 to 3553)
  AUTHORS   Nakadai,T., Kishimoto,T., Kokura,K., Ohkawa,N., Makino,Y.,
            Muramatsu,M. and Tamura,T.
  TITLE     Cloning of a novel rat gene, DB83, that encodes a putative membrane
            protein
  JOURNAL   DNA Res 5 (5), 315-317 (1998)
   PUBMED   9872456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000252.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_021671.5.
            
            On Feb 10, 2021 this sequence version replaced NM_021671.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006135.1, CK359233.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JACYVU010000252.1  20898601-20898739   c
            140-209             JACYVU010000252.1  20898374-20898443   c
            210-304             JACYVU010000252.1  20895402-20895496   c
            305-492             JACYVU010000252.1  20894782-20894969   c
            493-560             JACYVU010000252.1  20891854-20891921   c
            561-694             JACYVU010000252.1  20890586-20890719   c
            695-778             JACYVU010000252.1  20881081-20881164   c
            779-3553            JACYVU010000252.1  20876509-20879283   c
FEATURES             Location/Qualifiers
     source          1..3553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..3553
                     /gene="Tmem33"
                     /note="transmembrane protein 33"
                     /db_xref="GeneID:59303"
                     /db_xref="RGD:708371"
     exon            1..139
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
     exon            140..209
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..908
                     /gene="Tmem33"
                     /note="isoform 1 is encoded by transcript variant 1; db83"
                     /codon_start=1
                     /product="transmembrane protein 33 isoform 1"
                     /protein_id="NP_067703.1"
                     /db_xref="GeneID:59303"
                     /db_xref="RGD:708371"
                     /translation="MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLP
                     LLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIF
                     VNSYPVTMSIFPVLLFSLLHAATYTKKVLDAKGSNSLPLLRSVLDKLSTNQQNILKFI
                     ACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRNLFNELRIVVEHI
                     IMKPSCPLFVRRLCLQSIAFISRLAPTVA"
     exon            210..304
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
     exon            305..492
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
     exon            493..560
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
     exon            561..694
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
     exon            695..778
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
     exon            779..3553
                     /gene="Tmem33"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaacgaaa ggatcacttc cggttttgca accccgggaa ccggcggcgt cgatcggccc
       61 tttaaggcct tactccgaag ctccgccttc gcttgggtct ttctagaaag gcagctttgg
      121 tctggaccca gcgggacagt gtcccgggct cccgtgtgtc ttccatggcg gatacgaccc
      181 cgaacggccc ccaaggggcg ggcgctgtgc aatttatgat gaccaataag ctggacacag
      241 cgatgtggct gtctcgcctg ttcacagttt attgctccgc tttgttcgtt ctgcctcttc
      301 ttgggttgca tgaagcagca agcttttacc agcgtgcttt gctggccaat gccctgacca
      361 gcgctctgag gctgcatcag agattaccac acttccagtt gagcagagca ttcctggcgc
      421 aggccttgtt agaggacagc tgccactacc tgctgtactc actcatcttc gtcaactcct
      481 acccagttac aatgagtatt ttcccagtct tgttattttc attgcttcat gctgccacat
      541 acactaagaa ggtcctggat gcaaagggtt caaatagttt acctctgttg agatccgtct
      601 tggataaatt aagtactaat caacaaaata ttctgaagtt catcgcttgt aatgaaatat
      661 tcttgatgcc cgctacagtt tttatgctct ttagtggtca aggaagtttg cttcagcctt
      721 ttatatatta tagatttctt actcttcgat attcctctag aagaaatccc tattgtcgga
      781 acttgtttaa cgaactgagg attgttgttg aacacattat catgaaaccc tcctgcccgc
      841 tgtttgtgag aagactgtgt ctccagagca ttgcctttat tagccggctg gcaccaacag
      901 ttgcgtagtt taacatctag ttaagctgtg tttagaagat tagcattatt agctggtaat
      961 tcggataggg gtcctaaatt acaggtctaa cactgacctc agttcaattt acatgattta
     1021 tatcaatgca tctcaagtca aaaataataa ttttcgtggc atgttaaatc aagcctttaa
     1081 cactttgtga ggaaatttta ctgtctatta ctgtcagtgg ttacatgagt tgtgtttagt
     1141 gatgaatgtt cgtacattgt tttagatgct gctgcgccta catcatgaag tacatttatt
     1201 tctttttttt tttttttttt tttttttttt tttttttttg gttctttttt tttttcggcg
     1261 ctggggaccg aacccagggc cttgcgcttc ctaggcaagc gctctaccac tgagctaaat
     1321 ccccaacccc acatttattt cttttaaaaa gaattctgaa attcatttta ccctaactat
     1381 taacccaagt tatgtttgga atgagttcat tatggtaata gatgagttca gtatattttg
     1441 aaactgtatt tttccattct gtaattttgg ttgagatttt aggagaagca catctccctg
     1501 caggttcagt tcacattgta cttgtgctgc tttctaggac aaatgtgttc agcttgcact
     1561 attataaaga agttctgtat gcattttatg acctgttaag ctttcatttc cataaaccat
     1621 ctgtggcttt gaatgatgtt tgaaaagtgg tttgactgta aacctctttt ggattagatc
     1681 tttagggtca tgtaatcatt tactctagac acagagacct actgactaac ttttataaat
     1741 gtcaaccaat agattatcag tgttgcaata aagtgtagaa ctatatagtt ccagaatgtt
     1801 gactttagtt ttcttggttt cttaggcttg aaatttccta gccatgtgca gcagcagttc
     1861 agaggccttt gaaaggatgt gattgaagac agcatgtgat tacacttgta tgttctgaaa
     1921 taatgaagaa tattctgtag attacatgtt tatccagcag atatgattca gagggtttaa
     1981 tggagagggt tatgggtaag gtaattattg gggaatgggc ctggggagta gttgagggga
     2041 gtaatgggtg tttacataga taagttgggg gactgaatgt ataatgcatc tgtgattgag
     2101 actgtataac atggtcaatt ctcttaattg agttcccatc tattccttta taaaagtcat
     2161 tctgatcctt attacttact gttgcatgat tgggagtact taaaacacta cacagtttta
     2221 gtatacagta atgtaatgtg gctttttttt gtacccagtt ctatctgcat gtaatttgga
     2281 tttttcaaat acattcatta gtaacttata atatcagttt tctttgtgtt taagttccta
     2341 atctacagaa aggtgatagt cttggagtag atttccagaa aatactactt gatagcttag
     2401 ctttaaccag ctacttttat atttttgtaa tatttatcca ccaagttgga gaagcaacct
     2461 cataatatcc agtcgatttt tttatgtgtg cctagcctcc ttatcactat gtaatctgat
     2521 ggttttaaaa atacaacttt gggggctggg gatttagctc agtggtagag tgcttaccta
     2581 ggaagcgcaa ggcccagggt tcggtcccca gctccgaaaa aaagaacaaa aaaaaaaaaa
     2641 aatacaactt tgtagagcaa taaagtgact atcttgttat gtaaacatac tgatttctaa
     2701 tgatgtttta aagcattgtc tggaatgaca attgagttat ggcagctaaa gggatattta
     2761 ttttgaaatg tttttttctc ctacattttt ttcccccaat cttggaacat tttagattta
     2821 caacagcttc taaaacagtg ctgagagtgc ctgtgtccct ctttctttcc tatttttata
     2881 ttagtatctt ttaattggta ggacatatat gcaaagaaag atattaacct cagattagct
     2941 aaagtacaaa atgtatttgt atttcaccaa tttttccatt tgtgttgtac gtgtgctgta
     3001 tttgtaccag gattgccttt taagtttcaa ggcctatcaa tgagtttgtt ctttatgata
     3061 attggtccaa aagcttccct tagaagagcc aataatgctg agtttaacaa gaattttttt
     3121 cttaaaactt gtaatttcaa atgtttagtg atataatcaa gactctttaa tgatattgca
     3181 gaatttcgtt tctgataact tgtacttgaa tggaggtgta gatttgtttc ttaaggaaag
     3241 atacagtata taaataatat tctcaagccc atgaaaaggc aaattttata atttgaacat
     3301 tgctagatgt taatttgcat gaagttgtag ttagaaatct taccttctgt gaatatgtac
     3361 agtcagctga tctggagtct gcagttagtg tttccatgta cacctatcaa aaccaggaca
     3421 tagaatggtg cataaagtgt gtgttacgaa ggaatttaac actgtatagc tatgcagttt
     3481 aaaggaagtt gatttaccgt gtagaacatc tagtgcttta gaaacgggaa taaatagtgc
     3541 ttttggtttt aaa
//
